Insight into the mechanism of a peptide inhibitor of HIV reverse transcriptase dimerization

Biochemistry

Volumn 44, Issue 6, 2005, Pages 1909-1918

  Depollier, Julien ^a   Hourdou, Marie Laure ^a   Aldrian Herrada, Gudrun ^a   Rothwell, Paul ^b   Restle, Tobias ^c   Divita, Gilles ^a  

^a Centre National de la Recherche Scientifique   (France)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c Institut fuer Molekulare Medizin   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BIODIVERSITY; DIMERIZATION; MECHANISMS; RESIDUAL FUELS; STABILIZATION;

ANTIVIRAL; HETERODIMERS; HUMAN IMMUNODEFICIENCY VIRUS (HIV); REVERSE TRANSCRIPTASE (RT);

VIRUSES;

ANTIVIRUS AGENT; PEP 7; PEPTIDE DERIVATIVE; PHENYLALANINE; PROTEIN; PROTEIN P51; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; TRYPTOPHAN; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; DIMERIZATION; DRUG DESIGN; DRUG MECHANISM; DRUG TARGETING; ENZYME CONFORMATION; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; VIRUS INFECTION;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANTI-HIV AGENTS; ANTIVIRAL AGENTS; DIMERIZATION; ENZYME STABILITY; HIV-1 REVERSE TRANSCRIPTASE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OLIGOPEPTIDES; PHENYLALANINE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; TRYPTOPHAN; VIRAL PROTEINS;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 13544274130     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0484264     Document Type: Article

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