-
1
-
-
0030868897
-
+ T cell homeostasis and function in advanced HIV disease
-
DOI 10.1126/science.277.5322.112
-
Autran, B., Carcelain, G., Li, T. S., Blanc, C., Mathez, D., Tubiana, R., Katlama, C., Debre, P., and Leibowitch, J. (1997) Positive effects of combined antiretroviral therapy on CD4(+) T cell homeostasis and function in advanced HIV disease. Science 277, 112-116. (Pubitemid 27450659)
-
(1997)
Science
, vol.277
, Issue.5322
, pp. 112-116
-
-
Autran, B.1
Carcelain, G.2
Li, T.S.3
Blanc, C.4
Mathez, D.5
Tubiana, R.6
Katlama, C.7
Debre, P.8
Leibowitch, J.9
-
2
-
-
0033576816
-
Efavirenz plus zidovudine and lamivudine, efavirenz plus indinavir, and indinavir plus zidovudine and lamivudine in the treatment of HIV-1 infection in adults. Study 006 Team
-
Staszewski, S., Morales-Ramirez, J., Tashima, K. T., Rachlis, A., Skiest, D., Stanford, J., Stryker, R., Johnson, P., Labriola, D. F., Farina, D., Manion, D. J., and Ruiz, N. M. (1999) Efavirenz plus zidovudine and lamivudine, efavirenz plus indinavir, and indinavir plus zidovudine and lamivudine in the treatment of HIV-1 infection in adults. Study 006 Team. N, Engel. J. Med. 341, 1865-1873.
-
(1999)
N, Engel. J. Med.
, vol.341
, pp. 1865-1873
-
-
Staszewski, S.1
Morales-Ramirez, J.2
Tashima, K.T.3
Rachlis, A.4
Skiest, D.5
Stanford, J.6
Stryker, R.7
Johnson, P.8
Labriola, D.F.9
Farina, D.10
Manion, D.J.11
Ruiz, N.M.12
-
3
-
-
2942620594
-
Proteolytic processing of an HIV-1 pol polyprotein precursor: Insights into the mechanism of reverse transcriptase p66/p51 heterodimer formation
-
Sluis-Cremer, N., Arion, D., Abram, M. E., and. Parniak, M. A. (2004) Proteolytic processing of an HIV-1 pol polyprotein precursor: Insights into the mechanism of reverse transcriptase p66/p51 heterodimer formation. Int. J. Biochem. Cell Biol. 36, 1836-1847.
-
(2004)
Int. J. Biochem. Cell Biol.
, vol.36
, pp. 1836-1847
-
-
Sluis-Cremer, N.1
Arion, D.2
Abram, M.E.3
Parniak, M.A.4
-
4
-
-
0035912717
-
Nonnucleoside reverse transcriptase inhibitors are chemical enhancers of dimerization of the HIV type 1 reverse transcriptase
-
DOI 10.1073/pnas.121055998
-
Tachedjian, G., Orlova, M., Sarafianos, S. G., Arnold, E., and Goff, S. P. (2001) Nonnucleoside reverse transcriptase inhibitors are chemical enhancers of dimerization of the HIV type 1 reverse transcriptase. Proc. Natl. Acad. Sci. U.S.A. 98, 7188-7193. (Pubitemid 32567924)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.13
, pp. 7188-7193
-
-
Tachedjian, G.1
Orlova, M.2
Sarafianos, S.G.3
Arnold, E.4
Goff, S.P.5
-
5
-
-
33644683832
-
Effects of efavirenz binding on the subunit equilibria of HIV-1 reverse transcriptase
-
DOI 10.1021/bi051915z
-
Venezia, C. F., Howard, K. J., Ignatov, M. E., Holladay, L. A., and Barkley, M. D. (2006) Effects of efavirenz binding on the subunit equilibria of HIV-1 reverse transcriptase. Biochemistry 45, 2779-2789. (Pubitemid 43334527)
-
(2006)
Biochemistry
, vol.45
, Issue.9
, pp. 2779-2789
-
-
Venezia, C.F.1
Howard, K.J.2
Ignatov, M.E.3
Holladay, L.A.4
Barkley, M.D.5
-
6
-
-
33646501535
-
Dimerization of human immunodeficiency virus type 1 reverse transcriptase as an antiviral target
-
Srivastava, S., Sluis-Cremer, N., and Tachedjian, G. (2006) Dimerization of human immunodeficiency virus type 1 reverse transcriptase as an antiviral target. Curr. Pharm, Des. 12, 1879-1894.
-
(2006)
Curr. Pharm, Des.
