Neurobiology of attention-deficit hyperactivity disorder

Biological Psychiatry

Volumn 44, Issue 10, 1998, Pages 951-958

  Faraone, Stephen V ^a,b,c,d   Biederman, Joseph ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS MENTAL HEALTH CENTER   (United States)

^d Harvard Inst Psychiat E   (United States)

Author keywords

ADHD; Adversity; Genetics; Neuroimaging; Neurotransmitters

Indexed keywords

DOPAMINE 2 RECEPTOR; DOPAMINE 4 RECEPTOR; DOPAMINE TRANSPORTER; PSYCHOSTIMULANT AGENT;

ATTENTION DEFICIT DISORDER; FAMILY STUDY; GENE OVEREXPRESSION; HERITABILITY; HUMAN; HYPERACTIVITY; NEUROPHARMACOLOGY; NEURORADIOLOGY; NEUROTRANSMISSION; PRIORITY JOURNAL; RECEPTOR GENE; REVIEW; TWINS;

ADULT; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; BRAIN; BRAIN CHEMISTRY; FEMALE; HUMANS; PREGNANCY;

EID: 0032533256     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(98)00240-6     Document Type: Review

References (84)

1. Bailey J.N., Cantwell D., Asarnow J., Smalley S.L. Segregation analysis of attention deficit hyperactivity disorder. Genet Epidemiol. 14:1997;518-519.
2. Bailey J.N., Palmer C.G.S., Ramsey C., Cantwell D., Kim K., Woodward J.A., et al. DRD4 gene and susceptibility to attention deficit hyperactivity disorder Differences in familial and sporadic cases . Am J Med Genet Neuropsychiatr Genet. 74:1997;623.
3. Barkley R.A. Attention Deficit Hyperactivity Disorder A Handbook for Diagnosis and Treatment . 1990;Guilford Press, New York.
4. Barkley R.A. ADHD and the Nature of Self-Control. 1997;Guilford, New York.
5. Barkley R.A., Fischer M., Edelbrock C.S., Smallish L. The adolescent outcome of hyperactive children diagnosed by research criteria I. An 8-year prospective follow-up study . J Am Acad Child Adolesc Psychiatry. 29:1990;546-557.
6. Benjamin J., Patterson C., Greenberg B.D., Murphy D.L., Hamer D.H. Population and familial association between the D4 dopamine receptor gene and measures of novelty seeking. Nat Genet. 12:1996;81-84.
7. Biederman J., Faraone S.V., Keenan K., Knee D., Tsuang M.T. Family-genetic and psychosocial risk factors in DSM-III attention deficit disorder. J Am Acad Child Adolesc Psychiatry. 29:1990;526-533.
8. Biederman J., Faraone S.V., Keenan K., Steingard R., Tsuang M.T. Familial association between attention deficit disorder and anxiety disorders. Am J Psychiatry. 148:1991;251-256.
9. Biederman J., Faraone S.V., Keenan K., Tsuang M.T. Evidence of familial association between attention deficit disorder and major affective disorders. Arch Gen Psychiatry. 48:1991;633-642.
10. Biederman J., Faraone S.V., Keenan K., Benjamin J., Krifcher B., Moore C., et al. Further evidence for family-genetic risk factors in attention deficit hyperactivity disorder (ADHD) Patterns of comorbidity in probands and relatives in psychiatrically and pediatrically referred samples . Arch Gen Psychiatry. 49:1992;728-738.
11. Biederman J., Milberger S., Faraone S., Kiely K., Guite J., Mick E., et al. Family-environment risk factors for ADHD A test of Rutter's indicators of adversity . Arch Gen Psychiatry. 52:1995;464-470.
12. Biederman J., Milberger S., Faraone S., Kiely K., Guite J., Mick E., et al. Impact of adversity on functioning and comorbidity in children with attention-deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 34:1995;1495-1504.
13. Blum K., Braverman E.R., Wu S., Cull J.G., Chen T.J., Gill J., et al. Association of polymorphisms of dopamine D2 receptor (DRD2), and dopamine transporter (DAT1) genes with schizoid/avoidant behaviors (SAB). Mol Psychiatry. 2:1997;239-246.
14. Cantwell D.P. Genetics of hyperactivity. J Child Psychol Psychiatry. 16:1975;261-264.
15. Castellanos F.X., Lau E., Tayebi N., Lee P., Long R.E., Giedd J.N., et al. Evidence that a D4DR*7R dopamine receptor polymorphism is not correlated with attention deficit/hyperactivity disorder. Am J Med Genet Neuropsyhiatr Genet. 74:1997;623.
16. Chang F.M., Kidd J.R., Livak K.J., Pakstis A.J., Kidd K.K. The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus. Hum Genet. 98:1996;91-101.
17. Clarke P. Dopaminergic mechanisms in the locomotor stimulant effects of nicotine. Biochem Pharmacol. 42:1990;595-596.
