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Volumn 118, Issue 4, 2010, Pages 297-307

CDKN2A promoter methylation is related to the tumor location and histological subtype and associated with Helicobacter pylori flaA(+) strains in gastric adenocarcinomas

Author keywords

Gastric cancer; Helicobacter pylori genotypes; Histological subtypes; Methylation; P16INK4A; Tumor location

Indexed keywords

BACTERIAL PROTEIN; CAGA PROTEIN; CAGE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; GENOMIC DNA; PROTEIN FLAA; PROTEIN VIRB11; UNCLASSIFIED DRUG; VACUOLATING TOXIN;

EID: 77949879997     PISSN: 09034641     EISSN: 16000463     Source Type: Journal    
DOI: 10.1111/j.1600-0463.2010.02591.x     Document Type: Article
Times cited : (15)

References (53)
  • 3
    • 33644757018 scopus 로고    scopus 로고
    • Alterations of tumor suppressor and tumor-related genes in the development and progression of gastric cancer
    • Tamura G. Alterations of tumor suppressor and tumor-related genes in the development and progression of gastric cancer. World J Gastroenterol 2006 12 : 192 198.
    • (2006) World J Gastroenterol , vol.12 , pp. 192-198
    • Tamura, G.1
  • 4
    • 0037075887 scopus 로고    scopus 로고
    • Cyclin D-dependent kinases, INK4 inhibitors and cancer
    • Ortega S, Malumbres M, Barbacid M. Cyclin D-dependent kinases, INK4 inhibitors and cancer. Biochim Biophys Acta 2002 1602 : 73 87.
    • (2002) Biochim Biophys Acta , vol.1602 , pp. 73-87
    • Ortega, S.1    Malumbres, M.2    Barbacid, M.3
  • 5
    • 40149101884 scopus 로고    scopus 로고
    • H. pylori (CagA) and Epstein-Barr virus infection in gastric carcinomas: Correlation with p53 mutation and c-Myc, Bcl-2 and Bax expression
    • Lima VP, de Lima MA, André AR, Ferreira MV, Barros MA, Rabenhorst SH. H. pylori (CagA) and Epstein-Barr virus infection in gastric carcinomas: correlation with p53 mutation and c-Myc, Bcl-2 and Bax expression. World J Gastroenterol 2008 14 : 884 891.
    • (2008) World J Gastroenterol , vol.14 , pp. 884-891
    • Lima, V.P.1    De Lima, M.A.2    André, A.R.3    Ferreira, M.V.4    Barros, M.A.5    Rabenhorst, S.H.6
  • 7
    • 0037349716 scopus 로고    scopus 로고
    • Methylation and mutation analysis of p16 gene in gastric cancer
    • Ding Y, Le XP, Zhang QX, Du P. Methylation and mutation analysis of p16 gene in gastric cancer. World J Gastroenterol 2003 9 : 423 426.
    • (2003) World J Gastroenterol , vol.9 , pp. 423-426
    • Ding, Y.1    Le, X.P.2    Zhang, Q.X.3    Du, P.4
  • 9
    • 0342748644 scopus 로고    scopus 로고
    • Correlation of p16 hypermethylation with p16 protein loss in sporadic gastric carcinomas
    • Shim YH, Kang GH, Ro JY. Correlation of p16 hypermethylation with p16 protein loss in sporadic gastric carcinomas. Lab Invest 2000 80 : 689 695.
    • (2000) Lab Invest , vol.80 , pp. 689-695
    • Shim, Y.H.1    Kang, G.H.2    Ro, J.Y.3
  • 10
    • 67349124873 scopus 로고    scopus 로고
    • Biological significance of promoter hypermethylation of tumor-related genes in patients with gastric carcinoma
    • Ksiaa F, Ziadi S, Amara K, Korbi S, Trimeche M. Biological significance of promoter hypermethylation of tumor-related genes in patients with gastric carcinoma. Clin Chim Acta 2009 404 : 128 133.
    • (2009) Clin Chim Acta , vol.404 , pp. 128-133
    • Ksiaa, F.1    Ziadi, S.2    Amara, K.3    Korbi, S.4    Trimeche, M.5
  • 11
    • 15744378109 scopus 로고    scopus 로고
    • Clinicopathologic and protein expression differences between cardia carcinoma and noncardia carcinoma of the stomach
    • Kim MA, Lee HS, Yang HK, Kim WH. Clinicopathologic and protein expression differences between cardia carcinoma and noncardia carcinoma of the stomach. Cancer 2005 103 : 1439 1446.
