메뉴 건너뛰기




Volumn 26, Issue 5, 2005, Pages 258-264

Mitochondria are sensors for HIV drugs

Author keywords

[No Author keywords available]

Indexed keywords

ABACADIR; AMPRENAVIR; ANTIRETROVIRUS AGENT; ATAZANAVIR; DELAVIRDINE; DIDANOSINE; EFAVIRENZ; EMTRICITABINE; INDINAVIR; LAMIVUDINE; LOPINAVIR; NEVIRAPINE; RITONAVIR; SAQUINAVIR; STAVUDINE; TENOFOVIR; UNCLASSIFIED DRUG; ZALCITABINE; ZIDOVUDINE;

EID: 18044388520     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tips.2005.03.006     Document Type: Review
Times cited : (34)

References (80)
  • 1
    • 0242690396 scopus 로고    scopus 로고
    • Intrinsic and extrinsic pathways signaling during HIV-1 mediated cell death
    • F. Petit Intrinsic and extrinsic pathways signaling during HIV-1 mediated cell death Biochimie 85 2003 795 811
    • (2003) Biochimie , vol.85 , pp. 795-811
    • Petit, F.1
  • 2
    • 10644280992 scopus 로고    scopus 로고
    • Action of anti-HIV drugs and resistance: Reverse transcriptase inhibitors and protease inhibitors
    • T. Imamichi Action of anti-HIV drugs and resistance: reverse transcriptase inhibitors and protease inhibitors Curr. Pharm. Des. 10 2004 4039 4053
    • (2004) Curr. Pharm. Des. , vol.10 , pp. 4039-4053
    • Imamichi, T.1
  • 3
    • 0035922595 scopus 로고    scopus 로고
    • Prevalence of adverse events associated with potent antiretroviral treatment: Swiss HIV Cohort Study
    • J. Fellay Prevalence of adverse events associated with potent antiretroviral treatment: Swiss HIV Cohort Study Lancet 358 2001 1322 1327
    • (2001) Lancet , vol.358 , pp. 1322-1327
    • Fellay, J.1
  • 4
    • 0037721374 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and nucleoside reverse transcriptase inhibitor therapy: Experimental clarifications and persistent clinical questions
    • W. Lewis Mitochondrial dysfunction and nucleoside reverse transcriptase inhibitor therapy: experimental clarifications and persistent clinical questions Antiviral Res. 58 2003 189 197
    • (2003) Antiviral Res. , vol.58 , pp. 189-197
    • Lewis, W.1
  • 5
    • 0346995096 scopus 로고    scopus 로고
    • Toxicity of nucleoside analogues used to treat AIDS and the selectivity of the mitochondrial DNA polymerase
    • H. Lee Toxicity of nucleoside analogues used to treat AIDS and the selectivity of the mitochondrial DNA polymerase Biochemistry 42 2003 14711 14719
    • (2003) Biochemistry , vol.42 , pp. 14711-14719
    • Lee, H.1
  • 6
    • 0037820578 scopus 로고    scopus 로고
    • Mechanisms of CD4+ T lymphocyte cell death in human immunodeficiency virus infection and AIDS
    • J.B. Alimonti Mechanisms of CD4+ T lymphocyte cell death in human immunodeficiency virus infection and AIDS J. Gen. Virol. 84 2003 1649 1661
    • (2003) J. Gen. Virol. , vol.84 , pp. 1649-1661
    • Alimonti, J.B.1
  • 7
    • 0034329318 scopus 로고    scopus 로고
    • Mechanisms of HIV-associated lymphocyte apoptosis
    • A.D. Badley Mechanisms of HIV-associated lymphocyte apoptosis Blood 96 2000 2951 2964
    • (2000) Blood , vol.96 , pp. 2951-2964
    • Badley, A.D.1
  • 8
    • 13144266673 scopus 로고    scopus 로고
    • An inhibitor of HIV-1 protease modulates proteasome activity, antigen presentation, and T cell responses
    • P. Andre An inhibitor of HIV-1 protease modulates proteasome activity, antigen presentation, and T cell responses Proc. Natl. Acad. Sci. U. S. A. 95 1998 13120 13124
