Gene network analysis of oxidative stress-mediated drug sensitivity in resistant ovarian carcinoma cells

Pharmacogenomics Journal

Volumn 10, Issue 2, 2010, Pages 94-104

  Maiti, A K ^a  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

Cancer; Chlorambucil; Microarray; ROS

Indexed keywords

ANTIOXIDANT; CHLORAMBUCIL; CYCLIN DEPENDENT KINASE 6; DNA; FLICE INHIBITORY PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; HEAT SHOCK PROTEIN 70; HYDROGEN PEROXIDE; MESSENGER RNA; PROTEIN CDC42; PROTEIN P53; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 3;

APOPTOSIS; ARTICLE; CANCER RESISTANCE; CARCINOMA CELL; CELL KILLING; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; DRUG SENSITIVITY; GENE EXPRESSION; GENE REGULATORY NETWORK; HUMAN; HUMAN CELL; IONIZING RADIATION; MICROARRAY ANALYSIS; MOLECULAR INTERACTION; OVARY CARCINOMA; OXIDATIVE STRESS; PRIORITY JOURNAL; RADIATION RESPONSE; SIGNAL TRANSDUCTION;

APOPTOSIS; CARCINOMA; CELL LINE, TUMOR; CHLORAMBUCIL; DNA-ACTIVATED PROTEIN KINASE; DRUG RESISTANCE, NEOPLASM; FEMALE; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; NUCLEAR PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OVARIAN NEOPLASMS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77950023644     PISSN: 1470269X     EISSN: 14731150     Source Type: Journal    
DOI: 10.1038/tpj.2009.49     Document Type: Article

References (59)