    • (2005) Cancer , vol.103 , pp. 1439-1446
    • Kim, M.A.1    Lee, H.S.2    Yang, H.K.3    Kim, W.H.4
  • 12
    • 0036370334 scopus 로고    scopus 로고
    • Helicobacter pylori and gastrointestinal tract adenocarcinomas
    • Peek RM Jr., Blaser MJ. Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat Rev Cancer 2002 2 : 28 37.
    • (2002) Nat Rev Cancer , vol.2 , pp. 28-37
    • Peek, Jr.R.M.1    Blaser, M.J.2
  • 13
    • 33645740999 scopus 로고    scopus 로고
    • The pathogenesis of Helicobacter pylori-induced gastro-duodenal diseases
    • Atherton JC. The pathogenesis of Helicobacter pylori-induced gastro-duodenal diseases. Annu Rev Pathol 2006 1 : 63 96.
    • (2006) Annu Rev Pathol , vol.1 , pp. 63-96
    • Atherton, J.C.1
  • 16
    • 26244445594 scopus 로고    scopus 로고
    • Regulation of interleukin-6 promoter activation in gastric epithelial cells infected with Helicobacter pylori
    • Lu H, Wu JY, Kudo T, Ohno T, Graham DY, Yamaoka Y. Regulation of interleukin-6 promoter activation in gastric epithelial cells infected with Helicobacter pylori. Mol Biol Cell 2005 16 : 4954 4966.
    • (2005) Mol Biol Cell , vol.16 , pp. 4954-4966
    • Lu, H.1    Wu, J.Y.2    Kudo, T.3    Ohno, T.4    Graham, D.Y.5    Yamaoka, Y.6
  • 17
  • 18
    • 0034112006 scopus 로고    scopus 로고
    • Enzymology of type IV macromolecule secretion systems: The conjugative transfer regions of plasmids RP4 and R388 and the cag pathogenicity island of Helicobacter pylori encode structurally and functionally related nucleoside triphosphate hydrolases
    • Krause S, Pansegrau W, Lurz R, Cruz F, Lanka E. Enzymology of type IV macromolecule secretion systems: the conjugative transfer regions of plasmids RP4 and R388 and the cag pathogenicity island of Helicobacter pylori encode structurally and functionally related nucleoside triphosphate hydrolases. J Bacteriol 2000 182 : 2761 2770.
    • (2000) J Bacteriol , vol.182 , pp. 2761-2770
    • Krause, S.1    Pansegrau, W.2    Lurz, R.3    Cruz, F.4    Lanka, E.5
  • 19
    • 0033018042 scopus 로고    scopus 로고
    • Structure of cag pathogenicity island in Japanese Helicobacter pylori isolates
    • Maeda S, Yoshida H, Ikenoue T, Ogura K, Kanai F, Kato N, et al. Structure of cag pathogenicity island in Japanese Helicobacter pylori isolates. Gut 1999 44 : 336 341.
    • (1999) Gut , vol.44 , pp. 336-341
    • Maeda, S.1    Yoshida, H.2    Ikenoue, T.3    Ogura, K.4    Kanai, F.5    Kato, N.6
  • 20
    • 0029302605 scopus 로고
    • The complex flagella of gastric Helicobacter species
    • Suerbaum S. The complex flagella of gastric Helicobacter species. Trends Microbiol 1995 3 : 168 170.
    • (1995) Trends Microbiol , vol.3 , pp. 168-170
    • Suerbaum, S.1
  • 21
    • 33747346442 scopus 로고    scopus 로고
    • Stability of E-cadherin methylation status in gastric mucosa associated with histology changes
    • Chan AO, Huang C, Hui WM, Cho CH, Yuen MF, Lam SK, et al. Stability of E-cadherin methylation status in gastric mucosa associated with histology changes. Aliment Pharmacol Ther 2006 24 : 831 836.
    • (2006) Aliment Pharmacol Ther , vol.24 , pp. 831-836
    • Chan, A.O.1    Huang, C.2    Hui, W.M.3    Cho, C.H.4    Yuen, M.F.5    Lam, S.K.6
  • 22
    • 58249084931 scopus 로고    scopus 로고
    • Promoter methylation of p16 associated with Helicobacter pylori infection in precancerous gastric lesions: A population-based study
    • Dong CX, Deng DJ, Pan KF, Zhang L, Zhang Y, Zhou J, et al. Promoter methylation of p16 associated with Helicobacter pylori infection in precancerous gastric lesions: a population-based study. Int J Cancer 2009 124 : 434 439.
