Compensatory airway dilation and additive ventilatory augmentation mediated by dorsomedial medullary 5-hydroxytryptamine 2 receptor activity and hypercapnia

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 293, Issue 2, 2007, Pages

  Kanamaru, Mitsuko ^a   Homma, Ikuo ^a  

^a SHOWA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Airway resistance; Hypoglossal nucleus; Respiration; Serotonin; Solitary tract nucleus

Indexed keywords

1 ISOPROPYL 6 METHYLERGOLINE 8 CARBOXYLIC ACID 2 HYDROXY 1 METHYLPROPYL ESTER; CARBON DIOXIDE; FLUOXETINE; OXYGEN; SEROTONIN 2 RECEPTOR;

AIRWAY; AIRWAY RESISTANCE; ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBON DIOXIDE BREATHING; CONTROLLED STUDY; DORSAL RAPHE NUCLEUS; HYPERCAPNIA; LUNG CAPACITY; LUNG MINUTE VOLUME; LUNG PERFUSION; MALE; MEDULLA OBLONGATA; MICRODIALYSIS; MOUSE; NONHUMAN; PLETHYSMOGRAPH; PRIORITY JOURNAL; TIDAL VOLUME;

AIRWAY RESISTANCE; ANIMALS; CARBON DIOXIDE; ERGOLINES; FLUOXETINE; HYPERCAPNIA; HYPOGLOSSAL NERVE; MALE; MICE; MICE, INBRED C57BL; RECEPTORS, SEROTONIN, 5-HT2; RESPIRATORY MECHANICS; SEROTONIN; SEROTONIN ANTAGONISTS; SEROTONIN UPTAKE INHIBITORS; SOLITARY NUCLEUS;

EID: 34547631039     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00829.2006     Document Type: Article

References (52)