1. Horton JK, Roy G, Piper JT, Van Houten B, Awasthi YC, Mitra S et al. Characterization of a chlorambucil-resistant human ovarian carcinoma cell line overexpressing glutathione S-transferase mu. Biochem Pharmacol 1999; 58: 693-702.
2. Roy G, Horton JK, Roy R, Denning T, Mitra S, Boldogh I. Acquired alkylating drug resistance of a human ovarian carcinoma cell line is unaffected by altered levels of pro-and anti-apoptotic proteins. Oncogene 2000; 19: 141-150.
3. Mitra S, Izumi T, Boldogh I, Bhakat KK, Hill JW, Hazra TK. Choreography of oxidative damage repair in mammalian genomes. Free Radic Biol Med 2002; 33: 15-28.
4. Ruller S, Stahl C, Kohler G, Eickhoff B, Breder J, Schlaak M et al. Sensitization of tumor cells to ribotoxic stress-induced apoptotic cell death: a new therapeutic strategy. Clin Cancer Res 1999; 5: 2714-2725.
5. Fang J, Seki T, Maeda H. Therapeutic strategies by modulating oxygen stress in cancer and inflammation. Adv Drug Deliv Rev 2009; 61: 290-302.
6. Morel Y, Barouki R. Repression of gene expression by oxidative stress. Biochem J 1999; 342: 481-496.
7. Keyse SM. Protein phosphatases and the regulation of mitogen-activated protein kinase signalling. Curr Opin Cell Biol 2000; 12: 186-192.
8. Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B. A model for p53-induced apoptosis. Nature 1997; 389: 300-305.
9. Laurent A, Nicco C, Chereau C, Goulvestre C, Alexandre J, Alves A et al. Controlling tumor growth by modulating endogenous production of reactive oxygen species. Cancer Res 2005; 65: 948-956.
10. Kong Q, Beel JA, Lillehei KO. A threshold concept for cancer therapy. Med Hypotheses 2000; 55: 29-35.
11. Mookerjee A, Basu JM, Majumder S, Chatterjee S, Panda GS, Dutta P et al. A novel copper complex induces ROS generation in doxorubicin resistant Ehrlich ascitis carcinoma cells and increases activity of antioxidant enzymes in vital organs in vivo. BMC Cancer 2006; 6: 267.
12. Mookerjee A, Mookerjee Basu J, Dutta P, Majumder S, Bhattacharyya S, Biswas J et al. Overcoming drug-resistant cancer by a newly developed copper chelate through host-protective cytokine-mediated apoptosis. Clin Cancer Res 2006; 12: 4339-4349.
13. Vermes I, Haanen C, Steffens-Nakken H, Reutelingsperger C. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J Immunol Methods 1995; 184: 39-51.
14. Das GC, Bacsi A, Shrivastav M, Hazra TK, Boldogh I. Enhanced gamma-glutamylcysteine synthetase activity decreases drug-induced oxidative stress levels and cytotoxicity. Mol Carcinog 2006; 45: 635-647.
15. Boldogh I, Roy G, Lee MS, Bacsi A, Hazra TK, Bhakat KK et al. Reduced DNA double strand breaks in chlorambucil resistant cells are related to high DNA-PKcs activity and low oxidative stress. Toxicology 2003; 193: 137-152.
16. Anderson ME. Glutathione: an overview of biosynthesis and modulation. Chem Biol Interact 1998; 111-112: 1-14.
17. Davies KJ. The broad spectrum of responses to oxidants in proliferating cells: a new paradigm for oxidative stress. IUBMB Life 1999; 48: 41-47.
18. 2+-dependent DNA damage in human peripheral blood lymphocytes. Free Radic Biol Med 1999; 26: 548-556.
19. Casentini-Borocz D, Bringman T. Enzyme immunoconjugates utilizing glucose oxidase and myeloperoxidase are cytotoxic to Candida tropicalis. Antimicrob Agents Chemother 1990; 34: 875-880.
20. Mates JM, Sanchez-Jimenez FM. Role of reactive oxygen species in apoptosis: implications for cancer therapy. Int J Biochem Cell Biol 2000; 32: 157-170.
21. Le Romancer M, Cosulich SC, Jackson SP, Clarke PR. Cleavage and inactivation of DNA-dependent protein kinase catalytic subunit during apoptosis in Xenopus egg extracts. J Cell Sci 1996; 109: 3121-3127.
22. Macip S, Igarashi M, Berggren P, Yu J, Lee SW, Aaronson SA. Influence of induced reactive oxygen species in p53-mediated cell fate decisions. Mol Cell Biol 2003; 23: 8576-8585.
23. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS et al. Generation and initial analysis of more than 15 000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci USA 2002; 99: 16899-16903.
24. Inohara N, Koseki T, Hu Y, Chen S, Nunez G. CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis. Proc Natl Acad Sci USA 1997; 94: 10717-10722.
25. Schickling O, Stegh AH, Byrd J, Peter ME. Nuclear localization of DEDD leads to caspase-6 activation through its death effector domain and inhibition of RNA polymerase I dependent transcription. Cell Death Differ 2001; 8: 1157-1168.
26. Messina E, Lupi F, Barile L, Giacomello A. Cyclic nucleotides and neuroblastoma differentiation. Nucleosides Nucleotides Nucleic Acids 2004; 23: 1551-1554.
27. Zegers MM, Forget MA, Chernoff J, Mostov KE, ter Beest MB, Hansen SH. Pak1 and PIX regulate contact inhibition during epithelial wound healing. EMBO J 2003; 22: 4155-4165.
28. 2. Mol Cell Biol 2004; 24: 4384-4394.
29. Srivastava RK, Srivastava AR, Cho-Chung YS, Longo DL. Synergistic effects of retinoic acid and 8-Cl-cAMP on apoptosis require caspase-3 activation in human ovarian cancer cells. Oncogene 1999; 18: 1755-1763.
30. Bacsi A, Kannan S, Lee MS, Hazra TK, Boldogh I. Modulation of DNA-dependent protein kinase activity in chlorambucil-treated cells. Free Radic Biol Med 2005; 39: 1650-1659.
31. Yin Y, Liu YX, Jin YJ, Hall EJ, Barrett JC. PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression. Nature 2003; 422: 527-531.
32. Cardile V, Scifo C, Russo A, Falsaperla M, Morgia G, Motta M et al. Involvement of HSP70 in resveratrol-induced apoptosis of human prostate cancer. Anticancer Res 2003; 23: 4921-4926.
