메뉴 건너뛰기




Volumn 4, Issue 3, 2010, Pages

Nelfinavir, an HIV-1 protease inhibitor, induces oxidative stress-mediated, caspase-independent apoptosis in Leishmania Amastigotes

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; AURINTRICARBOXYLIC ACID; CASPASE; CASPASE INHIBITOR; CELL NUCLEUS DNA; ENDONUCLEASE G; GENOMIC DNA; GLUTATHIONE; MILTEFOSINE; NELFINAVIR; PROTOZOAL DNA; ANTIPROTOZOAL AGENT; DEOXYRIBONUCLEASE;

EID: 77950371903     PISSN: None     EISSN: None     Source Type: Journal    
DOI: 10.1371/journal.pntd.0000642     Document Type: Article
Times cited : (32)

References (46)
  • 2
    • 0033971837 scopus 로고    scopus 로고
    • Leishmania, Trypanosoma and monoxenous trypanosomatids as emerging opportunistic agents
    • Dedet JP, Pratlong F (2000) Leishmania, Trypanosoma and monoxenous trypanosomatids as emerging opportunistic agents. J Eukaryot Microbiol 47: 37-39.
    • (2000) J Eukaryot Microbiol , vol.47 , pp. 37-39
    • Dedet, J.P.1    Pratlong, F.2
  • 4
    • 1342324596 scopus 로고    scopus 로고
    • Leishmania infantum promotes replication of HIV type 1 in human lymphoid tissue cultured ex vivo by inducing secretion of the proinflammatory cytokines TNF-alpha and IL-1 alpha
    • Zhao C, Papadopoulou B, Tremblay MJ (2004) Leishmania infantum promotes replication of HIV type 1 in human lymphoid tissue cultured ex vivo by inducing secretion of the proinflammatory cytokines TNF-alpha and IL-1 alpha. J Immunol 172: 3086-3093.
    • (2004) J Immunol , vol.172 , pp. 3086-3093
    • Zhao, C.1    Papadopoulou, B.2    Tremblay, M.J.3
  • 5
    • 33646125622 scopus 로고    scopus 로고
    • In primary human monocyte-derived macrophages exposed to Human immunodeficiency virus type 1, does the increased intracellular growth of Leishmania infantum rely on its enhanced uptake?
    • Zhao C, Thibault S, Messier N, Ouellette M, Papadopoulou B, et al. (2006) In primary human monocyte-derived macrophages exposed to Human immunodeficiency virus type 1, does the increased intracellular growth of Leishmania infantum rely on its enhanced uptake? J Gen Virol 87: 1295-1302.
    • (2006) J Gen Virol , vol.87 , pp. 1295-1302
    • Zhao, C.1    Thibault, S.2    Messier, N.3    Ouellette, M.4    Papadopoulou, B.5
  • 6
    • 0031024623 scopus 로고    scopus 로고
    • HIV-1 protease inhibitors. A review for clinicians
    • Deeks SG, Smith M, Holodniy M, Kahn JO (1997) HIV-1 protease inhibitors. A review for clinicians. JAMA 277: 145-153.
    • (1997) JAMA , vol.277 , pp. 145-153
    • Deeks, S.G.1    Smith, M.2    Holodniy, M.3    Kahn, J.O.4
  • 7
    • 0035864513 scopus 로고    scopus 로고
    • Influence of highly active antiretroviral therapy on the outcome of subclinical visceral leishmaniasis in human immunodeficiency virus-infected patients
    • de la Rosa R, Pineda JA, Delgado J, Macias J, Morillas F, et al. (2001) Influence of highly active antiretroviral therapy on the outcome of subclinical visceral leishmaniasis in human immunodeficiency virus-infected patients. Clin Infect Dis 32: 633-635.
