메뉴 건너뛰기




Volumn 3, Issue 4, 2009, Pages 520-528

Pro-apoptotic protein Bax and anti-apoptotic protein Bcl-2 expression in streptozotocin model of Alzheimer's disease

Author keywords

Anti Bax and anti Bcl2 polyclonal antibodies; Experimental model of sporadic alzheimer's disease; Immunohistochemistry; Rat; STZ

Indexed keywords


EID: 77949472400     PISSN: 18402291     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (2)

References (47)
  • 1
    • 1842734659 scopus 로고    scopus 로고
    • The source of cerebral insulin
    • Banks W.A.(2004) The source of cerebral insulin. Eur.J.Pharmacol. 490, 5-12.
    • (2004) Eur.J.Pharmacol , vol.490 , pp. 5-12
    • Banks, W.A.1
  • 2
    • 0025755283 scopus 로고
    • Insulin in the cerebrospinal fluid
    • Plata-Salaman C.R. (1991)Insulin in the cerebrospinal fluid. Neurosci.Biobehav.Rev. 15, 243-258
    • (1991) Neurosci.Biobehav.Rev , vol.15 , pp. 243-258
    • Plata-Salaman, C.R.1
  • 3
    • 0035967193 scopus 로고    scopus 로고
    • Schechter R.and Abboud M.(2001) Neuronal synthesized insulin roles on neural differentiation within fetal rat neuron cell cultures. Brain Res.Dev. BrainRes. 127, 41-49.
    • Schechter R.and Abboud M.(2001) Neuronal synthesized insulin roles on neural differentiation within fetal rat neuron cell cultures. Brain Res.Dev. BrainRes. 127, 41-49.
  • 5
    • 0025856239 scopus 로고    scopus 로고
    • Hoyer S., Nitsch R.and Oesterreich K. (1991) Predominant abnormality in cerebral glucose utilization in late-onset dementia of the Alzheimer type: a cross sectional comparison against advanced late-onset and incipient early-onset cases. J.NeuralTransm.Park.Dis.Dement.Sect. 3, 1-14.
    • Hoyer S., Nitsch R.and Oesterreich K. (1991) Predominant abnormality in cerebral glucose utilization in late-onset dementia of the Alzheimer type: a cross sectional comparison against advanced late-onset and incipient early-onset cases. J.NeuralTransm.Park.Dis.Dement.Sect. 3, 1-14.
  • 6
    • 1842785179 scopus 로고    scopus 로고
    • Glucose metabolism and insulin receptor signal transduction in Alzheimer disease
    • Hoyer S. (2004) Glucose metabolism and insulin receptor signal transduction in Alzheimer disease. Eur.J.Pharmacol. 490, 115-17.
    • (2004) Eur.J.Pharmacol , vol.490 , pp. 115-117
    • Hoyer, S.1
  • 7
    • 1842633872 scopus 로고    scopus 로고
    • Insulin and the insulin receptorin experimental models of learning and memory
    • Zhao W.Q., Chen H.,Quon M.J. and Alkon D.L.(2004) Insulin and the insulin receptorin experimental models of learning and memory. Eur.J.Pharmacol. 490, 71-81.
    • (2004) Eur.J.Pharmacol , vol.490 , pp. 71-81
    • Zhao, W.Q.1    Chen, H.2    Quon, M.J.3    Alkon, D.L.4
  • 8
    • 0034012731 scopus 로고    scopus 로고
    • Intracerebroventricular insulin enhances memory in a passive-avoidance task
    • Park C.R., Seeley R.J., Craft S.and Woods S.C.(2000) Intracerebroventricular insulin enhances memory in a passive-avoidance task. Physiol. Behav. 68, 509-514.
    • (2000) Physiol. Behav , vol.68 , pp. 509-514
    • Park, C.R.1    Seeley, R.J.2    Craft, S.3    Woods, S.C.4
  • 9
    • 15444339756 scopus 로고    scopus 로고
    • F rolichL., Blum-Degen D., Bernstein H.G. et al. (1998) Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease. J.Neural Transm. 105, 423-438.
    • F rolichL., Blum-Degen D., Bernstein H.G. et al. (1998) Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease. J.Neural Transm. 105, 423-438.