18. Coger R., Moe K.L., Serafetinides E.A. Attention deficit disorder in adults and nicotine dependence Psychobiological factors in resistance to recovery? J Psychoactive Drugs. 28:1996;229-240.
19. Comings D.E., Comings B.G., Muhleman D., Dietz G., Shahbahrami B., Tast D., et al. The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders. JAMA. 266:1991;1793-1800.
20. Conners C.K. Food Additives and Hyperactive Children. 1980;Plenum, New York.
21. Conners C., Levin E.D., Sparron E., Hinton S.C., Erhardt D., Meck W.H., et al. Nicotine and attention deficit hyperactivity disorder (ADHD). Psychopharmocol Bull. 32:1996;67-73.
22. Cook E.H., Stein M.A., Krasowski M.D., Cox N.J., Olkon D.M., Kieffer J.E., et al. Association of attention deficit disorder and the dopamine transporter gene. Am J Hum Genet. 56:1995;993-998.
23. Deutsch C.K., Matthysse S., Swanson J.M., Farkas L.G. Genetic latent structure analysis of dysmorphology in attention deficit disorder. J Am Acad Child Adolesc Psychiatry. 29:1990;189-194.
24. Eaves L., Silberg J., Hewitt J., Meyer J., Rutter M., Simonoff E., et al. Genes, personality, and psychopathology A latent class analysis of liability to symptoms of attention-deficit hyperactivity disorder in twins . Plomin R., McLearn G. Nature, Nurture and Psychology. 1993;285-306 American Psychological Association, Washington, DC.
25. Ebstein R.P., Novick O., Umansky R., Priel B., Osher Y., Blaine D., et al. Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking. Nat Genet. 12:1996;78-80.
26. Edelbrock C, Rende RD, Plomin R, Thompson LA (1992): A twin study of behavior problems in early adolescence. Paper presented at the Behavior Genetics Association, 22nd Annual Meeting, July 2-5, 1992, Clarion Harvest House Hotel, Boulder, Colorado.
27. Faraone S., Biederman J. Genetics of attention-deficit hyperactivity disorder. Child Adolesc Psychiatr Clin North Am. 3:1994;285-302.
28. Faraone S., Biederman J. Is attention deficit hyperactivity disorder familial? Harvard Rev Psychiatry. 1:1994;271-287.
29. Faraone S., Biederman J. Do attention deficit hyperactivity disorder and major depression share familial risk factors? J Nerv Ment Dis. 185:1997;533-541.
30. Faraone SV, Biederman J (in press): Neurobiology of attention deficit hyperactivity disorder. In: Charney DS, Nestler EJ, Bunney BS, editors. Neurobiology of Mental Illness. New York: Oxford University Press.
31. Faraone S.V., Biederman J., Keenan K., Tsuang M.T. Separation of DSM-III attention deficit disorder and conduct disorder Evidence from a family-genetic study of American child psychiatric patients . Psychol Med. 21:1991;109-121.
32. Faraone S., Beiderman J., Chen W.J., Krifcher B., Keenan K., Moore C., et al. Segregation analysis of attention deficit hyperactivity disorder Evidence for single gene transmission . Psychiatr Genet. 2:1992;257-275.
33. Faraone S., Biederman J., Krifcher Lehman B., Keenan K., Norman D., Seidman L., et al. Evidence for the independent familial transmission of attention deficit hyperactivity disorder and learning disabilities Results from a family genetic study . Am J Psychiatry. 150:1993;891-895.
34. Faraone S.V., Biederman J., Mennin D., Wozniak J., Spencer T. Attention deficit hyperactivity disorder with bipolar disorder A familial subtype? J Am Acad Child Adolesc Psychiatry. 36:1997;1378-1387.
35. Faraone SV, Biederman J, Weiffenbach B, Keith T, Chu MP, Weaver A, et al (in submission): The dopamine D4 gene 7-repeat allele is associated with attention deficit hyperactivity disorder in families ascertained through ADHD adults.
36. Freedman R., Adler L., Bickford P., Byerley W., Coon H., Cullum C., et al. Schizophrenia and nicotinic receptors. Harvard Rev Psychiatry. 2:1994;179-192.
37. Gill M., Daly G., Heron S., Hawi Z., Fitzgerald M. Confirmation of association between attention deficit hyperactivity disorder and a dopamine transporter polymorphism. Mol Psychiatry. 2:1997;311-313.
38. Gillis J.J., Gilger J.W., Pennington B.F., DeFries J.C. Attention deficit disorder in reading-disabled twins Evidence for a genetic etiology . J Abnormal Child Psychol. 20:1992;303-315.
39. Giros B., Jaber M., Jones S.R., Wightman R.M., Caron M.G. Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature. 379:1996;606-612.
