Cellular processes of v-Src transformation revealed by gene profiling of primary cells - Implications for human cancer

BMC Cancer

Volumn 10, Issue , 2010, Pages

  Maślikowski, Bart M ^a   Néel, Benjamin D ^b   Wu, Ying ^a   Wang, Lizhen ^a   Rodrigues, Natalie A ^c   Gillet, Germain ^b   Bédard, Pierre André ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b INSTITUT DE BIOLOGIE ET CHIMIE DES PROTÉINES   (France)

^c SUNNYBROOK RESEARCH INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; PROTEIN TYROSINE KINASE; PROTEIN KINASE P60;

ANIMAL CELL; ARTICLE; BREAST CANCER; CANCER SURVIVAL; CARCINOGENESIS; CELL CYCLE; CELL TYPE; CHICKEN; CONTROLLED STUDY; DISEASE FREE SURVIVAL; DNA DAMAGE; DNA REPLICATION; EMBRYO; ENZYME ACTIVITY; FIBROBLAST; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENETIC CODE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; LUNG CANCER; MALIGNANT TRANSFORMATION; MICROARRAY ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PROGNOSIS; RETINA CELL; ROUS SARCOMA ONCOVIRUS; SIGNAL TRANSDUCTION; STRESS; TEMPERATURE SENSITIVE MUTANT; TUMOR GENE; TUMOR VASCULARIZATION; VIRUS CELL TRANSFORMATION; VIRUS GENOME; VIRUS STRAIN; ANIMAL; BIOSYNTHESIS; BREAST TUMOR; CELL TRANSFORMATION; CHICK EMBRYO; CLUSTER ANALYSIS; COHORT ANALYSIS; CYTOLOGY; DNA MICROARRAY; GENETICS; LUNG TUMOR; METABOLISM; METASTASIS; ONCOGENE SRC; RETINA;

ANIMALS; BREAST NEOPLASMS; CELL TRANSFORMATION, NEOPLASTIC; CHICK EMBRYO; CLUSTER ANALYSIS; COHORT STUDIES; DISEASE-FREE SURVIVAL; FIBROBLASTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, SRC; HUMANS; LUNG NEOPLASMS; NEOPLASM METASTASIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ONCOGENE PROTEIN PP60(V-SRC); PROGNOSIS; RETINA;

EID: 77949483084     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-10-41     Document Type: Article

References (104)

1. Thomas SM, Brugge JS. Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol 1997, 13:513-609. 10.1146/annurev.cellbio.13.1.513, 9442882.
2. Irby RB, Yeatman TJ. Role of Src expression and activation in human cancer. Oncogene 2000, 19(49):5636-5642. 10.1038/sj.onc.1203912, 11114744.
3. Biscardi JS, Ishizawar RC, Silva CM, Parsons SJ. Tyrosine kinase signalling in breast cancer: epidermal growth factor receptor and c-Src interactions in breast cancer. Breast Cancer Res 2000, 2(3):203-210. 10.1186/bcr55, 138776, 11250711.
4. Irby RB, Mao W, Coppola D, Kang J, Loubeau JM, Trudeau W, Karl R, Fujita DJ, Jove R, Yeatman TJ. Activating SRC mutation in a subset of advanced human colon cancers [In Process Citation]. Nat Genet 1999, 21(2):187-190. 10.1038/5971, 9988270.
5. Sugimoto Y, Erikson RL. Phosphatidylinositol kinase activities in normal and Rous sarcoma virus-transformed cells. Mol Cell Biol 1985, 5(11):3194-3198. 369134, 3018507.
6. Aftab DT, Kwan J, Martin GS. Ras-independent transformation by v-Src. Proc Natl Acad Sci USA 1997, 94(7):3028-3033. 10.1073/pnas.94.7.3028, 20316, 9096340.
7. Webb BL, Jimenez E, Martin GS. v-Src generates a p53-independent apoptotic signal. Mol Cell Biol 2000, 20(24):9271-9280. 10.1128/MCB.20.24.9271-9280.2000, 102184, 11094078.
8. Shah AN, Gallick GE. Src, chemoresistance and epithelial to mesenchymal transition: are they related?. Anticancer Drugs 2007, 18(4):371-375. 10.1097/CAD.0b013e32801265d7, 17351389.
