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Volumn 251, Issue 1-2, 1998, Pages 487-495

p66/p51 and p51/p51 recombinant forms of reverse transcriptase from human immunodeficiency virus type 1 - Interactions with primer tRNA(Lys3), initiation of cDNA synthesis, and effect of inhibitors

Author keywords

Cross linking; Human immunodeficiency virus type 1; Non nucleoside reverse transcriptase inhibitor; Primer tRNA(Lys3); Reverse transcriptase p66 p51 and p51 p51

Indexed keywords

COMPLEMENTARY DNA; RECOMBINANT ENZYME; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; TRANSFER RNA;

EID: 0032518621     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1998.2510487.x     Document Type: Article
Times cited : (23)

References (48)
  • 5
    • 0030047819 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 reverse transcriptase and early events in reverse transcription
    • Arts, E. J. & Wainberg, M. A. (1996a) Human immunodeficiency virus type 1 reverse transcriptase and early events in reverse transcription, Adv. Virus Res. 46, 97-163.
    • (1996) Adv. Virus Res. , vol.46 , pp. 97-163
    • Arts, E.J.1    Wainberg, M.A.2
  • 6
    • 0029912274 scopus 로고    scopus 로고
    • Mechanisms of nucleoside analog antiviral activity and resistance during human immunodeficiency virus reverse transcription
    • Arts, E. J. & Wainberg, M. A. (1996b) Mechanisms of nucleoside analog antiviral activity and resistance during human immunodeficiency virus reverse transcription. Antimicrob. Agents Chemotherapy 40, 527-540.
    • (1996) Antimicrob. Agents Chemotherapy , vol.40 , pp. 527-540
    • Arts, E.J.1    Wainberg, M.A.2
  • 8
    • 0026100895 scopus 로고
    • Interaction of H1V-1 reverse transcriptase with a synthetic form of its replication primer
    • Barat, C., Le Grice, S. F. J. & Darlix, J. L. (1991) Interaction of H1V-1 reverse transcriptase with a synthetic form of its replication primer, Nucleic Acids Res. 19, 751-757.
    • (1991) Nucleic Acids Res. , vol.19 , pp. 751-757
    • Barat, C.1    Le Grice, S.F.J.2    Darlix, J.L.3
  • 10
    • 0026527228 scopus 로고
    • Identification of the primer binding domain of human immunodeficiency virus reverse transcriptase
    • Basu, A., Ahluwalia, K. K., Basu, S. & Modak, M. J. (1992) Identification of the primer binding domain of human immunodeficiency virus reverse transcriptase, Biochemistry 31, 616-623.
    • (1992) Biochemistry , vol.31 , pp. 616-623
    • Basu, A.1    Ahluwalia, K.K.2    Basu, S.3    Modak, M.J.4
  • 11
    • 0027441816 scopus 로고
    • HIV-1 reverse transcriptase: Polymerization properties of the p51 homodimer compared to the p66/p51 heterodimer
    • Bavand, M. R., Wagner, R. & Richmond, T. J. (1993) HIV-1 reverse transcriptase: polymerization properties of the p51 homodimer compared to the p66/p51 heterodimer, Biochemistry 32, 10543-10552.
    • (1993) Biochemistry , vol.32 , pp. 10543-10552
    • Bavand, M.R.1    Wagner, R.2    Richmond, T.J.3
  • 13
    • 0018125212 scopus 로고
    • Reactions at the termini of tRNA with T4 RNA ligase
    • Bruce, A. G. & Uhlenbeck, O. C. (1978) Reactions at the termini of tRNA with T4 RNA ligase, Nucleic Acids Res. 5, 3665-3677.
    • (1978) Nucleic Acids Res. , vol.5 , pp. 3665-3677
    • Bruce, A.G.1    Uhlenbeck, O.C.2
  • 14
    • 0029585377 scopus 로고
    • First glimpses at structure-function relationships of the nucleocapsid protein of retroviruses
    • Darlix, J.-L., Lapadat-Tapolsky, M., De Rocquigny, H. & Roques, B. P. (1995) First glimpses at structure-function relationships of the nucleocapsid protein of retroviruses. J. Mol. Biol. 254, 523-537.
    • (1995) J. Mol. Biol. , vol.254 , pp. 523-537
