A strategy for adenovirus vector targeting with a secreted single chain antibody

PLoS ONE

Volumn 4, Issue 12, 2009, Pages

  Glasgow, Joel N ^a,b   Mikheeva, Galina ^c   Krasnykh, Victor ^c   Curiel, David T ^b  

^a University of Alabama at Birmingham   (United States)

^b and Clinical Center   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; CAPSID PROTEIN; CELL RECEPTOR; LEUCINE ZIPPER PROTEIN; LIGAND; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

ANTIBODY PRODUCTION; ARTICLE; CONTROLLED STUDY; DIMERIZATION; EMBRYO; HUMAN; HUMAN CELL; NONHUMAN; PROTEIN DOMAIN; PROTEIN PROCESSING; PROTEIN STRUCTURE; PROTEIN TARGETING; PROTEIN TRANSPORT; VIRAL GENE DELIVERY SYSTEM; VIRION;

ADENOVIRIDAE; AMINO ACID SEQUENCE; CAPSID; CELL LINE; EPITOPES; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; LEUCINE ZIPPERS; MOLECULAR SEQUENCE DATA; ORGAN SPECIFICITY; PEPTIDES; PROTEIN BINDING; PROTEIN MULTIMERIZATION; RECOMBINANT FUSION PROTEINS; SINGLE-CHAIN ANTIBODIES;

ADENOVIRIDAE; MIRIDAE;

EID: 77949536402     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0008355     Document Type: Article

References (44)