    • (2009) Int J Cancer , vol.124 , pp. 434-439
    • Dong, C.X.1    Deng, D.J.2    Pan, K.F.3    Zhang, L.4    Zhang, Y.5    Zhou, J.6
  • 23
    • 67449134096 scopus 로고    scopus 로고
    • Increased number of methylated CpG islands correlates with Helicobacter pylori infection, histological and serological severity of chronic gastritis
    • Tahara T, Arisawa T, Shibata T, Nakamura M, Yoshioka D, Okubo M, et al. Increased number of methylated CpG islands correlates with Helicobacter pylori infection, histological and serological severity of chronic gastritis. Eur J Gastroenterol Hepatol 2009 21 : 613 619.
    • (2009) Eur J Gastroenterol Hepatol , vol.21 , pp. 613-619
    • Tahara, T.1    Arisawa, T.2    Shibata, T.3    Nakamura, M.4    Yoshioka, D.5    Okubo, M.6
  • 25
    • 0037537477 scopus 로고    scopus 로고
    • Promoter methylation of E-cadherin gene in gastric mucosa associated with Helicobacter pylori infection and in gastric cancer
    • Chan AO, Lam SK, Wong BC, Wong WM, Yuen MF, Yeung YH, et al. Promoter methylation of E-cadherin gene in gastric mucosa associated with Helicobacter pylori infection and in gastric cancer. Gut 2003 52 : 502 506.
    • (2003) Gut , vol.52 , pp. 502-506
    • Chan, A.O.1    Lam, S.K.2    Wong, B.C.3    Wong, W.M.4    Yuen, M.F.5    Yeung, Y.H.6
  • 28
    • 0029143308 scopus 로고
    • Diagnosis of Helicobacter pylori infection by PCR: Comparison with other invasive techniques and detection of cagA gene in gastric biopsy specimens
    • Lage AP, Godfroid E, Fauconnier A, Burette A, Butzler JP, Bollen A, et al. Diagnosis of Helicobacter pylori infection by PCR: comparison with other invasive techniques and detection of cagA gene in gastric biopsy specimens. J Clin Microbiol 1995 33 : 2752 2756.
    • (1995) J Clin Microbiol , vol.33 , pp. 2752-2756
    • Lage, A.P.1    Godfroid, E.2    Fauconnier, A.3    Burette, A.4    Butzler, J.P.5    Bollen, A.6
  • 29
    • 0029059733 scopus 로고
    • Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration
    • Atherton JC, Cao P, Peek RM, Tummuru MK, Blaser MJ, Cover TL. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. J Biol Chem 1995 270 : 17771 17777.
    • (1995) J Biol Chem , vol.270 , pp. 17771-17777
    • Atherton, J.C.1    Cao, P.2    Peek, R.M.3    Tummuru, M.K.4    Blaser, M.J.5    Cover, T.L.6
  • 31
    • 0034082148 scopus 로고    scopus 로고
    • Genetic variability determinants of Helicobacter pylori: Influence of clinical background and geographic origin of isolates
    • Göttke MU, Fallone CA, Barkun AN, Vogt K, Loo V, Trautmann M, et al. Genetic variability determinants of Helicobacter pylori: influence of clinical background and geographic origin of isolates. J Infect Dis 2000 181 : 1674 1681.
    • (2000) J Infect Dis , vol.181 , pp. 1674-1681
    • Göttke, M.U.1    Fallone, C.A.2    Barkun, A.N.3    Vogt, K.4    Loo, V.5    Trautmann, M.6
  • 32
    • 0027321373 scopus 로고
    • Proliferating cell nuclear antigen and Ki-67 antigen expression in human haematopoietic cells during growth stimulation and differentiation
    • Landberg G, Roos G. Proliferating cell nuclear antigen and Ki-67 antigen expression in human haematopoietic cells during growth stimulation and differentiation. Cell Prolif 1993 26 : 427 437.
    • (1993) Cell Prolif , vol.26 , pp. 427-437
    • Landberg, G.1    Roos, G.2
  • 33
    • 0022358182 scopus 로고
    • Estrogen receptor analyses. Correlation of biochemical and immunohistochemical methods using monoclonal antireceptor antibodies
    • McCarty KS Jr., Miller LS, Cox EB, Konrath J, McCarty KS Sr. Estrogen receptor analyses. Correlation of biochemical and immunohistochemical methods using monoclonal antireceptor antibodies. Arch Pathol Lab Med 1985 109 : 716 721.