    • Darlix, J.-L.1    Lapadat-Tapolsky, M.2    De Rocquigny, H.3    Roques, B.P.4
  • 15
    • 0029775166 scopus 로고    scopus 로고
    • What can be expected from non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the treatment of HIV-1 infections?
    • De Clercq, E. (1996) What can be expected from non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the treatment of HIV-1 infections? Rev. Med. Virol. 6, 97-117.
    • (1996) Rev. Med. Virol. , vol.6 , pp. 97-117
    • De Clercq, E.1
  • 16
    • 0028877325 scopus 로고
    • A new series of pyridone derivatives as potent non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors
    • Dollé, V., Fan, E., Nguyen, C. H., Aubertin, A. M., Kirn, A., Andreola, M. L., Jamieson, G., Tarrago-Litvak, L. & Bisagni, E. (1995) A new series of pyridone derivatives as potent non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors. J. Med. Chem. 38, 4679-4686.
    • (1995) J. Med. Chem. , vol.38 , pp. 4679-4686
    • Dollé, V.1    Fan, E.2    Nguyen, C.H.3    Aubertin, A.M.4    Kirn, A.5    Andreola, M.L.6    Jamieson, G.7    Tarrago-Litvak, L.8    Bisagni, E.9
  • 17
    • 0026602859 scopus 로고
    • Biochemical characterization of the p51 subunit of human immunodeficiency virus reverse transcriptase in homo-and heterodimeric recombinant forms of the enzyme
    • El Dirani-Diab, R., Andreola, M. L., Nevinsky, G., Tharaud, D., Barr, P. J., Litvak, S. & Tarrago-Litvak, L. (1992) Biochemical characterization of the p51 subunit of human immunodeficiency virus reverse transcriptase in homo-and heterodimeric recombinant forms of the enzyme, FEBS Lett. 301, 23-28.
    • (1992) FEBS Lett. , vol.301 , pp. 23-28
    • El Dirani-Diab, R.1    Andreola, M.L.2    Nevinsky, G.3    Tharaud, D.4    Barr, P.J.5    Litvak, S.6    Tarrago-Litvak, L.7
  • 18
    • 0342524024 scopus 로고
    • Expression of soluble, enzymatically active, human immunodeficiency virus reverse transcriptase in Escherichia coli and analysis of mutants
    • Hizi, A., McGill, C. & Hughes, S. H. (1988) Expression of soluble, enzymatically active, human immunodeficiency virus reverse transcriptase in Escherichia coli and analysis of mutants, Proc. Natl Acad. Sci. USA 85, 1218-1222.
    • (1988) Proc. Natl Acad. Sci. USA , vol.85 , pp. 1218-1222
    • Hizi, A.1    McGill, C.2    Hughes, S.H.3
  • 19
    • 0026519216 scopus 로고
    • Reverse transcriptase of human immunodeficiency virus type 1 : Functionality of subunits of the heterodimer in DNA synthesis
    • Hostomsky, Z., Hostomska, Z., Fu, T. B. & Taylor, J. (1992) Reverse transcriptase of human immunodeficiency virus type 1 : functionality of subunits of the heterodimer in DNA synthesis, J. Virol. 66, 3179-3182.
    • (1992) J. Virol. , vol.66 , pp. 3179-3182
    • Hostomsky, Z.1    Hostomska, Z.2    Fu, T.B.3    Taylor, J.4
  • 21
    • 0028096227 scopus 로고
    • Modulation of HIV-1 reverse transcriptase function in 'selectively deleted' p66/p51 heterodimers
    • Jacques, P. S., Wöhrl, B. M., Howard, K. J. & Le Grice, S. F. J. (1994) Modulation of HIV-1 reverse transcriptase function in 'selectively deleted' p66/p51 heterodimers, J. Biol. Chem. 269, 1388-1393.
    • (1994) J. Biol. Chem. , vol.269 , pp. 1388-1393
    • Jacques, P.S.1    Wöhrl, B.M.2    Howard, K.J.3    Le Grice, S.F.J.4
  • 22
    • 0027166763 scopus 로고
    • Identification of tRNAs incorporated into wildtype and mutant human immunodeficiency virus type 1
    • Jiang, M., Mak, J., Ladha, A., Cohen, E., Klein, M., Rovinski, B. & Kleiman, L. (1993) Identification of tRNAs incorporated into wildtype and mutant human immunodeficiency virus type 1, J. Virol. 67, 3246-3253.
