T helper cell subset ratios in patients with severe sepsis

Intensive Care Medicine

Volumn 25, Issue 1, 1999, Pages 106-109

  Ferguson, N R ^a   Galley, H F ^a   Webster, N R ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Cytokines; Interferon ; Interleukin 4; Leukocytes; Sepsis; T cells

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 4;

ADULT; AGED; ARTICLE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FLOW CYTOMETRY; HELPER CELL; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IMMUNE RESPONSE; MALE; MONOCYTE; SEPSIS; STATISTICAL ANALYSIS;

ADULT; AGED; APACHE; CASE-CONTROL STUDIES; CRITICAL ILLNESS; FEMALE; FLOW CYTOMETRY; HUMANS; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; SEPSIS; TH1 CELLS; TH2 CELLS;

EID: 0032983831     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001340050795     Document Type: Article

References (11)

1. 1. Mosmann TR (1991) Cytokine secretion patterns and cross regulation of T cell subsets. Immunol Res 10: 183-188
2. 2. Mosmann TR, Sad S (1996) The expanding universe of T cell subsets: Th1, Th2 and more. Immunol Today 17: 138-146
3. 3. Fiorentino DF, Zlotnik A, Vieira P, Mosmann TR, Howard M, Moore KW, O'Garra A (1991) IL-10 acts on the antigen presenting cell to inhibit cytokine production by Th1 cells. J Immunol 146: 3444-3451
4. 4. Bundschuh DS, Barsig J, Hartung T, Randow F, Docke WD, Volk HD, Wendel A (1997) Granulocyte-macrophage colony-stimulating factor and IFN-gamma restore the systemic TNF-alpha response to endotoxin in lipopolysaccharide-desensitized mice. J Immunol 158: 2862-2871
5. 5. Marchant A, Deviere J, Byl B, De Groote D, Vincent J-L, Goldman M (1994) Interleukin-10 production during septicaemia. Lancet 343: 707-708
6. 6. Neidhardt R, Keel M, Steckholzer U, Safret A, Ungethuem U, Trentz O, Ertel W (1997) Relationship of inlerleukin-10 plasma levels to severity of injury and clinical outcome in injured patients. J Trauma 42: 863-870
7. 7. Van der Poll T, De Waal Malefyt R, Coyle SM, Lowry SF (1997) Anti-inflammatory responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10 and IL-13. J Infect Dis 175: 118-122
8. 8. Remick DG, Garg SJ, Newcomb DE, Wollenberg G, Huie TK, Bolgos GL (1998) Exogenous interleukin-10 fails to decrease the mortality or morbidity of sepsis. Crit Care Med 26: 895-904
9. 9. Ayala A, Deol ZK, Lehamn DL, Herdon CD, Chaudry IH (1994) Polymicrobial sepsis but not low dose endotoxin infusion causes decreased splenocyte IL-2/IFN-gamma release while increasing IL-4/IL-10 production. J Surg Res 56: 579-585
10. 10. Fitzpatrick DR, Kelso A (1998) Independent regulation of cytokine genes in T cells. Transplantation 65: 1-5
11. 11. Docke WD, Randow F, Syrbe U, Krausch D, Asadullah K, Reinke P, Volk HD, Kox W (1997) Monocyte deactivation in septic patients: restoration by IFN-gamma treatment. Nature Med 3: 678-681