Serotonergic mechanisms on breathing modulation in the rat locus coeruleus

Pflugers Archiv European Journal of Physiology

Volumn 459, Issue 3, 2010, Pages 357-368

  De Moreno, Vanessa Souza ^a   Bícego, Kênia C ^a   Szawka, Raphael E ^b   Anselmo Franci, Janete A ^b   Gargaglioni, Luciane H ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

5 ht 1a; 5ht2a; A6 region; Chemosensitivity; Hypercapnia; Pons; Serotonin; Ventilation

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; CARBON DIOXIDE; SEROTONIN; SEROTONIN 1A RECEPTOR; SEROTONIN 2 RECEPTOR; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; 4-IODO-2,5-DIMETHOXYPHENYLISOPROPYLAMINE; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; AMPHETAMINE DERIVATIVE; IDAZOXAN; KETANSERIN; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; PIPERAZINE DERIVATIVE; PYRIDINE DERIVATIVE; SEROTONIN 2A RECEPTOR; SEROTONIN AGONIST; SEROTONIN ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREATHING MECHANICS; CARBON DIOXIDE BREATHING; CONTROLLED STUDY; HYPERCAPNIA; LOCUS CERULEUS; LUNG VENTILATION; MALE; NONHUMAN; PLETHYSMOGRAPHY; PRIORITY JOURNAL; RAT; SEROTONIN BRAIN LEVEL; SEROTONIN RELEASE; SEROTONINERGIC SYSTEM; TIDAL VOLUME; ANIMAL; BREATHING; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; METABOLISM; MICROINJECTION; PHYSIOLOGY; WISTAR RAT;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ADRENERGIC ALPHA-ANTAGONISTS; AMPHETAMINES; ANIMALS; HYDROXYINDOLEACETIC ACID; HYPERCAPNIA; IDAZOXAN; KETANSERIN; LOCUS COERULEUS; MALE; MICROINJECTIONS; PIPERAZINES; PULMONARY VENTILATION; PYRIDINES; RATS; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTOR, SEROTONIN, 5-HT2A; RESPIRATION; SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS;

EID: 77949903496     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-009-0741-4     Document Type: Article

References (61)