, vol.12
, pp. 1879-1894
-
-
Srivastava, S.1
Sluis-Cremer, N.2
Tachedjian, G.3
-
7
-
-
0033609895
-
A new potent HIV-1 reverse transcriptase inhibitor: A synthetic peptide derived from the interface subunit domains
-
Morris,M.C.,Robert-Hebmann,V.,Chaloin,L.,Mery,J.,Heitz,F.,Devaux,C., Goody,R.S.,andDivita,G.(1999)AnewpotentHIV-1reversetranscriptaseinhibitor. Asyntheticpeptidederivedfromtheinterfacesubunitdomains.J.Biol.Chem.274, 24941-24946.(Pubitemid129529385)
-
(1999)
Journal of Biological Chemistry
, vol.274
, Issue.35
, pp. 24941-24946
-
-
Morris, M.C.1
Robert-Hebmann, V.2
Chaloin, L.3
Mery, J.4
Heitz, F.5
Devaux, C.6
Goody, R.S.7
Divita, G.8
-
8
-
-
0027191463
-
Characterization of the dimerization process of HIV-1 reverse transcriptase heterodimer using intrinsic protein fluorescence
-
Divita, G., Restle, T., and. Goody, R. S. (1993) Characterization of the dimerization process of HIV-1 reverse transcriptase heterodimer using intrinsic protein fluorescence. FEBS Lett. 324, 153-158.
-
(1993)
FEBS Lett.
, vol.324
, pp. 153-158
-
-
Divita, G.1
Restle, T.2
Goody, R.S.3
-
9
-
-
0028308202
-
Inhibition of human immunodeficiency virus type 1 reverse transcriptase dimerization using synthetic peptides derived from the connection domain
-
Divita, G., Restle, T., Goody, R. S., Chermann, J. C., and. Baillon, J. G. (1994) Inhibition of human immunodeficiency virus type 1 reverse transcriptase dimerization using synthetic peptides derived from the connection domain. J. Biol. Chem. 269, 13080-13083.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 13080-13083
-
-
Divita, G.1
Restle, T.2
Goody, R.S.3
Chermann, J.C.4
Baillon, J.G.5
-
10
-
-
33646506098
-
TSAO derivatives, inhibitors of HIV-1 reverse transcriptase dimerization: Recent progress
-
Camarasa, M. J., Velazquez, S., San-Felix, A., Perez-Perez, M. J., Bonache, M. C., and De Castro, S. (2006) TSAO derivatives, inhibitors of HIV-1 reverse transcriptase dimerization: Recent progress. Curr. Pharm. Des. 12, 1895-1907.
-
(2006)
Curr. Pharm. Des.
, vol.12
, pp. 1895-1907
-
-
Camarasa, M.J.1
Velazquez, S.2
San-Felix, A.3
Perez-Perez, M.J.4
Bonache, M.C.5
De Castro, S.6
-
11
-
-
33746948397
-
Structure-activity relationships of [2',5'-bis-O-(tert- butyldimethylsilyl)-β-D-ribofuranosyl]-3'spiro-5"-(4"-amino- 1",2"-oxathiole-2",2"-dioxide)thymine derivatives as inhibitors of HIV-1 reverse transcriptase dimerization
-
Sluis-Cremer, N., Hamamouch, N., San Felix, A., Velazquez, S., Balzarini, J., and Camarasa, M. J. (2006) Structure-activity relationships of [2' ,5'-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]-3'spiro-5"- (4"-amino-1",2"-oxathiole-2",2"-dioxide)thymine derivatives as inhibitors of HIV-1 reverse transcriptase dimerization. J. Med. Chem. 49, 4834-4841.
-
(2006)
J. Med. Chem.
, vol.49
, pp. 4834-4841
-
-
Sluis-Cremer, N.1
Hamamouch, N.2
San Felix, A.3
Velazquez, S.4
Balzarini, J.5
Camarasa, M.J.6
-
12
-
-
13544274130
-
Insight into the mechanism of a peptide inhibitor of HIV reverse transcriptase dimerization
-
DOI 10.1021/bi0484264
-
Depollier, J., Hourdou, M. L., Aldrian-Herrada, G., Rothwell, P., Restle, T., and Divita, G. (2005) Insight into the mechanism of a peptide inhibitor of HIV reverse transcriptase dimerization. Biochemistry. 44, 1909-1918. (Pubitemid 40223620)
-
(2005)
Biochemistry
, vol.44
, Issue.6
, pp. 1909-1918
-
-
Depollier, J.1
Hourdou, M.-L.2
Aldrian-Herrada, G.3
Rothwell, P.4
Restle, T.5
Divita, G.6
-
13
-
-
44049097439
-
Small molecule inhibitors targeting HIV-1 reverse transcriptase dimerization
-
Grohmann, D., Corradi, V., Elbasyouny, M., Baude, A., Horenkamp, F., Laufer, S. D., Manetti, F., Botta, M., and Restle, T. (2008) Small molecule inhibitors targeting HIV-1 reverse transcriptase dimerization. ChemBioChem 9, 916-922.
