Omega-3 Fatty Acids Supplementation in Children with Autism: A Double-blind Randomized, Placebo-controlled Pilot Study

Biological Psychiatry

Volumn 61, Issue 4, 2007, Pages 551-553

  Amminger, G Paul ^a,b   Berger, Gregor E ^b   Schäfer, Miriam R ^a   Klier, Claudia ^a   Friedrich, Max H ^a   Feucht, Martha ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Autism; children; hyperactive behaviors; omega 3 fatty acids; pilot study; randomized controlled trial

Indexed keywords

DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; OMEGA 3 FATTY ACID;

ADOLESCENT; AGGRESSION; ANALYSIS OF VARIANCE; ANGER; ARTICLE; AUTISM; AUTOMUTILATION; CHILDHOOD DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG FEVER; DRUG INDUCED HEADACHE; FEMALE; HUMAN; HYPERACTIVITY; MALE; OUTCOME ASSESSMENT; PILOT STUDY; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; STEREOTYPY; SUPPLEMENTATION;

ADOLESCENT; AGGRESSION; ANALYSIS OF VARIANCE; AUTISTIC DISORDER; CHILD; DOUBLE-BLIND METHOD; FATTY ACIDS, OMEGA-3; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; PILOT PROJECTS; PSYCHIATRIC STATUS RATING SCALES; STEREOTYPED BEHAVIOR;

EID: 33846620522     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2006.05.007     Document Type: Article

References (21)

1. Aman M.G., Singh N.N., Stewart A.W., and Field C.J. The aberrant behavior checklist: A behavior rating scale for the assessment of treatment effects. Am J Ment Defic 89 (1985) 485-491
2. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. (1994), American Psychiatric Press, Washington, DC
3. Bell J.G., MacKinlay E.E., Dick J.R., MacDonald D.J., Boyle R.M., and Glen A.C. Essential fatty acids and phospholipase A2 in autistic spectrum disorders. Prostaglandins Leukot Essent Fatty Acids 71 (2004) 201-204
4. Berger G.E., Wood S.J., Pantelis C., Velakoulis D., Wellard R.M., and McGorry P.D. Implications of lipid biology for the pathogenesis of schizophrenia. Aust N Z J Psychiatry 36 (2002) 355-366
5. Bolte S., and Poustka F. Diagnostic Observation Scale for Autistic Disorders: Initial results of reliability and validity. Z Kinder Jugendpsychiatr Psychother 32 (2004) 45-50
6. Gesch C.B., Hammond S.M., Hampson S.E., Eves A., and Crowder M.J. Influence of supplementary vitamins, minerals and essential fatty acids on the antisocial behaviour of young adult prisoners. Randomised, placebo-controlled trial. Br J Psychiatry 181 (2002) 22-28
7. Hamazaki K., Itomura M., Huan M., Nishizawa H., Sawazaki S., Tanouchi M., et al. Effect of omega-3 fatty acid-containing phospholipids on blood catecholamine concentrations in healthy volunteers: A randomized, placebo-controlled, double-blind trial. Nutrition 21 (2005) 705-710
8. Helland I.B., Smith L., Saarem K., Saugstad O.D., and Drevon C.A. Maternal supplementation with very-long-chain n-3 fatty acids during pregnancy and lactation augments children's IQ at 4 years of age. Pediatrics 111 (2003) e39-e44
9. Hibbeln J.R., Linnoila M., Umhau J.C., Rawlings R., George D.T., and Salem Jr. N. Essential fatty acids predict metabolites of serotonin and dopamine in cerebrospinal fluid among healthy control subjects, and early- and late-onset alcoholics. Biol Psychiatry 44 (1998) 235-242
10. Lingjaerde O., Ahlfors U.G., Bech P., Dencker S.J., and Elgen K. The UKU side effect rating scale. A new comprehensive rating scale for psychotropic drugs and a cross-sectional study of side effects in neuroleptic-treated patients. Acta Psychiatr Scand Suppl 334 (1987) 1-100
11. McDougle C.J., Scahill L., Aman M.G., McCracken J.T., Tierney E., Davies M., et al. Risperidone for the core symptom domains of autism: Results from the study by the Autism Network of the Research Units on Pediatric Psychopharmacology. Am J Psychiatry 162 (2005) 1142-1148
12. Posey D.J., and McDougle C.J. Pharmacotherapeutic management of autism. Expert Opin Pharmacother 2 (2001) 587-600
13. Poustka F., Lisch S., Ruhl D., Sacher A., Schmotzer G., and Werner K. The standardized diagnosis of autism, Autism Diagnostic Interview-Revised: Interrater reliability of the German form of the interview. Psychopathology 29 (1996) 145-153
14. Research Units on Pediatric Psychopharmacology Autism Network. Risperidone in children with autism and serious behavioral problems. N Engl J Med 347 (2002) 314-321
15. Richardson A.J. Long-chain polyunsaturated fatty acids in childhood developmental and psychiatric disorders. Lipids 39 (2004) 1215-1222
16. Richardson A.J., and Montgomery P. The Oxford-Durham study: A randomized, controlled trial of dietary supplementation with fatty acids in children with developmental coordination disorder. Pediatrics 115 (2005) 1360-1366
17. Vancassel S., Durand G., Barthelemy C., Lejeune B., Martineau J., Guilloteau D., et al. Plasma fatty acid levels in autistic children. Prostaglandins Leukot Essent Fatty Acids 65 (2001) 1-7
18. Wainwright P.E. Dietary essential fatty acids and brain function: A developmental perspective on mechanisms. Proc Nutr Soc 61 (2002) 61-69
19. Willatts P., Forsyth J.S., DiModugno M.K., Varma S., and Colvin M. Effect of long-chain polyunsaturated fatty acids in infant formula on problem solving at 10 months of age. Lancet 352 (1998) 688-691
20. Young G., and Conquer J. Omega-3 fatty acids and neuropsychiatric disorders. Reprod Nutr Dev 45 (2005) 1-28
21. Zanarini M.C., and Frankenburg F.R. Omega-3 fatty acid treatment of women with borderline personality disorder: A double-blind, placebo-controlled pilot study. Am J Psychiatry 160 (2003) 167-169