Cell cycle-dependent regulation of the DNA-dependent protein kinase

Cell Proliferation

Volumn 32, Issue 4, 1999, Pages 239-248

  Nilsson, A ^a,b   Sirzen F ^a   Lewensohn, R ^a   Wang, N ^a   Skog, S ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ENZYME; DNA BINDING PROTEIN; DNA DEPENDENT PROTEIN KINASE; PHOSPHOTRANSFERASE; PROTEIN SERINE THREONINE KINASE;

ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA DETERMINATION; DNA RECOMBINATION; DNA REPAIR; DNA TRANSCRIPTION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SUBUNIT; HELA CELL; HUMAN; HUMAN CELL; MOLECULAR WEIGHT;

EID: 0033428710     PISSN: 09607722     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2184.1999.3240239.x     Document Type: Article

References (21)

1. AJAY KA, SATOH M, REAP E, COHEN PL, REEVES WH. (1995) Absence of autoantigen ku in mature human neutrophils and human promyelocyte leukemia line (HL60) cells and lymphocytes undergoing apoptosis. J. Exp. Med. 181, 2049.
2. BLUNT T, NICHOLAS FJ, TACCIOLI GE et al. (1995) Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell 80, 813.
3. BOUBNOV NV, WEAVER DT. (1995) Scid cells are deficient in Ku and RPA phosphorylation by the DNA-dependent protein kinase. Mol. Cell. Biol. 15, 5700-5706.
4. CARTER T, VANCUROVÁ I, SUN I, LOU W, DELEON S. (1990) A DNA-activated protein kinase from HeLa cell nuclei. Mol. Cell Biol. 10, 6460.
5. DANSKA JS, HOLLAND D, MARIATHASAN S, WILLIAMS KM, GUIDOS CJ. (1996) Biochemical and genetic defects in the DNA-Dependent protein kinase in murine scid lymphocytes. Mol. Cell Biol. 16, 5507.
6. DIN S, BRILL SJ, FAIRMAN M, STILLMAN B. (1990) Cell-cycle-regulated phosphorylation of DNA replication factor A from human and yeat cells. Genes Dev. 4, 968-977.
7. FLYGARE J, BENSON F, HELLGREN D. (1996) Expression of the human RAD51 gene during the cell cycle in primary human peripheral blood lymphocytes. Biochem. Biophys. Acta 1312, 231.
8. GOTTLIEB TM, JACKSON SP. (1993) The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell 72, 131.
9. KEITH CT, SCHREIBER SL. (1995) PIK-related kinases. DNA repair, recombination, and cell cycle checkpoints. Science 270, 50.
10. KIRCHGESSNER CU, PATIL CK, EVANS JW et al. (1995) DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect. Science 267, 1178.
11. LEE SE, MITCHELL RA, CHENG A, HEDRICKSON EA. (1997) Evidence for DNA-PK-dependent and independent double-strand break repair pathways in mammalian cells as a function of the cell cycle. Mol. Cell Biol. 17, 1425.
12. 2-terminal threonine residues. J. Biol. Chem. 264, 17275.
13. LEES-MILLER S, GODBOUT R, CHAN DW et al. (1995) Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line. Science 267, 1183.
14. METZGER L, ILIAKIS G. (1991) Kinetics of DNA-double-stranded break repair throughout the cell cycle as assayed by pulse field gel electrophoresis in CHO cells. Int. J. Radiat. Biol. 59, 1325.
15. MOROZOV VE, FALZON M, ANDERSON CW, KUFF EL. (1994) DNA-dependent protein kinase is activated by nicks and larger single-stranded gaps. J. Biol. Chem. 269, 16684.
16. NAGASAWA M, WATANABE F, SUWA A, YAMAMOTO K, TERAOKA H. (1997) Nuclear translocation of the catalytic component of DNA-dependent protein kinase upon growth stimulation in normal human T lymphocytes. Cell Struct. Funct. 22, 585.
17. SCHUSSEL M, CONSTANTINESCU A, MORROW T, BAXTER M, PENG A. (1993) Double-strand signal sequence breaks in V(D)J recombination are blunt, 5-phosphorylated, RAG, and cell cycle-regulated. Genes Dev. 7, 2520.
18. SMIDER V, RATHMELL WK, LIEBER MR, CHU G. (1994) Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA. Science 266, 288.
19. SUWA A, HIRAKATA M, TAKEDA Y, JESCH SA, MIMORI T, HARDIN JA. (1994) DNA-dependent protein kinase (Ku protein-p350 complex) assembles on double-stranded DNA. Proc. Natl. Acad. Sci. USA 91, 6904.
20. TACCIOLI, GE, GOTTLIEB TM, BLUNT T et al. (1994) Ku 80. Product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. Science 265, 1442.
21. YANEVA M, JHIANG S. (1991) Expression of the Ku protein during cell proliferation. Bichem. Biophys. Acta 1090, 181.