Synthesis of thieno[2,3-d]pyrimidin-2-ylmethanamine combinatorial library with four diversity points

Journal of Combinatorial Chemistry

Volumn 9, Issue 4, 2007, Pages 661-667

  Bogolubsky, Andrey V ^a   Ryabukhin, Sergey V ^a,b   Stetsenko, Svetlana V ^a   Chupryna, Alexandr A ^a   Volochnyuk, Dmitriy M ^a,c   Tolmachev, Andrey A ^a,b  

^a ENAMINE LTD   (Ukraine)

^b TARAS SHEVCHENKO NATIONAL UNIVERSITY OF KYIV   (Ukraine)

^c INSTITUTE OF ORGANIC CHEMISTRY   (Ukraine)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE; CHLORINE; HYDRAZINE DERIVATIVE; METHANE; PYRIMIDINE; PYRIMIDINE DERIVATIVE; THIOL DERIVATIVE;

ALKYLATION; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; COMBINATORIAL CHEMISTRY; FACTUAL DATABASE; HYDROXYLATION; SYNTHESIS;

ALKYLATION; AMINES; CHLORINE; COMBINATORIAL CHEMISTRY TECHNIQUES; DATABASES, FACTUAL; HYDRAZINES; HYDROXYLATION; METHANE; MOLECULAR STRUCTURE; PYRIMIDINES; SULFHYDRYL COMPOUNDS;

EID: 34547301277     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc070005t     Document Type: Article

References (34)

1. An, H.; Cook, P. D. Chem. Rev. 2000, 100, 3311-3340.
2. Franzen, R. J. J. Comb. Chem. 2000, 2, 195-214.
3. (a) Walter, H. Int. Patent WO 9911631, 1999;
4. Chem. Abstr. 1999, 130, 237580e.
5. (b) Walter, H. Int. Patent WO 9914202, 1999;
6. Chem. Abstr. 1999, 130, 252368k.
7. (c) Aboulwafa, O, M.; Ismail, K. A.; Koreshin, E. A. Farmaco 1992, 47, 631.
8. (d) Chambhare, R. V.; Khadse, B. G.; Bobde, A. S.; Bahekar, R. H. Eur. J. Med. Chem. 2003, 38, 89.
9. (e) Santagati. M.; Modica, M.; Santagati, A.; Russo, F.; Spampinato, S. Pharmazie 1996, 51, 7.
10. (f) Taguchi, M.; Ota, T.; Hatayama, K. Int. Patent WO 9303040, 1993;
11. Chem. Abstr. 1993, 119, 160309m.
12. (g) Shishoo, C. J.; Shirsath, V. S.; Radhod, I. S.; Yande, V. D. Eur. J. Med. Chem. 2000, 35, 351.
13. (h) De Laszlo, S. E.; Patchett, A. A.; Allen, E. E.; Greenlee, W. J. Patent EP 502725, 1992;
14. Chem. Abstr. 1992, 118, 22249v.
15. (a) Ivachtchenko, A.; Kovalenko, S.; Tkachenko, O. V.; Parkhomenko, O. J. Comb. Chem. 2004, 6, 573-583.
16. (a) Jonas, R.; Schelling, P.; Christadler, M.; Beier, N. Int. Patent WO 2002000664, 2002;
17. Chem. Abstr. 2002, 136, 85819.
18. (b) Eiermann, V.; Jonas, R. Patent DE 19944604, 2001; Chem. Abstr. 2001, 134, 237491.
19. (c) Arita, M.; Fukumasu, Y.; Sano, M.; Hoshino, Y; Komatsu, H. U.S. Patent 5124331, 1992.
20. (d) Sohda, T.; Makino, H.; Baba, A. U.S. Patent 5747486, 1998.
21. (e) Coleman, P. J.; Hartman, G. D. Int. Patent WO 2006078574, 2006.
22. (f) Ford, J.; Palmer, N. J.; Atherall, J. F.; Madge, D. J.; Sherborne, B.; Bushfield, M.; Stevens, E. B. Int. Patent WO 2004111057, 2004.
23. (a) Shishoo, C. J.; Devani, M. B.; Bhadti, V. S. Indian Patent IN 151496, 1983;
24. Chem Abstr. 1984, 100, 209858.
25. (b) Shishoo, C. J.; Devani, M. B.; Pathak, U. S.; Ananthan, S.; Bhadti, V. S.; Ullas, G. V.; Jain, K. S.; Rathod, I. S.; Talati, D. S.; Doshi, N. H. J. Heterocyclic Chem. 1984, 21, 375-380.
26. This type of compounds was described recently, see:
27. (a) Shishoo, C. J.; Devani, M. B.; Bhadti, V. S.; Jain, K. S.; Ananthan, S. J. Heterocyclic Chem. 1990, 27, 119-126.
28. (b) Shishoo, C. J.; Devani, M. B.; Bhadti, V. S.; Ananthan, S.; Ullas, G. V. Tetrahedron Lett. 1983, 24, 4611-4612.
29. (c) Sauter, F. Monatsh. Chem. 1968, 99, 2100-2106.
30. Solua, G. J. Org. Chem. 1985, 50, 3717-3721.
31. Mukaiyama, T. Angew. Chem. 1979, 91, 798-812.
32. Lipinski, C. A.; Lombardo, F.; Dominy, B. W.; Feene, P. J. Adv. Drug Delivery Rev. 1997, 23, 3-25.
33. Veber, D. F.; Johnson, S. R.; Cheng, H.-Y.; Smith. B. R.; Ward, K. W.; Kopple. K. D. J. Med. Chem. 2002, 45, 2615-2623.
34. Hann, M. M.; Oprea, T. I. Curr. Opin. Chem. Biol. 2004, 8, 255-263.