Assessment of 1H NMR spectroscopy and multivariate analysis as a technique for metabolite fingerprinting of Arabidopsis thaliana

Phytochemistry

Volumn 62, Issue 6, 2003, Pages 949-957

  Ward, Jane L ^a   Harris, Cassandra ^a   Lewis, Jennie ^a   Beale, Michael H ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Arabidopsis thaliana; Metabolite fingerprints; Metabolomics; Multivariate analysis; NMR spectroscopy; Principal component analysis

Indexed keywords

FUMARIC ACID; GLUCOSE; PLANT EXTRACT;

ANALYTIC METHOD; ARABIDOPSIS; ARTICLE; COMPARATIVE STUDY; EXTRACTION; MULTIVARIATE ANALYSIS; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; REPRODUCIBILITY; STATISTICAL ANALYSIS; TECHNIQUE; CHEMISTRY; METABOLISM; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ARABIDOPSIS; ARABIDOPSIS THALIANA;

ARABIDOPSIS; MAGNETIC RESONANCE SPECTROSCOPY; MULTIVARIATE ANALYSIS; PLANT EXTRACTS; REPRODUCIBILITY OF RESULTS;

EID: 0037371977     PISSN: 00319422     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-9422(02)00705-7     Document Type: Article

References (16)

1. 1H NMR-derived urinary spectral data. J. Chemometrics 16, 461-468.
2. Beckwith-Hall, B.M., Holmes, E., Lindon, J.C., Gounarides, J., Vickers, A., Shapiro, M., Nicholoson, J.K., 2002. NMR-based metabonomic studies on the biochemical effects of commonly used drug carrier vehicles in the rat. Chem. Res. Toxicol. 15, 1136-1141.
3. Boyes, D.C., Zayed, A.M., Ascenzi, R., McCaskill, A.J., Hoffman, N.E., Davis, K.R., Görlach, J., 2001. Growth stage-based phenotypic analysis of Arabidopsis: a model for high throughput functional genomics in plants. Plant Cell 13, 1499-1510.
4. Fan, T.W.-M., Lane, A., Shenker, M., Bartley, J.P., Crowley, D., Higashi, R.M., 2001. Comprehensive chemical profiling of gramineous plant root exudates using high-resolution NMR and MS. Phytochemistry 57, 209-221.
5. Fiehn, O., Altmann, T., Trethewey, R.N., Willmitzer, L., 2000. Metabolite profiling for plant functional genomics. Nature Biotech. 18, 1157-1161.
6. Fiehn, O., 2002. Metabolomics: the link between genotypes and phenotypes. Plant Mol. Biol. 48, 155-171.
7. Goodacre, R., Anklam, E., 2001. Fourier transform infrared spectroscopy and chemometrics as a tool for the rapid detection of other vegetable fats mixed in cocoa butter. J. Am. Oil Chem. Soc. 78, 9931000.
8. Hall, R., Beale, M.H., Fiehn, O., Hardy, N., Sumner, L., Bino, R., 2002. Plant metabolomics: the missing link in functional genomics strategies. Plant Cell 14, 1437-1440.
9. Holmes, E., Nicholl, A.W., Lindon, J.C., Connor, S.C., Conollelly, J.C., Haseldon, J.N., Damment, S.J.P., Spraul, M., Neidig, P., Nicholson, J.K., 2000. Chemometric methods for toxicity classification based on NMR spectra of biofluids. Chem. Res. Toxicol. 13, 471-478.
10. Massart, D.L., Vandeginste, B.G.M., Deming, S.N., Michotte, Y., Kauffman, L., 1988. Chemometrics: A Textbook. Elsevier, New York.
11. Nicholson, J.K., Wilson, I.D., 1989. High-resolution proton magnetic resonance spectroscopy of biological fluids. Prog. Nucl. Magn. Reson. Spectrosc. 21, 449-501.
12. Roessner, U., Luedemann, A., Brust, D., Fiehn, O., Linke, T., Willmitzer, L., Fernie, A., 2001. Metabolic profiling allows comprehensive phenotyping of genetically or environmentally modified plant systems. Plant Cell 13, 11-29.
13. The Arabidopsis Genome Initiative, 2000. Analysis of the genome sequence of the flowering plant Arabidopsis thaliana. Nature 408, 796-815.
14. Trethewey, R.N., 2001. Gene discovery via metabolite profiling. Curr. Opin. Biotechnol. 12, 135-138.
15. Tweeddale, H., Notley-McRobb, L., Ferenci, T., 1998. Effect of slow growth on metabolism of Escherichia coli, as revealed by global metabolite pool ("metabolome") analysis. J. Bacteriol. 180, 5109-5116.
16. Wixon, J., 2001. Featured organism: Arabidopsis thaliana. Comp. Funct. Genom. 2, 91-98.