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 13120-13124
    • Andre, P.1
  • 9
    • 0034667552 scopus 로고    scopus 로고
    • Protease inhibitors stimulate hematopoiesis and decrease apoptosis and ICE expression in CD34(+) cells
    • E.M. Sloand Protease inhibitors stimulate hematopoiesis and decrease apoptosis and ICE expression in CD34(+) cells Blood 96 2000 2735 2739
    • (2000) Blood , vol.96 , pp. 2735-2739
    • Sloand, E.M.1
  • 10
    • 0033179343 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 protease inhibitor modulates activation of peripheral blood CD4(+) T cells and decreases their susceptibility to apoptosis in vitro and in vivo
    • E.M. Sloand Human immunodeficiency virus type 1 protease inhibitor modulates activation of peripheral blood CD4(+) T cells and decreases their susceptibility to apoptosis in vitro and in vivo Blood 94 1999 1021 1027
    • (1999) Blood , vol.94 , pp. 1021-1027
    • Sloand, E.M.1
  • 11
    • 0034630359 scopus 로고    scopus 로고
    • Decreased HIV-associated T cell apoptosis by HIV protease inhibitors
    • B.N. Phenix Decreased HIV-associated T cell apoptosis by HIV protease inhibitors AIDS Res. Hum. Retroviruses 16 2000 559 567
    • (2000) AIDS Res. Hum. Retroviruses , vol.16 , pp. 559-567
    • Phenix, B.N.1
  • 12
    • 0034235402 scopus 로고    scopus 로고
    • HIV protease inhibitors restore impaired T-cell proliferative response in vivo and in vitro: A viral-suppression-independent mechanism
    • W. Lu, and J.M. Andrieu HIV protease inhibitors restore impaired T-cell proliferative response in vivo and in vitro: a viral-suppression-independent mechanism Blood 96 2000 250 258
    • (2000) Blood , vol.96 , pp. 250-258
    • Lu, W.1    Andrieu, J.M.2
  • 13
    • 0035880249 scopus 로고    scopus 로고
    • The HIV protease inhibitor Indinavir inhibits cell-cycle progression in vitro in lymphocytes of HIV-infected and uninfected individuals
    • S. Chavan The HIV protease inhibitor Indinavir inhibits cell-cycle progression in vitro in lymphocytes of HIV-infected and uninfected individuals Blood 98 2001 383 389
    • (2001) Blood , vol.98 , pp. 383-389
    • Chavan, S.1
  • 14
    • 0029095014 scopus 로고
    • Mitochondrial dysfunctions in circulating T lymphocytes from human immunodeficiency virus-1 carriers
    • A. Macho Mitochondrial dysfunctions in circulating T lymphocytes from human immunodeficiency virus-1 carriers Blood 86 1995 2481 2487
    • (1995) Blood , vol.86 , pp. 2481-2487
    • MacHo, A.1
  • 15
    • 0028230429 scopus 로고
    • Oxidative stress and apoptosis in HIV infection: A role for plant-derived metabolites with synergistic antioxidant activity
    • H.C. Greenspan, and O.I. Aruoma Oxidative stress and apoptosis in HIV infection: a role for plant-derived metabolites with synergistic antioxidant activity Immunol. Today 15 1994 209 213
    • (1994) Immunol. Today , vol.15 , pp. 209-213
    • Greenspan, H.C.1    Aruoma, O.I.2
  • 16
    • 17644431629 scopus 로고    scopus 로고
    • Death of bystander cells by a novel pathway involving early mitochondrial damage in human immunodeficiency virus-related lymphadenopathy
    • M. Carbonari Death of bystander cells by a novel pathway involving early mitochondrial damage in human immunodeficiency virus-related lymphadenopathy Blood 90 1997 209 216
    • (1997) Blood , vol.90 , pp. 209-216
    • Carbonari, M.1
  • 17
    • 0037427473 scopus 로고    scopus 로고
    • Mitochondria in HIV-1-induced apoptosis