1. (2008) Clinicals Trials Database. The Journal of Gene Medicine Clinical Trials Database. http://wwwwileycouk/genmed/clinical.
2. Wirtz P, Steipe B (1999) Intrabody construction and expression III: engineering hyperstable V(H) domains. Protein Sci 8: 2245-2250.
3. Magnusson MK, Hong SS, Henning P, Boulanger P, Lindholm L (2002) Genetic retargeting of adenovirus vectors: functionality of targeting ligands and their influence on virus viability. J Gene Med 4: 356-370.
4. Iyer SV, Davis DL, Seal SN, Burch JB (1991) Chicken vitellogenin gene-binding protein, a leucine zipper transcription factor that binds to an important control element in the chicken vitellogenin II promoter, is related to rat DBP. Mol Cell Biol 11: 4863-4875.
5. Krylov D, Mikhailenko I, Vinson C (1994) A thermodynamic scale for leucine zipper stability and dimerization specificity: e and g interhelical interactions. Embo J 13: 2849-2861.
6. Katz BZ, Krylov D, Aota S, Olive M, Vinson C, et al. (1998) Green fluorescent protein labeling of cytoskeletal structures-novel targeting approach based on leucine zippers. Biotechniques 25: 298-302, 304.
7. Moll JR, Ruvinov SB, Pastan I, Vinson C (2001) Designed heterodimerizing leucine zippers with a ranger of pIs and stabilities up to 10(-15) M. Protein Sci 10: 649-655.
8. Pereboev AV, Asiedu CK, Kawakami Y, Dong SS, Blackwell JL, et al. (2002) Coxsackievirus-adenovirus receptor genetically fused to anti-human CD40 scFv enhances adenoviral transduction of dendritic cells. Gene Ther 9: 1189-1193.
9. Wu H, Seki T, Dmitriev I, Uil T, Kashentseva E, et al. (2002) Double modification of adenovirus fiber with RGD and polylysine motifs improves coxsackievirus-adenovirus receptor-independent gene transfer efficiency. Hum Gene Ther 13: 1647-1653.
10. Krasnykh V, Dmitriev I, Mikheeva G, Miller CR, Belousova N, et al. (1998) Characterization of an adenovirus vector containing a heterologous peptide epitope in the HI loop of the fiber knob. J Virol 72: 1844-1852.
11. Krasnykh V, Belousova N, Korokhov N, Mikheeva G, Curiel DT (2001) Genetic targeting of an adenovirus vector via replacement of the fiber protein with the phage T4 fibritin. J Virol 75: 4176-4183.
12. Belousova N, Korokhov N, Krendelshchikova V, Simonenko V, Mikheeva G, et al. (2003) Genetically targeted adenovirus vector directed to CD40-expressing cells. J Virol 77: 11367-11377.
13. Belousova N, Krendelchtchikova V, Curiel DT, Krasnykh V (2002) Modulation of adenovirus vector tropism via incorporation of polypeptide ligands into the fiber protein. J Virol 76: 8621-8631.
14. Noureddini SC, Krendelshchikov A, Simonenko V, Hedley SJ, Douglas JT, et al. (2006) Generation and selection of targeted adenoviruses embodying optimized vector properties. Virus Res 116: 185-195.
15. Hedley SJ, Auf der Maur A, Hohn S, Escher D, Barberis A, et al. (2006) An adenovirus vector with a chimeric fiber incorporating stabilized single chain antibody achieves targeted gene delivery. Gene Ther 13: 88-94.
16. Jakubczak JL, Rollence ML, Stewart DA, Jafari JD, Von Seggern DJ, et al. (2001) Adenovirus type 5 viral particles pseudotyped with mutagenized fiber proteins show diminished infectivity of coxsackie B-adenovirus receptor-bearing cells. J Virol 75: 2972-2981.
17. Korokhov N, Mikheeva G, Krendelshchikov A, Belousova N, Simonenko V, et al. (2003) Targeting of adenovirus via genetic modification of the viral capsid combined with a protein bridge. J Virol 77: 12931-12940.
18. Stocks M (2005) Intrabodies as drug discovery tools and therapeutics. Curr Opin Chem Biol 9: 359-365.
19. Tse E, Lobato MN, Forster A, Tanaka T, Chung GT, et al. (2002) Intracellular antibody capture technology: application to selection of intracellular antibodies recognising the BCR-ABL oncogenic protein. J Mol Biol 317: 85-94.
20. Auf der Maur A, Tissot K, Barberis A (2004) Antigen-independent selection of intracellular stable antibody frameworks. Methods 34: 215-224.
21. Auf der Maur AA, Zahnd C, Fischer F, Spinelli S, Honegger A, et al. (2002) Direct in vivo screening of intrabody libraries constructed on a highly stable single-chain framework. J Biol Chem 277: 45075-45085.
22. Visintin M, Settanni G, Maritan A, Graziosi S, Marks JD, et al. (2002) The intracellular antibody capture technology (IACT): towards a consensus sequence for intracellular antibodies. J Mol Biol 317: 73-83.
23. Visintin M, Quondam M, Cattaneo A (2004) The intracellular antibody capture technology: towards the high-throughput selection of functional intracellular antibodies for target validation. Methods 34: 200-214.