40. Gjone H., Stevenson J., Sundet J.M. Genetic influence on attention problems in a general population twin sample. J Am Acad Child Adolesc Psychiatry. 45:1996;588-596.
41. Goodman R., Stevenson J. A twin study of hyperactivity - I. An examination of hyperactivity scores and categories derived from Rutter teacher and parent questionnaires. J Child Psychol Psychiatry. 30:1989;671-689.
42. Hagino N., Lee J. Effect of maternal nicotine on the development of sites for [3h] nicotine binding in the fetal brain. Int J Dev Neurosci. 3:1985;567-571.
43. Hartsough C.S., Lambert N.M. Pattern and progression of drug use among hyperactives and controls A prospective short-term longitudinal study . J Child Psychol Psychiatry. 28:1987;543-553.
44. Hauser P., Zametkin A., Martinez P., Vitiello B., Matochik J., Mixson A., et al. Attention deficit-hyperactivity disorder in people with generalized resistance to thyroid hormone. N Engl J Med. 328:1993;997-1001.
45. Hauser P., Soler R., Brucker-Davis F., Weintraub B.D. Thyroid hormones correlate with symptoms of hyperactivity but not inattention in attention deficit hyperactivity disorder. Psychoneuroendocrinology. 22:1997;107-114.
46. Hess E.J., Rogan P.K., Domoto M., Tinker D.E., Ladda R.L., Ramer J.C. Absence of linkage of apparently single gene mediated ADHD with the human syntenic region of the mouse mutant, Coloboma. Am J Med Genet. 60:1995;573-579.
47. Jensen P.S., Martin D., Cantwell D.P. Comorbidity in ADHD Implications for research, practice and DSM-V . J Am Acad Child Adolesc Psychiatry. 36:1997;1065-1079.
48. LaHoste G.J., Swanson J.M., Wigal S.B., Glabe C., Wigal T., King N., et al. Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder. Mol Psychiatry. 1:1996;128-131.
49. Leung P.W.L., Luk S.L., How T.P., Taylor E., Mak F.L., Bacon-Shone J. The diagnosis and prevalence of hyperactivity in Chinese schoolboys. Br J Psychiatry. 168:1996;486-496.
50. Levin E., Conners C.K., Sparrow E., Hinton S.C., Erhardt D., Meck W.H., et al. Nicotine effects on adults with attention-deficit/hyperactivity disorder. Psychopharmacology (Berl). 123:1996;55-63.
51. Levy F., Hay D., McStephen M., Wood C., Waldman I. Attention-deficit hyperactivity disorder A category or a continuum? Genetic analysis of a large-scale twin study . J Am Acad Child Adoles Psychiatry. 36:1997;737-744.
52. Lynskey M., Fergusson D. Childhood conduct problems, attention deficit behaviors, and adolescent alcohol, tobacco, and illicit drug use. J Abnorm Child Psychol. 23:1995;281-302.
53. Malhotra A.K., Virkkunen M., Rooney W., Eggert M., Linnoila M., Goldman D. The association between the dopamine D4 receptor (D4DR) 16 amino acid repeat polymorphism and novelty seeking. Mol Psychiatry. 1:1996;388-391.
54. Marks M.J., Pauly J.R., Gross S.D., Deneris E.S., Hermans-Borgmeyer I., Heinemann F., et al. Nicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment. J Neurosci. 12:1992;2765-2784.
55. Marks M.J., Grady S.R., Collins A.C. Downregulation of nicotinic receptor function after chronic nicotine infusion. J Pharmacol Exp Ther. 266:1993;1268-1276.
56. Mattes J.A. The role of frontal lobe dysfunction in childhood hyperkinesis. Compr Psychiatry. 21:1980;358-369.
57. Milberger S., Biederman J., Faraone S., Chen L., Jones J. Further evidence of an association between attention-deficit/hyperactivity disorder and cigarette smoking Findings from a high-risk sample of siblings . Am J Addict. 6:1997;205-217.
58. Milberger S., Biederman J., Faraone S.V., Chen L., Jones J. Attention deficit hyperactivity disorder is associated with early initiation of cigarette smoking in children and adolescents. J Am Acad Child Adolesc Psychiatry. 36:1997;37-44.
59. Mitchell S. Role of the locus coeruleus in the noradrenergic response to a systemic administration of nicotine. Neuropharmacology. 32:1993;937-949.
60. Morrison J.R., Stewart M.A. The psychiatric status of the legal families of adopted hyperactive children. Arch Gen Psychiatry. 28:1973;888-891.
61. Morrison J.R., Stewart M.A. Bilateral inheritance as evidence for polygenicity in the hyperactive child syndrome. J Nerv Ment Dis. 158:1974;226-228.