    • D. Arnoult Mitochondria in HIV-1-induced apoptosis Biochem. Biophys. Res. Commun. 304 2003 561 574
    • (2003) Biochem. Biophys. Res. Commun. , vol.304 , pp. 561-574
    • Arnoult, D.1
  • 18
    • 0035883068 scopus 로고    scopus 로고
    • Antiapoptotic mechanism of HIV protease inhibitors: Preventing mitochondrial transmembrane potential loss
    • B.N. Phenix Antiapoptotic mechanism of HIV protease inhibitors: preventing mitochondrial transmembrane potential loss Blood 98 2001 1078 1085
    • (2001) Blood , vol.98 , pp. 1078-1085
    • Phenix, B.N.1
  • 19
    • 3042702514 scopus 로고    scopus 로고
    • Pancreatic toxic effects associated with co-administration of didanosine and tenofovir in HIV-infected adults
    • E. Martinez Pancreatic toxic effects associated with co-administration of didanosine and tenofovir in HIV-infected adults Lancet 364 2004 65 67
    • (2004) Lancet , vol.364 , pp. 65-67
    • Martinez, E.1
  • 20
    • 0033862761 scopus 로고    scopus 로고
    • Clinical manifestations and management of antiretroviral nucleoside analog-related mitochondrial toxicity
    • G. Moyle Clinical manifestations and management of antiretroviral nucleoside analog-related mitochondrial toxicity Clin. Ther. 22 2000 911 936
    • (2000) Clin. Ther. , vol.22 , pp. 911-936
    • Moyle, G.1
  • 21
    • 0035710888 scopus 로고    scopus 로고
    • Possible mechanism of toxicity of zidovudine by induction of apoptosis of CD4+ and CD8+ T-cells in vivo
    • O. Benveniste Possible mechanism of toxicity of zidovudine by induction of apoptosis of CD4+ and CD8+ T-cells in vivo Eur. J. Clin. Microbiol. Infect. Dis. 20 2001 896 897
    • (2001) Eur. J. Clin. Microbiol. Infect. Dis. , vol.20 , pp. 896-897
    • Benveniste, O.1
  • 22
    • 0025274663 scopus 로고
    • Mitochondrial myopathy caused by long-term zidovudine therapy
    • M.C. Dalakas Mitochondrial myopathy caused by long-term zidovudine therapy New Engl. J. Med. 322 1990 1098 1105
    • (1990) New Engl. J. Med. , vol.322 , pp. 1098-1105
    • Dalakas, M.C.1
  • 23
    • 0026356201 scopus 로고
    • Abnormal skeletal and cardiac muscle mitochondria induced by zidovudine (AZT) in human muscle in vitro and in an animal model
    • L. Lamperth Abnormal skeletal and cardiac muscle mitochondria induced by zidovudine (AZT) in human muscle in vitro and in an animal model Lab. Invest. 65 1991 742 751
    • (1991) Lab. Invest. , vol.65 , pp. 742-751
    • Lamperth, L.1
  • 24
    • 0026332740 scopus 로고
    • Ultrastructural characteristics and DNA immunocytochemistry in human immunodeficiency virus and zidovudine-associated myopathies
    • G. Pezeshkpour Ultrastructural characteristics and DNA immunocytochemistry in human immunodeficiency virus and zidovudine-associated myopathies Hum. Pathol. 22 1991 1281 1288
    • (1991) Hum. Pathol. , vol.22 , pp. 1281-1288
    • Pezeshkpour, G.1
  • 25
    • 0026046254 scopus 로고
    • Mitochondrial ultrastructural and molecular changes induced by zidovudine in rat hearts
    • W. Lewis Mitochondrial ultrastructural and molecular changes induced by zidovudine in rat hearts Lab. Invest. 65 1991 228 236
    • (1991) Lab. Invest. , vol.65 , pp. 228-236
    • Lewis, W.1
  • 26
    • 0025366021 scopus 로고
    • Zidovudine intolerance
    • J.E. Groopman Zidovudine intolerance Rev. Infect. Dis. 12 Suppl. 5 1990 S500 S506
    • (1990) Rev. Infect. Dis. , vol.12 , Issue.5 SUPPL.
