The phosphoramidate ProTide approach greatly enhances the activity of β-2′-C-methylguanosine against hepatitis C virus

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 15, 2009, Pages 4316-4320

  McGuigan, Christopher ^a   Perrone, Plinio ^a   Madela, Karolina ^a   Neyts, Johan ^b  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Antiviral; HCV; Nucleoside; Nucleotide; Phosphoramidate; Pro drug; Protide

Indexed keywords

BENZYL DERIVATIVE; BETA 2' C METHYLGUANOSINE; BETA 2' METHYLADENOSINE; CARBOXYPEPTIDASE; ESTER; GUANOSINE DERIVATIVE; N 6 PIVALOYL 2',3',5' TRIBENZOATE BETA 2'METHYLADENOSINE; NUCLEOSIDE; PHOSPHORAMIDIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG SYNTHESIS; HEPATITIS C VIRUS; HYDROLYSIS; NONHUMAN; REPLICON; VIRUS INHIBITION; VIRUS REPLICATION;

AMIDES; AMINO ACIDS; ANTIVIRAL AGENTS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ESTERS; GUANOSINE; HEPACIVIRUS; HEPATITIS C; HUMANS; HYDROLYSIS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; PHOSPHORIC ACIDS; PRODRUGS;

HEPATITIS C VIRUS;

EID: 67649999890     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.05.122     Document Type: Article

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