Coxsackievirus-adenovirus receptor genetically fused to anti-human CD40 scFv enhances adenoviral transduction of dendritic cells

Gene Therapy

Volumn 9, Issue 17, 2002, Pages 1189-1193

  Pereboev, A V ^a   Asiedu, C K ^a   Kawakami, Y ^a   Dong, S S ^a   Blackwell, J L ^a   Kashentseva, E A ^a   Triozzi, P L ^a   Aldrich, W A ^a   Curiel, D T ^a   Thomas, J M ^a   Dmitriev, I P ^a  

^a UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

Author keywords

Adenovirus; CAR; CD40; Dendritic cells; scFv; Transduction enhancement

Indexed keywords

ADENOVIRUS VECTOR; CD40 ANTIGEN; EPIDERMAL GROWTH FACTOR; LIGAND; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; VIRUS FUSION PROTEIN; VIRUS RECEPTOR;

ADENOVIRUS; ANIMAL CELL; ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ARTICLE; CELL SPECIFICITY; CELL SURFACE; CONTROLLED STUDY; COXSACKIE VIRUS; DENDRITIC CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENE FUSION; GENE TARGETING; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IMMUNOTHERAPY; MONKEY; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN INTERACTION; TRANSGENE; VIRAL GENE DELIVERY SYSTEM; VIRUS GENE; VIRUS LOAD;

ADENOVIRIDAE; ANTIGENS, CD40; DENDRITIC CELLS; ENTEROVIRUS; GENE THERAPY; GENETIC ENGINEERING; GENETIC VECTORS; HUMANS; IMMUNOGLOBULIN FRAGMENTS; IMMUNOTHERAPY; RECEPTORS, VIRUS; RECOMBINANT FUSION PROTEINS; TRANSDUCTION, GENETIC;

ADENOVIRIDAE; ANIMALIA; COXSACKIEVIRUS; DNA VIRUSES; MACACA MULATTA; RNA VIRUSES;

EID: 0036711756     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301767     Document Type: Article

References (21)

1. Gene-modified dendritic cells for use in tumor vaccines
2. Peptide-pulsed dendritic cells induce antigen-specific CTL-mediated protective tumor immunity
3. Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells
4. Human dendritic cells transfected with RNA encoding prostate-specific antigen stimulate prostate-specific CTL responses in vitro
5. DNA vaccination: Antigen presentation and the induction of immunity
6. Viral vectors for dendritic cell-based immunotherapy
7. Maturation of dendritic cells accompanies high-efficiency gene transfer by a CD40-targeted adenoviral vector
8. Recombinant adenovirus is an efficient and non-perturbing genetic vector for human dendritic cells
9. High efficiency adenovirus-mediated gene transfer to human dendritic cells
10. Highly efficient transduction of human monocyte-derived dendritic cells with subgroup B fiber-modified adenovirus vectors enhances transgene-encoded antigen presentation to cytotoxic T cells
11. Ectodomain of coxsackievirus and adenovirus receptor genetically fused to epidermal growth factor mediates adenovirus targeting to epidermal growth factor receptor-positive cells
12. A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas
13. Ligands and methods for augmenting B-cell proliferation
14. Production of a human antibody library in the phage display vector pSEX81
15. Screening of phage-displayed antibody libraries
16. Construction of scFv from hybridoma by two-step cloning
17. Purification, characterization, and biotinylation of single-chain antibodies
18. Generation of recombinant adenovirus vectors with modified fibers for altering viral tropism
19. Peritransplant tolerance induction in macaques: Early events reflecting the unique synergy between immunotoxin and deoxyspergualin
20. Phenotypic and functional differences between human dendritic cells derived in vitro from hematopoietic progenitors and from monocytes/macrophages
21. Endocytosis and degradation of monoclonal antibodies targeting human B cell malignancies