    • Groopman, J.E.1
  • 27
    • 0034648743 scopus 로고    scopus 로고
    • Absence of cardiac toxicity of zidovudine in infants. Pediatric Pulmonary and Cardiac Complications of Vertically Transmitted HIV Infection Study Group
    • S.E. Lipshultz Absence of cardiac toxicity of zidovudine in infants. Pediatric Pulmonary and Cardiac Complications of Vertically Transmitted HIV Infection Study Group New Engl. J. Med. 343 2000 759 766
    • (2000) New Engl. J. Med. , vol.343 , pp. 759-766
    • Lipshultz, S.E.1
  • 28
    • 0037071791 scopus 로고    scopus 로고
    • Antiretroviral therapy during pregnancy and the risk of an adverse outcome
    • R.E. Tuomala Antiretroviral therapy during pregnancy and the risk of an adverse outcome New Engl. J. Med. 346 2002 1863 1870
    • (2002) New Engl. J. Med. , vol.346 , pp. 1863-1870
    • Tuomala, R.E.1
  • 29
    • 0033604060 scopus 로고    scopus 로고
    • Persistent mitochondrial dysfunction and perinatal exposure to antiretroviral nucleoside analogues
    • S. Blanche Persistent mitochondrial dysfunction and perinatal exposure to antiretroviral nucleoside analogues Lancet 354 1999 1084 1089
    • (1999) Lancet , vol.354 , pp. 1084-1089
    • Blanche, S.1
  • 30
    • 0038078685 scopus 로고    scopus 로고
    • Long-term mitochondrial toxicity in HIV-uninfected infants born to HIV-infected mothers
    • M.C. Poirier Long-term mitochondrial toxicity in HIV-uninfected infants born to HIV-infected mothers J. Acquir. Immune Defic. Syndr. 33 2003 175 183
    • (2003) J. Acquir. Immune Defic. Syndr. , vol.33 , pp. 175-183
    • Poirier, M.C.1
  • 31
    • 0042232027 scopus 로고    scopus 로고
    • Persistent mitochondrial dysfunction in HIV-1-exposed but uninfected infants: Clinical screening in a large prospective cohort
    • B. Barret Persistent mitochondrial dysfunction in HIV-1-exposed but uninfected infants: clinical screening in a large prospective cohort AIDS 17 2003 1769 1785
    • (2003) AIDS , vol.17 , pp. 1769-1785
    • Barret, B.1
  • 32
    • 2342613668 scopus 로고    scopus 로고
    • Mitochondrial damage and DNA depletion in cord blood and umbilical cord from infants exposed in utero to Combivir
    • R.L. Divi Mitochondrial damage and DNA depletion in cord blood and umbilical cord from infants exposed in utero to Combivir AIDS 18 2004 1013 1021
    • (2004) AIDS , vol.18 , pp. 1013-1021
    • Divi, R.L.1
  • 33
    • 0037378552 scopus 로고    scopus 로고
    • Placenta and cord blood mitochondrial DNA toxicity in HIV-infected women receiving nucleoside reverse transcriptase inhibitors during pregnancy
    • B. Shiramizu Placenta and cord blood mitochondrial DNA toxicity in HIV-infected women receiving nucleoside reverse transcriptase inhibitors during pregnancy J. Acquir. Immune Defic. Syndr. 32 2003 370 374
    • (2003) J. Acquir. Immune Defic. Syndr. , vol.32 , pp. 370-374
    • Shiramizu, B.1
  • 34
    • 9144232859 scopus 로고    scopus 로고
    • Mitochondrial toxicity in fetal Erythrocebus patas monkeys exposed transplacentally to zidovudine plus lamivudine
    • M. Gerschenson Mitochondrial toxicity in fetal Erythrocebus patas monkeys exposed transplacentally to zidovudine plus lamivudine AIDS Res. Hum. Retroviruses 20 2004 91 100
    • (2004) AIDS Res. Hum. Retroviruses , vol.20 , pp. 91-100
    • Gerschenson, M.1
  • 35
    • 0035991993 scopus 로고    scopus 로고
    • Induction of apoptosis by a nonnucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitor
    • A.A. Pilon Induction of apoptosis by a nonnucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitor Antimicrob. Agents Chemother. 46 2002 2687 2691
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 2687-2691
    • Pilon, A.A.1
  • 36
    • 0042438992 scopus 로고    scopus 로고
    • Subcutaneous adipocyte apoptosis in HIV-1 protease inhibitor-associated lipodystrophy
    • P. Domingo Subcutaneous adipocyte apoptosis in HIV-1 protease inhibitor-associated lipodystrophy AIDS 13 1999 2261 2267
    • (1999) AIDS , vol.13 , pp. 2261-2267
    • Domingo, P.1
  • 37
    • 0032493043 scopus 로고    scopus 로고
    • A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors
    • A. Carr A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors AIDS 12 1998 F51 F58
