Cytidine deaminase - The methodological relevance of AraC deamination for ex vivo experiments using cultured cell lines, fresh leukemic blasts, and normal bone marrow cells

Annals of Hematology

Volumn 78, Issue 11, 1999, Pages 514-520

  Braess, J ^a   Pfortner J ^b   Kern, W ^a   Hiddemann, W ^a   Schleyer, E ^b  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

AML; AraC; Cytidine deaminase; Pharmacodynamics; Pharmacokinetics

Indexed keywords

CYTARABINE; CYTIDINE DEAMINASE; DRUG METABOLITE;

ARTICLE; BLAST CELL; BONE MARROW CELL; CELL CULTURE; CELL LINE; CLINICAL ARTICLE; CONTROLLED STUDY; DEAMINATION; DRUG DEGRADATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LEUKEMIA CELL; METHODOLOGY; MONONUCLEAR CELL; PRIORITY JOURNAL;

ACUTE DISEASE; BLAST CRISIS; BONE MARROW CELLS; CELL COUNT; CYTARABINE; CYTIDINE DEAMINASE; DEAMINATION; HUMANS; LEUKEMIA, MYELOID; TUMOR CELLS, CULTURED;

EID: 0345422719     PISSN: 09395555     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002770050548     Document Type: Article

References (17)

1. Camiener GW, Smith CG (1965) Studies of the enzymatic deamination of cytosine arabinoside. I. Enzyme distribution and species specificity. Biochem Pharmacol 14:1405-1416
2. Momparler RL (1969) Effect of cytosine arabinoside 5′-triphosphate on mammalian DNA polymerase. Biochem Biophys Res Commun 34:464-471
3. Kufe DW, Major PP, Egan EM, Beardsley GP (1980) Correlation of cytotoxicity with incorporation of ara-C into DNA. J Biol Chem 255:8997-8900
4. Capizzi RL, Yang JL, Rathmell JP, White JC, Cheng E, Cheng YC, Kute T (1985) Dose-related pharmacologic effects of high-dose ara-C and its self-potentiation. Semin Oncol 12:65-74
5. Datta R, Banach D, Kojima H, Talanian RV, Alnemri ES, Wong WW, Kufe DW (1996) Activation of the CPP32 protease in apoptosis induced by 1-beta-d-arabinofuranosylcytosine and other DNA-damaging agents. Blood 88:1936-1943
6. Momparler RL (1972) Kinetic and template studies with 1-beta-d-arabinofuranosylcytosine 5′-triphosphate and mammalian deoxyribonucleic acid polymerase. Mol Pharmacol 8:362-370
7. Braess J, Berkovic D, Feuring-Buske M, Fleer E, Pfortner J, Wegendt C, Keye S, Riggert J, Kern W, Unterhalt M, Hiddemann W, Schleyer E (1998) Ara-C metabolism in fresh leukemic blasts/ normal bone marrow/ hematopoietic stem cells and its impact on the lipid composition of leukemic cells (HL60). Haematol Blood Transfus 39:596-602
8. 31P nuclear magnetic resonance study. Cancer Res 50:552-557
9. Emoto Y, Kisaki H, Manome Y, Kharbanda S, Kufe D (1996) Activation of protein kinase C-delta in human myeloid leukemia cells treated with 1-beta-d-arabinofuranosylcytosine. Blood 87:1990-1996
10. 3. Biochim Biophys Acta 1312:99-104
11. Jahns Streubel G, Reuter C, Auf der Landwehr U, Unterhalt M, Schleyer E, Wormann B, Buchner T, Hiddemann W (1997) Activity of thymidine kinase and of polymerase alpha as well as activity and gene expression of deoxycytidine deaminase in leukemic blasts are correlated with clinical response in the setting of granulocyte-macrophage colony-stimulating factor-based priming before and during TAD-9 induction therapy in acute myeloid leukemia. Blood 90:1968-1976
12. Jahns Streubel G, Unterhalt M, Schleyer E, Reuter C, Wormann B, Buchner T, Hiddemann W (1997) Correlation of deoxycytidine deaminase, thymidine kinase and polymerase alpha actvity and deoxycytidine deaminase gene expression in vivo with clinical response to TAD-9 + GM-CSF induction therapy in acute myeloid leukemia. Haematol Blood Transfus 7:252-259
13. 3H] cytosine arabinoside by high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl 676:131-140
14. Heintzel G (1982) Curve fitting programs. In: Bozler G, Van Rossum J (eds) Pharmacokinetics during drug development. Data analysis and evaluation techniques. Springer, Berlin Heidelberg New York, p 207
15. Steuart CD, Burke PJ (1971) Cytidine deaminase and the development of resistance to arabinosyl cytosine. Nat New Biol 233:109-110
16. 3H-cytosine arabinoside and its metabolites. Haematol Blood Transfus 543-542
17. Perignon JL, Chaleon J, Leverger G, Houllier AM, Thuillier L, Cartier PH (1985) Cytidine deaminase activity of human normal and malignant lymphoid cells. Clin Chim Acta 147:67-74