Identification of contact residues and definition of the CAR-binding site of adenovirus type 5 fiber protein

Journal of Virology

Volumn 74, Issue 6, 2000, Pages 2804-2813

  Kirby, Ian ^a   Davison, Elizabeth ^a   Beavil, Andrew J ^b   Soh, Cecilia P C ^a   Wickham, Thomas J ^c   Roelvink, Peter W ^c   Kovesdi, Imre ^c   Sutton, Brian J ^b   Santis, George ^a,d  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c GENVEC INC   (United States)

^d GUY S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ARGININE; IMMUNOGLOBULIN; LEUCINE; PROLINE; SERINE; TYROSINE; VIRUS PROTEIN; VIRUS RECEPTOR;

ADENOVIRUS 5; ARTICLE; BINDING AFFINITY; BINDING SITE; CIRCULAR DICHROISM; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; SURFACE PLASMON RESONANCE; VIRUS ADSORPTION;

ADENOVIRUSES, HUMAN; ANIMALS; ASPARAGINE; BINDING SITES; CAPSID; CAPSID PROTEINS; CHO CELLS; CIRCULAR DICHROISM; CRICETINAE; HUMANS; LEUCINE; LYSINE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; RECEPTORS, VIRUS;

EID: 0033999577     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.6.2804-2813.2000     Document Type: Article

References (34)