    • (1998) AIDS , vol.12
    • Carr, A.1
  • 38
    • 0034731520 scopus 로고    scopus 로고
    • Suppression of preadipocyte differentiation and promotion of adipocyte death by HIV protease inhibitors
    • P. Dowell Suppression of preadipocyte differentiation and promotion of adipocyte death by HIV protease inhibitors J. Biol. Chem. 275 2000 41325 41332
    • (2000) J. Biol. Chem. , vol.275 , pp. 41325-41332
    • Dowell, P.1
  • 39
    • 0036100575 scopus 로고    scopus 로고
    • Effects of antiretroviral drugs on human immunodeficiency virus type 1-induced CD4(+) T-cell death
    • J. Estaquier Effects of antiretroviral drugs on human immunodeficiency virus type 1-induced CD4(+) T-cell death J. Virol. 76 2002 5966 5973
    • (2002) J. Virol. , vol.76 , pp. 5966-5973
    • Estaquier, J.1
  • 40
    • 0038620230 scopus 로고    scopus 로고
    • Mitochondrial membrane hyperpolarization hijacks activated T lymphocytes toward the apoptotic-prone phenotype: Homeostatic mechanisms of HIV protease inhibitors
    • P. Matarrese Mitochondrial membrane hyperpolarization hijacks activated T lymphocytes toward the apoptotic-prone phenotype: homeostatic mechanisms of HIV protease inhibitors J. Immunol. 170 2003 6006 6015
    • (2003) J. Immunol. , vol.170 , pp. 6006-6015
    • Matarrese, P.1
  • 41
    • 0036791645 scopus 로고    scopus 로고
    • HIV protease inhibitor ritonavir induces cytotoxicity of human endothelial cells
    • D.S. Zhong HIV protease inhibitor ritonavir induces cytotoxicity of human endothelial cells Arterioscler. Thromb. Vasc. Biol. 22 2002 1560 1566
    • (2002) Arterioscler. Thromb. Vasc. Biol. , vol.22 , pp. 1560-1566
    • Zhong, D.S.1
  • 42
    • 0037105651 scopus 로고    scopus 로고
    • The human immunodeficiency virus (HIV)-1 protease inhibitor saquinavir inhibits proteasome function and causes apoptosis and radiosensitization in non-HIV-associated human cancer cells
    • F. Pajonk The human immunodeficiency virus (HIV)-1 protease inhibitor saquinavir inhibits proteasome function and causes apoptosis and radiosensitization in non-HIV-associated human cancer cells Cancer Res. 62 2002 5230 5235
    • (2002) Cancer Res. , vol.62 , pp. 5230-5235
    • Pajonk, F.1
  • 43
    • 0036896223 scopus 로고    scopus 로고
    • Antitumor effect of the human immunodeficiency virus protease inhibitor ritonavir: Induction of tumor-cell apoptosis associated with perturbation of proteasomal proteolysis
    • S. Gaedicke Antitumor effect of the human immunodeficiency virus protease inhibitor ritonavir: induction of tumor-cell apoptosis associated with perturbation of proteasomal proteolysis Cancer Res. 62 2002 6901 6908
    • (2002) Cancer Res. , vol.62 , pp. 6901-6908
    • Gaedicke, S.1
  • 44
    • 0033944230 scopus 로고    scopus 로고
    • Once-daily dosing of saquinavir and low-dose ritonavir in HIV-1-infected individuals: A pharmacokinetic pilot study
    • R.P. van Heeswijk Once-daily dosing of saquinavir and low-dose ritonavir in HIV-1-infected individuals: a pharmacokinetic pilot study AIDS 14 2000 F103 F110
    • (2000) AIDS , vol.14
    • Van Heeswijk, R.P.1
  • 45
    • 0031785117 scopus 로고    scopus 로고
    • Pharmacokinetic interaction between ritonavir and indinavir in healthy volunteers
    • A. Hsu Pharmacokinetic interaction between ritonavir and indinavir in healthy volunteers Antimicrob. Agents Chemother. 42 1998 2784 2791
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 2784-2791
    • Hsu, A.1
  • 46
    • 0034456656 scopus 로고    scopus 로고
    • Multidrug resistance transporters and modulation
    • B. Tan Multidrug resistance transporters and modulation Curr. Opin. Oncol. 12 2000 450 458
    • (2000) Curr. Opin. Oncol. , vol.12 , pp. 450-458
    • Tan, B.1
  • 47
    • 0344825356 scopus 로고    scopus 로고
    • P-glycoprotein: From genomics to mechanism
    • S.V. Ambudkar P-glycoprotein: from genomics to mechanism Oncogene 22 2003 7468 7485
    • (2003) Oncogene , vol.22 , pp. 7468-7485
    • Ambudkar, S.V.1
  • 48
    • 0035958776 scopus 로고    scopus 로고
    • P-Glycoprotein and transporter MRP1 reduce HIV protease inhibitor uptake in CD4 cells: Potential for accelerated viral drug resistance?
