Abnormal expression of p16INK4a, cyclin D1, cyclin-dependent kinase 4 and retinoblastoma protein in gastric carcinomas

Journal of Surgical Oncology

Volumn 98, Issue 1, 2008, Pages 60-66

  Kishimoto, Ichiro ^a   Mitomi, Hiroyuki ^a,d   Ohkura, Yasuo ^b   Kanazawa, Hideki ^a   Fukui, Naoshi ^a   Watanabe, Masahiko ^c  

^a NATIONAL HOSPITAL ORGANIZATION   (Japan)

^b KYORIN UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c KITASATO UNIVERSITY   (Japan)

^d SAGAMIHARA NATIONAL HOSPITAL   (Japan)

Author keywords

CDK4; Cyclin D1; Gastric carcinoma; p16INK4a; Prognosis; Retinoblastoma protein

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR 2A; RETINOBLASTOMA PROTEIN;

ADULT; AGED; ARTICLE; CANCER INVASION; CANCER STAGING; CANCER SURVIVAL; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CLINICAL FEATURE; CORRELATION ANALYSIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; JAPAN; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; STOMACH CARCINOMA;

CARCINOMA; CYCLIN D1; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE INHIBITOR P16; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; MULTIVARIATE ANALYSIS; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PROGNOSIS; RETINOBLASTOMA PROTEIN; STOMACH NEOPLASMS; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL;

EID: 47149115531     PISSN: 00224790     EISSN: 10969098     Source Type: Journal    
DOI: 10.1002/jso.21087     Document Type: Article

References (34)