  • 10
    • 77949460781 scopus 로고    scopus 로고
    • Hoyer S.and Frolich L.(2006) Brain function and insulin signal transduction in sporadic Alzheimer's disease, in Research Progress in Alzheimer's Disease and Dementia (Sun M. K.,ed.), Chapter11. Nova Science, NewYork.
    • Hoyer S.and Frolich L.(2006) Brain function and insulin signal transduction in sporadic Alzheimer's disease, in Research Progress in Alzheimer's Disease and Dementia (Sun M. K.,ed.), Chapter11. Nova Science, NewYork.
  • 11
    • 5344256250 scopus 로고    scopus 로고
    • Hyperinsulinemia and risk of Alzheimer disease
    • Luchsinger JA, Tang MX, Shea S, Mayeux R. (2004) Hyperinsulinemia and risk of Alzheimer disease. Neurology.63(7):1187-92.
    • (2004) Neurology , vol.63 , Issue.7 , pp. 1187-1192
    • Luchsinger, J.A.1    Tang, M.X.2    Shea, S.3    Mayeux, R.4
  • 13
    • 33847061307 scopus 로고    scopus 로고
    • The effect of borderline diabetes on the risk of dementia and Alzheimer's disease
    • Xu W, Qiu C, Winblad B, Fratiglioni L. (2007) The effect of borderline diabetes on the risk of dementia and Alzheimer's disease. Diabetes. 56(1):211-6.
    • (2007) Diabetes , vol.56 , Issue.1 , pp. 211-216
    • Xu, W.1    Qiu, C.2    Winblad, B.3    Fratiglioni, L.4
  • 14
    • 34247324303 scopus 로고    scopus 로고
    • Grunblatt E, Salkovic-Petrisic M, Osmanovic J, Riederer P, Hoyer S. Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein (2007) J Neurochem. 101, 757-770
    • Grunblatt E, Salkovic-Petrisic M, Osmanovic J, Riederer P, Hoyer S. Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein (2007) J Neurochem. 101, 757-770
  • 15
    • 14044273642 scopus 로고    scopus 로고
    • Biomarkers for apoptosis in Alzheimer's disease
    • Ankarcrona M, Winblad B. (2005) Biomarkers for apoptosis in Alzheimer's disease. Int J Geriatr Psychiatry. 20(2):101-5.
    • (2005) Int J Geriatr Psychiatry , vol.20 , Issue.2 , pp. 101-105
    • Ankarcrona, M.1    Winblad, B.2
  • 17
    • 0034641918 scopus 로고    scopus 로고
    • The biochemistry of apoptosis
    • Hengartner MO.(2000) The biochemistry of apoptosis. Nature,407:770-6.
    • (2000) Nature , vol.407 , pp. 770-776
    • Hengartner, M.O.1
  • 18
    • 0030916669 scopus 로고    scopus 로고
    • Kroemer, G. (1997) The proto-oncogene Bcl-2 and its role in regulating apoptosis.Nat. Med. 3, 614- 620
    • Kroemer, G. (1997) The proto-oncogene Bcl-2 and its role in regulating apoptosis.Nat. Med. 3, 614- 620
  • 19
    • 0030979773 scopus 로고    scopus 로고
    • Double identity for proteins of the Bcl-2 family
    • Reed, J. C. (1997) Double identity for proteins of the Bcl-2 family. Nature 387, 773-776
    • (1997) Nature , vol.387 , pp. 773-776
    • Reed, J.C.1
  • 20
    • 0031728455 scopus 로고    scopus 로고
    • Hyperglycemia induces apoptosis in pre-implantation embryos through cell death effector pathways
    • Moley KH, Chi MM, Knudson CM, Korsmeyer SJ, Mueckler MM (1998) Hyperglycemia induces apoptosis in pre-implantation embryos through cell death effector pathways. Nat Med 4:1421-1424
    • (1998) Nat Med , vol.4 , pp. 1421-1424
    • Moley, K.H.1    Chi, M.M.2    Knudson, C.M.3    Korsmeyer, S.J.4    Mueckler, M.M.5
  • 21
    • 0035758153 scopus 로고    scopus 로고
    • Neuronal death in the rat hippocampus in experimental diabetes and cerebral ischaemia treated with antioxidants
    • Pietrowski PK, Wierzbicka K, Smiatek M (2001) Neuronal death in the rat hippocampus in experimental diabetes and cerebral ischaemia treated with antioxidants, Folia Neuropathol. 39:147- 154.
