A cellular automata-based mathematical model for thymocyte development

PLoS ONE

Volumn 4, Issue 12, 2009, Pages

  Souza e Silva, Hallan ^a,d   Savino, Wilson ^b   Feijóo, Raúl A ^a,c   Vasconcelos, Ana Tereza Ribeiro ^a  

^a LNCC/MCT   (Brazil)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

^c NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY   (Brazil)

^d FEDERAL UNIVERSITY OF VIÇOSA   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN;

ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL COUNT; CELL DIFFERENTIATION; CELL MATURATION; CELL MIGRATION; CHILD; COMPUTER MODEL; CONTROLLED STUDY; DEVELOPMENTAL STAGE; HUMAN; HUMAN TISSUE; MATHEMATICAL MODEL; MOUSE; NONHUMAN; PRESCHOOL CHILD; THYMOCYTE;

ANIMALS; CD4-CD8 RATIO; CELL DIFFERENTIATION; CELL MOVEMENT; CELL PROLIFERATION; CHEMOKINES; COMPUTER SIMULATION; EPITHELIAL CELLS; HUMANS; MICE; MODELS, BIOLOGICAL; T-LYMPHOCYTES; THYMUS GLAND; TIME FACTORS; WHOLE-BODY IRRADIATION;

ANIMALIA; MUS;

EID: 77949523812     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0008233     Document Type: Article

References (40)