9. Zhang XH, Wang Q, Gerald W, Hudis CA, Norton L, Smid M, Foekens JA, Massague J. Latent bone metastasis in breast cancer tied to Src-dependent survival signals. Cancer Cell 2009, 16(1):67-78. 10.1016/j.ccr.2009.05.017, 2749247, 19573813.
10. Sugano S, Stoeckle MY, Hanafusa H. Transformation by Rous sarcoma virus induces a novel gene with homology to a mitogenic platelet protein. Cell 1987, 49(3):321-328. 10.1016/0092-8674(87)90284-4, 3032449.
11. Simmons DL, Levy DB, Yannoni Y, Erikson RL. Identification of a phorbol ester-repressible v-src-inducible gene. Proc Natl Acad Sci USA 1989, 86(4):1178-1182. 10.1073/pnas.86.4.1178, 286649, 2537491.
12. Matrisian LM, Glaichenhaus N, Gesnel MC, Breathnach R. Epidermal growth factor and oncogenes induce transcription of the same cellular mRNA in rat fibroblasts. EMBO J 1985, 4(6):1435-1440. 554364, 3875482.
13. Gillet G, Guerin M, Trembleau A, Brun G. A Bcl-2-related gene is activated in avian cells transformed by the Rous sarcoma virus. EMBO J 1995, 14(7):1372-1381. 398222, 7729415.
14. Bedard PA, Alcorta D, Simmons DL, Luk KC, Erikson RL. Constitutive expression of a gene encoding a polypeptide homologous to biologically active human platelet protein in Rous sarcoma virus-transformed fibroblasts. Proc Natl Acad Sci USA 1987, 84(19):6715-6719. 10.1073/pnas.84.19.6715, 299154, 2821543.
15. Wasylyk C, Maira SM, Sobieszczuk P, Wasylyk B. Reversion of Ras transformed cells by Ets transdominant mutants. Oncogene 1994, 9(12):3665-3673.
16. Turkson J, Bowman T, Garcia R, Caldenhoven E, De Groot RP, Jove R. Stat3 activation by Src induces specific gene regulation and is required for cell transformation. Mol Cell Biol 1998, 18(5):2545-2552. 110634, 9566874.
17. Suzuki T, Murakami M, Onai N, Fukuda E, Hashimoto Y, Sonobe MH, Kameda T, Ichinose M, Miki K, Iba H. Analysis of AP-1 function in cellular transformation pathways. J Virol 1994, 68(6):3527-3535. 236856, 8189491.
18. Lloyd A, Yancheva N, Wasylyk B. Transformation suppressor activity of a Jun transcription factor lacking its activation domain. Nature 1991, 352(6336):635-638. 10.1038/352635a0, 1907719.
19. Johnson R, Spiegelman B, Hanahan D, Wisdom R. Cellular transformation and malignancy induced by ras require c-jun. Mol Cell Biol 1996, 16(8):4504-4511. 231449, 8754851.
20. Granger-Schnarr M, Benusiglio E, Schnarr M, Sassone-Corsi P. Transformation and transactivation suppressor activity of the c-Jun leucine zipper fused to a bacterial repressor. Proc Natl Acad Sci USA 1992, 89(10):4236-4239. 10.1073/pnas.89.10.4236, 49056, 1584758.
21. Bruder JT, Heidecker G, Rapp UR. Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase. Genes Dev 1992, 6(4):545-556. 10.1101/gad.6.4.545, 1313769.
22. Bromberg JF, Horvath CM, Besser D, Lathem WW, Darnell JE. Stat3 activation is required for cellular transformation by v-src. Mol Cell Biol 1998, 18(5):2553-2558. 110635, 9566875.
23. Masker K, Golden A, Gaffney CJ, Mazack V, Schwindinger WF, Zhang W, Wang LH, Carey DJ, Sudol M. Transcriptional profile of Rous Sarcoma Virus transformed chicken embryo fibroblasts reveals new signaling targets of viral-src. Virology 2007, 364(1):10-20. 10.1016/j.virol.2007.03.026, 1974879, 17448514.
24. Malek RL, Irby RB, Guo QM, Lee K, Wong S, He M, Tsai J, Frank B, Liu ET, Quackenbush J, et al. Identification of Src transformation fingerprint in human colon cancer. Oncogene 2002, 21(47):7256-7265. 10.1038/sj.onc.1205900, 12370817.
