Adenovirus targeting to c-erbB-2 oncoprotein by single-chain antibody fused to trimeric form of adenovirus receptor ectodomain

Cancer Research

Volumn 62, Issue 2, 2002, Pages 609-616

  Kashentseva, Elena A ^a   Seki, Toshiro ^a   Curiel, David T ^a   Dmitriev, Igor P ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; ADENOVIRUS RECEPTOR; ADENOVIRUS VECTOR; COXSACKIE VIRUS AND ADENOVIRUS RECEPTOR; HYBRID PROTEIN; MONOMER; ONCOPROTEIN; RECOMBINANT PROTEIN; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG; VIRUS RECEPTOR;

ARTICLE; BREAST ADENOCARCINOMA; CANCER CELL CULTURE; COMPLEX FORMATION; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; GENE TARGETING; GENE TRANSFER; HUMAN; HUMAN CELL; NONHUMAN; OVARY ADENOCARCINOMA; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN POLYMERIZATION; PROTEIN PROTEIN INTERACTION; RECEPTOR AFFINITY; TARGET CELL; VIRUS INFECTION;

ADENOVIRIDAE; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; IMMUNOCONJUGATES; IMMUNOGLOBULIN VARIABLE REGION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, ERBB-2; RECEPTORS, VIRUS; RECOMBINANT FUSION PROTEINS; TUMOR CELLS, CULTURED;

EID: 0037081279     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Adenoviridae: The viruses and their replication
2. Receptors mediating adenovirus attachment and internalization
3. Cell receptors involved in adenovirus entry
4. Cell-binding domain of adenovirus serotype 2 fiber
5. Human adenovirus serotypes 3 and 5 bind to two different cellular receptors via the fiber head domain
6. Role of α(v) integrins in adenovirus cell entry and gene delivery
7. Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5
8. HCAR and MCAR: The human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses
9. The coxsackievirus-adenovirus receptor protein can function as a cellular attachment protein for adenovirus serotypes from subgroups A, C, D, E, and F
10. The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses
11. Coxsackievirus and adenovirus receptor amino-terminal immunoglobulin V-related domain binds adenovirus type 2 and fiber knob from adenovirus type 12
12. Expression of the adenovirus receptor and its interaction with the fiber knob
13. Coxsackievirus and adenovirus receptor cytoplasmic and transmembrane domains are not essential for coxsackievirus and adenovirus infection
14. Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR
15. Identification of a conserved receptor-binding site on the fiber proteins of CAR-recognizing adenoviridae
16. Kinetic analysis of adenovirus fiber binding to its receptor reveals an avidity mechanism for trimeric receptor-ligand interactions
17. Development and application of adenoviral vectors for gene therapy of cancer
18. The dual impact of coxsackie and adenovirus receptor expression on human prostate cancer gene therapy
19. Differential susceptibility of primary and established human glioma cells to adenovirus infection: Targeting via the epidermal growth factor receptor achieves fiber receptor-independent gene transfer
20. Loss of adenoviral receptor expression in human bladder cancer cells: A potential impact on the efficacy of gene therapy
21. CAR-dependent and CAR-independent pathways of adenovirus vector-mediated gene transfer and expression in human fibroblasts
22. Targeting adenovirus
23. Advanced generation adenoviral vectors possess augmented gene transfer efficiency based upon coxsackie adenovirus receptor-independent cellular entry capacity
24. Genetic targeting of adenoviral vectors
25. The 'adenobody' approach to viral targeting: Specific and enhanced adenoviral gene delivery
26. Targeting of adenoviral vectors through a bispecific single-chain antibody
27. Cell-specific viral targeting mediated by a soluble retroviral receptor-ligand fusion protein
28. Improved gene transfer efficiency to primary and established human pancreatic carcinoma target cells via epidermal growth factor receptor and integrin-targeted adenoviral vectors
29. Ectodomain of coxsackievirus and adenovirus receptor genetically fused to epidermal growth factor mediates adenovirus targeting to epidermal growth factor receptor-positive cells
30. Functional and selective targeting of adenovirus to high-affinity Fcγ receptor I-positive cells by using a bispecific hybrid adapter
31. Basic science of HER-2/neu: A review
32. HER-2/neu as a therapeutic target in non-small cell lung cancer, prostate cancer, and ovarian cancer
33. A monoclonal antibody specific for the cellular receptor for the group B coxsackieviruses
34. Artificial extension of adenoviral fiber alternates infectivity profiles in a coxsackievirus and adenovirus receptor-dependent manner
35. The polypeptides of adenovirus. I. Evidence for multiple protein components in the virion and a comparison of types 2, 7A, and 12
36. Evaluation of the concentration and bioactivity of adenovirus vectors for gene therapy
37. Structure of bacteriophage T4 fibritin: A segmented coiled coil and the role of the C-terminal domain
38. Structure of bacteriophage T4 fibritin M: A troublesome packing arrangement
39. Generation of recombinant adenovirus vectors with modified fibers for altering viral tropism
40. Isolation of picomolar affinity anti-c-erbB-2 single-chain Fv by molecular evolution of the complementarity determining regions in the center of the antibody binding site
41. Prolonged in vivo tumour retention of a human diabody targeting the extracellular domain of human HER2/neu
42. Fibroblast growth factor 2 retargeted adenovirus has redirected cellular tropism: Evidence for reduced toxicity and enhanced antitumor activity in mice
43. Fibroblast growth factor 2-retargeted adenoviral vectors exhibit a modified biolocalization pattern and display reduced toxicity relative to native adenoviral vectors
44. Basic fibroblast growth factor enhancement of adenovirus-mediated delivery of the herpes simplex virus thymidine kinase gene results in augmented therapeutic benefit in a murine model of ovarian cancer
45. A targetable, injectable adenoviral vector for selective gene delivery to pulmonary endothelium in vivo