1. Aguiar CL, Romcy-Pereira RN, Szawka RE, Galvis-Alonso OY, Anselmo-Franci JA, Leite JP (2008) Muscarinic acetylcholine neurotransmission enhances the late-phase of long-term potentiation in. the hippocampal-prefrontal cortex pathway of rats in vivo: a possible involvement of monoaminergic systems. Neuroscience 153: 309-1319
2. Astier B, Van Bockstaele EJ, Aston-Jones G, Pieribone VA (1990) Anatomical evidence for multiple pathways leading from the rostral ventrolateral medulla (nucleus paragigantocellularis) to the locus coeruleus in rat. Neurosci Lett 118(2): 141-214
3. Aston-Jones G, Rajkowski J, Kubiak P, Valentino RJ, Shipley MT (1.996) Role of the locus coeruleus in emotional activation. Prog Brain Res 107: 379-402
4. Aston-Jones G, Shipley MT, Chouvet G, Ennis M, van. Bockstaele E, Pieribone V, Shiekhattar R, Akaoka H, Drolet G, Astier B et al (1991) Afferent regulation of locus coeruleus neurons: anatomy, physiology and pharmacology. Prog Brain Res 88: 47-75
5. Bartlett D, Tenney SM (1970) Control of breathing in. experimental anemia. Respir Physiol 10: 384-395
6. Berridge CW, Waterhouse BD (2003) The locus coeruleusnoradrenergic system: modulation of behavioral state and statedependent cognitive processes. Brain. Res Brain Res Rev 42(1):33-84
7. Biancardi V, Bicego KC, Almeida MC, Gargaglioni LH (2008) Locus coeruleus noradrenergic neurons and CO(2) drive to breathing. Pflugers Arch 455(6): 1119-1128
8. Blandina P, Goldfarb J, Walcott J, Green JP (1991) Serotonergic modulation of the release of endogenous norepinephrine from rat hypothalamic slices. J Pharmacol Exp Ther 256(1):341-347
9. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem 72: 248-254
10. 2-Adrenoceptor subtypes and imidazoline-like binding sites in. the rat brain. Br J Pharmacol 99: 803-809
11. Cedarbaum JM, Aghajanian GK (1978) Afferent projections to the rat locus coeruleus as determined by a retrograde tracing technique. J Comp Neurol 178 (1):1-16
12. Chiang C, Aston-Jones G (1993) 5-Hydroxytryptamine2 agonist augments gamma-aminobutyric acid and excitatory amino acid inputs to noradrenergic locus coeruleus neurons. Neuroscience 54 (2): 409-420
13. Crespi F, Buda M, Mcrae-Degueurce A, Pujol JF (1980) Alteration in tyrosine hydroxylase activity in. the LC after administration of P-chlorophenylalanine. Brain Res 9: 501-509
14. Curet O, de Montigny C (1.989) Electrophysiological characterization of adrenoceptors in. the rat dorsal, hippocampus. III. Evidence for the physiological role of terminal alpha 2-adrenergic autoreceptors. Brain Res 499: 18-26
15. Dejours P (.1981.) Principle of comparative respiratory physiology, 2nd edn. Elsevier, New York
16. Dias MB, Nucci TB, Margatho LO, Antunes-Rodrigues J, Gargaglioni LH, Branco LG (2007) Raphe magnus nucleus is involved in ventilatory but not hypothermic response to COa. J Appl Physiol. 103: 1780-1788
17. Dobbins EG, Feldman JL (1994) Brainstem network controlling descending drive to phrenic motoneurons in rat. J Comp Neurol. 347(1):64-86
18. Done CJG, Sharp T (1.992) Evidence that 5-H.T2 receptor activation decreases noradrenaline release in rat hippocampus in vivo. Br J Pharmacol 107: 240-245
19. Elam M, Yao T, Thoren R Svensson TH (1.98.1) Hypercapnia and hypoxia: chemoreceptor-mediated control of locus coeruleus neurons and splanchnic, sympathetic nerves. Brain. Res 222: 373-381
20. Filosa JA, Dean JB, Putnam RW (2002) Role of intracellular and. extracellular pH in the chemosensitive response of rat locus coeruleus neurones. J Physiol 541: 493-509
21. Foote SL, Bloom FE, Aston-Jones G (1.983) Nucleus locus ceruleus: new evidence of anatomical and physiological specificity. Physiol Rev 63: 844-914
