Kinetic evidence for interdomain communication in the allosteric regulation of α-isopropylmalate synthase from Mycobacterium tuberculosis

Biochemistry

Volumn 48, Issue 9, 2009, Pages 1996-2004

  De Carvalho, Luiz Pedro S ^a,b   Frantom, Patrick A ^a   Argyrou, Argyrides ^c   Blanchard, John S ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE RESIDUES; ACTIVE SITES; ALLOSTERIC MECHANISMS; ALLOSTERIC REGULATIONS; CATALYTIC DOMAINS; CONFORMATIONAL CHANGES; CRITICAL DETERMINANTS; FEEDBACK INHIBITIONS; INTER-DOMAIN COMMUNICATIONS; KINETIC EVIDENCES; L LEUCINES; MYCOBACTERIUM TUBERCULOSIS; QUATERNARY STRUCTURES; REGULATORY DOMAINS; RIGID BODIES; SIGNAL TRANSMISSIONS; SITE-DIRECTED MUTAGENESIS; STRUCTURAL STUDIES; SYNTHASE;

AMINO ACIDS; ENZYMES; LAWS AND LEGISLATION;

BINDING SITES;

2 ISOPROPYLMALATE SYNTHASE; LEUCINE;

ALLOSTERISM; ARTICLE; CATALYSIS; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME MECHANISM; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL; PROTEIN QUATERNARY STRUCTURE; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

2-ISOPROPYLMALATE SYNTHASE; ALLOSTERIC REGULATION; BACTERIAL PROTEINS; BINDING SITES; CALORIMETRY; CATALYSIS; KINETICS; LEUCINE; MAGNETIC RESONANCE SPECTROSCOPY; MALATES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE; MYCOBACTERIUM TUBERCULOSIS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; TITRIMETRY;

MYCOBACTERIUM TUBERCULOSIS;

EID: 64549143351     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi801707t     Document Type: Article

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