-
(2008)
. ChemBioChem
, vol.9
, pp. 916-922
-
-
Grohmann, D.1
Corradi, V.2
Elbasyouny, M.3
Baude, A.4
Horenkamp, F.5
Laufer, S.D.6
Manetti, F.7
Botta, M.8
Restle, T.9
-
14
-
-
58649097300
-
A new generation of peptide-based inhibitors targeting HIV-1 reverse transcriptase conformational flexibility
-
Agopian, A., Gros, E., Aldrian-Herrada, G., Bosquet, N., Clayette, P., and. Divita, G. (2009) A new generation of peptide-based inhibitors targeting HIV-1 reverse transcriptase conformational flexibility. J. Biol. Chem. 284, 254-264.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 254-264
-
-
Agopian, A.1
Gros, E.2
Aldrian-Herrada, G.3
Bosquet, N.4
Clayette, P.5
Divita, G.6
-
15
-
-
0027769772
-
Structure/function studies of HIV-1 reverse transcriptase: Dimerization- Defective mutant L289K
-
DOI 10.1021/bi00211a009
-
Goel, R., Beard, W. A., Kumar, A., Casas-Finet, J. R., Strub, M. P., Stahl, S. J., Lewis, M. S., Bebenek, K., Becerra, S. P., and Kunkel, T. A.; et al. (1993) Structure/function studies of HIV-1(1) reverse transcriptase: Dimerization-defective mutant L289K. Biochemistry 32, 13012-13018. (Pubitemid 24005906)
-
(1993)
Biochemistry
, vol.32
, Issue.48
, pp. 13012-13018
-
-
Goel, R.1
Beard, W.A.2
Kumar, A.3
Casas-Finet, J.R.4
Strub, M.-P.5
Stahl, S.J.6
Lewis, M.S.7
Bebenek, K.8
Becerra, S.P.9
Kunkel, T.A.10
Wilson, S.H.11
-
16
-
-
0030008999
-
Alterations to the primer grip of p66 HIV-1 reverse transcriptase and their consequences for template-primer utilization
-
DOI 10.1021/bi952773j
-
Ghosh, M., Jacques, P. S., Rodgers, D. W., Ottman, M., Darlix, J. L., and Le Grice, S. F. (1996) Alterations to the primer grip of p66 HIV-1 reverse transcriptase and their consequences for template-primer utilization. Biochemistry 35, 8553-8562. (Pubitemid 26240189)
-
(1996)
Biochemistry
, vol.35
, Issue.26
, pp. 8553-8562
-
-
Ghosh, M.1
Jacques, P.S.2
Rodgers, D.W.3
Ottman, M.4
Darlix, J.-L.5
Le Grice, S.F.J.6
-
17
-
-
0030859022
-
Kinetic analysis of four HIV-1 reverse transcriptase enzymes mutated in the primer grip region of p66: Implications for DNA synthesis and dimerization
-
DOI 10.1074/jbc.272.28.17581
-
Wohrl, B. M., Krebs, R., Thrall, S. H., Le Grice, S. F., Scheidig, A. J., and Goody, R. S. (1997) Kinetic analysis of four HIV-1 reverse transcriptase enzymes mutated in the primer grip region of p66. Implications for DNA synthesis and dimerization. J. Biol. Chem. 272, 17581-17587. (Pubitemid 27311192)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.28
, pp. 17581-17587
-
-
Wohrl, B.M.1
Krebs, R.2
Thrall, S.H.3
Le Grice, S.F.J.4
Scheidig, A.J.5
Goody, R.S.6
-
18
-
-
0034612275
-
Analysis of mutations and suppressors affecting interactions between the subunits of the HIV type 1 reverse transcriptase
-
DOI 10.1073/pnas.97.12.6334
-
Tachedjian, G., Aronson, H. E., and Goff, S. P. (2000) Analysis of mutations and suppressors affecting interactions between the subunits of the HIV type 1 reverse transcriptase. Proc. Natl. Acad. Sci. U.S.A 97, 6334-6339. (Pubitemid 30412714)
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.12
, pp. 6334-6339
-
-
Tachedjian, G.1
Aronson, H.-E.G.2
Goff, S.P.3
-
19
-
-
0036428535
-
Modulation of the oligomeric structures of HIV-1 retroviral enzymes by synthetic peptides and small molecules
-
DOI 10.1046/j.1432-1033.2002.03216.x
-
Sluis-Cremer, N., and Tachedjian, G. (2002) Modulation of the oligomeric structures of HIV-1 retroviral enzymes by synthetic peptides and small molecules. Eur. J. Biochem, 269, 5103-5111. (Pubitemid 35340819)
-
(2002)
European Journal of Biochemistry
, vol.269
, Issue.21
, pp. 5103-5111
-
-
Sluis-Cremer, N.1
Tachedjian, G.2
-
20
-
-
20244372866
-
The N137 and P140 amino acids in the p51 and the P95 amino acid in the p66 subunit of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase are instrumental to maintain catalytic activity and to design new classes of anti-HIV-1 drugs
-
Auwerx, J., Van Nieuwenhove, J., Rodriguez-Barrios, F., de Castro, S., Velazquez, S., Ceccherini-Silberstein, F., De Clercq, E., Camarasa, M. J., Perno, C. F., Gago, F., and. Baizarini, J. (2005) The N137 and P140 amino acids in the p51 and the P95 amino acid in the p66 subunit of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase are instrumental to maintain catalytic activity and to design new classes of anti-HIV-1 drugs. FERS Lett. 579, 2294-2300.
-
(2005)
FERS Lett.