25. Paz K, Socci ND, van Nimwegen E, Viale A, Darnell JE. Transformation fingerprint: induced STAT3-C, v-Src and Ha-Ras cause small initial changes but similar established profiles in mRNA. Oncogene 2004, 23(52):8455-8463. 10.1038/sj.onc.1207803, 15378015.
26. Liu Y, Gao L, Gelman IH. SSeCKS/Gravin/AKAP12 attenuates expression of proliferative and angiogenic genes during suppression of v-Src-induced oncogenesis. BMC Cancer 2006, 6:105. 10.1186/1471-2407-6-105, 1463002, 16638134.
27. Crisanti P, Pessac B, Calothy G. Avian neuroretina cells in oncogene studies. Methods Enzymol 1995, 254:77-97. full_text, 8531721.
28. Garber EA, Mayer BJ, Jove R, Hanafusa H. Analysis of p60v-src mutants carrying lesions involved in temperature sensitivity. J Virol 1987, 61(2):354-360. 253956, 3027366.
29. Cross FR, Garber EA, Pellman D, Hanafusa H. A short sequence for the p60src n terminus is required for p60src myristylation and membrane association and for cell transformation. Mol Cell Biol 1984, 4:1834-1842. 368993, 6092942.
30. Gagliardi M, Maynard S, Bojovic B, Bedard PA. The constitutive activation of the CEF-4/9E3 chemokine gene depends on C/EBPbeta in v-src transformed chicken embryo fibroblasts. Oncogene 2001, 20(18):2301-2313. 10.1038/sj.onc.1204354, 11402325.
31. Abramoff MD, Magelhaes PJ, Ram SJ. Image Processing with ImageJ. Biophotonics International 2004, 11(7):36-42.
32. Li CW. DNA-Chip Analyzer (dChip). The analysis of gene expression data:methods and software 2003, New York: Spinger, Parmigiani EG, Irizarry R, Zeger SL.
33. Li C, Hung Wong W. Model-based analysis of oligonucleotide arrays: model validation, design issues and standard error application. Genome Biol 2001, 2(8):RESEARCH0032. 55329, 11532216.
34. Li C, Wong WH. Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. Proc Natl Acad Sci USA 2001, 98(1):31-36. 10.1073/pnas.011404098, 14539, 11134512.
35. Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 2001, 98(9):5116-5121. 10.1073/pnas.091062498, 33173, 11309499.
36. Eisen MB, Spellman PT, Brown PO, Botstein D. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA 1998, 95(25):14863-14868. 10.1073/pnas.95.25.14863, 24541, 9843981.
37. Kestler HA, Muller A, Gress TM, Buchholz M. Generalized Venn diagrams: a new method of visualizing complex genetic set relations. Bioinformatics 2005, 21(8):1592-1595. 10.1093/bioinformatics/bti169, 15572472.
38. Dennis G, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC, Lempicki RA. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol 2003, 4(5):P3. 10.1186/gb-2003-4-5-p3, 12734009.
39. Hosack DA, Dennis G, Sherman BT, Lane HC, Lempicki RA. Identifying biological themes within lists of genes with EASE. Genome Biol 2003, 4(10):R70. 10.1186/gb-2003-4-10-r70, 328459, 14519205.
40. Draghici S, Khatri P, Tarca AL, Amin K, Done A, Voichita C, Georgescu C, Romero R. A systems biology approach for pathway level analysis. Genome Res 2007, 17(10):1537-1545. 10.1101/gr.6202607, 1987343, 17785539.
41. Pawitan Y, Bjohle J, Amler L, Borg AL, Egyhazi S, Hall P, Han X, Holmberg L, Huang F, Klaar S, et al. Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts. Breast Cancer Res 2005, 7(6):R953-964. 10.1186/bcr1325, 1410752, 16280042.
42. Ivshina AV, George J, Senko O, Mow B, Putti TC, Smeds J, Lindahl T, Pawitan Y, Hall P, Nordgren H, et al. Genetic reclassification of histologic grade delineates new clinical subtypes of breast cancer. Cancer Res 2006, 66(21):10292-10301. 10.1158/0008-5472.CAN-05-4414, 17079448.
43. Minn AJ, Gupta GP, Siegel PM, Bos PD, Shu W, Giri DD, Viale A, Olshen AB, Gerald WL, Massague J. Genes that mediate breast cancer metastasis to lung. Nature 2005, 436(7050):518-524. 10.1038/nature03799, 1283098, 16049480.