    • (2001) Clin Infect Dis , vol.32 , pp. 633-635
    • De La Rosa, R.1    Pineda, J.A.2    Delgado, J.3    Macias, J.4    Morillas, F.5
  • 8
    • 0345659210 scopus 로고    scopus 로고
    • The impact of highly active antiretroviral therapy (HAART) on visceral leishmaniasis in Spanish patients who are co-infected with HIV
    • Lopez-Velez R (2003) The impact of highly active antiretroviral therapy (HAART) on visceral leishmaniasis in Spanish patients who are co-infected with HIV. Ann Trop Med Parasitol 97 Suppl 1: 143-147.
    • (2003) Ann Trop Med Parasitol , vol.97 , Issue.SUPPL. 1 , pp. 143-147
    • Lopez-Velez, R.1
  • 9
    • 0035876158 scopus 로고    scopus 로고
    • Declining incidence of visceral leishmaniasis in HIV-infected individuals in the era of highly active antiretroviral therapy
    • Rosenthal E, Tempesta S, Del Giudice P, Marty P, Desjeux P, et al. (2001) Declining incidence of visceral leishmaniasis in HIV-infected individuals in the era of highly active antiretroviral therapy. AIDS 15: 1184-1185.
    • (2001) AIDS , vol.15 , pp. 1184-1185
    • Rosenthal, E.1    Tempesta, S.2    Del Giudice, P.3    Marty, P.4    Desjeux, P.5
  • 10
    • 20744432777 scopus 로고    scopus 로고
    • Antileishmanial activity of HIV protease inhibitors
    • Savoia D, Allice T, Tovo PA (2005) Antileishmanial activity of HIV protease inhibitors. Int J Antimicrob Agents 26: 92-94.
    • (2005) Int J Antimicrob Agents , vol.26 , pp. 92-94
    • Savoia, D.1    Allice, T.2    Tovo, P.A.3
  • 11
    • 54249094595 scopus 로고    scopus 로고
    • Intracellular survival of Leishmania species that cause visceral leishmaniasis is significantly reduced by HIV-1 protease inhibitors
    • Trudel N, Garg R, Messier N, Sundar S, Ouellette M, et al. (2008) Intracellular survival of Leishmania species that cause visceral leishmaniasis is significantly reduced by HIV-1 protease inhibitors. J Infect Dis 198: 1292-1299.
    • (2008) J Infect Dis , vol.198 , pp. 1292-1299
    • Trudel, N.1    Garg, R.2    Messier, N.3    Sundar, S.4    Ouellette, M.5
  • 12
    • 34548827350 scopus 로고    scopus 로고
    • Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo
    • Gills JJ, Lopiccolo J, Tsurutani J, Shoemaker RH, Best CJ, et al. (2007) Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo. Clin Cancer Res 13: 5183-5194.
    • (2007) Clin Cancer Res , vol.13 , pp. 5183-5194
    • Gills, J.J.1    Lopiccolo, J.2    Tsurutani, J.3    Shoemaker, R.H.4    Best, C.J.5
  • 13
    • 63449107184 scopus 로고    scopus 로고
    • HIV aspartyl peptidase inhibitors interfere with cellular proliferation, ultrastructure and macrophage infection of Leishmania amazonensis
    • Santos LO, Marinho FA, Altoe EF, Vitorio BS, Alves CR, et al. (2009) HIV aspartyl peptidase inhibitors interfere with cellular proliferation, ultrastructure and macrophage infection of Leishmania amazonensis. PLoS ONE 4: e4918.
    • (2009) PLoS ONE , vol.4
    • Santos, L.O.1    Marinho, F.A.2    Altoe, E.F.3    Vitorio, B.S.4    Alves, C.R.5
  • 14
    • 0036081335 scopus 로고    scopus 로고
    • Nitric oxide-mediated proteasome-dependent oligonucleosomal DNA fragmentation in Leishmania amazonensis amastigotes
    • Holzmuller P, Sereno D, Cavaleyra M, Mangot I, Daulouede S, et al. (2002) Nitric oxide-mediated proteasome-dependent oligonucleosomal DNA fragmentation in Leishmania amazonensis amastigotes. Infect Immun 70: 3727-3735.
