Mechanism of LDL binding and release probed by structure-based mutagenesis of the LDL receptor

Journal of Lipid Research

Volumn 51, Issue 2, 2010, Pages 297-308

  Huang, Sha ^a   Henry, Lisa ^c   Ho, Yiu Kee ^d   Pownall, Henry J ^e   Rudenko, Gabby ^a,b  

^a Life Sciences Institute   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF TEXAS AT DALLAS   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^e BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Cell surface receptor; Cholesterol metabolism; Receptor:ligand interaction

Indexed keywords

CHOLESTEROL; EPIDERMAL GROWTH FACTOR; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR;

ARTICLE; CELL SURFACE; CHOLESTEROL METABOLISM; CRYSTAL STRUCTURE; GEL FILTRATION; HUMAN; HYDRODYNAMICS; LIGAND BINDING; MOLECULAR MECHANICS; MUTANT; PH; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN SECRETION; SITE DIRECTED MUTAGENESIS; SOLID; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; METABOLISM; MUTATION; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; EPIDERMAL GROWTH FACTOR; HUMANS; HYDROGEN-ION CONCENTRATION; LIPOPROTEINS, LDL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, LDL; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77949512178     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M000422     Document Type: Article

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