44. Bild AH, Yao G, Chang JT, Wang Q, Potti A, Chasse D, Joshi MB, Harpole D, Lancaster JM, Berchuck A, et al. Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Nature 2006, 439(7074):353-357. 10.1038/nature04296, 16273092.
45. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. Journal of the American Statistical Association 1958, 53(282):457-481.
46. Papaconstantinou M, Wu Y, Pretorius HN, Singh N, Gianfelice G, Tanguay RM, Campos AR, Bedard PA. Menin is a regulator of the stress response in Drosophila melanogaster. Mol Cell Biol 2005, 25(22):9960-9972. 10.1128/MCB.25.22.9960-9972.2005, 1280255, 16260610.
47. Petropoulos CJ, Hughes SH. Replication-competent retrovirus vectors for the transfer and expression of gene cassettes in avian cells. J Virol 1991, 65(7):3728-3737. 241397, 2041092.
48. Boettiger D, Roby K, Brumbaugh J, Biehl J, Holtzer H. Transformation of chicken embryo retinal melanoblasts by a temperature-sensitive mutant of Rous sarcoma virus. Cell 1977, 11(4):881-890. 10.1016/0092-8674(77)90299-9, 196765.
49. Tato F, Alema S, Dlugosz A, Boettiger D, Holtzer H, Cossu G, Pacifici M. Development of 'revertant' myotubes in cultures of Rous sarcoma virus transformed avian myogenic cells. Differentiation 1983, 24(2):131-139. 10.1111/j.1432-0436.1983.tb01312.x, 6309590.
50. Pacifici M, Boettiger D, Roby K, Holtzer H. Transformation of chondroblasts by Rous sarcoma virus and synthesis of the sulfated proteoglycan matrix. Cell 1977, 11(4):891-899. 10.1016/0092-8674(77)90300-2, 196766.
51. Menko AS, Boettiger D. Inhibition of chicken embryo lens differentiation and lens junction formation in culture by pp60v-src. Mol Cell Biol 1988, 8(4):1414-1420. 363298, 2837640.
52. Crisanti-Combes P, Lorinet AM, Girard A, Pessac B, Wasseff M, Calothy G. Effects of Rous sarcoma virus on the differentiation of chick and quail neuroretina cells in culture. Adv Exp Med Biol 1982, 158:115-122.
53. Yoshimura M, Iwasaki Y, Kaji A. In vitro differentiation of chicken embryo skin cells transformed by Rous sarcoma virus. J Cell Physiol 1981, 109(3):373-385. 10.1002/jcp.1041090302, 6172432.
54. Kruger A, Anderson SM. The v-src oncogene blocks the differentiation of a murine myeloid progenitor cell line and induces a tumorigenic phenotype. Oncogene 1991, 6(2):245-256.
55. Gillet G, Michel D, Crisanti P, Guerin M, Herault Y, Pessac B, Calothy G, Brun G, Volovitch M. Serum factors and v-src control two complementary mitogenic pathways in quail neuroretinal cells in culture. Oncogene 1993, 8(3):565-574.
56. Ladeda V, Frankel P, Feig LA, Foster DA, Bal de Kier Joffe E, Aguirre-Ghiso JA. RalA mediates v-Src, v-Ras, and v-Raf regulation of CD44 and fibronectin expression in NIH3T3 fibroblasts. Biochem Biophys Res Commun 2001, 283(4):854-861. 10.1006/bbrc.2001.4845, 11350063.
57. Jamal HH, Cano-Gauci DF, Buick RN, Filmus J. Activated ras and src induce CD44 overexpression in rat intestinal epithelial cells. Oncogene 1994, 9(2):417-423.
58. Scholz G, Martinerie C, Perbal B, Hanafusa H. Transcriptional down regulation of the nov proto-oncogene in fibroblasts transformed by p60v-src. Mol Cell Biol 1996, 16(2):481-486. 231025, 8552074.
59. Gonneville L, Martins TJ, Bedard PA. Complex expression pattern of the CEF-4 cytokine in transformed and mitogenically stimulated cells. Oncogene 1991, 6(10):1825-1833.
60. Calothy G, Poirier F, Dambrine G, Mignatti P, Combes P, Pessac B. Expression of viral oncogenes in differentiating chick embryo neuroretinal cells infected with avian tumor viruses. Cold Spring Harb Symp Quant Biol 1980, 44(Pt 2):983-990.