33. Vafa O, Wade M, Kern S, Beeche M, Pandita TK, Hampton GM et al. c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability. Mol Cell 2002; 9: 1031-1044.
34. Mates JM, Segura JA, Alonso FJ, Marquez J. Intracellular redox status and oxidative stress: implications for cell proliferation, apoptosis, and carcinogenesis. Arch Toxicol 2008; 82: 273-299.
35. Hayden RE, Pratt G, Davies NJ, Khanim FL, Birtwistle J, Delgado J et al. Treatment of primary CLL cells with bezafibrate and medroxyproges-terone acetate induces apoptosis and represses the pro-proliferative signal of CD40-ligand, in part through increased 15dDelta12,14,PGJ2. Leukemia 2009; 23: 292-304.
36. Ferriero DM. Oxidant mechanisms in neonatal hypoxia-ischemia. Dev Neurosci 2001; 23: 198-202.
37. Ricci JE, Munoz-Pinedo C, Fitzgerald P, Bailly-Maitre B, Perkins GA, Yadava N et al. Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain. Cell 2004; 117: 773-786.
38. Lawley PD, Phillips DH. DNA adducts from chemotherapeutic agents. Mutat Res 1996; 355: 13-40.
39. Marra M, Santini D, Meo G, Vincenzi B, Zappavigna S, Baldi A et al. CYR61 down-modulation potentiates the anti-cancer effects of zole-dronic acid in androgen-independent prostate cancer cells. Int J Cancer 2009; 125: 2004-2013.
40. Karpinich NO, Tafani M, Rothman RJ, Russo MA, Farber JL. The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c. J Biol Chem 2002; 277: 16547-16552.
41. Jack MT, Woo RA, Motoyama N, Takai H, Lee PW. DNA-dependent protein kinase and checkpoint kinase 2 synergistically activate a latent population of p53 upon DNA damage. J Biol Chem 2004; 279: 15269-15273.
42. Koike M, Shiomi T, Koike A. Ku70 can translocate to the nucleus independent of Ku80 translocation and DNA-PK autophosphorylation. Biochem Biophys Res Commun 2000; 276: 1105-1111.
43. Nilsson A, Sirzen F, Lewensohn R, Wang N, Skog S. Cell cycle-dependent regulation of the DNA-dependent protein kinase. Cell Prolif 1999; 32: 239-248.
44. Mahyar-Roemer M, Katsen A, Mestres P, Roemer K. Resveratrol induces colon tumor cell apoptosis independently of p53 and precede by epithelial differentiation, mitochondrial proliferation and membrane potential collapse. Int J Cancer 2001; 94: 615-622.
45. Dai C, Chung IJ, Jiang S, Price JO, Krantz SB. Reduction of cell cycle progression in human erythroid progenitor cells treated with tumour necrosis factor alpha occurs with reduced CDK6 and is partially reversed by CDK6 transduction. Br J Haematol 2003; 121: 919-927.
46. Hacker H, Karin M. Is NF-kappaB2/p100 a direct activator of programmed cell death? Cancer Cell 2002; 2: 431-433.
47. Han DC, Lee MY, Shin KD, Jeon SB, Kim JM, Son KH et al. 2-Benzoyloxycinnamaldehyde induces apoptosis in human carcinoma via reactive oxygen species. J Biol Chem 2004; 279: 6911-6920.
48. Gamper C, van Eyndhoven WG, Schweiger E, Mossbacher M, Koo B, Lederman S. TRAF-3 interacts with p62 nucleoporin, a component of the nuclear pore central plug that binds classical NLS-containing import complexes. Mol Immunol 2000; 37: 73-84.
49. Aghdassi A, Phillips P, Dudeja V, Dhaulakhandi D, Sharif R, Dawra R et al. Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma. Cancer Res 2007; 67: 616-625.
50. Carboni GL, Gao B, Nishizaki M, Xu K, Minna JD, Roth JA et al. CACNA2D2-mediated apoptosis in NSCLC cells is associated with alterations of the intracellular calcium signaling and disruption of mitochondria membrane integrity. Oncogene 2003; 22: 615-626.
51. Vilenchik M, Raffo AJ, Benimetskaya L, Shames D, Stein CA. Antisense RNA down-regulation of bcl-xL expression in prostate cancer cells leads to diminished rates of cellular proliferation and resistance to cytotoxic chemotherapeutic agents. Cancer Res 2002; 62: 2175-2183.
52. Deverman BE, Cook BL, Manson SR, Niederhoff RA, Langer EM, Rosova I et al. Bcl-xL deamidation is a critical switch in the regulation of the response to DNA damage. Cell 2002; 111: 51-62.
53. Takehara T, Takahashi H. Suppression of Bcl-xL deamidation in human hepatocellular carcinomas. Cancer Res 2003; 63: 3054-3057.
54. Zhang D, Fan D. Multidrug resistance in gastric cancer: recent research advances and ongoing therapeutic challenges. Expert Rev Anticancer Ther 2007; 7: 1369-1378.
55. Nooter K, Stoter G. Molecular mechanisms of multidrug resistance in cancer chemotherapy. Pathol Res Pract 1996; 192: 768-780.
56. Jaksic B, Brugiatelli M, Krc I, Losonczi H, Holowiecki J, Planinc-Peraica A et al. High dose chlorambucil versus Binet's modified cyclophos-phamide, doxorubicin, vincristine, and prednisone regimen in the treatment of patients with advanced B-cell chronic lymphocytic leukemia. Results of an international multicenter randomized trial. International Society for Chemo-Immunotherapy, Vienna. Cancer 1997; 79: 2107-2114.
57. Silvennoinen R, Malminiemi K, Malminiemi O, Seppala E, Vilpo J. Pharmacokinetics of chlorambucil in patients with chronic lymphocytic leukaemia: comparison of different days, cycles and doses. Pharmacol Toxicol 2000; 87: 223-228.
58. Philpott GW, Bower RJ, Parker KL, Shearer WT, Parker CW. Affinity cytotoxicity of tumor cells with antibody-glucose oxidase conjugates, peroxidase, and arsphenamine. Cancer Res 1974; 34: 2159-2164.
59. Starke PE, Farber JL. Endogenous defenses against the cytotoxicity of hydrogen peroxide in cultured rat hepatocytes. J Biol Chem 1985; 260: 86-92.