Mechanisms of unusually high antioxidant activity of RSV-SR-transformed cells and of its suppression by activated p21ras

International Journal of Cancer

Volumn 66, Issue 6, 1996, Pages 747-752

  Deichman, Galina I ^a,d   Kashkina, Lydia M ^a   Mizenina, Olga A ^a   Gorojanskaya, Erna G ^b   Nikiforov, Mikhail A ^c   Gudkov, Andrei V ^c   Dyakova, Natalia A ^a   Komelkov, Andrei V ^a   Prilutskaya, Marina O ^a   Kushlinsky, Nicolai E ^b   Tatosyan, Alexander G ^a  

^a Institute of Carcinogenesis   (Russian Federation)

^b N N BLOKHIN RUSSIAN CANCER RESEARCH CENTER   (Russian Federation)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^d INSTITUTE OF BIOMEDICAL CHEMISTRY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; CATALASE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HYDROGEN PEROXIDE; PROTEIN KINASE P60; PROTEIN P21; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL TRANSFORMATION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; GENE ACTIVATION; GENETIC TRANSFECTION; LIPID PEROXIDATION; NONHUMAN; ONCOGENE H RAS; ONCOGENE RAS; ONCOGENE SRC; PRIORITY JOURNAL; ROUS SARCOMA ONCOVIRUS; SIMIAN VIRUS 40; SYRIAN HAMSTER;

ANIMALS; ANTIOXIDANTS; AVIAN SARCOMA VIRUSES; CATALASE; CATTLE; CELL LINE, TRANSFORMED; CELL TRANSFORMATION, VIRAL; CRICETINAE; FIBROBLASTS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE EXPRESSION REGULATION, VIRAL; GENES, RAS; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HYDROGEN PEROXIDE; MASTADENOVIRUS; MESOCRICETUS; NEOPLASM PROTEINS; ONCOGENE PROTEIN PP60(V-SRC); OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS P21(RAS); SIMIAN VIRUS 40; SUPEROXIDE DISMUTASE; TRANSFECTION;

EID: 0029888107     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1097-0215(19960611)66:6<747::aid-ijc7>3.0.co;2-%23     Document Type: Article

References (23)

1. ADAMS, D.O. and NATHAN, C.F., Molecular mechanisms in tumor cell killing by activated macrophages. Immunol. Today. 4, 166-169 (1983).
2. AEBI, H., Catalase. In. H.U. Bergmever (ed.). Methods of enzymatic analysis, Vol. 2, pp. 673-684 (1984).
3. BEAUCUAMP, C. and FRIDOVICH, J., Superoxide dismutase: improved assays and assay applicable to acrylamide. Anal. Biochem.. 44, 276-287 (1971).
4. CERRUTI, P.A. and TRUMP, B.F., Inflammation and oxidative stress in carcinogenesis. Cancer Cells. 3, 1-7 (1991).
5. DEICHMAN, G.I. and KASHLEVA, E.A.. Susceptibility to hydrogene peroxide and the in vivo survival of Syrian hamster cells transformed by RSV-SR. DAN, 292, 473-476 (1987). (In Russian).
6. DEICHMAN, G.I., KASHLEVA, H.A., KLUSHAREVA, T.E. and MATVEEVA, V.A., Clustering of discrete cell properties essential for tumorigenicity and metastasis. II. Studies of Syrian hamster embryo fibroblasts transformed by Rous Sarcoma Virus. Int. J. Cancer, 44, 908-910 (1989a).
7. DEICHMAN, G.I., KLUCHAREVA, T.E., MATVEEVA, V.A., KUSHLINSKY, N.E., BASSALYK, L.S. and VENDROV. E.L., Clustering of discrete cell properties essential for tumorigenicity and metastasis. I. Studies of Syrian hamster embryo fibroblasts spontaneously transformed in vitro. Int. J. Cancer, 44, 904-907 (1989b).
8. DEICHMAN, G.I., TOPOL, L.Z., KLUCHAREVA, T.E., MATVEEVA, V.A., ZAKAMALDIN A. T.A., UVAROVA, E.N. and TATOSYAN, A.G., Clustering of discrete cell properties essential for tumorigenicity and metastasis. III. Dissociation of the properties in N-ras-transfected RSV-SR-transformed cells. Int. J. Cancer. 51, 903-908 (1992).
9. DEICHMAN, G.I. and VENDROV, E.L., Characteristics of in vitro transformed cells essential for their in vivo survival, selection and metastasizing activity. Int. J. Cancer, 37, 401-409 (1986).
10. src protein. Mol. cell Biol., 11, 1972-1979 (1991).
11. HALLIWELL, B., Antioxidant characterization - methodology and mechanism. Biochem. Pharmacol, 49, 1341-1348 (1995).
12. ITO, N. and HIROSE, M., The role of antioxidants in chemical carcinogenesis. Jap. J. Cancer Res., 78, 1011-1026 (1987).
13. KLAPPER, A., MCKAY, B. and RESH, M.D., Rapid high-resolution Western blotting: from gel to image in a single day. Biotechniques, 12, 651-654 (1992).
14. KLUCHAREVA, T.E., MATVEEVA, V.A. and KUSHLINSKY, N.E., In vitro bioassay for type E prostaglandins based on their NK immunodepressing activity, Immunol. Lett., 33, 239-246 (1992).
15. KUMAR, G.S. and DAS, U.N., Free radical-dependent suppression of growth of mouse myeloma cells by α-linolenic acid. Cancer Lett., 92, 27-38 (1995).
16. KUNDU, N., ZHANG, S. and FULTON, A.M., Sublethal oxidative stress inhibits tumor cell adhesion and enhances experimental metastasis of murine mammary carcinoma. Clin. exp. Metast., 13, 16-22 (1995).
17. MARKLUND, S.L., WESTMANN, N.G., LUNDGREN, E. and ROOS, G., Copper and zinc-containing Superoxide dismutase and glutathione peroxidase in normal and neoplastic human cell lines and normal human tissues. Cancer Res., 42, 1955-1961 (1982).
18. NATHAN, C.F., SILVERSTEIN, S.C., BRUKNER, L.H. and COHN, Z.A., Extracellular cytolysis by activated macrophages and granulocytes. II Hydrogen peroxide as a mediator of cytotoxicity. J. exp. Med., 149, 100-113 (1979).
19. O'DONNELL-TORMEY, J., DE BOER, C.J. and NATHAN, C.F., Resistance of human tumor cells in vitro to oxidative cytolysis. J. clin. Invest., 76. 80-86 (1985).
20. ras with phosphatidylinositol 3-kinase. Proc. nat. Acad. Sci. (Wash.), 88, 7908-7912 (1991).
21. TIETZE, F., Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione. Anal. Biochem., 27, 502-522 (1969).
22. c-src expression in Rous Sarcoma Virus-transformed hamster fibroblasts transfected with activated N-ras. Mol. Carcinogen., 8, 167-176 (1993).
23. VUILLAUME, M., Reduced oxigen species, mutation, induction and cancer initiation. Mut. Res., 186, 43-72 (1987).