61. Yang J, Mani SA, Donaher JL, Ramaswamy S, Itzykson RA, Come C, Savagner P, Gitelman I, Richardson A, Weinberg RA. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 2004, 117(7):927-939. 10.1016/j.cell.2004.06.006, 15210113.
62. Yu K, Lee CH, Tan PH, Hong GS, Wee SB, Wong CY, Tan P. A molecular signature of the Nottingham prognostic index in breast cancer. Cancer Res 2004, 64(9):2962-2968. 10.1158/0008-5472.CAN-03-2430, 15126326.
63. Sotiriou C, Wirapati P, Loi S, Harris A, Fox S, Smeds J, Nordgren H, Farmer P, Praz V, Haibe-Kains B, et al. Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis. J Natl Cancer Inst 2006, 98(4):262-272.
64. Haibe-Kains B, Desmedt C, Piette F, Buyse M, Cardoso F, Van't Veer L, Piccart M, Bontempi G, Sotiriou C. Comparison of prognostic gene expression signatures for breast cancer. BMC Genomics 2008, 9:394. 10.1186/1471-2164-9-394, 2533026, 18717985.
65. Wang Y, Klijn JG, Zhang Y, Sieuwerts AM, Look MP, Yang F, Talantov D, Timmermans M, Meijer-van Gelder ME, Yu J, et al. Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer. Lancet 2005, 365(9460):671-679.
66. van't Veer LJ, Dai H, Vijver MJ, He YD, Hart AA, Mao M, Peterse HL, Kooy K, Marton MJ, Witteveen AT, et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature 2002, 415(6871):530-536. 10.1038/415530a, 11823860.
67. Yu JX, Sieuwerts AM, Zhang Y, Martens JW, Smid M, Klijn JG, Wang Y, Foekens JA. Pathway analysis of gene signatures predicting metastasis of node-negative primary breast cancer. BMC Cancer 2007, 7:182. 10.1186/1471-2407-7-182, 2077336, 17894856.
68. Vafa O, Wade M, Kern S, Beeche M, Pandita TK, Hampton GM, Wahl GM. c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability. Mol Cell 2002, 9(5):1031-1044. 10.1016/S1097-2765(02)00520-8, 12049739.
69. Lee AC, Fenster BE, Ito H, Takeda K, Bae NS, Hirai T, Yu ZX, Ferrans VJ, Howard BH, Finkel T. Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species. J Biol Chem 1999, 274(12):7936-7940. 10.1074/jbc.274.12.7936, 10075689.
70. Bartkova J, Rezaei N, Liontos M, Karakaidos P, Kletsas D, Issaeva N, Vassiliou LV, Kolettas E, Niforou K, Zoumpourlis VC, et al. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 2006, 444(7119):633-637. 10.1038/nature05268, 17136093.
71. Di Micco R, Fumagalli M, Cicalese A, Piccinin S, Gasparini P, Luise C, Schurra C, Garre M, Nuciforo PG, Bensimon A, et al. Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature 2006, 444(7119):638-642. 10.1038/nature05327, 17136094.
72. Mallette FA, Gaumont-Leclerc MF, Ferbeyre G. The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence. Genes Dev 2007, 21(1):43-48. 10.1101/gad.1487307, 1759898, 17210786.
73. Deichman GI, Kashkina LM, Mizenina OA, Gorojanskaya EG, Nikiforov MA, Gudkov AV, Dyakova NA, Komelkov AV, Prilutskaya MO, Kushlinsky NE, et al. Mechanisms of unusually high antioxidant activity of RSV-SR-transformed cells and of its suppression by activated p21ras. Int J Cancer 1996, 66(6):747-752. 10.1002/(SICI)1097-0215(19960611)66:6<747::AID-IJC7>3.0.CO;2-#, 8647644.
74. Kocanova S, Buytaert E, Matroule JY, Piette J, Golab J, de Witte P, Agostinis P. Induction of heme-oxygenase 1 requires the p38 MAPK and PI3K pathways and suppresses apoptotic cell death following hypericin-mediated photodynamic therapy. Apoptosis 2007, 12(4):731-741. 10.1007/s10495-006-0016-x, 17219054.
75. Zuckerbraun BS, Billiar TR. Heme oxygenase-1: a cellular Hercules. Hepatology 2003, 37(4):742-744. 10.1053/jhep.2003.50139, 12668964.