    • (2002) Infect Immun , vol.70 , pp. 3727-3735
    • Holzmuller, P.1    Sereno, D.2    Cavaleyra, M.3    Mangot, I.4    Daulouede, S.5
  • 15
    • 0036792472 scopus 로고    scopus 로고
    • Cell death in Leishmania induced by stress and differentiation: Programmed cell death or necrosis?
    • Zangger H, Mottram JC, Fasel N (2002) Cell death in Leishmania induced by stress and differentiation: programmed cell death or necrosis? Cell Death Differ 9: 1126-1139.
    • (2002) Cell Death Differ , vol.9 , pp. 1126-1139
    • Zangger, H.1    Mottram, J.C.2    Fasel, N.3
  • 16
  • 17
    • 0036142979 scopus 로고    scopus 로고
    • On the evolution of programmed cell death: Apoptosis of the unicellular eukaryote Leishmania major involves cysteine proteinase activation and mitochondrion permeabilization
    • Arnoult D, Akarid K, Grodet A, Petit PX, Estaquier J, et al. (2002) On the evolution of programmed cell death: apoptosis of the unicellular eukaryote Leishmania major involves cysteine proteinase activation and mitochondrion permeabilization. Cell Death Differ 9: 65-81.
    • (2002) Cell Death Differ , vol.9 , pp. 65-81
    • Arnoult, D.1    Akarid, K.2    Grodet, A.3    Petit, P.X.4    Estaquier, J.5
  • 18
    • 0034919499 scopus 로고    scopus 로고
    • Hydrogen peroxide induces apoptosis-like death in Leishmania donovani promastigotes
    • Das M, Mukherjee SB, Shaha C (2001) Hydrogen peroxide induces apoptosis-like death in Leishmania donovani promastigotes. J Cell Sci 114: 2461-2469.
    • (2001) J Cell Sci , vol.114 , pp. 2461-2469
    • Das, M.1    Mukherjee, S.B.2    Shaha, C.3
  • 19
    • 33846186314 scopus 로고    scopus 로고
    • Apoptosis is induced in leishmanial cells by a novel protein kinase inhibitor withaferin A and is facilitated by apoptotic topoisomerase I-DNA complex
    • Sen N, Banerjee B, Das BB, Ganguly A, Sen T, et al. (2007) Apoptosis is induced in leishmanial cells by a novel protein kinase inhibitor withaferin A and is facilitated by apoptotic topoisomerase I-DNA complex. Cell Death Differ 14: 358-367.
    • (2007) Cell Death Differ , vol.14 , pp. 358-367
    • Sen, N.1    Banerjee, B.2    Das, B.B.3    Ganguly, A.4    Sen, T.5
  • 21
    • 39449083014 scopus 로고    scopus 로고
    • Conservation of the proapoptotic nuclease activity of endonuclease G in unicellular trypanosomatid parasites
    • Gannavaram S, Vedvyas C, Debrabant A (2008) Conservation of the proapoptotic nuclease activity of endonuclease G in unicellular trypanosomatid parasites. J Cell Sci 121: 99-109.
    • (2008) J Cell Sci , vol.121 , pp. 99-109
    • Gannavaram, S.1    Vedvyas, C.2    Debrabant, A.3
  • 22
    • 52149102504 scopus 로고    scopus 로고
    • The caspase-independent algorithm of programmed cell death in Leishmania induced by baicalein: The role of LdEndoG, LdFEN-1 and LdTatD as a DNA 'degradesome'
    • BoseDasgupta S, Das BB, Sengupta S, Ganguly A, Roy A, et al. (2008) The caspase-independent algorithm of programmed cell death in Leishmania induced by baicalein: the role of LdEndoG, LdFEN-1 and LdTatD as a DNA 'degradesome'. Cell Death Differ 15: 1629-1640.
    • (2008) Cell Death Differ , vol.15 , pp. 1629-1640
    • BoseDasgupta, S.1    Das, B.B.2    Sengupta, S.3    Ganguly, A.4    Roy, A.5
  • 23
    • 56549114782 scopus 로고    scopus 로고
    • Leishmania infantum expresses a mitochondrial nuclease homologous to EndoG that migrates to the nucleus in response to an apoptotic stimulus
    • Rico E, Alzate JF, Arias AA, Moreno D, Clos J, et al. (2009) Leishmania infantum expresses a mitochondrial nuclease homologous to EndoG that migrates to the nucleus in response to an apoptotic stimulus. Mol Biochem Parasitol 163: 28-38.