    • (1993) J. Virol. , vol.67 , pp. 3246-3253
    • Jiang, M.1    Mak, J.2    Ladha, A.3    Cohen, E.4    Klein, M.5    Rovinski, B.6    Kleiman, L.7
  • 23
    • 0026693137 scopus 로고
    • Crystal structure at 3.5 Å resolution of HIV-1 reverse transcriptase complexed with an inhibitor
    • Kohlstaedt, L. A., Wang, J., Friedman, J. M., Rice, P. A. & Steitz, T. A. (1992) Crystal structure at 3.5 Å resolution of HIV-1 reverse transcriptase complexed with an inhibitor, Science 256, 1783-1790.
    • (1992) Science , vol.256 , pp. 1783-1790
    • Kohlstaedt, L.A.1    Wang, J.2    Friedman, J.M.3    Rice, P.A.4    Steitz, T.A.5
  • 25
    • 0026070438 scopus 로고
    • Subunit-selective mutagenesis indicates minimal polymerase activity in heterodimer-associated p51 HIV-1 reverse transcriptase
    • Le Grice, S. F. J., Naas, T., Wohlgensinger, B & Schatz, O. (1991) Subunit-selective mutagenesis indicates minimal polymerase activity in heterodimer-associated p51 HIV-1 reverse transcriptase. EMBO J. 10, 3905-3911.
    • (1991) EMBO J. , vol.10 , pp. 3905-3911
    • Le Grice, S.F.J.1    Naas, T.2    Wohlgensinger, B.3    Schatz, O.4
  • 27
    • 0003939772 scopus 로고    scopus 로고
    • Retroviral reverse transcriptases
    • Landes, R., ed. Chapman & Hall, New York/Springer Verlag, Heidelberg
    • Litvak, S. (1996) Retroviral reverse transcriptases, in Molecular biology intelligency unit series (Landes, R., ed.) pp. 1-206, Chapman & Hall, New York/Springer Verlag, Heidelberg.
    • (1996) Molecular Biology Intelligency Unit Series , pp. 1-206
    • Litvak, S.1
  • 29
    • 0023775755 scopus 로고
    • Studies on the mechanism of human immunodeficiency virus reverse transcriptase: Steady-state kinetics, processivity and polynucleotide inhibition
    • Majumdar, C., Abbotts, J., Broder, S. & Wilson, S. H. (1988) Studies on the mechanism of human immunodeficiency virus reverse transcriptase: steady-state kinetics, processivity and polynucleotide inhibition, J. Biol. Chem. 263, 15657-15665.
    • (1988) J. Biol. Chem. , vol.263 , pp. 15657-15665
    • Majumdar, C.1    Abbotts, J.2    Broder, S.3    Wilson, S.H.4
  • 32
    • 0029061471 scopus 로고
    • Lys3 to reverse transcriptase from human immunodeficiency virus type 1
    • Lys3 to reverse transcriptase from human immunodeficiency virus type 1, EMBO J. 14, 2679-2687.
    • (1995) EMBO J. , vol.14 , pp. 2679-2687
    • Mishima, Y.1    Steitz, J.2
  • 34
    • 0028842534 scopus 로고
    • Lys to reverse transcriptase of human immunodeficiency virus type 1
    • Lys to reverse transcriptase of human immunodeficiency virus type 1, J. Biol. Chem. 270, 23867-23874.
    • (1995) J. Biol. Chem. , vol.270 , pp. 23867-23874
    • Oude-Essink, B.1    Das, A.T.2    Berkhout, B.3
  • 35
    • 0025297454 scopus 로고
    • Dimerisation of human immunodeficiency virus type 1 reverse transcriptase
    • Restle, T., Müller, B. & Goody, R. S. (1990) Dimerisation of human immunodeficiency virus type 1 reverse transcriptase, J. Biol. Chem. 265, 8986-8988.
    • (1990) J. Biol. Chem. , vol.265 , pp. 8986-8988
    • Restle, T.1    Müller, B.2    Goody, R.S.3
  • 38
    • 0021111237 scopus 로고
    • 2] complex - Reluctance in binding to Watson-Crick base pairs within double helix
    • 2] complex - reluctance in binding to Watson-Crick base pairs within double helix, Nucleic Acids Res. 11, 6571-6586.
    • (1983) Nucleic Acids Res. , vol.11 , pp. 6571-6586
    • Rubin, J.R.1    Sabat, M.2    Sundaralingam, M.3
  • 41
    • 0026315090 scopus 로고
    • Localization of a polynucleotide binding region in the HIV-1 reverse transcriptase: Implications for primer binding
