Nelfinavir, an HIV-1 protease inhibitor, induces oxidative stress-mediated, caspase-independent apoptosis in Leishmania Amastigotes

PLoS Neglected Tropical Diseases

Volumn 4, Issue 3, 2010, Pages

  Kumar, Pranav ^a   Lodge, Robert ^a   Trudel, Nathalie ^a   Ouellet, Michel ^a   Ouellette, Marc ^a   Tremblay, Michel J ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; AURINTRICARBOXYLIC ACID; CASPASE; CASPASE INHIBITOR; CELL NUCLEUS DNA; ENDONUCLEASE G; GENOMIC DNA; GLUTATHIONE; MILTEFOSINE; NELFINAVIR; PROTOZOAL DNA; ANTIPROTOZOAL AGENT; DEOXYRIBONUCLEASE;

AMASTIGOTE; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA CONTENT; DNA DEGRADATION; DNA FRAGMENTATION; DRUG MECHANISM; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; LEISHMANIA DONOVANI; LEISHMANIA INFANTUM; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; VISCERAL LEISHMANIASIS; ANIMAL; DRUG EFFECT; LEISHMANIA; METABOLISM;

ANIMALS; ANTIPROTOZOAL AGENTS; APOPTOSIS; CASPASES; DNA FRAGMENTATION; ENDODEOXYRIBONUCLEASES; LEISHMANIA; MEMBRANE POTENTIAL, MITOCHONDRIAL; NELFINAVIR; OXIDATIVE STRESS;

EID: 77950371903     PISSN: None     EISSN: None     Source Type: Journal    
DOI: 10.1371/journal.pntd.0000642     Document Type: Article

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