1. Serrano M, Hannon GJ, Beach D: A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 1993;366:704-707.
2. Weinberg RA: The retinoblastoma protein and cell cycle control. Cell 1995;81:323-330.
3. Myung N, Kim MR, Chung IP, et al.: Loss of p16 and p27 is associated with progression of human gastric cancer. Cancer Lett 2000;153:129-136.
4. Feakins RM, Nickols CD, Bidd H, et al.: Abnormal expression of pRb, p16, and cyclin D1 in gastric adenocarcinoma and its lymph node metastases: Relationship with pathological features and survival. Hum Pathol 2003;34:1276-1282.
5. Lauren P: The two histological main types of gastric carcinoma: Diffuse and so-called intestinal-type carcinoma. Acta Path Microbiol Scandinav 1965;64:31-49.
6. Sobin LH, Wittekind CH, editors. TNM classification of malignant tumours. 6th edition. New York: Wiley-Liss; 2002.
7. Schneider BG, Gulley ML, Eagan P, et al.: Loss of p16/CDKN2A tumor suppressor protein in gastric adenocarcinoma is associated with Epstein-Barr virus and anatomic location in the body of the stomach. Hum Pathol 2000;31:45-50.
8. INK4 products in primary gastric cancer. Oncology 2000;58:126-136.
9. Zhao G-H, Li T-C, Shi L-H, et al.: Relationship between inactivation of p16 gene and gastric carcinoma. World J Gastroenterol 2003;9:905-909.
10. He X-S, Rong Y-H, Su Q, et al.: Expression of p16 gene and Rb protein in gastric carcinoma and their clinicopathological significance. World J Gastroenterol 2005;11:2218-2223.
11. WAF1, Ki-67 expression patterns in gastric cancer. J Cell Physiol 2007;210:183-191.
12. Ohhara M, Esumi M, Kurosu Y: Activation but not inactivation of the MTS1 gene is associated with primary colorectal carcinomas. Biochem Biophys Res Commun 1996;226:791-795.
13. INK4a expression begins early in human colon neoplasia and correlates inversely with markers of cell proliferation. Gastroenterology 2000;119:929-942.
14. INK4a. Cell 1997;88:593-602.
15. Lin AW, Barradas M, Stone JC, et al.: Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genev Dev 1998;12:3008-3019.
16. Shim Y-H, Kang GH, Ro JY: Correlation of p16 hypermethylation with p16 protein loss in sporadic gastric carcinomas. Lab Invest 2000;80:689-695.
17. Honda T, Tamura G, Endoh Y, et al.: Expression of tumor suppressor and tumor-related proteins in differentiated carcinoma, undifferentiated carcinoma with tubular component and pure undifferentiated carcinoma of the stomach. Jpn J Clin Oncol 2005;35:580-586.
18. Kim MA, Lee HS, Yang H-K, et al.: Clinicopathologic and protein expression differences between cardia carcinoma and noncardia carcinoma of the stomach. Cancer 2005;103:1439-1446.
19. INK4a expression in gastric adenocarcinoma. Int J Cancer 2000;87:236-240.
20. 1NK4B genes in gastric carcinomas. Cancer 1997;80:1889-1896.
21. Oue N, Oshimo Y, Nakayama H, et al.: DNA methylation of multiple genes in gastric carcinoma: association with histological type and CpG island methylator phenotype. Cancer Sci 2003; 94:901-905.
22. Hou P, Ji M-J, Shen J-Y, et al.: Detection of p16 hypermethylation in gastric carcinomas using a seminested methylation-specific PCR. Biochem Genet 2005;43:1-9.
23. Osawa T, Chong J-M, Sudo M, et al.: Reduced expression and promoter methylation of p16 gene in Epstein-Barr virus-associated gastric carcinoma. Jpn J Cancer Res 2002;93:1195-1200.
24. Song HS, Kim IH, Sohn SS, et al.: Prognostic significance of immunohistochemical expression of p53 and retinoblastoma gene protein (pRb) in curatively resected gastric cancer. Korean J Intern Med 2005;20:1-7.
25. Chou N-H, Chen H-C, Chou N-S, et al.: Expression of altered retinoblastoma protein inversely correlates with tumor invasion in gastric carcinoma. World J Gastroenterol 2006;12:7188-7191.
26. Songun I, van de Velde CJH, Hermans J, et al.: Expression of oncoproteins and the amount of eosinophilic and lymphocytic infiltrates can be used as prognostic factors in gastric cancer. Dutch Gastric Cancer Group (DGCG). Br J Cancer 1996;74: 1783-1788.
27. Müller W, Noguchi T, Wirtz H-C, et al.: Expression of cell-cycle regulatory proteins cyclin D1, cyclin E, and their inhibitor p21 waf1/cip1 in gastric cancer. J Pathol 1999;189:186-193.
28. Gao P, Zhou G-Y, Liu Y, et al.: Alteration of cyclin D1 in gastric carcinoma and its clinicopathologic significance. World J Gastroenterol 2004;10:2936-2939.
29. Bizari L, Borim AA, Leite KRM, et al.: Alterations of the CCND1 and HER-2/neu (ERBB2) proteins in esophageal and gastric cancers. Cancer Genet Cytogenet 2006;165:41-50.
30. Arber N, Gammon MD, Hibshoosh H, et al.: Overexpression of cyclin D1 occurs in both squamous carcinomas and adenocarcinomas of the esophagus and in adenocarcinomas of the stomach. Hum Pathol 1999;30:1087-1092.
31. Takano Y, Kato Y, Masuda M, et al.: Cyclin D2, but not cyclin D1, overexpression closely correlates with gastric cancer progression and prognosis. J Pathol 1999;189:194-200.
32. Han S, Kim H-Y, Park K, et al.: Expression of p27Kip1 and cyclin D1 proteins is inversely correlated and is associated with poor clinical outcome in human gastric cancer. J Surg Oncol 1999;71: 147-154.
33. Takano Y, Kato Y, van Diest PJ, et al.: Cyclin D2 overexpression and lack of p27 correlate positively and cyclin E inversely with a poor prognosis in gastric cancer cases. Am J Pathol 2000;156: 585-594.
34. Tenderenda M: A study on the prognostic value of cyclins D1 and E expression levels in resectable gastric cancer and on some correlations between cyclins expression, histoclinical parameters and selected protein products of cell-cycle regulatory genes. J Exp Clin Cancer Res 2005;24:405-414.