, vol.579
, pp. 2294-2300
-
-
Auwerx, J.1
Van Nieuwenhove, J.2
Rodriguez-Barrios, F.3
De Castro, S.4
Velazquez, S.5
Ceccherini-Silberstein, F.6
De Clercq, E.7
Camarasa, M.J.8
Perno, C.F.9
Gago, F.10
Baizarini, J.11
-
21
-
-
22444443468
-
The amino acid Asn136 in HIV-1 reverse transcriptase (RT) maintains efficient association of both RT subunits and enables the rational design of novel RT inhibitors
-
DOI 10.1124/mol.105.012435
-
Balzarini, J., Auwerx, J., Rodriguez-Barrios, F., Chedad, A., Farkas, V., Ceccherini-Silberstein, F., Garcia-Aparicio, C., Velazquez, S., De Clercq, E., Perno, C. F., Camarasa, M. J., and Gago, F. (2005) The amino acid Asn 136 in HIV-1 reverse transcriptase (RT) maintains efficient association of both RT subunits and enables the rational design of novel RT inhibitors. Mol. Pharmacol. 68, 49-60. (Pubitemid 41007052)
-
(2005)
Molecular Pharmacology
, vol.68
, Issue.1
, pp. 49-60
-
-
Balzarini, J.1
Auwerx, J.2
Rodriguez-Barrios, F.3
Chedad, A.4
Farkas, V.5
Ceccherini-Silberstein, F.6
Garcia-Aparicio, C.7
Velazquez, S.8
De Clercq, E.9
Perno, C.-F.10
Camarasa, M.-J.11
Gago, F.12
-
22
-
-
19444375120
-
Identification of amino acid residues in the human immunodeficiency virus type-1 reverse transcriptase tryptophan-repeat motif that are required for subunit interaction using infectious virions
-
DOI 10.1016/j.jmb.2005.03.057, PII S0022283605003487
-
Mulky, A., Sarafianos, S. G., Jia, Y., Arnold, E., and Kappes, J. C. (2005) Identification of amino acid residues in the human immunodeficiency virus type-1 reverse transcriptase tryptophan-repeat motif that are required for subunit interaction using infectious virions. J. Mol. Biol. 349, 673-684. (Pubitemid 40725947)
-
(2005)
Journal of Molecular Biology
, vol.349
, Issue.4
, pp. 673-684
-
-
Mulky, A.1
Sarafianos, S.G.2
Jia, Y.3
Arnold, E.4
Kappes, J.C.5
-
23
-
-
33846069355
-
Analysis of Amino Acids in the β7-β8 Loop of Human Immunodeficiency Virus Type 1 Reverse Transcriptase for their Role in Virus Replication
-
DOI 10.1016/j.jmb.2006.10.089, PII S0022283606015178
-
Mulky, A., Vu, B. C., Conway, J. A., Hughes, S. H., and Kappes, J. C. (2007) Analysis of amino acids in the β7-β8 loop of human immunodeficiency virus type 1 reverse transcriptase for their role in virus replication. J. Mol. Biol. 365, 1368-1378. (Pubitemid 46061425)
-
(2007)
Journal of Molecular Biology
, vol.365
, Issue.5
, pp. 1368-1378
-
-
Mulky, A.1
Vu, B.C.2
Conway, J.A.3
Hughes, S.H.4
Kappes, J.C.5
-
24
-
-
23244448649
-
Mutations that abrogate human immunodeficiency virus type 1 reverse transcriptase dimerization affect maturation of the reverse transcriptase heterodimer
-
DOI 10.1128/JVI.79.16.10247-10257.2005
-
Wapling, J., Moore, K. L., Sonza, S., Mak, J., and Tachedjian, G. (2005) Mutations that abrogate human immunodeficiency virus type 1 reverse transcriptase dimerization affect maturation of the reverse transcriptase heterodimer. J. Virol. 79, 10247-10257. (Pubitemid 41098566)
-
(2005)
Journal of Virology
, vol.79
, Issue.16
, pp. 10247-10257
-
-
Wapling, J.1
Moore, K.L.2
Sonza, S.3
Mak, J.4
Tachedjian, G.5
-
25
-
-
41249088246
-
Impact of residues in the nonnucleoside reverse transcriptase inhibitor binding pocket on HIV-1 reverse transcriptase heterodimer stability
-
Figueiredo, A., Zelina, S., Sluis-Cremer, N., and Tachedjian, G. (2008) Impact of residues in the nonnucleoside reverse transcriptase inhibitor binding pocket on HIV-1 reverse transcriptase heterodimer stability. Curr. HIV Res. 130-137.
-
(2008)
Curr. HIV Res.
, pp. 130-137
-
-
Figueiredo, A.1
Zelina, S.2
Sluis-Cremer, N.3
Tachedjian, G.4
-
26
-
-
0035080919
-
Factors affecting the dimerization of the p66 form of HIV-1 reverse transcriptase
-
Cabodevilla, J. F., Odriozola, L., Santiago, E., and. Martinez-Irujo, J. J. (2001) Factors affecting the dimerization of the p66 form of HIV-1 reverse transcriptase. Eur. J. Biochem. 268, 1163-1172.