22. Gargaglioni LH, Steiner AA, Branco LG (2005) Involvement of serotoninergic receptors in the anteroventral preoptic region, on. hypoxia-indueed hypothermia. Brain Res 1044(1): 16-24
23. Grzanna R, Molliver ME (1980) The locus coeruleus in the rat: an immunohistochemical delineation. Neuroscience 5: 21-40
24. Haddjeri N, de Montigny C, Blier P (1997) Modulation of the firing activity of noradrenergic neurones in the rat locus coeruleus by the 5-hydroxtryptami.ne system. Br J Pharmacol 120: 865-875
25. 2induced c-fos expression in the CNS catecholaminergic neurons. Respir Physiol 105: 35-45
26. Hedlund U, Järvholm B, Lundbäck B (2004) Respiratory symptoms and obstructive lung diseases in iron ore miners: report from the obstructive lung disease in. northern Sweden studies. Eur J Epidemiol 19(10): 953-958
27. Hilaire G, Viemari JC, Coulon P, Simonneau M, Bévengut M. (2004) Modulation of the respiratory rhythm generation by the pontine A5 and A6 groups in rodents. Resp Physiol Neurobiol 143: 187-197
28. Hodges MR, Richerson GB (2008) Interaction between defects in ventilatory and thermoregulatory control in mice lacking 5-HT neurons. Respir Physiol Neurobiol. 164(3): 350-357
29. Hodges MR, Tattersall GJ, Harris MB, McEvoy SD, Richerson DN, Deneris ES, Johnson RL, Chen ZF, Richerson GB (2008) Defects in breathing and 40 thermoregulation in mice with nearcomplete absence of central serotonin neurons. J Neurosci 28: 2495-2505
30. 2/ H+ responses in primary cell culture. J Appl Physiol 105(4):1301-1311
31. Kaehler ST, Singewald N, Philippu A (1999) Dependence of Serotonin release in the locus coeruleus on dorsal raphe neuronal activity. Naunyn Schmiedebergs Arch Pharmacol 359(5): 386-393
32. Kanamaru M, Homma I (2007) Compensatory airway dilation and additive ventilatory augmentation mediated by dorsomedial medullary 5-hydroxytryptami.ne 2 receptor activity and hypercapnia. Am J Physiol Regul Integr Comp Physiol 293(2): R854-R860
33. Kim. MA, Lee HS, Lee BY, Waterhouse BD (2004) Reciprocal connections between, subdivisions of the dorsal, raphe and the nuclear core of the locus coeruleus in the rat. Brain Res 1.026(l): 56-67
34. Leger L, Descarries L (1978) Serotonin nerve terminals in the locus coeruleus of adult rat: a radioautographic study. Brain Res 145: 1-13 (Pubitemid 8322179)
35. Li A, Nattie E (2008) Serotonin transporter knockout mice have a reduced ventilatory response to hypercapnia (predominantly in males) but not to hypoxia. J Physiol 5 86(9) :2321-2329
36. Malan A (1973) Ventilation measured by body plethysmography in hibernating mammals and in poikilotherms. Respir Physiol 17 (1):32-44
37. Matsumoto M, Yioshioka M, Togashi H, Tochihara M, Ikeda T, Saito H (1995) Modulation, of norepinephrine release by serotonergic receptors in the rat hippocampus as measured by in vivo microdialysis. J Pharmacol Exp Ther 272: 1044-1051.
38. McRae-Degueurce A, Berod A, Mermet A, Keller A, Chouvet G, Joh TH, Pujol JF (1982) Alterations in tyrosine hydroxylase activity elicited by raphe nuclei lesions in the rat locus coeruleus: evidence for the involvement of serotonin afférents. Brain Res 235(2): 285-301. (Pubitemid 12180778)
39. Mongeau R, De Montigny C, Blier P (1994) Effect of long-term administration of antidepressant drugs on the 5-HT3 receptors that enhance the electrically evoked release of [3H]noradrenaline in the rat hippocampus. Eur J Pharmacol 271. (1): 121-129
40. Nattie EE, Li A (2008) Muscimol dialysis into the caudal aspect of the nucleus tractus solitarii of conscious rats inhibits chemoreception. Respir Physiol Neurobiol 164(3): 394-400
41. Nosjean A, Guyenet PG (1991) Role of ventrolateral medulla in sympatholytic effect of 8-OHDPAT in. rats. Am J Physiol 260(3 Pt 2):R600-R609
42. Nucci TB, Branco LGS, Gargaglioni LH (2008) 5-HT1A but not 5HT2 and 5-HT7 receptors in the nucleus raphe magnus. Acta Physiologica Scandinavica 193: 403-414