    • (1985) Arch Pathol Lab Med , vol.109 , pp. 716-721
    • McCarty, Jr.K.S.1    Miller, L.S.2    Cox, E.B.3    Konrath, J.4    McCarty, Sr.K.S.5
  • 34
    • 0034486048 scopus 로고    scopus 로고
    • Study on the relationship of alteration and expression of p16 gene to pancreatic carcinoma
    • Zhou J, Yang D, Zhang L, Wang J, Yao Q, Su Z, et al. Study on the relationship of alteration and expression of p16 gene to pancreatic carcinoma. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2000 17 : 399 403.
    • (2000) Zhonghua Yi Xue Yi Chuan Xue Za Zhi , vol.17 , pp. 399-403
    • Zhou, J.1    Yang, D.2    Zhang, L.3    Wang, J.4    Yao, Q.5    Su, Z.6
  • 35
    • 61449239306 scopus 로고    scopus 로고
    • Aberrant methylation of the p16 gene is frequently detected in advanced colorectal cancer
    • Goto T, Mizukami H, Shirahata A, Sakata M, Saito M, Ishibashi K, et al. Aberrant methylation of the p16 gene is frequently detected in advanced colorectal cancer. Anticancer Res 2009 29 : 275 277.
    • (2009) Anticancer Res , vol.29 , pp. 275-277
    • Goto, T.1    Mizukami, H.2    Shirahata, A.3    Sakata, M.4    Saito, M.5    Ishibashi, K.6
  • 37
    • 34548840830 scopus 로고    scopus 로고
    • Methylation of tumor-related genes in neoadjuvant-treated gastric cancer: Relation to therapy response and clinicopathologic and molecular features
    • Napieralski R, Ott K, Kremer M, Becker K, Boulesteix AL, Lordick F, et al. Methylation of tumor-related genes in neoadjuvant-treated gastric cancer: relation to therapy response and clinicopathologic and molecular features. Clin Cancer Res 2007 13 : 5095 5102.
    • (2007) Clin Cancer Res , vol.13 , pp. 5095-5102
    • Napieralski, R.1    Ott, K.2    Kremer, M.3    Becker, K.4    Boulesteix, A.L.5    Lordick, F.6
  • 38
    • 18744390492 scopus 로고    scopus 로고
    • Expression of p16 gene and Rb protein in gastric carcinoma and their clinicopathological significance
    • He XS, Rong YH, Su Q, Luo Q, He DM, Li YL, et al. Expression of p16 gene and Rb protein in gastric carcinoma and their clinicopathological significance. World J Gastroenterol 2005 11 : 2218 2223.
    • (2005) World J Gastroenterol , vol.11 , pp. 2218-2223
    • He, X.S.1    Rong, Y.H.2    Su, Q.3    Luo, Q.4    He, D.M.5    Li, Y.L.6
  • 39
    • 18644376449 scopus 로고    scopus 로고
    • PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest
    • Liang J, Zubovitz J, Petrocelli T, Kotchetkov R, Connor MK, Han K, et al. PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest. Nat Med 2002 8 : 1153 1160.
    • (2002) Nat Med , vol.8 , pp. 1153-1160
    • Liang, J.1    Zubovitz, J.2    Petrocelli, T.3    Kotchetkov, R.4    Connor, M.K.5    Han, K.6
  • 40
    • 27944493981 scopus 로고    scopus 로고
    • Expression of tumor suppressor and tumor-related proteins in differentiated carcinoma, undifferentiated carcinoma with tubular component and pure undifferentiated carcinoma of the stomach
    • Honda T, Tamura G, Endoh Y, Nishizuka S, Kawata S, Motoyama T. Expression of tumor suppressor and tumor-related proteins in differentiated carcinoma, undifferentiated carcinoma with tubular component and pure undifferentiated carcinoma of the stomach. Jpn J Clin Oncol 2005 35 : 580 586.
    • (2005) Jpn J Clin Oncol , vol.35 , pp. 580-586
    • Honda, T.1    Tamura, G.2    Endoh, Y.3    Nishizuka, S.4    Kawata, S.5    Motoyama, T.6
  • 41
    • 47149115531 scopus 로고    scopus 로고
    • Abnormal expression of p16(INK4a), cyclin D1, cyclin-dependent kinase 4 and retinoblastoma protein in gastric carcinomas
    • Kishimoto I, Mitomi H, Ohkura Y, Kanazawa H, Fukui N, Watanabe M. Abnormal expression of p16(INK4a), cyclin D1, cyclin-dependent kinase 4 and retinoblastoma protein in gastric carcinomas. J Surg Oncol 2008 98 : 60 6.