-
(2001)
Eur. J. Biochem.
, vol.268
, pp. 1163-1172
-
-
Cabodevilla, J.F.1
Odriozola, L.2
Santiago, E.3
Martinez-Irujo, J.J.4
-
27
-
-
0025297454
-
Dimerization of human immunodeficiency virus type 1 reverse transcriptase. A target for chemotherapeutic intervention
-
Restle, T., Muller, B., and. Goody, R. S. (1990) Dimerization of human immunodeficiency virus type 1 reverse transcriptase. A target for chemotherapeutic intervention. J. Biol. Chem. 265, 8986-8988.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 8986-8988
-
-
Restle, T.1
Muller, B.2
Goody, R.S.3
-
28
-
-
0028964233
-
Dimerization kinetics of HIV-1 and HIV-2 reverse transcriptase: A two step process
-
Divita, G., Rittinger, K., Geourjon, C., Deleage, G., and Goody, R. S. (1995) Dimerization kinetics of HIV-1 and HIV-2 reverse transcriptase: A two step process. J. Mol. Biol. 245, 508-521.
-
(1995)
J. Mol. Biol.
, vol.245
, pp. 508-521
-
-
Divita, G.1
Rittinger, K.2
Geourjon, C.3
Deleage, G.4
Goody, R.S.5
-
29
-
-
0029561990
-
Conformational stability of dimeric HIV-1 and HIV-2 reverse transcriptases
-
DOI 10.1021/bi00050a014
-
Divita, G., Rittinger, K., Restle, T., Immendorfer, U., and Goody, R. S. (1995) Conformational stability of dimeric HIV-1 and HIV-2 reverse transcriptases. Biochemistry 34, 16337-16346. (Pubitemid 26006477)
-
(1995)
Biochemistry
, vol.34
, Issue.50
, pp. 16337-16346
-
-
Divita, G.1
Rittinger, K.2
Restle, T.3
Immendorfer, U.4
Goody, R.S.5
-
30
-
-
0034673154
-
Human immunodeficiency virus type 1 reverse transcriptase dimer destabilization by 1-{spiro[4'-amino-2',2'-dioxo- 1',2'-oxathiole-5',3'- [2',5'-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]]}-3-ethylthymine
-
DOI 10.1021/bi991682+
-
Sluis-Cremer, N., Dmitrienko, G. I., Balzarini, J., Camarasa, M. J., and Parniak, M. A. (2000) Human immunodeficiency virus type 1 reverse transcriptase dimer destabilization by 1-[spiro[4″-amino2″,2″-dioxo- 1″,2″-oxathiole-5″,3′-[2″,5″'-bis-O-(tert- butyldimethylsilyl)β-D-ribofuranosyl]]]-3-ethvlthvmine. Biochemistrey 39, 1427-1433. (Pubitemid 30090712)
-
(2000)
Biochemistry
, vol.39
, Issue.6
, pp. 1427-1433
-
-
Sluis-Cremer, N.1
Dmitrienko, G.I.2
Balzarini, J.3
Camarasa, M.-J.4
Parniak, M.A.5
-
31
-
-
11844282799
-
Efavirenz enhances the proteolytic processing of an HIV-1 pol polyprotein precursor and reverse transcriptase homodimer formation
-
DOI 10.1016/j.febslet.2004.11.099, PII S001457930401511X
-
Tachedjian, G., Moore, K. L., Goff, S. P., and Sluis-Cremer, N. (2005) Efavirenz enhances the proteolytic processing of an HIV-1 pol polyprotein precursor and reverse transcriptase homodimer formation. FEBS Lett. 579, 379-384. (Pubitemid 40092415)
-
(2005)
FEBS Letters
, vol.579
, Issue.2
, pp. 379-384
-
-
Tachedjian, G.1
Moore, K.L.2
Goff, S.P.3
Sluis-Cremer, N.4
-
32
-
-
0027441816
-
HIV-1 reverse transcriptase: Polymerization properties of the p51 homodimer compared to the p66/p51 heterodimer
-
Bavand, M. R., Wagner, R., and Richmond, T. J. (1993) HIV-1 reverse transcriptase: Polymerization properties of the p51 homodimer compared to the p66/p51 heterodimer. Biochemistry 32, 10543-10552.
-
(1993)
Biochemistry
, vol.32
, pp. 10543-10552
-
-
Bavand, M.R.1
Wagner, R.2
Richmond, T.J.3
-
33
-
-
0043011942
-
Structure-activity relationships in HIV-1 reverse transcriptase revealed by radiation target analysis
-
DOI 10.1110/ps.03130503
-
Sluis-Cremer, N., Kempner, E., and Parniak, M. A. (2003) Structureactivity relationships in HIV-1 reverse transcriptase revealed by radiation target analysis. Protein Sci., 12, 2081-2086. (Pubitemid 37022829)
-
(2003)
Protein Science
, vol.12
, Issue.9
, pp. 2081-2086
-
-
Sluis-Cremer, N.1
Kempner, E.2
Parniak, M.A.3
-
34
-
-
0034714106
-
Temperature-dependent equilibrium between the open and closed conformation of the p66 subunit of HIV-1 reverse transcriptase revealed by site-directed spin labelling
-
Kensch, O., Restle, T., Wohrl, B. M., Goody, R. S., and Steinhoff, H. J. (2000) Temperature-dependent equilibrium between the open and closed conformation of the p66 subunit of HIV-1 reverse transcriptase revealed by site-directed spin labelling. J. Mol. Biol. 301, 1029-1039.