1. 2 and temperature on the relationship between lung volume and inspiratory duration (Hering-Breuer threshold curve). Acta Physiol Scand 92: 351-363, 1974.
2. Brodin E, Linderoth B, Goiny M, Yamamoto Y, Gazelius B, Millhorn DE, Hokfelt T, Ungerstedt U. In vivo release of serotonin in cat dorsal vagal complex and cervical ventral horn induced by electrical stimulation of the medullary raphe nuclei. Brain Res 535: 227-236, 1990.
3. Clark FJ, von Euler C. On the regulation of depth and rate of breathing. J Physiol 222: 267-295, 1972.
4. Dahan A, Romberg R, Teppema L, Sarton E, Bijl H, Olofsen E. Simultaneous measurement and integrated analysis of analgesia and respiration after an intravenous morphine infusion. Anesthesiology 101: 1201-1209, 2004.
5. Duranti R, Pantaleo T, Bellini F, Bongianni F, Scano G. Respiratory responses induced by the activation of somatic nociceptive afferents in humans. J Appl Physiol 71: 2440-2448, 1991.
6. Ejlersen E, Andersen HB, Eliasen K, Mogensen T. A comparison between preincisional and postincisional lidocaine infiltration and postoperative pain. Anesth Analg 74: 495-498, 1992.
7. Fenik P, Veasey SC. Pharmacological characterization of serotonergic receptor activity in the hypoglossal nucleus. Am J Respir Crit Care Med 167: 563-569, 2003.
8. Fenik VB, Davies RO, Kubin L. REM sleep-like atonia of hypoglossal (XII) motoneurons is caused by loss of noradrenergic and serotonergic inputs. Am J Respir Crit Care Med 172: 1322-1330, 2005.
9. Garay SM, Rapoport D, Sorkin B, Epstein H, Feinberg I, Goldring RM. Regulation of ventilation in the obstructive sleep apnea syndrome. Am Rev Respir Dis 124: 451-457, 1981.
10. Gourine AV, Llaudet E, Dale N, Spyer KM. ATP is a mediator of chemosensory transduction in the central nervous system. Nature 436: 108-111, 2005.
11. Guyenet PG, Stornetta RL, Bayliss DA, Mulkey DK. Retrotrapezoid nucleus: a litmus test for the identification of central chemoreceptors. Exp Physiol 90: 247-253; discussion 253-247, 2005.
12. Hanzel DA, Proia NG, Hudgel DW. Response of obstructive sleep apnea to fluoxetine and protriptyline. Chest 100: 416-421, 1991.
13. Haxhiu MA, Tolentino-Silva F, Pete G, Kc P, Mack SO. Monoaminergic neurons, chemosensation and arousal. Respir Physiol 129: 191-209, 2001.
14. Hudgel DW, Gordon EA, Meltzer HY. Abnormal serotonergic stimulation of cortisol production in obstructive sleep apnea. Am J Respir Crit Care Med 152: 186-192, 1995.
15. Izumizaki M, Iwase M, Kimura H, Kuriyama T, Homma I. Central histamine contributed to temperature-induced polypnea in mice. J Appl Physiol 89: 770-776, 2000.
16. Izumizaki M, Tamaki M, Suzuki Y, Iwase M, Shirasawa T, Kimura H, Homma I. The affinity of hemoglobin for oxygen affects ventilatory responses in mutant mice with Presbyterian hemoglobinopathy. Am J Physiol Regul Integr Comp Physiol 285: R747-R753, 2003.
17. Jacobs BL, Fornal CA. 5-HT and motor control: a hypothesis. Trends Neurosci 16: 346-352, 1993.
18. 2. Pflügers Arch 431: 876-881, 1996.
19. Jelev A, Sood S, Liu H, Nolan P, Horner RL. Microdialysis perfusion of 5-HT into hypoglossal motor nucleus differentially modulates genioglossus activity across natural sleep-wake states in rats. J Physiol 532: 467-481, 2001.
20. John J, Bailey EF, Fregosi RF. Respiratory-related discharge of genioglossus muscle motor units. Am J Respir Crit Care Med 172: 1331-1337, 2005.
21. Kraiczi H, Hedner J, Dahlof P, Ejnell H, Carlson J. Effect of serotonin uptake inhibition on breathing during sleep and daytime symptoms in obstructive sleep apnea. Sleep 22: 61-67, 1999.
22. Kubin L, Davies RO. Mechanisms of arway hypotonia. In: Lung Biology in Health and Disease, Sleep Apnea, Pathogenesis Diagnosis and Treatment, edited by Pack AI. New York: Marcel Dekker, 2002, p. 99-154.
23. Kubin L, Tojima H, Davies RO, Pack AI. Serotonergic excitatory drive to hypoglossal motoneurons in the decerebrate cat. Neurosci Lett 139: 243-248, 1992.
24. Loeschcke HH. Central chemosensitivity and the reaction theory. J Physiol 332: 1-24, 1982.
25. Malmberg AB, Yaksh TL. Cyclooxygenase inhibition and the spinal release of prostaglandin E2 and amino acids evoked by paw formalin injection: a microdialysis study in unanesthetized rats. J Neurosci 15: 2768-2776, 1995.
26. Manaker S, Tischler LJ. Origin of serotoninergic afferents to the hypoglossal nucleus in the rat. J Comp Neurol 334: 466-476, 1993.
27. Morrison JL, Sood S, Liu H, Park E, Nolan P, Horner RL. GABAA receptor antagonism at the hypoglossal motor nucleus increases genioglossus muscle activity in NREM but not REM sleep. J Physiol 548: 569-583, 2003.