    • K. Jones P-Glycoprotein and transporter MRP1 reduce HIV protease inhibitor uptake in CD4 cells: potential for accelerated viral drug resistance? AIDS 15 2001 1353 1358
    • (2001) AIDS , vol.15 , pp. 1353-1358
    • Jones, K.1
  • 49
    • 12944270590 scopus 로고    scopus 로고
    • Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs
    • J. Wijnholds Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs Proc. Natl. Acad. Sci. U. S. A. 97 2000 7476 7481
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 7476-7481
    • Wijnholds, J.1
  • 50
    • 4444383451 scopus 로고    scopus 로고
    • Induction of cellular resistance to nucleoside reverse transcriptase inhibitors by the wild-type breast cancer resistance protein
    • X. Wang Induction of cellular resistance to nucleoside reverse transcriptase inhibitors by the wild-type breast cancer resistance protein Biochem. Pharmacol. 68 2004 1363 1370
    • (2004) Biochem. Pharmacol. , vol.68 , pp. 1363-1370
    • Wang, X.1
  • 51
    • 0242664934 scopus 로고    scopus 로고
    • MDR1 gene polymorphisms and phase 1 viral decay during HIV-1 infection: An adult AIDS Clinical Trials Group study
    • D.W. Haas MDR1 gene polymorphisms and phase 1 viral decay during HIV-1 infection: an adult AIDS Clinical Trials Group study J. Acquir. Immune Defic. Syndr. 34 2003 295 298
    • (2003) J. Acquir. Immune Defic. Syndr. , vol.34 , pp. 295-298
    • Haas, D.W.1
  • 52
    • 0042127239 scopus 로고    scopus 로고
    • MDR1 C3435T genetic polymorphism does not influence the response to antiretroviral therapy in drug-naive HIV-positive patients
    • M. Nasi MDR1 C3435T genetic polymorphism does not influence the response to antiretroviral therapy in drug-naive HIV-positive patients AIDS 17 2003 1696 1698
    • (2003) AIDS , vol.17 , pp. 1696-1698
    • Nasi, M.1
  • 53
    • 0037462209 scopus 로고    scopus 로고
    • Influence of polymorphisms within the CX3CR1 and MDR-1 genes on initial antiretroviral therapy response
    • Z.L. Brumme Influence of polymorphisms within the CX3CR1 and MDR-1 genes on initial antiretroviral therapy response AIDS 17 2003 201 208
    • (2003) AIDS , vol.17 , pp. 201-208
    • Brumme, Z.L.1
  • 54
    • 0036864550 scopus 로고    scopus 로고
    • Intracellular concentration of protease inhibitors in HIV-1-infected patients: Correlation with MDR-1 gene expression and low dose of ritonavir
    • S. Chaillou Intracellular concentration of protease inhibitors in HIV-1-infected patients: correlation with MDR-1 gene expression and low dose of ritonavir HIV Clin. Trials 3 2002 493 501
    • (2002) HIV Clin. Trials , vol.3 , pp. 493-501
    • Chaillou, S.1
  • 55
    • 0037159922 scopus 로고    scopus 로고
    • Allele frequency of three functionally active polymorphisms of the MDR-1 gene in high-risk HIV-negative and HIV-positive Caucasians
    • I. Ifergan Allele frequency of three functionally active polymorphisms of the MDR-1 gene in high-risk HIV-negative and HIV-positive Caucasians AIDS 16 2002 2340 2342
    • (2002) AIDS , vol.16 , pp. 2340-2342
    • Ifergan, I.1
  • 56
    • 85030803129 scopus 로고    scopus 로고
    • The implications of P-glycoprotein in HIV: Friend or foe?
    • (in press)
    • Owen, A. and Chandler, B. The implications of P-glycoprotein in HIV: friend or foe? Fundam. Clin. Pharmacol. (in press)
    • Fundam. Clin. Pharmacol.