1. Janeway CA, Travers P, Walport M, Shlomchik MJ (2005) Immunobiology: the immune system in health and disease. New York, NY: Garland Science Publishing.
2. Petrie HT, Zuniga-Pflucker JC (2007) Zoned out: Functional maing of stromal signaling microenvironments in the thymus. Annu Rev Immunol 25: 649-679.
3. Savino W, Mendes-da-Cruz DA, Smaniotto S, Silva-Monteiro E, VillaVerde DMS (2004) Molecular mechanisms governing thymocyte migration: combined role of chemokines and extracellular matrix. J Leukoc Biol 75: 951-961.
4. Normenta AM, Bevana MJ (2000) Role of chemokines in thymocyte development. Seminars in Immunology 12: 445-455.
5. Robey E, Chang D, Cado AID, Alexander H, Weinmaster DLG, et al. (1996) An activated form of Notch influences the choice between CD4 and CD8 T cell lineages. Cell 87: 483-492.
6. Robey E (1999) Regulation of T cell fate by Notch. Annu Rev Immunol 17: 283-295.
7. Singer A (2002) New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision. Current Opinion in Immunology 14: 207-215.
8. Liu X, Bosselut R (2004) Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo. Nature Immunology 5: 280-288.
9. van Ewijk W, Shores EW, Singer A (1994) Crosstalk in the mouse thymus. Immunology Today 15: 214-217.
10. Mehr R, Abel L, Ubezio P, Globerson A, Agur Z (1993) A mathematical model of the effect of aging on bone marrow cells colonizing the thymus. Mechanisms of Aging and Development 67: 159-172.
11. Hazenberg MD, Otto SA, Stuart JWTC, Verschuren MCM, Borleffs JCC, et al. (2000) Increased cell division but not thymic dysfunction rapidly affects the T- cell receptor excision circle content of the naive t cell population in HIV-1 infection. Nature Medicine 6: 1036-1042.
12. Mehr R, Globerson A, Perelson AS (1995) Modeling positive and negative selection and differentiation processes in the thymus. J Theor Biol 175: 103-126.
13. Mehr R, Perelson AS, Fridkis-Hareli M, Globerson A (1996) Feedback regulation of T cell development in the thymus. J Theor Biol 181: 157-167.
14. Efroni S, Harel D, Cohen I (2007) Emergent dynamics of thymocyte development and lineage determination. PLoS Computational Biology 3: 127-135.
15. Thomas-Vaslin V, Altes HK, de Boer RJ, Klatzmann D (2008) Comprehensive assessment and mathematical modeling of T cell population dynamics and homeostasis. The Journal of Immunology 180: 2240-2250.
16. Eren R, Zharhry D, Abel L, Globerson A (1988) Age-related changes in the capacity of bone marrow cells to differentiate in thymic organ cultures. Cellular Immunology 112: 449-455.
17. von Boehmer H, Kisielow P (1993) Lymphocyte lineage commitment: Instruction versus selection. Cell 73: 207-208.
18. Germain RN (2002) T-cell development and the CD4-CD8 lineage decision. Nature Reviews Immunology 2: 309-322.
19. Scollay R, Godfrey DI (1995) Thymic emigration: conveyor belts or lucky dips? Immunology Today 16: 268-273.
20. Efroni S, Harel D, Cohen IR (2005) Reactive animation: Realistic modeling of complex dynamic systems. Computer 38: 38-47.
21. Efroni S, Harel D, Cohen IR (2003) Toward rigorous comprehension of biological complexity: Modeling, execution, and visualization of thymic T-cell maturation. Genomic Research 13: 2485-2497.
22. Wolfram S (1986) Theory and Apllications of Cellular Automata. Singapore: World Scientific.
23. Lewin R (1993) Complexity, Life at the Edger of Chaos. Chicago: Chicago University Press
24. Dalmau SR, Freitas CS, Savino W (1999) Upregulated expression of fibronectin receptors underlines the adhesive capability of thymocytes to thymic epithelial cells during the early stages of differentiation: Lessons from sublethally irradiated mice. Blood 93: 974-990.
25. Takahama Y (2006) Journey through the thymus: Stromal guides for T-cell development and selection. Nature Reviews Immunology 6: 127-135.
26. Zhou R, Flaswinkel H, Schneider MR, Lahm H, Hoeflich A, et al. (2004) Insulin-like growth factor-binding protein-4 inhibits growth of the thymus in transgenic mice. Journal of Molecular Endocrinology 32: 349-364.
27. Shi H, Ma W (2006) An improved model of T cell development in the thymus and its stability analysis. Mathematical Biosciences and Engineering 3: 237-248.
28. Savino W, Mendes-da-Cruz DA, Silva JS, Dardenne M, Cotta-de-Almeida V (2002) Intrathymic T-cell migration: a combinatorial interplay of extracellular matrix and chemokines? Trends in Immunology 23: 305-313.
29. Mendes-da-Cruz DA, Smaniotto S, Keller AC, Dardenne M, Savino W (2008) Multivectorial abnormal cell migration in the NOD mouse thymus. The Journal of Immunology 180: 11-16. 8.
30. Savino W (2007) Neuroendocrine control of T cell development in mammals: role of growth hormone in modulating thymocyte migration. Exp Physiol 92: 813-817.
31. Savino W, Dardenne M, Veloso LA, Silva-Barbosa SD (2007) The thymus is a common target in malnutrition and infection. Brit J Nutr 98: 11-16.
32. Salinas FA, Smith LH, Goodman JW (1972) Cell size distribution in the thymus as a function of age. Journal of Cellular Physiology 80: 339-345.
33. van Ewijk W, Wang B, Hollander G, Kawamoto H, Spanopoulou E, et al. (1999) Thymic microenvironments, 3-D versus 2-D? Seminars in Immunology 11: 57-64.
34. Geankoplis CJ (1993) Transport Process and Unit Operations. New Jersey: Prentice Hall.
35. Plotkin J, Prockop SE, Lepique A, Petrie HT (2003) Critical role for CXCR4 signaling in progenitor localization and T cell differentiation in the postnatal thymus. The Journal of Immunology 171: 4521-4527.
36. Suzuki G, Sawa H, Kobayashi Y, Nakata Y, Nakagawa K, et al. (1999) Pertussis toxin-sensitive signal controls the trafficking of thymocytes across the corticomedullary junction in the thymus. The Journal of Immunology 162: 5981-5985.
37. Ueno T, Saito F, Gray DH, Kuse S, Hieshima K, et al. (2004) CCR7 signals are essential for cortex-medulla migration of developing thymocytes. J Exp Med 200: 493-505.
38. Kurobe H, Liu C, Ueno T, Saito F, Ohigashi I, et al. (2006) CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance. Immunity 24: 165-177.
39. Yasutomo K, Doyle C, Miele L, Germain RN (2000) The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate. Nature 404: 506-510.
40. Pappu R, Schwab SR, Cornelissen I, ao P Pereira J, Regard JB, et al. (2007) Promotion of lymphocyte egress into blood and lhymph by distinct sources of Sphingosine-1-Phosphate. Science 316: 295-298.