28. 2 dialysis in nucleus tractus solitarius region of rat increases ventilation in sleep and wakefulness. J Appl Physiol 92: 2119-2130, 2002.
29. Nosjean A, Compoint C, Buisseret-Delmas C, Orer HS, Merahi N, Puizillout JJ, Laguzzi R. Serotonergic projections from the nodose ganglia to the nucleus tractus solitarius: an immunohistochemical and double labeling study in the rat. Neurosci Lett 114: 22-26, 1990.
30. Oliven A, Odeh M, Gavriely N. Effect of hypercapnia on upper airway resistance and collapsibility in anesthetized dogs. Respir Physiol 75: 29-38, 1989.
31. Parisi RA, Neubauer JA, Frank MM, Edelman NH, Santiago TV. Correlation between genioglossal and diaphragmatic responses to hypercapnia during sleep. Am Rev Respir Dis 135: 378-382, 1987.
32. Paxinos G, Franklin KBJ. The Mouse Brain in Stereotaxic Coordinates (2nd ed.) San Diego, CA: Academic, 2001.
33. Pennock BE, Cox CP, Rogers RM, Cain WA, Wells JH. A noninvasive technique for measurement of changes in specific airway resistance. J Appl Physiol 46: 399-406, 1979.
34. Raul L. Serotonin 2 receptors in the nucleus tractus solitarius: characterization and role in the baroreceptor reflex arc. Cell Mol Neurobiol 23: 709-726, 2003.
35. Richerson GB. Serotonergic neurons as carbon dioxide sensors that maintain pH homeostasis. Nat Rev Neurosci 5: 449-461, 2004.
36. Rikard-Bell GC, Bystrzycka EK, Nail BS. Brainstem projections to the phrenic nucleus: a HRP study in the cat. Brain Res Bull 12: 469-477, 1984.
37. Schaffar N, Kessler JP, Bosler O, Jean A. Central serotonergic projections to the nucleus tractus solitarii: evidence from a double labeling study in the rat. Neuroscience 26: 951-958, 1988.
38. Sevoz-Couche C, Wang Y, Ramage AG, Spyer KM, Jordan D. In vivo modulation of nucleus tractus solitarius (NTS) neurones by activation of 5-hydroxytryptamine2 receptors in rats. Neuropharmacology 39: 2006-2016, 2000.
39. Sood S, Morrison JL, Liu H, Horner RL. Role of endogenous serotonin in modulating genioglossus muscle activity in awake and sleeping rats. Am J Respir Crit Care Med 172: 1338-1347, 2005.
40. Sood S, Raddatz E, Liu X, Liu H, Horner RL. Inhibition of serotonergic medullary raphe obscurus neurons suppresses genioglossus and diaphragm activities in anesthetized but not conscious rats. J Appl Physiol 100: 1807-1821, 2006.
41. Sunderram J, Parisi RA, Strobel RJ. Serotonergic stimulation of the genioglossus and the response to nasal continuous positive airway pressure. Am J Respir Crit Care Med 161: 925-929, 2000.
42. 2-induced c-fos gene expression in the nucleus tractus solitarii of inbred mouse strains. J Appl Physiol 92: 1277-1284, 2002.
43. Thor KB, Helke CJ. Serotonin- and substance P-containing projections to the nucleus tractus solitarii of the rat. J Comp Neurol 265: 275-293, 1987.
44. Tverskoy M, Cozacov C, Ayache M, Bradley EL Jr, Kissin I. Postoperative pain after inguinal herniorrhaphy with different types of anesthesia. Anesth Analg 70: 29-35, 1990.
45. Veasey SC, Fornal CA, Metzler CW, Jacobs BL. Response of serotonergic caudal raphe neurons in relation to specific motor activities in freely moving cats. J Neurosci 15: 5346-5359, 1995.
46. Verin E, Tardif C, Marie JP, Buffet X, Lacoume Y, Delapille P, Pasquis P. Upper airway resistance during progressive hypercapnia and progressive hypoxia in normal awake subjects. Respir Physiol 124: 35-42, 2001.
47. Vijayaraghavan R, Schaper M, Thompson R, Stock MF, Alarie Y. Characteristic modifications of the breathing pattern of mice to evaluate the effects of airborne chemicals on the respiratory tract. Arch Toxicol 67: 478-490, 1993.
48. von-Euler C. Brain stem mechanisms for generation and control of breathing pattern. In: Handbook of Physiology. The Respiratory System. Control of Breathing, Bethesda, MD: Am. Phys. Soc., 1986, sect. 3, vol II, pt. 1, chapt. 1, p. 1-67.
49. White PF. The changing role of non-opioid analgesic techniques in the management of postoperative pain. Anesth Analg 101: S5-S22, 2005.
50. Xi L, Chow CM, Smith CA, Dempsey JA. Effects of REM sleep on the ventilatory response to airway occlusion in the dog. Sleep 17: 674-687, 1994.
51. Younes M. Contributions of upper airway mechanics and control mechanisms to severity of obstructive apnea. Am J Respir Crit Care Med 168: 645-658, 2003.
52. Younes M. Role of arousals in the pathogenesis of obstructive sleep apnea. Am J Respir Crit Care Med 169: 623-633, 2004.