    • Owen, A.1    Chandler, B.2
  • 57
    • 0033975098 scopus 로고    scopus 로고
    • Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier
    • J. Wijnholds Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier J. Clin. Invest. 105 2000 279 285
    • (2000) J. Clin. Invest. , vol.105 , pp. 279-285
    • Wijnholds, J.1
  • 58
    • 0002545509 scopus 로고    scopus 로고
    • Characterization of P-glycoprotein (Pgp) and multidrug resistance related protein (MRP) function in peripheral blood cells
    • B.J. Taylor Characterization of P-glycoprotein (Pgp) and multidrug resistance related protein (MRP) function in peripheral blood cells Cytometry 9 Suppl. 1998 60
    • (1998) Cytometry , vol.9 , Issue.SUPPL. , pp. 60
    • Taylor, B.J.1
  • 59
    • 6344294111 scopus 로고    scopus 로고
    • Functional correlation of P-glycoprotein expression and genotype with expression of the human immunodeficiency virus type 1 coreceptor CXCR4
    • A. Owen Functional correlation of P-glycoprotein expression and genotype with expression of the human immunodeficiency virus type 1 coreceptor CXCR4 J. Virol. 78 2004 12022 12029
    • (2004) J. Virol. , vol.78 , pp. 12022-12029
    • Owen, A.1
  • 60
    • 7244225172 scopus 로고    scopus 로고
    • Expression of PXR transcript in peripheral blood mononuclear cells and correlation with MDR1 mRNA
    • A. Owen Expression of PXR transcript in peripheral blood mononuclear cells and correlation with MDR1 mRNA Antivir. Ther. 9 2004 819 821
    • (2004) Antivir. Ther. , vol.9 , pp. 819-821
    • Owen, A.1
  • 61
    • 1642420430 scopus 로고    scopus 로고
    • P glycoprotein in human immunodeficiency virus type 1 infection and therapy
    • S.U. Sankatsing P glycoprotein in human immunodeficiency virus type 1 infection and therapy Antimicrob. Agents Chemother. 48 2004 1073 1081
    • (2004) Antimicrob. Agents Chemother. , vol.48 , pp. 1073-1081
    • Sankatsing, S.U.1
  • 62
    • 0033562673 scopus 로고    scopus 로고
    • HIV protease inhibitor ritonavir: A more potent inhibitor of P-glycoprotein than the cyclosporine analog SDZ PSC 833
    • J. Drewe HIV protease inhibitor ritonavir: a more potent inhibitor of P-glycoprotein than the cyclosporine analog SDZ PSC 833 Biochem. Pharmacol. 57 1999 1147 1152
    • (1999) Biochem. Pharmacol. , vol.57 , pp. 1147-1152
    • Drewe, J.1
  • 63
    • 0030199966 scopus 로고    scopus 로고
    • Clinical toxicity of antiretroviral nucleoside analogs
    • B.A. Styrt Clinical toxicity of antiretroviral nucleoside analogs Antiviral Res. 31 1996 121 135
    • (1996) Antiviral Res. , vol.31 , pp. 121-135
    • Styrt, B.A.1
  • 64
    • 0031467604 scopus 로고    scopus 로고
    • Interference with cell cycle progression and induction of apoptosis by dideoxynucleoside analogs
    • M. Viora Interference with cell cycle progression and induction of apoptosis by dideoxynucleoside analogs Int. J. Immunopharmacol. 19 1997 311 321
    • (1997) Int. J. Immunopharmacol. , vol.19 , pp. 311-321
    • Viora, M.1
  • 65
    • 2642583241 scopus 로고    scopus 로고
    • The ins and outs of mitochondrial dysfunction in NASH
    • B. Fromenty The ins and outs of mitochondrial dysfunction in NASH Diabetes Metab. 30 2004 121 138
    • (2004) Diabetes Metab. , vol.30 , pp. 121-138
    • Fromenty, B.1
  • 66
    • 0035127783 scopus 로고    scopus 로고
    • Chronic in vitro exposure to 3′-azido-2′, 3′-dideoxythymidine induces senescence and apoptosis and reduces tumorigenicity of metastatic mouse mammary tumor cells
    • A.M. Tejera Chronic in vitro exposure to 3′-azido-2′, 3′-dideoxythymidine induces senescence and apoptosis and reduces tumorigenicity of metastatic mouse mammary tumor cells Breast Cancer Res. Treat. 65 2001 93 99
    • (2001) Breast Cancer Res. Treat. , vol.65 , pp. 93-99
    • Tejera, A.M.1
  • 67
    • 0033231191 scopus 로고    scopus 로고
    • Azidothymidine and interferon-alpha induce apoptosis in herpesvirus-associated lymphomas
    • R.K. Lee Azidothymidine and interferon-alpha induce apoptosis in herpesvirus-associated lymphomas Cancer Res. 59 1999 5514 5520
    • (1999) Cancer Res. , vol.59 , pp. 5514-5520
    • Lee, R.K.1
  • 68
    • 0036840098 scopus 로고    scopus 로고
    • Impaired glucose phosphorylation and transport in skeletal muscle cause insulin resistance in HIV-1-infected patients with lipodystrophy
