Mechanism of low density lipoprotein (LDL) release in the endosome: Implications of the stability and Ca2+ affinity of the fifth binding module of the LDL receptor

Journal of Biological Chemistry

Volumn 283, Issue 33, 2008, Pages 22670-22679

  Arias Moreno, Xabier ^a   Velazquez Campoy, Adrián ^a   Rodríguez, José Carlos ^b   Pocoví, Miguel ^a   Sancho, Javier ^a  

^a UNIVERSITY OF ZARAGOZA   (Spain)

^b UNIVERSITY OF CANTABRIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; CALCIUM; CALCIUM ALLOYS; CRYSTAL STRUCTURE; IONS;

BINDING MODULES; CALCIUM CONCENTRATIONS; CALCIUM DEPLETIONS; CALCIUM IONS; CONFORMATIONAL STABILITIES; DISULFIDE BONDS; DO-MAINS; ENDOSOME; EPIDERMAL GROWTH FACTORS; EXTRACELLULAR; EXTRACELLULAR CALCIUMS; EXTRACELLULAR CONDITIONS; HUMAN POPULATIONS; HYPERCHOLESTEROLEMIA; LDL RECEPTORS; LOW DENSITIES; MODULAR PROTEINS; NEW MECHANISMS;

PLASMA STABILITY;

CALCIUM ION; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; CALCIUM; PRIMER DNA; RECOMBINANT PROTEIN;

ACIDITY; AMINO ACID SEQUENCE; ARTICLE; CELL PH; CONCENTRATION RESPONSE; DISULFIDE BOND; ENDOSOME; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN SECRETION; PROTEIN STABILITY; BINDING SITE; CHEMISTRY; ESCHERICHIA COLI; GENETICS; HUMAN; HYPERCHOLESTEROLEMIA; KINETICS; METABOLISM; MOLECULAR CLONING; MUTATION; NUCLEOTIDE REPEAT; PH; POLYMERASE CHAIN REACTION; RESTRICTION MAPPING;

BINDING SITES; CALCIUM; CLONING, MOLECULAR; DNA PRIMERS; ENDOSOMES; ESCHERICHIA COLI; HUMANS; HYDROGEN-ION CONCENTRATION; HYPERCHOLESTEROLEMIA; KINETICS; LIPOPROTEINS, LDL; MUTATION; POLYMERASE CHAIN REACTION; RECEPTORS, LDL; RECOMBINANT PROTEINS; REPETITIVE SEQUENCES, NUCLEIC ACID; RESTRICTION MAPPING;

EID: 53049086015     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M802153200     Document Type: Article

References (62)