76. Choi JW, Yoo BK, Shin CY, Ryu MK, Ryu JH, el Kouni MH, Lee JC, Kim WK, Ko KH. Uridine prevents the glucose deprivation-induced death of immunostimulated astrocytes via the action of uridine phosphorylase. Neurosci Res 2006, 56(1):111-118. 10.1016/j.neures.2006.06.004, 16839635.
77. Choi JW, Shin CY, Choi MS, Yoon SY, Ryu JH, Lee JC, Kim WK, El Kouni MH, Ko KH. Uridine protects cortical neurons from glucose deprivation-induced death: possible role of uridine phosphorylase. J Neurotrauma 2008, 25(6):695-707. 10.1089/neu.2007.0409, 18457515.
78. Sohara Y, Ishiguro N, Machida K, Kurata H, Thant AA, Senga T, Matsuda S, Kimata K, Iwata H, Hamaguchi M. Hyaluronan activates cell motility of v-Src-transformed cells via Ras-mitogen-activated protein kinase and phosphoinositide 3-kinase-Akt in a tumor-specific manner. Mol Biol Cell 2001, 12(6):1859-1868. 37347, 11408591.
79. Platek A, Mettlen M, Camby I, Kiss R, Amyere M, Courtoy PJ. v-Src accelerates spontaneous motility via phosphoinositide 3-kinase, phospholipase C and phospholipase D, but abrogates chemotaxis in Rat-1 and MDCK cells. J Cell Sci 2004, 117(Pt 20):4849-4861. 10.1242/jcs.01359, 15340010.
80. Gimona M, Buccione R, Courtneidge SA, Linder S. Assembly and biological role of podosomes and invadopodia. Curr Opin Cell Biol 2008, 20(2):235-241. 10.1016/j.ceb.2008.01.005, 18337078.
81. Tehrani S, Faccio R, Chandrasekar I, Ross FP, Cooper JA. Cortactin has an essential and specific role in osteoclast actin assembly. Mol Biol Cell 2006, 17(7):2882-2895. 10.1091/mbc.E06-03-0187, 1483026, 16611741.
82. Kempiak SJ, Yamaguchi H, Sarmiento C, Sidani M, Ghosh M, Eddy RJ, Desmarais V, Way M, Condeelis J, Segall JE. A neural Wiskott-Aldrich Syndrome protein-mediated pathway for localized activation of actin polymerization that is regulated by cortactin. J Biol Chem 2005, 280(7):5836-5842. 10.1074/jbc.M410713200, 15579908.
83. Yamaguchi H, Lorenz M, Kempiak S, Sarmiento C, Coniglio S, Symons M, Segall J, Eddy R, Miki H, Takenawa T, et al. Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin. J Cell Biol 2005, 168(3):441-452. 10.1083/jcb.200407076, 2171731, 15684033.
84. Webb BA, Eves R, Mak AS. Cortactin regulates podosome formation: roles of the protein interaction domains. Exp Cell Res 2006, 312(6):760-769. 10.1016/j.yexcr.2005.11.032, 16434035.
85. Laurila E, Savinainen K, Kuuselo R, Karhu R, Kallioniemi A. Characterization of the 7q21-q22 amplicon identifies ARPC1A, a subunit of the Arp2/3 complex, as a regulator of cell migration and invasion in pancreatic cancer. Genes Chromosomes Cancer 2009, 48(4):330-339. 10.1002/gcc.20643, 19145645.
86. Assinder SJ, Stanton JA, Prasad PD. Transgelin: an actin-binding protein and tumour suppressor. Int J Biochem Cell Biol 2009, 41(3):482-486. 10.1016/j.biocel.2008.02.011, 18378184.
87. Nair RR, Solway J, Boyd DD. Expression cloning identifies transgelin (SM22) as a novel repressor of 92-kDa type IV collagenase (MMP-9) expression. J Biol Chem 2006, 281(36):26424-26436. 10.1074/jbc.M602703200, 16835221.
88. Morita T, Mayanagi T, Sobue K. Reorganization of the actin cytoskeleton via transcriptional regulation of cytoskeletal/focal adhesion genes by myocardin-related transcription factors (MRTFs/MAL/MKLs). Exp Cell Res 2007, 313(16):3432-3445. 10.1016/j.yexcr.2007.07.008, 17714703.
89. Yoshio T, Morita T, Kimura Y, Tsujii M, Hayashi N, Sobue K. Caldesmon suppresses cancer cell invasion by regulating podosome/invadopodium formation. FEBS Lett 2007, 581(20):3777-3782. 10.1016/j.febslet.2007.06.073, 17631293.