    • G.M. Behrens Impaired glucose phosphorylation and transport in skeletal muscle cause insulin resistance in HIV-1-infected patients with lipodystrophy J. Clin. Invest. 110 2002 1319 1327
    • (2002) J. Clin. Invest. , vol.110 , pp. 1319-1327
    • Behrens, G.M.1
  • 69
    • 0036828824 scopus 로고    scopus 로고
    • Altered myocellular and abdominal fat partitioning predict disturbance in insulin action in HIV protease inhibitor-related lipodystrophy
    • S.K. Gan Altered myocellular and abdominal fat partitioning predict disturbance in insulin action in HIV protease inhibitor-related lipodystrophy Diabetes 51 2002 3163 3169
    • (2002) Diabetes , vol.51 , pp. 3163-3169
    • Gan, S.K.1
  • 70
    • 0034904776 scopus 로고    scopus 로고
    • Growth factors can influence cell growth and survival through effects on glucose metabolism
    • M.G. Vander Heiden Growth factors can influence cell growth and survival through effects on glucose metabolism Mol. Cell. Biol. 21 2001 5899 5912
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 5899-5912
    • Vander Heiden, M.G.1
  • 71
    • 0033635249 scopus 로고    scopus 로고
    • In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability
    • J.C. Rathmell In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability Mol. Cell 6 2000 683 692
    • (2000) Mol. Cell , vol.6 , pp. 683-692
    • Rathmell, J.C.1
  • 72
    • 0034520312 scopus 로고    scopus 로고
    • High insulin-like growth factor 1 (IGF-1) and insulin concentrations trigger apoptosis in the mouse blastocyst via down-regulation of the IGF-1 receptor
    • M.M. Chi High insulin-like growth factor 1 (IGF-1) and insulin concentrations trigger apoptosis in the mouse blastocyst via down-regulation of the IGF-1 receptor Endocrinology 141 2000 4784 4792
    • (2000) Endocrinology , vol.141 , pp. 4784-4792
    • Chi, M.M.1
  • 73
    • 0021382386 scopus 로고
    • Haemopoietic cell growth factor mediates cell survival via its action on glucose transport
    • A.D. Whetton Haemopoietic cell growth factor mediates cell survival via its action on glucose transport EMBO J. 3 1984 409 413
    • (1984) EMBO J. , vol.3 , pp. 409-413
    • Whetton, A.D.1
  • 74
    • 2342565881 scopus 로고    scopus 로고
    • Advances in protein kinase B signalling: AKTion on multiple fronts
    • D.P. Brazil Advances in protein kinase B signalling: AKTion on multiple fronts Trends Biochem. Sci. 29 2004 233 242
    • (2004) Trends Biochem. Sci. , vol.29 , pp. 233-242
    • Brazil, D.P.1
  • 75
    • 0033575290 scopus 로고    scopus 로고
    • Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1
    • A. Barthel Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1 J. Biol. Chem. 274 1999 20281 20286
    • (1999) J. Biol. Chem. , vol.274 , pp. 20281-20286
    • Barthel, A.1
  • 76
    • 0029908016 scopus 로고    scopus 로고
    • Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation
    • A.D. Kohn Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation J. Biol. Chem. 271 1996 31372 31378
    • (1996) J. Biol. Chem. , vol.271 , pp. 31372-31378
    • Kohn, A.D.1
  • 77
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • D.A. Cross Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B Nature 378 1995 785 789
    • (1995) Nature , vol.378 , pp. 785-789
    • Cross, D.A.1
  • 78
    • 0034982374 scopus 로고    scopus 로고
    • The HIV protease inhibitor indinavir decreases insulin- and contraction-stimulated glucose transport in skeletal muscle
    • L.A. Nolte The HIV protease inhibitor indinavir decreases insulin- and contraction-stimulated glucose transport in skeletal muscle Diabetes 50 2001 1397 1401
    • (2001) Diabetes , vol.50 , pp. 1397-1401
    • Nolte, L.A.1
  • 79
    • 10744221245 scopus 로고    scopus 로고
    • Indinavir uncovers different contributions of GLUT4 and GLUT1 towards glucose uptake in muscle and fat cells and tissues
    • A. Rudich Indinavir uncovers different contributions of GLUT4 and GLUT1 towards glucose uptake in muscle and fat cells and tissues Diabetologia 46 2003 649 658
    • (2003) Diabetologia , vol.46 , pp. 649-658
    • Rudich, A.1
  • 80
    • 0037415059 scopus 로고    scopus 로고
    • Agent and cell-type specificity in the induction of insulin resistance by HIV protease inhibitors
    • R. Ben-Romano Agent and cell-type specificity in the induction of insulin resistance by HIV protease inhibitors AIDS 17 2003 23 32
    • (2003) AIDS , vol.17 , pp. 23-32
    • Ben-Romano, R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.