-
(2000)
J. Mol. Biol.
, vol.301
, pp. 1029-1039
-
-
Kensch, O.1
Restle, T.2
Wohrl, B.M.3
Goody, R.S.4
Steinhoff, H.J.5
-
35
-
-
14844294424
-
Protein production by auto-induction in high density shaking cultures
-
Studier, F. W. (2005) Protein production by auto-induction in high density shaking cultures. Protein Expression Purif. 41, 207-234.
-
(2005)
Protein Expression Purif.
, vol.41
, pp. 207-234
-
-
Studier, F.W.1
-
36
-
-
0024836418
-
Expression and nitrogen-15 labeling of proteins for proton and nitrogen-15 nuclear magnetic resonance
-
Muchmore, D. C., Mcintosh, L. P., Russell, C. B., Anderson, D. E., and Dahlquist, F. W. (1989) Expression and nitrogen-15 labeling of proteins for proton and nitrogen-15 nuclear magnetic resonance. Methods Enzymol. 177, 44-73.
-
(1989)
Methods Enzymol.
, vol.177
, pp. 44-73
-
-
Muchmore, D.C.1
Mcintosh, L.P.2
Russell, C.B.3
Anderson, D.E.4
Dahlquist, F.W.5
-
37
-
-
1442338399
-
High-level expression and purification of untagged and histidine-tagged HIV-1 reverse transcriptase
-
DOI 10.1016/j.pep.2003.10.018
-
Hou, E. W., Prasad, R., Beard, W. A., and Wilson, S. H. (2004) High-level expression and purification of untagged and histidinetagged HIV-1 reverse transcriptase. Protein Expression Purif. 34, 75-86. (Pubitemid 38272315)
-
(2004)
Protein Expression and Purification
, vol.34
, Issue.1
, pp. 75-86
-
-
Hou, E.W.1
Prasad, R.2
Beard, W.A.3
Wilson, S.H.4
-
39
-
-
0029400480
-
NMRPipe: A multidimensional spectral processing system based on UNIX pipes
-
Delaglio, F., Grzesiek, S., Vuister, G. W., Zhu, G., Pfeifer, J., and Bax, A. (1995) NMRPipe: A multidimensional spectral processing system based on UNIX pipes. J. Biomol. NMR 6, 277-293.
-
(1995)
J. Biomol. NMR
, vol.6
, pp. 277-293
-
-
Delaglio, F.1
Grzesiek, S.2
Vuister, G.W.3
Zhu, G.4
Pfeifer, J.5
Bax, A.6
-
40
-
-
34249765651
-
Nmr view: A computer program for the visualization and analysis of Nmr data
-
Johnson, B. A., and. Blevins, R. A. (1994) Nmr View: A Computer Program for the Visualization and Analysis of Nmr Data. J. Biomol. NMR 4, 603-614.
-
(1994)
J. Biomol. NMR
, vol.4
, pp. 603-614
-
-
Johnson, B.A.1
Blevins, R.A.2
-
41
-
-
0141484613
-
PRIMUS: A Windows PC-based system for small-angle scattering data analysis
-
Konarev, P. V., Volkov, V. V., Sokolova, A. V., Koch, M. H. J., and Svergun, D. I. (2003) PRIMUS: A Windows PC-based system for small-angle scattering data analysis. J. Appl. Crystallogr. 36, 1277-1282.
-
(2003)
J. Appl. Crystallogr.
, vol.36
, pp. 1277-1282
-
-
Konarev, P.V.1
Volkov, V.V.2
Sokolova, A.V.3
Koch, M.H.J.4
Svergun, D.I.5
-
42
-
-
0029185933
-
CRYSOL - A program to evaluate X-ray solution scattering of biological macromolecules from atomic coordinates
-
DOI 10.1107/S0021889895007047
-
Svergun, D., Barberato, C., and Koch, M. H. J. (1995) CRYSOL: A program to evaluate X-ray solution scattering of biological macromolecules from atomic coordinates. J. Appl. Crystallogr. 28, 768-773. (Pubitemid 3014671)
-
(1995)
Journal of Applied Crystallography
, vol.28
, Issue.6
, pp. 768-773
-
-
Svergun, D.1
Barberato, C.2
Koch, M.H.3
-
43
-
-
36849047420
-
Crystal structures of HIV-1 reverse transcriptase complexes with thiocarbamate non-nucleoside inhibitors
-
DOI 10.1016/j.bbrc.2007.11.036, PII S0006291X07024461
-
Spallarossa, A., Cesarini, S., Ranise, A., Ponassi, M., Unge, T., and Bolognesi, M. (2008) Crystal structures of HIV-1 reverse transcriptase complexes with thiocarbamate non-nucleoside inhibitors. Biochem. Biophys. Res. Commun. 365, 764-770. (Pubitemid 350234856)
-
(2008)
Biochemical and Biophysical Research Communications
, vol.365
, Issue.4
, pp. 764-770
-
-
Spallarossa, A.1
Cesarini, S.2
Ranise, A.3
Ponassi, M.4
Unge, T.5
Bolognesi, M.6
-
44
-
-
50849105061
-
Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design
-
Bauman, J. D., Das, K., Ho, W. C., Baweja, M., Himmel, D. M., Clark, A. D., Oren, D. A., Boyer, P. L., Hughes, S. H., Shatkin, A. J., and Arnold, E. (2008) Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design. Nucleic Acids Res. 36, 5083-5092.