    • (2001) Folia Neuropathol , vol.39 , pp. 147-154
    • Pietrowski, P.K.1    Wierzbicka, K.2    Smiatek, M.3
  • 23
    • 0032529103 scopus 로고    scopus 로고
    • Neural apoptosis in the retina during experimental and human diabetes: Early onset and effect of insulin
    • Barber AJ, Lieth E, Khim SA, Antonetti DA, Buchanan AG, Gardner TW (1998) Neural apoptosis in the retina during experimental and human diabetes: early onset and effect of insulin. J Clin Invest 102:783-791
    • (1998) J Clin Invest , vol.102 , pp. 783-791
    • Barber, A.J.1    Lieth, E.2    Khim, S.A.3    Antonetti, D.A.4    Buchanan, A.G.5    Gardner, T.W.6
  • 24
    • 0031695496 scopus 로고    scopus 로고
    • Noninsulin-dependent diabetes mellitus as a mitochondrial genomic disease
    • Mathew CE, Berdanier CD (1998) Noninsulin-dependent diabetes mellitus as a mitochondrial genomic disease. Proc Soc Exper Biol Med 219:97-108
    • (1998) Proc Soc Exper Biol Med , vol.219 , pp. 97-108
    • Mathew, C.E.1    Berdanier, C.D.2
  • 25
    • 0031728455 scopus 로고    scopus 로고
    • Hyperglycemia induces apoptosis in pre-implantation embryos through cell death effector pathways
    • Moley KH, Chi MM, Knudson CM, Korsmeyer SJ, Mueckler MM (1998) Hyperglycemia induces apoptosis in pre-implantation embryos through cell death effector pathways. Nat Med 4:1421-1424
    • (1998) Nat Med , vol.4 , pp. 1421-1424
    • Moley, K.H.1    Chi, M.M.2    Knudson, C.M.3    Korsmeyer, S.J.4    Mueckler, M.M.5
  • 27
    • 0032509773 scopus 로고    scopus 로고
    • Kitamura, Y., Shimohama, S., Kamoshima, W., Ota, T., Matsuoka,Y., Nomura,Y., Smith, M.A., Whitehouse, P.J., Taniguchi, T. (1998). Alteration of proteins regulating apoptosis,Bcl-2,Bcl-x, Bax,Bak,Bad, ICH-1and CPP32 inAlzheimer's disease. BrainRes.780, 260-269
    • Kitamura, Y., Shimohama, S., Kamoshima, W., Ota, T., Matsuoka,Y., Nomura,Y., Smith, M.A., Whitehouse, P.J., Taniguchi, T. (1998). Alteration of proteins regulating apoptosis,Bcl-2,Bcl-x, Bax,Bak,Bad, ICH-1and CPP32 inAlzheimer's disease. BrainRes.780, 260-269
  • 28
    • 0031044644 scopus 로고    scopus 로고
    • MacGibbon,G.A., Lawlor,P.A., Sirimanne,S.E.,Wa lton,M.R.,Connor, B.,Young,D., Williams,C., Gluckman, P., Faull, R.L.M., Hughes,P., Dragunow,M., (1997) Bax expression in mammalian neurons undergoing apoptosis, and in Alzheimer's disease hippocampus. BrainRes.750. 223-234
    • MacGibbon,G.A., Lawlor,P.A., Sirimanne,S.E.,Wa lton,M.R.,Connor, B.,Young,D., Williams,C., Gluckman, P., Faull, R.L.M., Hughes,P., Dragunow,M., (1997) Bax expression in mammalian neurons undergoing apoptosis, and in Alzheimer's disease hippocampus. BrainRes.750. 223-234
  • 29
    • 0034805535 scopus 로고    scopus 로고
    • Alteration of caspases and apoptosis-related proteins in brains of Patients with Alzheimer's disease
    • Engidawork, E., Gulesserian, T., Yoo, B.C., Cairns, N., Lubec, G., (2001) Alteration of caspases and apoptosis-related proteins in brains of Patients with Alzheimer's disease. Biochem.Biophys. Res.Commun. 281,84-93.
