N-Methyltetrahydro-β-carboline analogs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin are oxidized to neurotoxic β-carbolinium cations by heme peroxidases

Biochemical and Biophysical Research Communications

Volumn 356, Issue 1, 2007, Pages 118-123

  Herraiz, Tomás ^a   Guillén, Hugo ^a   Galisteo, Juan ^a  

^a INSTITUTO DE FERMENTACIONES INDUSTRIALES CSIC   (Spain)

Author keywords

Carbolines; Carbolinium; 1 Methyl 4 phenyl 1,2,3,6 tetrahydropyridine; 1 Methyl 4 phenylpyridinium; CYP2D6; Cytochrome P450; Heme peroxidases; Horseradish peroxidase; Lactoperoxidase; Monoamine oxidase (MAO); MPP+; MPTP; Myeloperoxidase; N Methyltetrahydro carbolines; Neurotoxins; Parkinson's disease

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 1,2,3,4 TETRAHYDRO 2 METHYL BETA CARBOLINE; 1,2,3,4 TETRAHYDRO 2,9 DIMETHYL BETA CARBOLINE; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; ASCORBIC ACID; BETA CARBOLINE DERIVATIVE; CYTOCHROME P450 2D6; HORSERADISH PEROXIDASE; HYDROXYLAMINE; LACTOPEROXIDASE; MYELOPEROXIDASE; NEUROTOXIN; PEROXIDASE; SODIUM AZIDE; UNCLASSIFIED DRUG;

AROMATIZATION; ARTICLE; CATALYSIS; ENZYME ACTIVITY; ENZYME KINETICS; HUMAN; NEUROTOXICITY; NEUROTOXICOLOGY; OXIDATION; PARKINSON DISEASE; PRIORITY JOURNAL;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; 1-METHYL-4-PHENYLPYRIDINIUM; CARBOLINES; CATIONS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HEME; KINETICS; MODELS, CHEMICAL; NEUROTOXINS; OXIDATION-REDUCTION; PEROXIDASES; PYRIDINIUM COMPOUNDS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, ULTRAVIOLET;

ARMORACIA RUSTICANA; PARKINSONIA;

EID: 33947141371     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.02.089     Document Type: Article

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