    • (2009) Mol Biochem Parasitol , vol.163 , pp. 28-38
    • Rico, E.1    Alzate, J.F.2    Arias, A.A.3    Moreno, D.4    Clos, J.5
  • 24
    • 33646539188 scopus 로고    scopus 로고
    • Involvement of endonuclease G in nucleosomal DNA fragmentation under sustained endogenous oxidative stress
    • Ishihara Y, Shimamoto N (2006) Involvement of endonuclease G in nucleosomal DNA fragmentation under sustained endogenous oxidative stress. J Biol Chem 281: 6726-6733.
    • (2006) J Biol Chem , vol.281 , pp. 6726-6733
    • Ishihara, Y.1    Shimamoto, N.2
  • 25
    • 26844440672 scopus 로고    scopus 로고
    • Trypanosomatid protozoa: A simplified DNA isolation procedure
    • Rotureau B, Gego A, Carme B (2005) Trypanosomatid protozoa: a simplified DNA isolation procedure. Exp Parasitol 111: 207-209.
    • (2005) Exp Parasitol , vol.111 , pp. 207-209
    • Rotureau, B.1    Gego, A.2    Carme, B.3
  • 26
    • 0030612749 scopus 로고    scopus 로고
    • JC-1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess delta psi changes in intact cells: Implications for studies on mitochondrial functionality during apoptosis
    • Salvioli S, Ardizzoni A, Franceschi C, Cossarizza A (1997) JC-1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess delta psi changes in intact cells: implications for studies on mitochondrial functionality during apoptosis. FEBS Lett 411: 77-82.
    • (1997) FEBS Lett , vol.411 , pp. 77-82
    • Salvioli, S.1    Ardizzoni, A.2    Franceschi, C.3    Cossarizza, A.4
  • 27
    • 0141457689 scopus 로고    scopus 로고
    • Characterisation of Leishmania donovani promastigotes resistant to hexadecylphosphocholine (miltefosine)
    • Seifert K, Matu S, Javier Perez-Victoria F, Castanys S, Gamarro F, et al. (2003) Characterisation of Leishmania donovani promastigotes resistant to hexadecylphosphocholine (miltefosine). Int J Antimicrob Agents 22: 380-387.
    • (2003) Int J Antimicrob Agents , vol.22 , pp. 380-387
    • Seifert, K.1    Matu, S.2    Javier Perez-Victoria, F.3    Castanys, S.4    Gamarro, F.5
  • 28
    • 3342943546 scopus 로고    scopus 로고
    • Possible mechanism of miltefosine-mediated death of Leishmania donovani
    • Verma NK, Dey CS (2004) Possible mechanism of miltefosine-mediated death of Leishmania donovani. Antimicrob Agents Chemother 48: 3010-3015.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 3010-3015
    • Verma, N.K.1    Dey, C.S.2
  • 29
    • 33846554383 scopus 로고    scopus 로고
    • A proteomics screen implicates HSP83 and a small kinetoplastid calpain-related protein in drug resistance in Leishmania donovani clinical field isolates by modulating drug-induced programmed cell death
    • Vergnes B, Gourbal B, Girard I, Sundar S, Drummelsmith J, et al. (2007) A proteomics screen implicates HSP83 and a small kinetoplastid calpain-related protein in drug resistance in Leishmania donovani clinical field isolates by modulating drug-induced programmed cell death. Mol Cell Proteomics 6: 88-101.
    • (2007) Mol Cell Proteomics , vol.6 , pp. 88-101
    • Vergnes, B.1    Gourbal, B.2    Girard, I.3    Sundar, S.4    Drummelsmith, J.5
  • 30
    • 0031760626 scopus 로고    scopus 로고
    • Axenically grown amastigotes of Leishmania infantum used as an in vitro model to investigate the pentavalent antimony mode of action
    • Sereno D, Cavaleyra M, Zemzoumi K, Maquaire S, Ouaissi A, et al. (1998) Axenically grown amastigotes of Leishmania infantum used as an in vitro model to investigate the pentavalent antimony mode of action. Antimicrob Agents Chemother 42: 3097-3102.