    • (2001) Biochem.Biophys. Res.Commun , vol.281 , pp. 84-93
    • Engidawork, E.1    Gulesserian, T.2    Yoo, B.C.3    Cairns, N.4    Lubec, G.5
  • 30
    • 0030638139 scopus 로고    scopus 로고
    • Bax protein expression is increased in Alzheimer's brain: Correlations with DNA damage, Bcl-2 expression, and brain pathology
    • Su, J. H., Deng, G., Cotman, C. W. (1997) Bax protein expression is increased in Alzheimer's brain: correlations with DNA damage, Bcl-2 expression, and brain pathology. J. Neuropathol. Exp. Neurol. 56,
    • (1997) J. Neuropathol. Exp. Neurol , vol.56
    • Su, J.H.1    Deng, G.2    Cotman, C.W.3
  • 31
    • 0347479366 scopus 로고    scopus 로고
    • Accumulation of caspase cleaved amyloid precursor protein represents anearly neurodegenerative event in aging and in Alzheimer's disease
    • Zhao, M., Su, J., Head, E., Cotman, C. W. (2003) Accumulation of caspase cleaved amyloid precursor protein represents anearly neurodegenerative event in aging and in Alzheimer's disease. Neurobiol. Dis.14, 391-401.
    • (2003) Neurobiol. Dis , vol.14 , pp. 391-401
    • Zhao, M.1    Su, J.2    Head, E.3    Cotman, C.W.4
  • 32
    • 0037336851 scopus 로고    scopus 로고
    • Pompl, P. N., Yemul, S., Xiang, Z., Ho, L., Harutunian, V., Purohit, D., Mohs, R., Pasinetti, G. M., (2003) Caspase gene expression in the brain as a function of the clinical progression of Alzheimer disease.Arch.Neurol.60,360- 376.
    • Pompl, P. N., Yemul, S., Xiang, Z., Ho, L., Harutunian, V., Purohit, D., Mohs, R., Pasinetti, G. M., (2003) Caspase gene expression in the brain as a function of the clinical progression of Alzheimer disease.Arch.Neurol.60,360- 376.
  • 33
    • 0035664134 scopus 로고    scopus 로고
    • Rohn, T. T., Head, E., Nessen, W. H., Cotman, C. E., Cribbs, D. H. (2001) Activation of caspase-8 in the Alzheimer's disease brain.Neurobiol. Dis.8,1006-1016.
    • Rohn, T. T., Head, E., Nessen, W. H., Cotman, C. E., Cribbs, D. H. (2001) Activation of caspase-8 in the Alzheimer's disease brain.Neurobiol. Dis.8,1006-1016.
  • 34
    • 0036968953 scopus 로고    scopus 로고
    • Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain
    • Rohn, T. T., Rissman, R. A., Davis, M. C., Kim, Y. E., Cotman, C. W., Head, E. (2002) Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain. Neurobiol.Dis.11,341-354.
    • (2002) Neurobiol.Dis , vol.11 , pp. 341-354
    • Rohn, T.T.1    Rissman, R.A.2    Davis, M.C.3    Kim, Y.E.4    Cotman, C.W.5    Head, E.6
  • 35
    • 33646489799 scopus 로고    scopus 로고
    • No difference in expression of apoptosis-related proteins and apoptotic morphology in control, pathologically aged and Alzheimer's disease cases
    • Woodhouse A, et al. (2006) No difference in expression of apoptosis-related proteins and apoptotic morphology in control, pathologically aged and Alzheimer's disease cases. Neurobiol Dis. 22:323-33
    • (2006) Neurobiol Dis , vol.22 , pp. 323-333
    • Woodhouse, A.1
  • 36
    • 0033198217 scopus 로고    scopus 로고
    • Bax translocation is a critical event in neuronal apoptosis: Regulation by neuroprotectants, Bcl-2, and caspases
    • Putcha GV, Deshmukh M, Johnson Jr EM (1999) Bax translocation is a critical event in neuronal apoptosis: regulation by neuroprotectants, Bcl-2, and caspases. J Neurosci 19: 7476-7485
    • (1999) J Neurosci , vol.19 , pp. 7476-7485
    • Putcha, G.V.1    Deshmukh, M.2    Johnson Jr, E.M.3
  • 37
    • 0035956874 scopus 로고    scopus 로고
    • Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease
    • Przedborski S (2001) Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Proc Natl Acad Sci USA 98: 2837-2842.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 2837-2842
    • Przedborski, S.1
  • 38
    • 11144353586 scopus 로고    scopus 로고
    • ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease
    • Lustbader, J.W. et al. ( 2004) ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease. Science. 304:448-452.