90. Eves R, Webb BA, Zhou S, Mak AS. Caldesmon is an integral component of podosomes in smooth muscle cells. J Cell Sci 2006, 119(Pt 9):1691-1702. 10.1242/jcs.02881, 16595550.
91. Vanhaesebroeck B, Jones GE, Allen WE, Zicha D, Hooshmand-Rad R, Sawyer C, Wells C, Waterfield MD, Ridley AJ. Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages. Nat Cell Biol 1999, 1(1):69-71. 10.1038/9045, 10559867.
92. Sawyer C, Sturge J, Bennett DC, O'Hare MJ, Allen WE, Bain J, Jones GE, Vanhaesebroeck B. Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-kinase p110delta. Cancer Res 2003, 63(7):1667-1675.
93. Duxbury MS, Ito H, Zinner MJ, Ashley SW, Whang EE. siRNA directed against c-Src enhances pancreatic adenocarcinoma cell gemcitabine chemosensitivity. J Am Coll Surg 2004, 198(6):953-959. 10.1016/j.jamcollsurg.2004.01.037, 15194078.
94. Griffiths GJ, Koh MY, Brunton VG, Cawthorne C, Reeves NA, Greaves M, Tilby MJ, Pearson DG, Ottley CJ, Workman P, et al. Expression of kinase-defective mutants of c-Src in human metastatic colon cancer cells decreases Bcl-xL and increases oxaliplatin- and Fas-induced apoptosis. J Biol Chem 2004, 279(44):46113-46121. 10.1074/jbc.M408550200, 15326164.
95. Chen T, Pengetnze Y, Taylor CC. Src inhibition enhances paclitaxel cytotoxicity in ovarian cancer cells by caspase-9-independent activation of caspase-3. Mol Cancer Ther 2005, 4(2):217-224.
96. Hiscox S, Morgan L, Green TP, Barrow D, Gee J, Nicholson RI. Elevated Src activity promotes cellular invasion and motility in tamoxifen resistant breast cancer cells. Breast Cancer Res Treat 2006, 97(3):263-274. 10.1007/s10549-005-9120-9, 16333527.
97. Masumoto N, Nakano S, Fujishima H, Kohno K, Niho Y. v-src induces cisplatin resistance by increasing the repair of cisplatin-DNA interstrand cross-links in human gallbladder adenocarcinoma cells. Int J Cancer 1999, 80(5):731-737. 10.1002/(SICI)1097-0215(19990301)80:5<731::AID-IJC17>3.0.CO;2-H, 10048975.
98. Pham CG, Bubici C, Zazzeroni F, Knabb JR, Papa S, Kuntzen C, Franzoso G. Upregulation of Twist-1 by NF-kappaB blocks cytotoxicity induced by chemotherapeutic drugs. Mol Cell Biol 2007, 27(11):3920-3935. 10.1128/MCB.01219-06, 1900008, 17403902.
99. Cheng GZ, Chan J, Wang Q, Zhang W, Sun CD, Wang LH. Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel. Cancer Res 2007, 67(5):1979-1987. 10.1158/0008-5472.CAN-06-1479, 17332325.
100. Talamonti MS, Roh MS, Curley SA, Gallick GE. Increase in activity and level of pp60c-src in progressive stages of human colorectal cancer. J Clin Invest 1993, 91(1):53-60. 10.1172/JCI116200, 329994, 7678609.
101. Termuhlen PM, Curley SA, Talamonti MS, Saboorian MH, Gallick GE. Site-specific differences in pp60c-src activity in human colorectal metastases. J Surg Res 1993, 54(4):293-298. 10.1006/jsre.1993.1046, 7687314.
102. Kanehisa M, Goto S. KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res 2000, 28(1):27-30. 10.1093/nar/28.1.27, 102409, 10592173.
103. Morey JS, Ryan JC, Van Dolah FM. Microarray validation: factors influencing correlation between oligonucleotide microarrays and real-time PCR. Biol Proced Online 2006, 8:175-193. 10.1251/bpo126, 1779618, 17242735.
104. Ding Y, Xu L, Jovanovic BD, Helenowski IB, Kelly DL, Catalona WJ, Yang XJ, Pins M, Bergan RC. The methodology used to measure differential gene expression affects the outcome. J Biomol Tech 2007, 18(5):321-330. 2392989, 18166675.