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 3097-3102
    • Sereno, D.1    Cavaleyra, M.2    Zemzoumi, K.3    Maquaire, S.4    Ouaissi, A.5
  • 31
    • 0035811496 scopus 로고    scopus 로고
    • Endonuclease G is an apoptotic DNase when released from mitochondria
    • Li LY, Luo X, Wang X (2001) Endonuclease G is an apoptotic DNase when released from mitochondria. Nature 412: 95-99.
    • (2001) Nature , vol.412 , pp. 95-99
    • Li, L.Y.1    Luo, X.2    Wang, X.3
  • 32
    • 0035674047 scopus 로고    scopus 로고
    • Endonuclease G: A mitochondrial protein released in apoptosis and involved in caspase-independent DNA degradation
    • van Loo G, Schotte P, van Gurp M, Demol H, Hoorelbeke B, et al. (2001) Endonuclease G: a mitochondrial protein released in apoptosis and involved in caspase-independent DNA degradation. Cell Death Differ 8: 1136-1142.
    • (2001) Cell Death Differ , vol.8 , pp. 1136-1142
    • Van Loo, G.1    Schotte, P.2    Van Gurp, M.3    Demol, H.4    Hoorelbeke, B.5
  • 34
    • 0030924243 scopus 로고    scopus 로고
    • Co-amplification of the gamma-glutamylcysteine synthetase gene gsh1 and of the ABC transporter gene pgpA in arsenite-resistant Leishmania tarentolae
    • Grondin K, Haimeur A, Mukhopadhyay R, Rosen BP, Ouellette M (1997) Co-amplification of the gamma-glutamylcysteine synthetase gene gsh1 and of the ABC transporter gene pgpA in arsenite-resistant Leishmania tarentolae. EMBO J 16: 3057-3065.
    • (1997) EMBO J , vol.16 , pp. 3057-3065
    • Grondin, K.1    Haimeur, A.2    Mukhopadhyay, R.3    Rosen, B.P.4    Ouellette, M.5
  • 35
    • 0345659212 scopus 로고    scopus 로고
    • Leishmania/HIV co-infections: Epidemiology in Europe
    • Desjeux P, Alvar J (2003) Leishmania/HIV co-infections: epidemiology in Europe. Ann Trop Med Parasitol 97 Suppl 1: 3-15.
    • (2003) Ann Trop Med Parasitol , vol.97 , Issue.SUPPL. 1 , pp. 3-15
    • Desjeux, P.1    Alvar, J.2
  • 36
    • 43949118839 scopus 로고    scopus 로고
    • Concordant HIV infection and visceral leishmaniasis in Ethiopia: The influence of antiretroviral treatment and other factors on outcome
    • ter Horst R, Collin SM, Ritmeijer K, Bogale A, Davidson RN (2008) Concordant HIV infection and visceral leishmaniasis in Ethiopia: the influence of antiretroviral treatment and other factors on outcome. Clin Infect Dis 46: 1702-1709.
    • (2008) Clin Infect Dis , vol.46 , pp. 1702-1709
    • Ter Horst, R.1    Collin, S.M.2    Ritmeijer, K.3    Bogale, A.4    Davidson, R.N.5
  • 38
    • 0344394925 scopus 로고    scopus 로고
    • HIV and the transmission of Leishmania
    • Molina R, Gradoni L, Alvar J (2003) HIV and the transmission of Leishmania. Ann Trop Med Parasitol 97 Suppl 1: 29-45.
