Growth arrest and suppression of tumorigenicity of bladder-carcinoma cell lines induced by the P16/CDKN2 (p16INK4A, MTS1) gene and other loci on human chromosome 9

International Journal of Cancer

Volumn 65, Issue 6, 1996, Pages 840-846

  Wu, Qiang ^a   Possati, Laura ^b   Montesi, Marco ^b   Gualandi, Francesca ^a   Rimessi, Paola ^a   Morelli, Cristina ^a   Trabanelli, Cecilia ^a   Barbanti Brodano, Giuseppe ^a,c  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^c UNIVERSITY OF FERRARA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BLADDER CARCINOMA; CARCINOGENICITY; CHROMOSOME 9; CONTROLLED STUDY; GENETIC TRANSFECTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR CELL LINE; TUMOR SUPPRESSOR GENE;

ANIMALS; BASE SEQUENCE; CARCINOMA, TRANSITIONAL CELL; CARRIER PROTEINS; CELL DIVISION; CHO CELLS; CHROMOSOMES, HUMAN, PAIR 9; CRICETINAE; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA, COMPLEMENTARY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; MOLECULAR SEQUENCE DATA; TRANSFECTION; TUMOR CELLS, CULTURED; URINARY BLADDER NEOPLASMS;

EID: 0029866249     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19960315)65:6<840::AID-IJC22>3.0.CO;2-6     Document Type: Article

References (26)