-
(2008)
Nucleic Acids Res.
, vol.36
, pp. 5083-5092
-
-
Bauman, J.D.1
Das, K.2
Ho, W.C.3
Baweja, M.4
Himmel, D.M.5
Clark, A.D.6
Oren, D.A.7
Boyer, P.L.8
Hughes, S.H.9
Shatkin, A.J.10
Arnold, E.11
-
45
-
-
0028360742
-
Structural basis of asymmetry in the human immunodeficiency virus type 1 reverse transcriptase heterodimer
-
DOI 10.1073/pnas.91.15.7242
-
Wang, J., Smerdon, S. J., Jager, J., Kohlstaedt, L. A., Rice, P. A., Friedman, J. M., and Steitz, T. A. (1994) Structural basis of asymmetry in the human immunodeficiency virus type 1 reverse transcriptase heterodimer. Proc. Natl. Acad. Sci. U.S.A. 91, 7242-7246. (Pubitemid 24226839)
-
(1994)
Proceedings of the National Academy of Sciences of the United States of America
, vol.91
, Issue.15
, pp. 7242-7246
-
-
Wang, J.1
Smerdon, S.J.2
Jager, J.3
Kohlstaedt, L.A.4
Rice, P.A.5
Friedman, J.M.6
Steitz, T.A.7
-
46
-
-
0028271687
-
Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1
-
Smerdon,S.J.,Jager,J.,Wang,J.,Kohlstaedt,L.A.,Chirino,A.J.,Friedman,J.M., Rice,P.A.,andSteitz,T.A.(1994) Structureofthebindingsitefornonnucleosideinhibitorsofthereversetranscriptaseofh umanimmunodeficiencyvirustype1.Proc.Natl.Acad.Sci.U.S.A.91,3911-3915. (Pubitemid24139542)
-
(1994)
Proceedings of the National Academy of Sciences of the United States of America
, vol.91
, Issue.9
, pp. 3911-3915
-
-
Smerdon, S.J.1
Jager, J.2
Wang, J.3
Kohlstaedt, L.A.4
Chirino, A.J.5
Friedman, J.M.6
Rice, P.A.7
Steitz, T.A.8
-
47
-
-
0028947588
-
High resolution structures of HIV-1 RT from four RT-inhibitor complexes
-
Ren, J., Esnouf, R., Garman, E., Somers, D., Ross, C., Kirby, I., Keeling, J., Darby, G., Jones, Y., and Stuart, D.; et al. (1995) High resolution structures of HIV-1 RT from four RT-inhibitor complexes. Nat. Struct. Biol. 2, 293-302.
-
(1995)
Nat. Struct. Biol.
, vol.2
, pp. 293-302
-
-
Ren, J.1
Esnouf, R.2
Garman, E.3
Somers, D.4
Ross, C.5
Kirby, I.6
Keeling, J.7
Darby, G.8
Jones, Y.9
Stuart, D.10
-
48
-
-
0025344721
-
Stabilization and activation of recombinant human immunodeficiency virus-1 reverse transcriptase-P66
-
Rowley, G. L., Ma, Q. F., Bathurst, I. C., Barr, P. J., and Kenyon, G. L. (1990) Stabilization and activation of recombinant human immunodeficiency virus-1 reverse transcriptase-P66. Biochem, Bio- phys. Res. Commun. 167, 673-679.
-
(1990)
Biochem, Bio- Phys. Res. Commun.
, vol.167
, pp. 673-679
-
-
Rowley, G.L.1
Ma, Q.F.2
Bathurst, I.C.3
Barr, P.J.4
Kenyon, G.L.5
-
49
-
-
69249097475
-
Therapeutic potential of peptide motifs against HIV-1 reverse transcriptase and integrase
-
Andreola, M. L. (2009) Therapeutic potential of peptide motifs against HIV-1 reverse transcriptase and integrase. Curr. Pharm, Des. 15, 2508-2519.
-
(2009)
Curr. Pharm, Des.