62. Nadder T.S., Silberg J.L., Eaves L.J., Maes H.H., Meyer J.M. Genetic effects of ADHD symptomatology in 7- to 13-year-old twins Results from a telephone survey . Behav Genet. 28:1998;83-100.
63. Needleman H.L. The neuropsychiatric implications of low level exposure to lead. Psychol Med. 12:1982;461-463.
64. Offord D.R., Boyle M.H., Racine Y.A., Fleming J.E., Cadman D.T., Blum H.M., et al. Outcome, prognosis and risk in a longitudinal follow-up study. J Am Acad Child Adolesc Psychiatry. 31:1992;916-923.
65. Pliszka S., McCracken J., Maas J. Catecholamines in attention-deficity hyperactivity disorder Current perspectives . J Am Acad Child Adolesc Psychiatry. 35:1996;264-272.
66. Plomin R., Bergman C.S. The nature of nurture Genetic influence on "environmental" measures . Behav Brain Sci. 14:1991;373-427.
67. Rutter M., Cox A., Tupling C., Berger M., Yule W. Attainment and adjustment in two geographical areas Vol. 1. The prevalence of psychiatric disorders . Br J Psychiatry. 126:1975;493-509.
68. Satterfield J.H., Dawson M.E. Electrodermal correlates of hyperactivity in children. Psychophysiology. 8:1971;191-197.
69. Schmitz S., Fulker D.W., Mrazek D.A. Problem behavior in early and middle childhood an initial behavior genetic analysis . J Child Psychol Psychiatry. 36:1995;1443-1458.
70. Sherman D., McGue M., Iacono W. Twin concordance for attention deficit hyperactivity disorder A comparison of teachers' and mothers' reports . Am J Psychiatry. 154:1997;532-535.
71. Silberg J., Rutter M., Meyer J., Maes H., Hewitt J., Simonoff E., et al. Genetic and environmental influences on the covariation between hyperactivity and conduct disturbance in juvenile twins. J Child Psychol Psychiatry. 37:1996;803-816.
72. Slotkin T.A., Lappi S.E., Seidler F.J. Impact of fetal nicotine exposure on development of rat brain regions Critical sensitive periods or effects of withdrawal? Brain Res Bull. 31:1993;319-328.
73. Sprich-Buckminster S., Biederman J., Milberger S., Faraone S., Krifcher Lehman B. Are perinatal complications relevant to the manifestation of ADD? Issues of comorbidity and familiality. J Am Acad Child Adolesc Psychiatry. 32:1993;1032-1037.
74. Sunohara G., Barr C., Jain U., Schachar R., Roberts W., Tannock R., et al. Association of the D4 Receptor Gene in Individuals with ADHD. 1997;American Society of Human Genetics, Baltimore.
75. Swanson J.M., Sunohara G.A., Kennedy J.L., Regino R., Fineberg E., Wigal T., et al. Association of the dopamine receptor D4 (DRD4) gene with a refined phenotype of attention deficit hyperactivity disorder (ADHD) A family-based approach . Mol Psychiatry. 3:1998;38-41.
76. Thapar A., Hervas A., McGuffin P. Childhood hyperactivity scores are highly heritable and show sibling competition effects Twin study evidence . Behav Genet. 25:1995;537-544.
77. van den Oord E.J., Boomsma D.I., Verhulst F.C. A study of problem behaviors in 10- to 15-year-old biologically related and unrelated international adoptees. Behav Genet. 24:1994;193-205.
78. Waldman L., Rowe D., Abramowitz A., Kozel S., Mohr J., Sherman S., et al. Association of the dopamine transporter gene (DAT1) and attention deficit hyperactivity disorder in children. Am J Hum Genet. 59:1996;A25.
79. Weiss R., Stein M., Trommer B., Refetoff S. Attention-deficit hyperactivity disorder and thyroid function. J Pediatr. 123:1993;539-545.
80. Weiss R.E., Stein M.A., Duck S.C., Chyna B., Phillips W., O'Brien T., et al. Low intelligence but not attention deficit hyperactivity disorder is associated with resistance to thyroid hormone caused by mutation R316H in the thyroid hormone receptor B Gene. J Clin Endocrinol Metab. 78:1994;1525-1528.
81. Willerman L. Activity level and hyperactivity in twins. Child Develop. 44:1973;288-293.
82. Wolraich M., Wilson D., White W. The effect of sugar on behavior or cognition in children. JAMA. 274:1995;1617-1621.
83. Zametkin A.J., Rapoport J.L. Neurobiology of attention deficit disorder with hyperactivity Where have we come in 50 years? J Am Acad Child Adolesc Psychiatry. 26:1987;676-686.
84. Zametkin A.J., Rapoport J.L. Noradrenergic hypothesis of attention deficit disorder with hyperactivity A critical review . Meltzer H.Y. Psychopharmacology The Third Generation of Progress . 1987;837-842 Raven Press, New York.