43. Oyamada Y, Ballantyne D, Muckenhoff K, Scheid P (1998) Respiration-modulated membrane potential and chemosensitivity of locus coeruleus neurones in the in vitro brainstem-spinal cord of the neonatal, rat. J Physiol 513: 381-398 (Pubitemid 28562956)
44. Palkovits M (1973) Isolated removal of hypothalamic or other brain nuclei of the rat. Brain. Res 59: 449-450
45. Paxinos G, Watson C (1998) The rat brain in stereotaxic coordinates. Academic, New York
46. Paxinos G, Watson C (2005) The rat brain, in. stereotaxic coordinates, 5th edn. Academic, San Diego
47. Pickel VM, Joh TH, Reis DJ (1.977) A serotonergic innervation of noradrenergic neurons in nucleus locus coeruleus: demonstration by immunocytochemical localization, of the transmitter specific enzymes tyrosine and tryptophan hydroxylase. Brain Res 131. (2): 197-214
48. Pieribone VA, Aston-Jones G (1991) Adrenergic innervation of the rat nucleus locus coeruleus arises predominantly from the C1 adrenergic cell group in the rostral medulla. Neuroscience 41.(2-3): 525-542
49. Poliacek I, Halasova E, Jakus J, Murin R Barani H, Stransky A, Boiser DC (2007) Brainstem regions involved in the expiration reflex. A c-fos study in anesthetized cats. Brain Res 1184: 168-177
50. Poncet L, Denoroy L, Dalmaz Y, Pequignot JM. (1.997) Activity of tryptophan hydroxylase and content of indolamines in discrete brain regions after a long-term hypoxic exposure in the rat. Brain Res 765(1):122-128
51. Pudovkina OL, Cremers TI, Westerink BH (2002) The interaction between the locus coeruleus and dorsal raphe nucleus studied with dual-probe microdialysis. Eur J Pharmacol 445 (1-2): 37-42
52. Reader TA, Briere R, Grondin. L, Ferren A (1986) Erects of pchlorophenylalanine on cortical monamines and on electrical activity of noradrenergic neurons. Neurochem Res 11: 1025-1035
53. Shannon NJ, Gunnet JW, Moore KE (1986) A comparison of biochemical indices of 5-hydroxytryptaminergic neuronal activity following electrical stimulation of the dorsal raphe nucleus. J Neurochem. 47: 958-965
54. Stunden CE, Filosa JA, Garcia AJ, Dean JB, Putnam RW (2001) Development of in vivo ventilatory and single chemosensitive neuron responses to hypercapnia in rats. Respir Physiol 127(2-3): 135-155
55. Stupfel M. (.1974) Carbon dioxide and temperature regulation of homeothermic mammals. In: Nahas G, Schaefer KE (eds) Carbon. dioxide and metabolic regulations. Springer, New York, pp 163-186
56. Svensson TH, Bunney BS, Aghajanian GK (1975) Inhibition of both NA and 5-HT neurons in brain by the α-adrenergic agonist Clonidine. Brain. Res 92: 291-306
57. Szabo ST, Blier P (2001.) Effect of the selective noradrenergic reuptake inhibitor reboxetine on the firing activity of noradrenaline and serotonin neurons. Eur J Neurosci. 13(11): 2077-2087
58. Szabo ST, Blier P (2002) Effects of serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibition plus 5-HT(2A) receptor antagonism on the firing activity of norepinephrine neurons. J Pharmacol Exp Ther 302(3): 983-991
59. Szawka RE, Rodovalho GV, Helena CV, Franci CR, Anselmo-Franci JA (2007) Prolactin, secretory surge during estrus coincides with increased dopamine activity in the hypothalamus and preoptic area and is not altered by ovariectomy on proestrus. Brain Res Bull 73: 127-134
60. Teppema LJ, Veening JG, Kranenburg A, Dahan A, Berkenbosch A, Olievier C (1997) Expression of c-fos in the rat brainstem after exposure to hypoxia and to norcnoxic and hyperoxic hypercapnia. J Comp Neurol 388: 169-190
61. Viemari JC, Bévengut M, Burnet H, Coulon P, Pequignot JM, Tiveron MC, Hilaire G (2004) Phox2a gene, A6 neurons, and noradrenaline are essential, for development of normal respiratory rhythm in mice. J Neurosci 24: 928-937