1. Brown, M. S., and Goldstein, J. L. (1986) Science 232, 34-47
2. Anderson, R. G., Vasile, E., Mello, R. J., Brown, M. S., and Goldstein, J. L. (1978) Cell 15, 919-933
3. Anderson, R. G., Goldstein, J. L., and Brown, M. S. (1977) Nature 270, 695-699
4. Anderson, R. G., Brown, M. S., and Goldstein, J. L. (1977) Cell 10, 351-364
5. Anderson, R. G., Goldstein, J. L., and Brown, M. S. (1976) Proc. Natl. Acad. Sci. U. S. A. 73, 2434-2438
6. Beffert, U., Stolt, P. C., and Herz, J. (2004) J. Lipid Res. 45, 403-409
7. Willnow, T. E., Nykjaer, A., and Herz, J. (1999) Nat. Cell Biol. 1, E157-E162
8. Strickland, D. K., Gonias, S. L., and Argraves, W. S. (2002) Trends Endocrinol. Metab. 13, 66-74
9. Blacklow, S. C. (2007) Curr. Opin. Struct. Biol. 17, 419-426
10. Lee, D., Walsh, J. D., Mikhailenko, I., Yu, P., Migliorini, M., Wu, Y., Krueger, S., Curtis, J. E., Harris, B., Lockett, S., Blacklow, S. C., Strickland, D. K., and Wang, Y. X. (2006) Mol. Cell 22, 423-430
11. Goldstein, J. L., and Brown, M. S. (1974) J. Biol. Chem. 249, 5153-5162
12. Brown, M. S., and Goldstein, J. L. (1974) Proc. Natl. Acad. Sci. U. S. A. 71, 788-792
13. Goldstein, J. L., and Brown, M. S. (1973) Proc. Natl. Acad. Sci. U. S. A. 70, 2804-2808
14. Chen, S. H., Yang, C. Y., Chen, P. F., Setzer, D., Tanimura, M., Li, W. H., Gotto, A. M., Jr., and Chan, L. (1986) J. Biol. Chem. 261, 12918-12921
15. Sudhof, T. C., Goldstein, J. L., Brown, M. S., and Russell, D. W. (1985) Science 228, 815-822
16. Yamamoto, T., Davis, C. G., Brown, M. S., Schneider, W. J., Casey, M. L., Goldstein, J. L., and Russell, D. W. (1984) Cell 39, 27-38
17. Russell, D. W., Brown, M. S., and Goldstein, J. L. (1989) J. Biol. Chem. 264, 21682-21688
18. Esser, V., Limbird, L. E., Brown, M. S., Goldstein, J. L., and Russell, D. W. (1988) J. Biol. Chem. 263, 13282-13290
19. Fisher, C., Abdul-Aziz, D., and Blacklow, S. C. (2004) Biochemistry 43, 1037-1044
20. Fass, D., Blacklow, S., Kim, P. S., and Berger, J. M. (1997) Nature 388, 691-693
21. Daly, N. L., Scanlon, M. J., Djordjevic, J. T., Kroon, P. A., and Smith, R. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 6334-6338
22. Beglova, N., and Blacklow, S. C. (2005) Trends Biochem. Sci. 30, 309-317
23. Beglova, N., Jeon, H., Fisher, C., and Blacklow, S. C. (2004) Biochem. Soc. Trans. 32, 721-723
24. Beglova, N., Jeon, H., Fisher, C., and Blacklow, S. C. (2004) Mol. Cell 16, 281-292
25. Saha, S., Boyd, J., Werner, J. M., Knott, V., Handford, P. A., Campbell, I. D., and Downing, A. K. (2001) Structure (Lond.) 9, 451-456
26. Davis, C. G., Goldstein, J. L., Sudhof, T. C., Anderson, R. G., Russell, D. W., and Brown, M. S. (1987) Nature 326, 760-765
27. Brown, M. S., Anderson, R. G., and Goldstein, J. L. (1983) Cell 32, 663-667
28. Rudenko, G., and Deisenhofer, J. (2003) Curr. Opin. Struct. Biol. 13, 683-689
29. Rudenko, G., Henry, L., Henderson, K., Ichtchenko, K., Brown, M. S., Goldstein, J. L., and Deisenhofer, J. (2002) Science 298, 2353-2358
30. Koduri, V., and Blacklow, S. C. (2001) Biochemistry 40, 12801-12807
31. North, C. L., and Blacklow, S. C. (2000) Biochemistry 39, 13127-13135
32. North, C. L., and Blacklow, S. C. (1999) Biochemistry 38, 3926-3935
33. Blacklow, S. C., and Kim, P. S. (1996) Nat. Struct. Biol. 3, 758-762
34. Schneider, W. J., Basu, S. K., McPhaul, M. J., Goldstein, J. L., and Brown, M. S. (1979) Proc. Natl. Acad. Sci. U. S. A. 76, 5577-5581
35. Dedoussis, G. V., Schmidt, H., and Genschel, J. (2004) Hum. Mutat. 24, 443-459
36. Goldstein, J. L., Hobbs, H. H., and Brown, M. S. (2001) in The Metabolic and Molecular Bases of Inherited Disease (Scrivor, C. R., Beaudet, A. L., Sly, W. S., and Valle, D., eds) 8th Ed., pp. 2863-2913, McGraw-Hill Book Co., New York
37. Li, Y., Lu, W., Schwartz, A. L., and Bu, G. (2002) Biochemistry 41, 4921-4928
38. Bu, G. (2001) Int. Rev. Cytol. 209, 79-116
39. Arias-Moreno, X., Arolas, J. L., Aviles, F. X., Sancho, J., and Ventura, S. (2008) J. Biol. Chem. 283, 13627-13637
40. Wilkins, M. R., Gasteiger, E., Bairoch, A., Sanchez, J. C., Williams, K. L., Appel, R. D., and Hochstrasser, D. F. (1999) Methods Mol. Biol. 112, 531-552
41. Pace, C. N., Laurents, D. V., and Thomson, J. A. (1990) Biochemistry 29, 2564-2572
42. Genzor, C. G., Beldarrain, A., Gomez-Moreno, C., Lopez-Lacomba, J. L., Cortijo, M., and Sancho, J. (1996) Protein Sci. 5, 1376-1388
43. Makhatadze, G. I., Kim, K. S., Woodward, C., and Privalov, P. L. (1993) Protein Sci. 2, 2028-2036
44. Campos, L. A., and Sancho, J. (2006) Proteins 63, 581-594
45. Straume, M., and Freire, E. (1992) Anal. Biochem. 203, 259-268
46. Nielsen, A. D., Fuglsang, C. C., and Westh, P. (2003) Anal. Biochem. 314, 227-234
47. Griko, Y. V. (1999) Biophys. Chem. 79, 117-127
48. Dolmer, K., Huang, W., and Gettins, P. G. (1998) Biochemistry 37, 17016-17023
49. Atkins, A. R., Brereton, I. M., Kroon, P. A., Lee, H. T., and Smith, R. (1998) Biochemistry 37, 1662-1670
50. Zhou, H. X. (2008) Arch. Biochem. Biophys. 469, 76-82
51. Minton, A. P. (2005) Biophys. J. 88, 971-985
52. Simonovic, M., Dolmer, K., Huang, W., Strickland, D. K., Volz, K., and Gettins, P. G. (2001) Biochemistry 40, 15127-15134
53. Cuesta-Lopez, S., Falo, F., and Sancho, J. (2007) Proteins 66, 87-95
54. Permyakov, S. E., Khokhlova, T. I., Nazipova, A. A., Zhadan, A. P., Morozova-Roche, L. A., and Permyakov, E. A. (2006) Proteins 65, 984-998
55. Saito, M., Hanson, P. I., and Schlesinger, P. (2007) J. Biol. Chem. 282, 27327-27333
56. Gerasimenko, J. V., Tepikin, A. V., Petersen, O. H., and Gerasimenko, O. V. (1998) Curr. Biol. 8, 1335-1338
57. Jeon, H., and Blacklow, S. C. (2005) Annu. Rev. Biochem. 74, 535-562
58. Uversky, V. N. (2002) Eur. J. Biochem. 269, 2-12
59. Kwon, H. J., Lagace, T. A., McNutt, M. C., Horton, J. D., and Deisenhofer, J. (2008) Proc. Natl. Acad. Sci. U. S. A. 105, 1820-1825
60. Kampmann, T., Mueller, D. S., Mark, A. E., Young, P. R., and Kobe, B. (2006) Structure (Lond.) 14, 1481-1487
61. Rainey, G. J., Wigelsworth, D. J., Ryan, P. L., Scobie, H. M., Collier, R. J., and Young, J. A. (2005) Proc. Natl. Acad. Sci. U. S. A. 102, 13278-13283
62. Debose-Boyd, R. A. (2004) Mol. Cell 16, 160-162