Interactions between CYP2C9 and CYP2C19 in reconstituted binary systems influence their catalytic activity: Possible rationale for the inability of CYP2C19 to catalyze methoxychlor demethylation in human liver microsomes

Drug Metabolism and Disposition

Volumn 33, Issue 1, 2005, Pages 157-164

  Hazai, Eszter ^a   Kupfer, David ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME B5; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 REDUCTASE; DICLOFENAC; LIPID; MEPHENYTOIN; METHOXYCHLOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ARTICLE; CATALYSIS; CONTROLLED STUDY; DEMETHYLATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME PURIFICATION; ENZYME RECONSTITUTION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; HYDROXYLATION; INHIBITION KINETICS; LIVER MICROSOME; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

ARYL HYDROCARBON HYDROXYLASES; CATALYTIC DOMAIN; HUMANS; METHOXYCHLOR; METHYLATION; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES;

EID: 11144328243     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.104.001578     Document Type: Article

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