, vol.15
, pp. 2508-2519
-
-
Andreola, M.L.1
-
50
-
-
0032518621
-
P66/p51 and p51/p51 recombinant forms of reverse transcriptase from human immunodeficiency virus type 1 - Interactions with primer tRNA(Lys3), initiation of cDNA synthesis, and effect of inhibitors
-
DOI 10.1046/j.1432-1327.1998.2510487.x
-
Dufour, E., El Dirani-Diab, R., Boulme, F., Fournier, M., Nevinsky, G., Tarrago-Litvak, L., Litvak, S., and Andreola, M. L. (1998) p66/ p51 and p51/p51 recombinant forms of reverse transcriptase from human immunodeficiency virus type 1: Interactions with primer tRNA(Lys3), initiation of cDNA synthesis, and effect of inhibitors. Eur. J. Biochem, 251, 487-495. (Pubitemid 28080951)
-
(1998)
European Journal of Biochemistry
, vol.251
, Issue.1-2
, pp. 487-495
-
-
Dufour, E.1
El Dirani-Diab, R.2
Boulme, F.3
Fournier, M.4
Nevinsky, G.5
Tarrago-Litvak, L.6
Litvak, S.7
Andreola, M.-L.8
-
51
-
-
0026693137
-
Crystal-Structure at 3.5 Angstrom Resolution of HIV-1 Reverse-Transcriptase Complexed with an Inhibitor
-
Kohlstaedt, L. A., Wang, J., Friedman, J. M., Rice, P. A., and Steitz, T. A. (1992) Crystal-Structure at 3.5 Angstrom Resolution of HIV-1 Reverse-Transcriptase Complexed with an Inhibitor. Science 256, 1783-1790.
-
(1992)
Science
, vol.256
, pp. 1783-1790
-
-
Kohlstaedt, L.A.1
Wang, J.2
Friedman, J.M.3
Rice, P.A.4
Steitz, T.A.5
-
52
-
-
0035965124
-
Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors
-
DOI 10.1006/jmbi.2001.4988
-
Ren, J., Nichols, C., Bird, L., Chamberlain, P., Weaver, K., Short, S., Stuart, D. I., and Stammers, D. K. (2001) Structural mechanisms of drug resistance for mutations at codons 181 and. 188 in HIV-1 reverse transcriptase and the improved resilience of second generation nonnucleoside inhibitors. J. Mol. Biol. 312, 795-805. (Pubitemid 33116741)
-
(2001)
Journal of Molecular Biology
, vol.312
, Issue.4
, pp. 795-805
-
-
Ren, J.1
Nichols, C.2
Bird, L.3
Chamberlain, P.4
Weaver, K.5
Short, S.6
Stuart, D.I.7
Stammers, D.K.8
-
53
-
-
0036776359
-
Crystal structures of zidovudine- Or lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215
-
Chamberlain, P. P., Ren, J., Nichols, C. E., Douglas, L., Lennerstrand, J., Larder, B. A., Stuart, D. I., and. Stammers, D. K. (2002) Crystal structures of zidovudine- or lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215. J. Virol. 76, 10015-10019.
-
(2002)
J. Virol.
, vol.76
, pp. 10015-10019
-
-
Chamberlain, P.P.1
Ren, J.2
Nichols, C.E.3
Douglas, L.4
Lennerstrand, J.5
Larder, B.A.6
Stuart, D.I.7
Stammers, D.K.8
-
54
-
-
70349776272
-
Kinetics of association and dissociation of HIV-1 reverse transcriptase subunits
-
Veneria, C. F., Meany, B. J., Braz, V. A., and Barkley, M. D. (2009) Kinetics of association and dissociation of HIV-1 reverse transcriptase subunits. Biochemistry. 48, 9084-9093.
-
(2009)
Biochemistry.
, vol.48
, pp. 9084-9093
-
-
Veneria, C.F.1
Meany, B.J.2
Braz, V.A.3
Barkley, M.D.4
-
55
-
-
0037469137
-
Solution structure of the RNase H domain of the HIV-1 reverse transcriptase in the presence of magnesium
-
DOI 10.1021/bi0204894
-
Pari, K., Mueller, G. A., DeRose, E. F., Kirby, T. W., and London, R. E. (2003) Solution structure of the RN'ase H domain of the HIV-1 reverse transcriptase in the presence of magnesium. Biochemistry. 42, 639-650. (Pubitemid 36133288)
-
(2003)
Biochemistry
, vol.42
, Issue.3
, pp. 639-650
-
-
Pari, K.1
Mueller, G.A.2
Derose, E.F.3
Kirby, T.W.4
London, R.E.5
-
56
-
-
0024231976
-
HIV-1 reverse transcriptase: Crystallization and analysis of domain structure by limited proteolysis
-
Lowe, D. M., Aitken, A., Bradley, C., Darby, G. K., Larder, B. A., Powell, K. L., Purifoy, D. J., Tisdale, M., and Stammers, D. K. (1988) HIV-1 reverse transcriptase: Crystallization and analysis of domain structure by limited proteolysis. Biochemistry 27, 8884-8889.
-
(1988)
Biochemistry
, vol.27
, pp. 8884-8889
-
-
Lowe, D.M.1
Aitken, A.2
Bradley, C.3
Darby, G.K.4
Larder, B.A.5
Powell, K.L.6
Purifoy, D.J.7
Tisdale, M.8
Stammers, D.K.9
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