1. Bai, M., L. Campisi, and P. Freimuth. 1994. Vitronectin receptor antibodies inhibit infection of HeLa and A549 cells by adenovirus type 12 but not by adenovirus type 2. J. Virol. 68:5925-5932.
2. Belin, M., and P. Boulanger. 1994. Involvement of cellular adhesion sequences in the attachment of adenovirus to the HeLa cell surface. J. Gen. Virol. 74:1485-1497.
3. Bergelson, J. M., J. A. Cunningham, G. Droguett, E. A. Kurt-Jones, A. Krithivas, J. Hong, M. S. Horwitz, R. L. Crowell, and R. W. Finberg. 1997. Isolation of a common receptor for coxsackie B viruses and adenoviruses 2 and 5. Science 275:1320-1323.
4. Chroboczek, J., R. W. Ruigrok, and S. Cusack. 1995. Adenovirus fiber. Curr. Top. Microbiol. Immunol. 199:163-200.
5. Davison, E., R. M. Diaz, I. R. Hart, G. Santis, and J. F. Marshall. 1997. Integrin α5β1-mediated adenovirus infection is enhanced by the integrin-activating antibody TS2/16. J. Virol. 71:6204-6207.
6. Davison, E., I. Kirby, T. Elliot, and G. Santis. 1999. The human HLA-A0201 allele, when expressed in hamster cells, is not a high-affinity receptor for adenovirus type 5 fiber. J. Virol. 73:4513-4517.
7. Devaux, C., M. Adrian, C. C. Berthet, S. Cusack, and B. Jacrot. 1990. Structure of adenovirus fibre. I. Analysis of crystals of fibre from adenovirus serotypes 2 and 5 by electron microscopy and X-ray crystallography. J. Mol. Biol. 215:567-588.
8. Freimuth, P., K. Springer, C. Berard, J. Hainfeld, M. Bewley, and J. Flanagan. 1999. Coxsackievirus and adenovirus receptor amino-terminal immunoglobulin V-related domain binds adenovirus type 2 and fiber knob from adenovirus type 12. J. Virol. 73:1392-1398.
9. Graham, F., and L. Prevec. 1992. Adenovirus based expression vectors and recombinant veccines, p. 363-390. In R. Ellis (ed.), Vaccine: new approaches to immunological problems. Butterworth-Heinemann, Oxford, England.
10. Greber, U. F., M. Willets, P. Webster, and A. Helenius. 1993. Stepwise dismantling of adenovirus 2 entry into cells. Cell 75:477-486.
11. Green, N. M., N. G. Wringley, W. C. Russell, S. R. Martin, and A. D. MacLachlan. 1983. Evidence of a repeating cross-∫ sheet structure in the adenovirus fibre. EMBO J. 2:1357-1365.
12. Hennache, B., and P. Boulanger. 1977. Biochemical study of KB-cell receptor for adenovirus. Biochem. J. 166:237-247.
13. Henry, L. J., D. Xia, M. E. Wilke, J. Deisenhofer, and R. D. Gerard. 1994. Characterization of the knob domain of the adenovirus type 5 fiber protein expressed in Escherichia coli. J. Virol. 68:5239-5246.
14. Hong, S. S., L. Karayan, J. Tournier, D. T. Curiel, and P. A. Boulanger. 1997. Adenovirus type 5 fiber knob binds to MHC class I alpha 2 domain at the surface of human epithelial and B lymphoblastoid cells. EMBO J. 16:2294-2306.
15. Horwitz, M. 1990. Adenoviruses, vol. 2. Raven Press, New York, N.Y.
16. Kirby, I., E. Davison, A. J. Beavil, C. P. C. Soh, T. J. Wickham, P. W. Roelvink, I. Kovesdi, B. J. Sutton, and G. Santis. 1999. Mutations in the DG loop of adenovirus 5 fiber protein abolish high-affinity binding to its cellular receptor CAR. J. Virol. 73:9508-9514.
17. Mathias, P., M. Galleno, and G. R. Nemerow. 1998. Interactions of soluble recombinant integrins αvβ5 with human adenoviruses. J. Virol. 72:8669-8675.
18. v integrins for infection. J. Virol. 68:6811-6814.
19. Meager, A., T. D. Butters, V. Mautner, and R. C. Hughes. 1976. Interaction of KB cell glycoproteins with an adenovirus capsid protein. Eur. J. Biochem. 61:345-355.
20. Miller, C. R., D. J. Buchsbaum, P. N. Reynolds, J. T. Douglas, G. Y. Gillespie, M. S. Mayo, D. Raben, and D. T. Curiel. 1998. Differential susceptibility of primary and established human glioma cells to adenovirus infection: targeting via the epidermal growth factor receptor achieves fiber receptor-independent gene transfer. Cancer Res. 58:5738-5748.
21. Novelli, A., and P. A. Boulanger. 1991. Deletion analysis of functional domains in baculovirus-expressed adenovirus type 2 fiber. Virology 185:365-376.
22. Pickles, R. J., D. McCarty, H. Matsui, P. J. Hart, S. H. Randell, and R. C. Boucher. 1998. Limited entry of adenovirus vectors into well-differentiated airway epithelium is responsible for inefficient gene transfer. J. Virol. 72: 6014-6023.
23. Provencher, S. W., and J. Glockner. 1981. Estimation of globular protein secondary structure from circular dichroism. Biochemistry 20:33-37.
24. Roelvink, P. W., A. Lizonova, J. G. M. Lee, Y. Li, J. M. Bergelson, R. W. Finberg, D. E. Brough, I. Kovesdi, and T. J. Wickham. 1998. The coxsackie-adenovirus receptor protein can function as a cellular attachment protein for adenovirus serotypes from subgroups A, C, D, E, and F. J. Virol. 72:7909-7915.
25. Santis, G., V. Legrand, S. Hong, E. Davison, I. Kirby, C. Chartier, A. Pavirani, J. Bergelson, M. Mehtali, and P. Boulanger. 1999. Molecular determinants and serotype specificity of Ad5 fiber binding to its high affinity receptor CAR. J. Gen. Virol. 80:1519-1527.
26. Svensson, U., R. Persson, and E. Everitt. 1981. Virus-receptor interaction in the adenovirus system: identification of virion attachment proteins of the HeLa cell plasma membrane. J. Virol. 38:70-81.
27. Tomko, R., R. Xu, and L. Philipson. 1997. HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses. Proc. Natl. Acad. Sci. USA 94:3352-3356.
28. Wadell, G. 1990. Adenoviruses, p. 267-287. In A. J. Zuckerman, J. E. Banatvala, and J. R. Pattison (ed.), Principles and practice of clinical virology. John Wiley & Sons, Chichester, England.
29. Walters, R., T. Grunst, J. Bergelson, R. Finberg, M. Welsh, and J. Zabner. 1999. Basolateral localization of fiber receptors limits adenovirus infection from the apical surface of airway epithelia. J. Biol. Chem. 274:10219-10226.
30. Wang, X., and J. M. Bergelson. 1999. Coxsackievirus and adenovirus receptor cytoplasmic and transmemhrane domains are not essential for coxsackievirus and adenovirus infection. J. Virol. 73:2559-2562.
31. Wickham, T. J., M. E. Carrion, and I. Kovesdi. 1995. Targeting of adenovirus penton hase to new receptors through the replacement of its RGD motif with other receptor-specific peptide motifs. Gene Ther. 2:750-758.
32. Wickham, T. J., E. J. Filardo, D. A. Cheresh, and G. R. Nemerow. 1994. Integrin αvβ5 selectively promotes adenovirus cell membrane permeability. J. Cell Biol. 127:257-264.
33. Wickham, T. J., P. Mathias, D. A. Cheresh, and G. R. Nenerow. 1993. Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment. Cell 73:309-319.
34. Xia, D., L. Henry, R. Gerard, and J. Desenhofer. 1994. Crystal structure of the receptor-binding domain of adenovirus type 5 fiber protein at 1.7 A resolution. Structure 2:1259-1270.