24. Haisma HJ, Pinedo HM, Rijswijk A, der Meulen-Muileman I, Sosnowski BA, et al. (1999) Tumor-specific gene transfer via an adenoviral vector targeted to the pan-carcinoma antigen EpCAM. Gene Ther 6: 1469-1474.
25. Haisma HJ, Grill J, Curiel DT, Hoogeland S, van Beusechem VW, et al. (2000) Targeting of adenoviral vectors through a bispecific single-chain antibody. Cancer Gene Ther 7: 901-904.
26. Kashentseva EA, Seki T, Curiel DT, Dmitriev IP (2002) Adenovirus targeting to c-erbB-2 oncoprotein by single-chain antibody fused to trimeric form of adenovirus receptor ectodomain. Cancer Res 62: 609-616.
27. Everts M, Kim-Park SA, Preuss MA, Passineau MJ, Glasgow JN, et al. (2005) Selective induction of tumor-associated antigens in murine pulmonary vasculature using double-targeted adenoviral vectors. Gene Ther 12: 1042-1048.
28. Dmitriev I, Kashentseva E, Rogers BE, Krasnykh V, Curiel DT (2000) Ectodomain of coxsackievirus and adenovirus receptor genetically fused to epidermal growth factor mediates adenovirus targeting to epidermal growth factor receptor-positive cells. J Virol 74: 6875-6884.
29. Hemminki A, Wang M, Hakkarainen T, Desmond RA, Wahlfors J, et al. (2003) Production of an EGFR targeting molecule from a conditionally replicating adenovirus impairs its oncolytic potential. Cancer Gene Ther 10: 583-588.
30. Hemminki A, Dmitriev I, Liu B, Desmond RA, Alemany R, et al. (2001) Targeting oncolytic adenoviral agents to the epidermal growth factor pathway with a secretory fusion molecule. Cancer Res 61: 6377-6381.
31. van Beusechem VW, Mastenbroek DC, van den Doel PB, Lamfers ML, Grill J, et al. (2003) Conditionally replicative adenovirus expressing a targeting adapter molecule exhibits enhanced oncolytic potency on CAR-deficient tumors. Gene Ther 10: 1982-1991.
32. Carette JE, Graat HC, Schagen FH, Mastenbroek DC, Rots MG, et al. (2007) A conditionally replicating adenovirus with strict selectivity in killing cells expressing epidermal growth factor receptor. Virology 361: 56-67.
33. Li HJ, Everts M, Yamamoto M, Curiel DT, Herschman HR (2009) Combined transductional untargeting/retargeting and transcriptional restriction enhances adenovirus gene targeting and therapy for hepatic colorectal cancer tumors. Cancer Res 69: 554-564.
34. Kirby I, Lord R, Davison E, Wickham TJ, Roelvink PW, et al. (2001) Adenovirus type 9 fiber knob binds to the coxsackie B virus-adenovirus receptor (CAR) with lower affinity than fiber knobs of other CAR-binding adenovirus serotypes. J Virol 75: 7210-7214.
35. Kirby I, Davison E, Beavil AJ, Soh CP, Wickham TJ, et al. (2000) Identification of contact residues and definition of the CAR-binding site of adenovirus type 5 fiber protein. J Virol 74: 2804-2813.
36. Davison E, Kirby I, Elliott T, Santis G (1999) The human HLA-A*0201 allele, expressed in hamster cells, is not a high-affinity receptor for adenovirus type 5 fiber. J Virol 73: 4513-4517.
37. Watkins SJ, Mesyanzhinov VV, Kurochkina LP, Hawkins RE (1997) The 'adenobody' approach to viral targeting: specific and enhanced adenoviral gene delivery. Gene Ther 4: 1004-1012.
38. Reynolds PN, Zinn KR, Gavrilyuk VD, Balyasnikova IV, Rogers BE, et al. (2000) A targetable, injectable adenoviral vector for selective gene delivery to pulmonary endothelium in vivo. Mol Ther 2: 562-578.
39. Reynolds PN, Nicklin SA, Kaliberova L, Boatman BG, Grizzle WE, et al. (2001) Combined transductional and transcriptional targeting improves the specificity of transgene expression in vivo. Nat Biotechnol 19: 838-842.
40. Li HJ, Everts M, Pereboeva L, Komarova S, Idan A, et al. (2007) Adenovirus tumor targeting and hepatic untargeting by a coxsackie/adenovirus receptor ectodomain anti-carcinoembryonic antigen bispecific adapter. Cancer Res 67: 5354-5361.
41. Krasnykh VN, Mikheeva GV, Douglas JT, Curiel DT (1996) Generation of recombinant adenovirus vectors with modified fibers for altering viral tropism. J Virol 70: 6839-6846.
42. Chartier C, Degryse E, Gantzer M, Dieterle A, Pavirani A, et al. (1996) Efficient generation of recombinant adenovirus vectors by homologous recombination in Escherichia coli. J Virol 70: 4805-4810.
43. Graham FL, Prevec L (1995) Methods for construction of adenovirus vectors. Mol Biotechnol 3: 207-220.
44. Maizel JV Jr, White DO, Scharff MD (1968) The polypeptides of adenovirus. I. Evidence for multiple protein components in the virion and a comparison of types 2, 7A, and 12. Virology 36: 115-125.