Muscimol dialysis into the caudal aspect of the Nucleus tractus solitarii of conscious rats inhibits chemoreception

Respiratory Physiology and Neurobiology

Volumn 164, Issue 3, 2008, Pages 394-400

  Nattie, Eugene ^a   Li, Aihua ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

cNTS; CO2; Control of breathing

Indexed keywords

CARBON DIOXIDE; MUSCIMOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; CHEMORECEPTOR; CONTROLLED STUDY; DRUG INHIBITION; ENVIRONMENTAL TEMPERATURE; HYPOXIA; MALE; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; SLEEP; SOLITARY TRACT NUCLEUS; WAKEFULNESS;

ANALYSIS OF VARIANCE; ANIMALS; ANOXIA; BODY TEMPERATURE; CARBON DIOXIDE; DIALYSIS; ELECTROENCEPHALOGRAPHY; ELECTROMYOGRAPHY; GABA AGONISTS; MALE; MUSCIMOL; OXYGEN CONSUMPTION; PULMONARY VENTILATION; RATS; RATS, SPRAGUE-DAWLEY; SLEEP; SOLITARY NUCLEUS; WAKEFULNESS;

EID: 56449100917     PISSN: 15699048     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resp.2008.09.004     Document Type: Article

References (49)

1. Akilesh M.R., Kamper M., Li A., and Nattie E.E. Effects of unilateral lesions of retrotrapezoid nucleus on breathing in awake rats. J. Appl. Physiol. 82 (1997) 469-479
2. Bailey T.W., Appleyard S.M., Jin Y.H., and Andresen M.C. Organization and properties of GABAergic neurons in solitary tract nucleus (NTS). J. Neurophysiol. 99 (2008) 1712-1722
3. 2 drive to breathing. Pflugers Arch. 455 (2008) 1119-1128
4. Braga V.A., Soriano R.N., Braccialli A.L., de Paula P.M., Bonagamba L.G.H., Paton J.F.R., and Machado B.H. Involvement of l-glutamate and ATP in the neurotransmission of the sympathoexcitatory component of the chemoreflex in the commissural nucleus tractus solitarii of awake rats and in the working heart-brainstem preparation. J. Physiol. 581 3 (2007) 1129-1145
5. Callera J.C., Bonagamba L.G.H., Nosjean A., Laguzzi R., and Machado B.H. Activation of GABA receptors in the NTS of awake rats reduces the gain of baroreflex bradycardia. Auton. Neurosci. 84 (2000) 58-67
6. Chung S., Ivy G.O., and Reid S.G. GABA-mediated neurotransmission in the nucleus of the solitary tract alters resting ventilation following exposure to chronic hypoxia in conscious rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 291 (2006) R1449-R1456
7. Chitravanshi V.C., and Sapru H.N. Chemoreceptor-sensitive neurons in commissural subnucleus of nucleus tractus solitarius of the rat. Am. J. Physiol. 268 (1995) R851-R858
8. Coates E.L., Li A., and Nattie E.E. Widespread sites of brain stem ventilatory chemoreceptors. J. Appl. Physiol. 75 (1993) 5-14
9. 2 decreases membrane conductance and depolarizes neurons in the nucleus tractus solitarii. Exp. Brain Res. 76 (1989) 656-661
10. Deng B.S., Nakamura A., Zhang W., Yanagisawa M., Fukuda Y., and Kuwaki T. Contribution of orexin in hypercapnic chemoreflex: evidence from genetic and pharmacological disruption and supplementation studies in mice. J. Appl. Physiol. 103 (2007) 1772-1779
11. 2 dialysis in the retrotrapezoid nucleus (RTN). J. Appl. Physiol. (2008)
12. Feldman J.L., Mitchell G.S., and Nattie E.E. Breathing: rhythmicity, plasticity, chemosensitivity. Annu. Rev. Neurosci. 26 (2003) 239-266
13. Fong A.Y., Stornetta R.L., Foley C.M., and Potts J.T. Immunohistochemical localization of GAD67-expressing neurons and processes in the rat brainstem: subregional distribution in the nucleus tractus solitarius. J. Comp. Neurol. 493 (2005) 274-290
14. Guyenet P.G., Stornetta R.L., and Bayliss D.A. Retrotrapezoid nucleus and central chemoreception. J. Physiol. 586 (2008) 2043-2048
15. Guyenet P.G., Stornetta R.L., Bayliss D.A., and Mulkey D.K. Retrotrapezoid nucleus: a litmus test for the identification of central chemoreceptors. Exp. Physiol. 90 (2005) 247-253 (discussion 253-247)
16. Hodges M.R., Martino P., Davis S., Opansky C., Pan L.G., and Forster H.V. Effects on breathing of focal acidosis at multiple medullary raphe sites in awake goats. J. Appl. Physiol. 97 (2004) 2303-2309
17. Hodges M.R., Tattersall G.J., Harris M.B., McEvoy S.D., Richerson D.N., Deneris E.S., Johnson R.L., Chen Z.F., and Richerson G.B. Defects in breathing and thermoregulation in mice with near-complete absence of central serotonin neurons. J. Neurosci. 28 (2008) 2495-2505
18. 2. Pflugers Arch. 431 (1996) 876-881
19. Kubin L., Alheid G.F., Zuperku E.J., and McCrimmon D.R. Invited review. Central pathways of pulmonary and lower airway vagal afferents. J. Appl. Physiol. 101 (2006) 618-627
20. 2 microdialysis in retrotrapezoid nucleus of the rat increases breathing in wakefulness but not in sleep. J. Appl. Physiol. 87 (1999) 910-919
21. 2 response in conscious rats. J. Physiol. 577 (2006) 307-318
