Deleterious iron-mediated oxidation of biomolecules

Free Radical Biology and Medicine

Volumn 32, Issue 7, 2002, Pages 577-583

  Welch, Kevin D ^a   Davis, T Zane ^a   Van Eden, Marc E ^b   Aust, Steven D ^a  

^a UTAH STATE UNIVERSITY   (United States)

^b Department of Molecular Virology and Microbiology ^*  (United States)

Author keywords

Biomolecule oxidation; Ceruloplasmin; Ferritin; Free radicals; Iron

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; CATALASE; CERULOPLASMIN; DNA; FERRITIN; GLUTATHIONE PEROXIDASE; IRON; IRON COMPLEX; LIPID; SUPEROXIDE DISMUTASE;

AUTOOXIDATION; DNA CLEAVAGE; GENOTOXICITY; HUMAN; IRON CHELATION; IRON KINETICS; IRON OVERLOAD; IRON STORAGE; LIPID PEROXIDATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW;

EID: 0036532282     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(02)00760-8     Document Type: Article

References (46)

1. Oxidation states, redox potentials and spin states
2. Transition metals as catalysts of "autoxidation" reactions
3. Biological oxidations catalyzed by iron released from ferritin
4. The role of metals in the enzymatic and nonenzymatic oxidation of epinephrine
5. In the absence of catalytic metals ascorbate does not autoxidize at pH 7: Ascorbate as a test for catalytic metals
6. DNA breakage induced by 1,2,4-benzenetriol: Relative contributions of oxygen-derived active species and transition metal ions
7. A site-specific mechanism for free radical induced biological damage: The essential role of redox-active transition metals
8. Comparison of iron-catalyzed DNA and lipid oxidation
9. Bleomycin-induced strand scission of DNA
10. Origin and cytotoxic properties of base propenols derived from DNA
11. Effect of chelating agents and metal ions on the degradation of DNA by bleomycin
12. Metal ion-catalyzed oxidation of proteins: Biochemical mechanism and biological consequences
13. Modification of ferritin during iron loading
14. The consequences of hydroxyl radical formation on the stoichiometry and kinetics of ferrous iron oxidation by human apoferritin
15. Evidence that peroxidation of lysosomal membranes is initiated by hydroxyl free radicals produced during flavin enzyme activity
16. Hydroxyl radical production in a purified NADPH-cytochrome c (p-450) reductase system
17. Unusual copper-induced sensitization of the biological damage due to superoxide radicals
18. The requirement for ferric in the initiation of lipid peroxidation by chelated ferrous iron
19. Effects of additional iron-chelators on Fe(II)-initiated lipid peroxidation: Evidence to support the Fe(II)...Fe(III) complex as the initiator
20. The requirement for iron(III) in the initiation of lipid peroxidation by iron(II) and hydrogen peroxide
21. The role of iron in the initiation of lipid peroxidation
22. Renal tumors in rats given trisodium nitriloacetic acid in drinking water for 2 years
23. Ferric nitriloacetate: A potent stimulant of in vivo lipid peroxidation in mice
24. Thiol-mediated NTA-Fe(III) reduction and lipid peroxidation
25. Arguments against the significance of the Fenton reaction contributing to signal pathways under in vivo conditions
26. The generation of hydroxyl radicals in the reaction of molecular oxygen with phosphate complexes of ferrous ion
27. Inorganic phosphate promotes redox cycling of iron in liver microsomes: Effects on free radical reactions
28. DNA breakage induced by 1,2,4-benzenetriol: Relative contributions of oxygen-derived active species and transition metal ions
29. Oxygen species in paraquat toxicity: The crypto-OH radical
30. Metal [ML(x); M=Fe, Cu, Co, Mn]/hydroperoxide-induced activation of dioxygen for the oxygenation of hydrocarbons: Oxygenated Fenton chemistry
31. Iron autoxidation and free radical generation: Effects of buffers, ligands and chelators
32. Iron and dioxygen chemistry is an important route to initiation of biological free radical oxidations: An electron paramagnetic resonance spin trapping study
33. Role of metals in oxygen radical reactions
34. Relationship between iron and phosphate in mammalian ferritins
35. Ferritin as a source of iron for oxidative damage
36. The role of superoxide anion radical in the reduction of ferritin iron by xanthine oxidase
37. Paraquat and ferritin-dependent lipid peroxidation
38. Inhibition of superoxide and ferritin-dependent lipid peroxidation by ceruloplasmin
39. Ceruloplasmin
40. The incorporation of iron into apoferritin as mediated by ceruloplasmin
41. Evidence for a protein-protein complex during iron loading into ferritin by ceruloplasmin
42. Biosynthesis of ceruloplasmin in various rat organs
43. Plasma ceruloplasmin. Evidence for its presence and uptake by heart and other organs of the rat
44. Iron loading into ferritin by an intracellular ferroxidase