    • (2003) Ann Trop Med Parasitol , vol.97 , Issue.SUPPL. 1 , pp. 29-45
    • Molina, R.1    Gradoni, L.2    Alvar, J.3
  • 39
    • 33846121304 scopus 로고    scopus 로고
    • HIV-1 replication is stimulated by sodium stibogluconate, the therapeutic mainstay in the treatment of leishmaniasis
    • Barat C, Zhao C, Ouellette M, Tremblay MJ (2007) HIV-1 replication is stimulated by sodium stibogluconate, the therapeutic mainstay in the treatment of leishmaniasis. J Infect Dis 195: 236-245.
    • (2007) J Infect Dis , vol.195 , pp. 236-245
    • Barat, C.1    Zhao, C.2    Ouellette, M.3    Tremblay, M.J.4
  • 40
    • 29244450454 scopus 로고    scopus 로고
    • High variability of indinavir and nelfinavir pharmacokinetics in HIV-infected patients with a sustained virological response on highly active antiretroviral therapy
    • Goujard C, Legrand M, Panhard X, Diquet B, Duval X, et al. (2005) High variability of indinavir and nelfinavir pharmacokinetics in HIV-infected patients with a sustained virological response on highly active antiretroviral therapy. Clin Pharmacokinet 44: 1267-1278.
    • (2005) Clin Pharmacokinet , vol.44 , pp. 1267-1278
    • Goujard, C.1    Legrand, M.2    Panhard, X.3    Diquet, B.4    Duval, X.5
  • 41
    • 0035853376 scopus 로고    scopus 로고
    • Differences in the intracellular accumulation of HIV protease inhibitors in vitro and the effect of active transport
    • Jones K, Hoggard PG, Sales SD, Khoo S, Davey R, et al. (2001) Differences in the intracellular accumulation of HIV protease inhibitors in vitro and the effect of active transport. AIDS 15: 675-681.
    • (2001) AIDS , vol.15 , pp. 675-681
    • Jones, K.1    Hoggard, P.G.2    Sales, S.D.3    Khoo, S.4    Davey, R.5
  • 42
    • 33745193691 scopus 로고    scopus 로고
    • Apoptosis in Leishmania species & its relevance to disease pathogenesis
    • Shaha C (2006) Apoptosis in Leishmania species & its relevance to disease pathogenesis. Indian J Med Res 123: 233-244.
    • (2006) Indian J Med Res , vol.123 , pp. 233-244
    • Shaha, C.1
  • 43
    • 35348920688 scopus 로고    scopus 로고
    • Characterization of metacaspases with trypsin-like activity and their putative role in programmed cell death in the protozoan parasite Leishmania
    • Lee N, Gannavaram S, Selvapandiyan A, Debrabant A (2007) Characterization of metacaspases with trypsin-like activity and their putative role in programmed cell death in the protozoan parasite Leishmania. Eukaryot Cell 6: 1745-1757.
    • (2007) Eukaryot Cell , vol.6 , pp. 1745-1757
    • Lee, N.1    Gannavaram, S.2    Selvapandiyan, A.3    Debrabant, A.4
  • 44
    • 33947102605 scopus 로고    scopus 로고
    • Miltefosine induces apoptosis in arsenite-resistant Leishmania donovani promastigotes through mitochondrial dysfunction
    • Verma NK, Singh G, Dey CS (2007) Miltefosine induces apoptosis in arsenite-resistant Leishmania donovani promastigotes through mitochondrial dysfunction. Exp Parasitol 116: 1-13.
    • (2007) Exp Parasitol , vol.116 , pp. 1-13
    • Verma, N.K.1    Singh, G.2    Dey, C.S.3
  • 45
    • 0036100575 scopus 로고    scopus 로고
    • Effects of antiretroviral drugs on human immunodeficiency virus type 1-induced CD4(+) T-cell death
    • Estaquier J, Lelievre JD, Petit F, Brunner T, Moutouh-De Parseval L, et al. (2002) Effects of antiretroviral drugs on human immunodeficiency virus type 1-induced CD4(+) T-cell death. J Virol 76: 5966-5973.
    • (2002) J Virol , vol.76 , pp. 5966-5973
    • Estaquier, J.1    Lelievre, J.D.2    Petit, F.3    Brunner, T.4    Moutouh-De Parseval, L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.