1. BASSAM, B.J., CAETANO-ANOLLÉS, G. and GRESSHOFF, P.M., Fast and sensitive silver staining of DNA in polyacrylamide gels. Anal. Biochem., 196, 80-83 (1991).
2. CAIRNS, P., MAO, L., MERLO, A., LEE, D.J., SCHWAB, D., EBY, Y., TOKINO, K., VAN DER RIET, P., BLAUGRUND, J E. and SIDRANSKY, D., Rates of p16 (P16/CDKN2) mutations in primary tumors with 9p loss. Science, 265, 415-416 (1994).
3. CAIRNS, P. and 20 OTHERS. Frequency of homozygous deletion at P16/CDKN2 in primary human tumours. Nature Genet., 11, 210-212 (1995).
4. CAIRNS, P., SHAW, M.E. and KNOWLES, M.A., Preliminary mapping of the deleted region of chromosome 9 in bladder cancer. Cancer Res., 53, 1230-1232 (1993).
5. CALDAS, C., HAHN, S.A., DA COSTA, L.T., REDSON, M.S., SCHUTTE, M., SEYMOUR, A.B., WEINSTEIN, C.L., HRUBAN, R.H., YEO, C.J. and KERN, S E., Frequent somatic mutations and homozygous deletions of the p16 (P16/CDKN2) gene in pancreatic adenocarcinoma. Nature Genet., 8, 27-32 (1994).
6. CHAGANTI, S.R., GAIDANO, G., LOUIE, D.C., DALUA FAVERA, R. and CHAGANTI, R.S.K., Diffuse large-cell lymphomas exhibit frequent deletions in 9p21-22 and 9q31-34 regions. Genes Chrom. Cancer. 12, 32-36 (1995).
7. CORDON-CARDO, C., DALBAGNI, G., SARKIS, A.S. and REUTER, V.E., Genetic alterations associated with bladder cancer. In: V.T. DeVita, S. Hellman and S.A. Rosenberg (eds.), Important advances in oncology, pp. 71-83. J.B. Lippincott, Philadelphia (1994).
8. DEVLIN, J., KEEN, A.J. and KNOWLES, M.A., Homozygous deletion mapping at 9p21 in bladder carcinoma defines a critical region within 2cM of IFNA. Oncogene, 9, 2757-2760 (1994).
9. GREEN, A.J., JOHNSON, P.H. and YATES, J.R.W., The tuberous sclerosis gene on chromosome 9q34 acts as a growth suppressor. Hum. mol. Genet., 3, 1833-1834 (1994).
10. HABUCHI, T., DEVLIN, J., ELDER, P.A. and KNOWLES, M.A., Detailed deletion mapping of chromosome 9q in bladder cancer: evidence for two tumour suppressor loci. Oncogene. 11, 1671-1674 (1995).
11. INK4B is a potential effector of TGF-β-induced cell cycle arrest. Nature (Lond.), 371, 257-261 (1994).
12. KAMB, A., GRUIS, N.A., WEAVER-FELDHAUS, J., LIU, Q., HARSHMAN, K . TAVTIGLAN, S.V., STOCKERT, E., DAY, R.S., JOHNSON, B.E. and SKOLNICK, M.H., A cell cycle regulator potentially involved in genesis of many tumors types. Science. 264, 436-440 (1994).
13. LINNENBACH, A.J., PRESSELER, L.B., SENG, B.A., KIMMEL, B.S., TOMASZEWSKI, J.E. and MALKOWICZ, S.B., Characterization of chromosome 9 deletions in transitional cell carcinoma by microsatellite assay. Hum. mol. Genet., 2, 1407-1411 (1993).
14. MARSHALL, C.J., FRANKS, L.M. and CARBONELL, A.W., Markers of neoplastic transformation in epithelial cell lines derived from human carcinomas. J. nat. Cancer Inst., 58, 1743-1751 (1977).
15. MIYAO, N., TSAI, Y.C., LERNER, S.P., OLUMI, A.F., SPRUCK III, C.H., GONZALES-ZULUETA, M., NICHOLS, P.W., SKINNER, D.G. and JONES, P.A., Role of chromosome 9 in human bladder cancer. Cancer Res., 53, 4066-4070 (1993).
16. MORI, T., MIURA, K., AOKI, T., NISHIHIRA, T., MORI, S. and NAKAMURA, Y., Frequent somatic mutation of the P16/CDKN2/CDK41 (multiple tumor-suppressor/cyclin-dependent kinase 4 inhibitor) gene in esophageal squamous cell carcinoma. Cancer Res., 54, 3396-3397 (1994).
17. NEGRINI, M., SABBIONI, S., HALDAR, S., POSSATI, L., CASTAGNOLI, A., CORALLINI, A., BARBANTI-BRODANO, G. and CROCE, C.M., Tumor and growth suppression of breast cancer cells by chromosome 17 associated functions. Cancer Res., 54, 1818-1824 (1994).
18. NOBORI, T., MIURA, K., WU, D.J., LOIS, A., TAKABAYASHI, K. and CARSON, D.A., Deletion of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature (Lond.), 368, 753-756 (1994).
19. INK4 in human cancer. Proc. nat. Acad. Sci. (Wash.), ), 91, 11045-11049 (1994).
20. POVEY, S., ARMOUR, J., FARNDON, P., HAINES, J.L., KNOWLES, M., OLOPADE, F., PILZ, A., WHITE, J.A. and KWIATKOWSKI, D.J., Report on the Third International Workshop on chromosome 9. Ann. hum Genet., 58, 117-250 (1994).
21. RUPPERT, J.M., TOKINO, K. and SIDRANSKY, D., Evidence for two bladder-cancer-suppressor loci on human chromosome 9. Cancer Res., 53, 5093-5095 (1993).
22. SAMBROOK, J., FRITSCH, E.F. and MANIATIS, T., Molecular cloning: a laboratory manual (2nd ed.), Cold Spring Harbor Laboratory. New York (1989).
23. SERRANO, M., HANNON, G.J. and BEACH, D., A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature (Lond.), 366, 704-707 (1993).
24. SPRUCK III, C.H., GONZALES-ZULUETA, M., SHIBATA, A., SIMONEAU, A.R., LIN, M.F., GONZALES, F., TSAI, Y.C. and JONES, P.A., p16 gene in uncultured tumours. Nature (Lond.), 370, 183-184 (1994).
25. STADLER, W.M., SHERMAN, J., BOHLANDER, S.K., ROULSTON, D., DREYLING, M., RUKSTALIS, D. and OLOPADE, O.I., Homozygous deletions within chromosomal bands 9p21-22 in bladder cancer. Cancer Res., 54, 2060-2063 (1994).
26. WARBURTON, D., GERSEN, S., YU, M.T., JACKSON, C., HANDELIN, B. and HOUSMAN, D., Monochromosomal rodent-human hybrids from microcell fusion of human lymphoblastoid cells containing an inserted dominant selectable marker. Genomics, 6, 358-366 (1990).