    • (2004) Science , vol.304 , pp. 448-452
    • Lustbader, J.W.1
  • 39
    • 0033179760 scopus 로고    scopus 로고
    • BCL-2 family members and the mitochondria in apoptosis
    • Gross A, McDonnell JM, Korsmeyer SJ. (1999) BCL-2 family members and the mitochondria in apoptosis. Genes Dev 13:1899-911.
    • (1999) Genes Dev , vol.13 , pp. 1899-1911
    • Gross, A.1    McDonnell, J.M.2    Korsmeyer, S.J.3
  • 40
    • 0035890085 scopus 로고    scopus 로고
    • Wang X.(2001)The expanding role of mitochondria in apoptosis.Genes Dev 2922-33
    • Wang X.(2001)The expanding role of mitochondria in apoptosis.Genes Dev 2922-33
  • 41
    • 3242749074 scopus 로고    scopus 로고
    • Caspase cleavage of tau is an early event in Alzheimer disease tangle pathology
    • Rissman RA, Poon WW, Blurton-Jones M , et al. (2004) Caspase cleavage of tau is an early event in Alzheimer disease tangle pathology J.Clin Invest, 114: 121-130
    • (2004) J.Clin Invest , vol.114 , pp. 121-130
    • Rissman, R.A.1    Poon, W.W.2    Blurton-Jones, M.3
  • 42
    • 17344365975 scopus 로고    scopus 로고
    • Tau cleavage and dephosphorylation in cerebellar granule neurons undergoing apoptosis
    • Canu, N. et al. 1998. Tau cleavage and dephosphorylation in cerebellar granule neurons undergoing apoptosis. J. Neurosci. 18:7061-7074
    • (1998) J. Neurosci , vol.18 , pp. 7061-7074
    • Canu, N.1
  • 44
    • 0033064119 scopus 로고    scopus 로고
    • Wang S, Rosengren LE, Franlund M, Hamberger A, Haglid KG.(1999) Bcl-2 expression regulates cell sensitivity to S100beta-mediated apoptosis. Brain Res Mol Brain Res. 18;70(1):167-76.
    • Wang S, Rosengren LE, Franlund M, Hamberger A, Haglid KG.(1999) Bcl-2 expression regulates cell sensitivity to S100beta-mediated apoptosis. Brain Res Mol Brain Res. 18;70(1):167-76.
  • 45
    • 85047693458 scopus 로고    scopus 로고
    • Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: Cause or effect?
    • Dickson DW (2004) Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect? J. Clin. Invest. 114:23-27
    • (2004) J. Clin. Invest , vol.114 , pp. 23-27
    • Dickson, D.W.1
  • 46
    • 2642680857 scopus 로고    scopus 로고
    • Alzheimer disease: DNA fragmentation indicates increased neuronal vulnerability, but not apoptosis
    • Stadelmann, C., Bruck, W., Bancher, C., Jellinger, K., and Lassmann, H. (1998). Alzheimer disease: DNA fragmentation indicates increased neuronal vulnerability, but not apoptosis. J. Neuropathol. Exp. Neurol. 57:456-464
    • (1998) J. Neuropathol. Exp. Neurol , vol.57 , pp. 456-464
    • Stadelmann, C.1    Bruck, W.2    Bancher, C.3    Jellinger, K.4    Lassmann, H.5
  • 47
    • 0035917831 scopus 로고    scopus 로고
    • Activated caspase-3 expression in Alzheimer's and aged control brain: Correlation with Alzheimer pathology
    • Su, J.H., Zhao, M., Anderson, A.J., Srinivasan, A., and Cotman, C.W. (2001). Activated caspase-3 expression in Alzheimer's and aged control brain: correlation with Alzheimer pathology. Brain Res. 898:350-357
    • (2001) Brain Res , vol.898 , pp. 350-357
    • Su, J.H.1    Zhao, M.2    Anderson, A.J.3    Srinivasan, A.4    Cotman, C.W.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.