Mechanism of substrate recognition and insight into feedback inhibition of homocitrate synthase from Thermus thermophilus

Journal of Biological Chemistry

Volumn 285, Issue 6, 2010, Pages 4195-4205

  Okada, Takuya ^a   Tomita, Takeo ^a   Wulandari, Asri P ^a   Kuzuyama, Tomohisa ^a   Nishiyama, Makoto ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b RIKEN SPring 8 Center   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A; ACETYL-COA; ACTIVE SITE; ALDOL-TYPE CONDENSATION; AMINO ACID BIOSYNTHETIC PATHWAYS; AMINO ACID RESIDUES; BIOSYNTHETIC PATHWAY; CARBOXYL GROUPS; CATALYTIC MECHANISMS; COMPETITIVE INHIBITION; CONFORMATIONAL CHANGE; CONSERVED RESIDUES; END-PRODUCTS; FEEDBACK INHIBITION; HOMOCITRATE SYNTHASE; KETOGLUTARATE; SUBSTRATE RECOGNITION; SUBSTRATE-BINDING SITES; THERMUS THERMOPHILUS;

BINDING ENERGY; BIOSYNTHESIS; CRYSTAL STRUCTURE; ENZYME INHIBITION; ORGANIC ACIDS; SULFUR COMPOUNDS;

AMINO ACIDS;

2 OXOGLUTARIC ACID; ACETYL COENZYME A; AMINO ACID; BACTERIAL ENZYME; CARBOXYL GROUP; HISTAMINE; HOMOCITRATE SYNTHASE; HYDROGEN; LEUCINE; LYSINE; UNCLASSIFIED DRUG; ALPHA-KETOGLUTARIC ACID; BACTERIAL PROTEIN; HISTIDINE; HOMOCITRIC ACID; LYASE; TRICARBOXYLIC ACID;

AMINO ACID ANALYSIS; ARTICLE; CATALYSIS; COMPETITIVE INHIBITION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME SUBSTRATE COMPLEX; ENZYME SYNTHESIS; HYDROGEN BOND; MOLECULAR MECHANICS; MOLECULAR RECOGNITION; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; THERMUS THERMOPHILUS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; FEEDBACK SYSTEM; GENETICS; KINETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY;

THERMUS THERMOPHILUS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BACTERIAL PROTEINS; BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; FEEDBACK, PHYSIOLOGICAL; HISTIDINE; HYDROGEN BONDING; KETOGLUTARIC ACIDS; KINETICS; LEUCINE; LYSINE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OXO-ACID-LYASES; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; THERMUS THERMOPHILUS; TRICARBOXYLIC ACIDS;

EID: 77950508172     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.086330     Document Type: Article

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