22. Loewy A.D. Central autonomic pathways. In: Loewy A.D., and Spyer K.M. (Eds). Central Regulation of Autonomic Functions (1990), Oxford University Press, New York 88-103
23. + chemoreceptors in the cerebellar fastigial nucleus do not uniformly affect breathing of awake goats. J. Appl. Physiol. 101 (2006) 241-248
24. Maskrey M. Body temperature effects on hypoxic and hypercapnic responses in awake rats. Am. J. Physiol. 259 (1990) R492-R498
25. Moreira T.S., Takakura A.C., Colombari E., and Guyenet P.G. Activation of 5-hydroxytryptamine type 3 receptor-expressing C-fiber vagal afferents inhibits retrotrapezoid nucleus chemoreceptors in rats. J. Neurophysiol. 98 (2007) 3627-3637
26. Nattie E. Multiple sites for central chemoreception: their roles in response sensitivity and in sleep and wakefulness. Respir. Physiol. 122 (2000) 223-235
27. Nattie E., and Li A. Muscimol dialysis in the retrotrapezoid nucleus region inhibits breathing in the awake rat. J. Appl. Physiol. 89 (2000) 153-162
28. Nattie E., and Li A. Central chemoreception 2005: a brief review. Auton. Neurosci. 126-127 (2006) 332-338
29. Nattie E., Shi J., and Li A. Bicuculline dialysis in the retrotrapezoid nucleus (RTN) region stimulates breathing in the awake rat. Respir. Physiol. 124 (2001) 179-193
30. Nattie E.E., and Li A. Central chemoreception in the region of the ventral respiratory group in the rat. J. Appl. Physiol. 81 (1996) 1987-1995
31. 2 dialysis in the medullary raphe of the rat increases ventilation in sleep. J. Appl. Physiol. 90 (2001) 1247-1257
32. 2 dialysis in nucleus tractus solitarius region of rat increases ventilation in sleep and wakefulness. J. Appl. Physiol. 92 (2002) 2119-2130
33. Nattie E.E., and Li A. Central chemoreception is a complex system function that involves multiple brainstem sites. J. Appl. Physiol. (2008)
34. Nattie E.E., Li A., Richerson G., and Lappi D.A. Medullary serotonergic neurones and adjacent neurones that express neurokinin-1 receptors are both involved in chemoreception in vivo. J. Physiol. 556 (2004) 235-253
35. Nattie E.E., Li A.H., and St John W.M. Lesions in retrotrapezoid nucleus decrease ventilatory output in anesthetized or decerebrate cats. J. Appl. Physiol. 71 (1991) 1364-1375
36. Nattie G., and Li A. Multiple central chemoreceptor sites: cell types and function in vivo. Adv. Exp. Med. Biol. 605 (2008) 343-347
37. Oikawa S., Hirakawa H., Kusakabe T., Nakashima Y., and Hayashida Y. Autonomic cardiovascular responses to hypercapnia in conscious rats: the roles of the chemo- and baroreceptors. Auton. Neurosci. 117 (2005) 105-114
38. Paxino G.W.C. The Rat Brain in Stereotaxic Coordinates (1998), Academic, San Diego, CA
39. Richerson G.B. Serotonergic neurons as carbon dioxide sensors that maintain pH homeostasis. Nat. Rev. Neurosci. 5 (2004) 449-461
40. Richerson G.B., Wang W., Hodges M.R., Dohle C.I., and Diez-Sampedro A. Homing in on the specific phenotype(s) of central respiratory chemoreceptors. Exp. Physiol. 90 (2005) 259-266 (discussion 266-259)
41. Rosin D.L., Chang D.A., and Guyenet P.G. Afferent and efferent connections of the rat retrotrapezoid nucleus. J. Comp. Neurol. 499 (2006) 64-89
42. Saupe K.W., Smith C.A., Henderson K.S., and Dempsey J.A. Respiratory and cardiovascular responses to increased and decreased carotid sinus pressure in sleeping dogs. J. Appl. Physiol. 78 (1995) 1688-1698
43. Sugimura M., Hirose Y., Hanamoto H., Okada K., Boku A., Morimoto Y., Taki K., and Niwa H. Influence of acute progressive hypoxia on cardiovascular variability in conscious spontaneously hypertensive rats. Auton. Neurosci. 141 (2008) 94-103
44. Tabata M., Kurosawa H., Kikuchi Y., Hida W., Ogawa H., Okabe S., Tun Y., Hattori T., and Shirato K. Role of GABA within the nucleus tractus solitarii in the hypoxic ventilatory decline of awake rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281 (2001) R1411-R1419
45. 2-sensitive neurons in rats. J. Physiol. 572 (2006) 503-523
46. Taylor N.C., Li A., and Nattie E.E. Medullary serotonergic neurones modulate the ventilatory response to hypercapnia, but not hypoxia in conscious rats. J. Physiol. 566 (2005) 543-557
47. Taylor N.C., Li A., and Nattie E.E. Ventilatory effects of muscimol microdialysis into the rostral medullary raphe region of conscious rats. Respir. Physiol. Neurobiol. 153 (2006) 203-216
48. Teppema L.J., Veening J.G., Kranenburg A., Dahan A., Berkenbosch A., and Olievier C. Expression of c-fos in the rat brainstem after exposure to hypoxia and to normoxic and hyperoxic hypercapnia. J. Comp. Neurol. 388 (1997) 169-190
49. 2. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 10685-10690