Phosphate prodrugs derived from N-acetylglucosamine have enhanced chondroprotective activity in explant cultures and represent a new lead in antiosteoarthritis drug discovery

Journal of Medicinal Chemistry

Volumn 51, Issue 18, 2008, Pages 5807-5812

  McGuigan, Christopher ^a   Serpi, Michaela ^a   Bibbo, Rita ^a   Roberts, Helen ^a   Hughes, Clare ^a   Caterson, Bruce ^a   Gibert, Ana Torrent ^b   Verson, Carlos Raúl Alaez ^b  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b BIOIBERICA SA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ESTER; GLYCOSAMINOGLYCAN; INTERLEUKIN 1; N ACETYLGLUCOSAMINE; PHOSPHATE; PHOSPHORAMIDIC ACID DERIVATIVE; PRODRUG; PROTEOGLYCAN;

ANIMAL TISSUE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHONDROPROTECTION; DEGRADATION; DIASTEREOISOMER; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; EXPLANT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; OSTEOARTHRITIS; REACTION ANALYSIS; STRUCTURE ANALYSIS; THIN LAYER CHROMATOGRAPHY;

ACETYLGLUCOSAMINE; ANIMALS; CARTILAGE, ARTICULAR; CATTLE; DRUG DESIGN; MAGNETIC RESONANCE SPECTROSCOPY; OSTEOARTHRITIS; PRODRUGS;

EID: 52449114293     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm800594c     Document Type: Article

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