Synthesis of new pyrrolo[1,2-a ]quinoxaline derivatives as potential inhibitors of Akt kinase

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 23, Issue 5, 2008, Pages 648-658

  Desplat, Vanessa ^a   Geneste, Ambre ^a,b   Begorre, Marc Antoine ^a,b   Fabre, Solene Belisle ^b   Brajot, Stephane ^a   Massip, Stephane ^b   Thiolat, Denis ^a   Mossalayi, Djavad ^a   Jarry, Christian ^b   Guillon, Jean ^b  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b Laboratoire de Pharmacochimie   (France)

Author keywords

Akt kinase; Antiproliferative agents; Inhibitor; Pyrrolo 1,2 a quinoxaline

Indexed keywords

1,3 DIHYDRO 1 [1 [(4 PHENYLPYRROLO[1,2 A]QUINOXALIN 1 YL)METHYL]PIPERIDIN 4 YL] 2H BENZIMIDAZOL 2 ONE; 1,3 DIHYDRO 1 [1 [4 (4 PHENYLPYRROLO[1,2 A]QUINOXALIN 1 YL)BENZYL]PIPERIDIN 4 YL] 2H BENZIMIDAZOL 2 ONE; 1,3 DIHYDRO 1 [1 [4 (4 PHENYLPYRROLO[1,2 A]QUINOXALIN 2 YL)METHYL]PIPERIDIN 4 YL] 2H BENZIMIDAZOL 2 ONE; 1,3 DIHYDRO 1 [1 [4 (7 METHOXYPYRROLO[1,2 A]QUINOXALIN 4 YL)BENZYL]PIPERIDIN 4 YL] 2H BENZIMIDAZOL 2 ONE; 1,3 DIHYDRO 1 [1 [4 (8 CYANOPYRROLO[1,2 A]QUINOXALIN 4 YL)BENZYL]PIPERIDIN 4 YL] 2H BENZIMIDAZOL 2 ONE; 1,3 DIHYDRO 1 [1 [4 (8 METHOXYPYRROLO[1,2 A]QUINOXALIN 4 YL)BENZYL]PIPERIDIN 4 YL] 2H BENZIMIDAZOL 2 ONE; 1,3 DIHYDRO 1 [1 [4 (8 PHENYLPYRROLO[1,2 A]QUINOXALIN 4 YL)BENZYL]PIPERIDIN 4 YL] 2H BENZIMIDAZOL 2 ONE; 1,3 DIHYDRO 1 [1 [4 (PYRROLO[1,2 A]QUINOXALIN 4 YL)BENZYL]PIPERIDIN 4 YL] 2H BENZIMIDAZOL 2 ONE; 1,3 DIHYDRO 1 [1 [4 (PYRROLO[1,2 A]QUINOXALIN 4 YL)BENZYL]PIPERIDIN 4 YL] 5 CHLORO 2H BENZIMIDAZOL 2 ONE; 1,3 DIHYDRO 1 [1 [4 [7 (1H TETRAZOL 5 YL)PYRROLO[1,2 A]QUINOXALIN 4 YL]BENZYL]PIPERIDIN 4 YL] 2H BENZIMIDAZOL 2 ONE; 1,3 DIHYDRO 1 [1 [ALPHA CYANO 4 (4 PHENYLPYRROLO[1,2 A]QUINOXALIN 2 YL)METHYL]PIPERIDIN 4 YL] 2H BENZIMIDAZOL 2 ONE; A 6730; ANTINEOPLASTIC AGENT; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; PYRROLO[1,2 A]QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; CELL STRAIN HL 60; CELL STRAIN K 562; CELL STRAIN MCF 7; CELL STRAIN U937; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; CYCLIZATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LEUKEMIA; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA;

EID: 53249130758     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.1080/14756360802205448     Document Type: Article

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