    • (2008) J Surg Oncol , vol.98 , pp. 60-6
    • Kishimoto, I.1    Mitomi, H.2    Ohkura, Y.3    Kanazawa, H.4    Fukui, N.5    Watanabe, M.6
  • 42
    • 33645749034 scopus 로고    scopus 로고
    • Frequent p16 CpG island hypermethylation in primary remnant gastric cancer suggesting an independent carcinogenic pathway
    • Mino A, Onoda N, Yashiro M, Aya M, Fujiwara I, Kubo N, et al. Frequent p16 CpG island hypermethylation in primary remnant gastric cancer suggesting an independent carcinogenic pathway. Oncol Rep 2006 15 : 615 620.
    • (2006) Oncol Rep , vol.15 , pp. 615-620
    • Mino, A.1    Onoda, N.2    Yashiro, M.3    Aya, M.4    Fujiwara, I.5    Kubo, N.6
  • 44
    • 0029866249 scopus 로고    scopus 로고
    • Growth arrest and suppression of tumorigenicity of bladder-carcinoma cell lines induced by the p16/CDKN2 (p16INK4A, MTS1) gene and other loci on human chromosome 9
    • Wu Q, Possati L, Montesi M, Gualandi F, Rimessi P, Morelli C, et al. Growth arrest and suppression of tumorigenicity of bladder-carcinoma cell lines induced by the p16/CDKN2 (p16INK4A, MTS1) gene and other loci on human chromosome 9. Int J Cancer 1996 65 : 840 846.
    • (1996) Int J Cancer , vol.65 , pp. 840-846
    • Wu, Q.1    Possati, L.2    Montesi, M.3    Gualandi, F.4    Rimessi, P.5    Morelli, C.6
  • 45
    • 0033229890 scopus 로고    scopus 로고
    • Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype
    • Toyota M, Ahuja N, Suzuki H, Itoh F, Ohe-Toyota M, Imai K, et al. Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype. Cancer Res 1999 59 : 5438 5442.
    • (1999) Cancer Res , vol.59 , pp. 5438-5442
    • Toyota, M.1    Ahuja, N.2    Suzuki, H.3    Itoh, F.4    Ohe-Toyota, M.5    Imai, K.6
  • 46
    • 1842851793 scopus 로고    scopus 로고
    • Genetic pathways of two types of gastric cancer
    • Tahara E. Genetic pathways of two types of gastric cancer. IARC Sci Publ 2004 157 : 327 349.
    • (2004) IARC Sci Publ , vol.157 , pp. 327-349
    • Tahara, E.1
  • 48
    • 13444281415 scopus 로고    scopus 로고
    • Identical cytokeratin expression pattern CK7+/CK20- in esophageal and cardiac cancer: Etiopathological and clinical implications
    • Driessen A, Nafteux P, Lerut T, Van Raemdonck D, De Leyn P, Filez L, et al. Identical cytokeratin expression pattern CK7+/CK20- in esophageal and cardiac cancer: etiopathological and clinical implications. Mod Pathol 2004 17 : 49 55.
    • (2004) Mod Pathol , vol.17 , pp. 49-55
    • Driessen, A.1    Nafteux, P.2    Lerut, T.3    Van Raemdonck, D.4    De Leyn, P.5    Filez, L.6
  • 50
    • 0034051262 scopus 로고    scopus 로고
    • Helicobacter pylori causes DNA damage in gastric epithelial cells
    • Obst B, Wagner S, Sewing KF, Beil W. Helicobacter pylori causes DNA damage in gastric epithelial cells. Carcinogenesis 2000 21 : 1111 1115.
    • (2000) Carcinogenesis , vol.21 , pp. 1111-1115
    • Obst, B.1    Wagner, S.2    Sewing, K.F.3    Beil, W.4
  • 51
    • 0033404952 scopus 로고    scopus 로고
    • Methylation-dependent gene silencing induced by interleukin 1beta via nitric oxide production
    • Hmadcha A, Bedoya FJ, Sobrino F, Pintado E. Methylation-dependent gene silencing induced by interleukin 1beta via nitric oxide production. J Exp Med 1999 190 : 1595 1604.
    • (1999) J Exp Med , vol.190 , pp. 1595-1604
    • Hmadcha, A.1    Bedoya, F.J.2    Sobrino, F.3    Pintado, E.4
  • 52
    • 33847660516 scopus 로고    scopus 로고
    • Helicobacter pylori: Present status and future prospects in Japan
    • Suzuki H, Hibi T, Marshall BJ. Helicobacter pylori: present status and future prospects in Japan. J Gastroenterol 2007 42 : 1 15.
    • (2007) J Gastroenterol , vol.42 , pp. 1-15
    • Suzuki, H.1    Hibi, T.2    Marshall, B.J.3


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