First example of phosphoramidate approach applied to a 4′-substituted purine nucleoside (4′-Azidoadenosine): Conversion of an inactive nucleoside to a submicromolar compound versus hepatitis C virus

Journal of Medicinal Chemistry

Volumn 50, Issue 22, 2007, Pages 5463-5470

  Perrone, Plinio ^a   Daverio, Felice ^a   Valente, Rocco ^a   Rajyaguru, Sonal ^b   Martin, Joseph A ^b   Lévêque, Vincent ^b   Le Pogam, Sophie ^b   Najera, Isabel ^b   Klumpp, Klaus ^b   Smith, David B ^b   McGuigan, Christopher ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b ROCHE BIOSCIENCE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 NAPHTHYLPHOSPHATE DERIVATIVE; 4' AZIDOADENOSINE; 4' AZIDOADENOSINE 5' O [ALPHA NAPHTHYL (ETHYLOXY 1 ALANINYL)]PHOSPHATE; 5' O [ALPHA NAPHTHYL (BENZYLOXY L ALANINYL)]PHOSPHATE; ALANINE DERIVATIVE; AMINO ACID; AZIDOTRIMETHYLSILANE; PHOSPHORAMIDIC ACID DERIVATIVE; PURINE NUCLEOSIDE; SILANE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; HEPATITIS C VIRUS; NONHUMAN; REPLICON; RING OPENING; STEREOCHEMISTRY; TECHNOLOGY; VIRUS INHIBITION; VIRUS REPLICATION;

ADENOSINE; ANTIVIRAL AGENTS; AZIDES; CELLS, CULTURED; HEPACIVIRUS; HUMANS; ORGANOPHOSPHORUS COMPOUNDS; REPLICON; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

EID: 35848930168     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070362i     Document Type: Article

References (24)

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