    • Sobol, R. W., Suhadolnik, R. J., Kumar, A., Lee, B. J., Hatfield, D. L. & Wilson, S. H. (1991) Localization of a polynucleotide binding region in the HIV-1 reverse transcriptase: Implications for primer binding, Biochemistry 30, 10623-10631.
    • (1991) Biochemistry , vol.30 , pp. 10623-10631
    • Sobol, R.W.1    Suhadolnik, R.J.2    Kumar, A.3    Lee, B.J.4    Hatfield, D.L.5    Wilson, S.H.6
  • 42
    • 0023886222 scopus 로고
    • Enzyme activity gel analysis of human immunodeficiency virus reverse transcriptase
    • Starnes, M. C., Gao, W., Ting, R. Y. C. & Cheng, Y.-C. ( 1988) Enzyme activity gel analysis of human immunodeficiency virus reverse transcriptase, J. Biol. Chem. 263, 5132-5134.
    • (1988) J. Biol. Chem. , vol.263 , pp. 5132-5134
    • Starnes, M.C.1    Gao, W.2    Ting, R.Y.C.3    Cheng, Y.-C.4
  • 43
    • 0029880341 scopus 로고    scopus 로고
    • Evaluation of human immunodeficiency virus type 1 reverse transcriptase primer tRNA binding by fluorescence spectroscopy : Specificity and comparison to primer/template binding
    • Thrall, S. H., Reinstein, J., Wöhrl, B. & Goody, R. S. (1996) Evaluation of human immunodeficiency virus type 1 reverse transcriptase primer tRNA binding by fluorescence spectroscopy : specificity and comparison to primer/template binding, Biochemistry 35, 4609-4618.
    • (1996) Biochemistry , vol.35 , pp. 4609-4618
    • Thrall, S.H.1    Reinstein, J.2    Wöhrl, B.3    Goody, R.S.4
  • 44
    • 0023788116 scopus 로고
    • Characterization of human immunodeficiency virus type 1 reverse transcriptase by using monoclonal antibodies: Role of the C-terminus in antibody reactivity and enzyme function
    • Tisdale, M., Ertl, P., Larder, B. A., Purifoy, D. J. M., Darby, G., & Powell, K. L. (1988) Characterization of human immunodeficiency virus type 1 reverse transcriptase by using monoclonal antibodies: role of the C-terminus in antibody reactivity and enzyme function, J. Virol. 62, 3662-3667.
    • (1988) J. Virol. , vol.62 , pp. 3662-3667
    • Tisdale, M.1    Ertl, P.2    Larder, B.A.3    Purifoy, D.J.M.4    Darby, G.5    Powell, K.L.6
  • 45
    • 0026606124 scopus 로고
    • Lys3(SUU) interact with HIV-1 reverse transcriptase and serve as specific primers for retroviral cDNA synthesis
    • Lys3(SUU) interact with HIV-1 reverse transcriptase and serve as specific primers for retroviral cDNA synthesis, Gene (Amst.) 111, 183-197.
    • (1992) Gene (Amst.) , vol.111 , pp. 183-197
    • Weiss, S.1    König, B.2    Müller, H.-J.3    Seidel, H.4    Goody, R.S.5
  • 46
    • 0026474681 scopus 로고
    • Recombinant HIV-1 nucleocapsid protein produces as a fusion protein with glutathione S-transferase in Escherichia coli mediates dimerization and enhances reverse transcription of retroviral RNA
    • Weiss, S., König, B., Morikawa, Y. & Jones, I. (1992b) Recombinant HIV-1 nucleocapsid protein produces as a fusion protein with glutathione S-transferase in Escherichia coli mediates dimerization and enhances reverse transcription of retroviral RNA, Gene (Amst.) 121, 203-212.
    • (1992) Gene (Amst.) , vol.121 , pp. 203-212
    • Weiss, S.1    König, B.2    Morikawa, Y.3    Jones, I.4
  • 47
    • 0028289939 scopus 로고
    • Alternative modes of polymerization distinguish the subunits of equine infectious anemia virus reverse transcriptase
    • Wöhrl, B., Howard, K. J., Jacques, P. S. & Le Grice, S. F. J. (1994) Alternative modes of polymerization distinguish the subunits of equine infectious anemia virus reverse transcriptase, J. Biol. Chem. 269, 8541-8548.
    • (1994) J. Biol. Chem. , vol.269 , pp. 8541-8548
    • Wöhrl, B.1    Howard, K.J.2    Jacques, P.S.3    Le Grice, S.F.J.4


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