Homocysteine may contribute to pathogenesis of RNA damage in brains with Alzheimer's disease

Neurodegenerative Diseases

Volumn 6, Issue 5-6, 2009, Pages 252-257

  Isobe, Chiaki ^a,b   Abe, Takashi ^b   Terayama, Yasuo ^b  

^a Chitose Daiichi Hospital   (Japan)

^b IWATE MEDICAL UNIVERSITY   (Japan)

Author keywords

8 Hydroxyguanosine; Alzheimer's disease; Cerebrospinal fluid; Homocysteine, free; Homocysteine, total

Indexed keywords

8 HYDROXYGUANOSINE; GUANOSINE DERIVATIVE; HOMOCYSTEINE; UNCLASSIFIED DRUG;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CEREBROSPINAL FLUID; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; NEUROPATHOLOGY; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RNA DEGRADATION; SERUM;

AGED; ALZHEIMER DISEASE; BRAIN; CASE-CONTROL STUDIES; FEMALE; GUANOSINE; HOMOCYSTEINE; HUMANS; MALE; MIDDLE AGED; RNA; STATISTICS AS TOPIC;

EID: 77949423007     PISSN: 16602854     EISSN: 16602862     Source Type: Journal    
DOI: 10.1159/000262443     Document Type: Article

References (31)

1. Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D'Agostino RB, Wilson PW: Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 2002; 346: 476-483.
2. Starkebaum G, Harlan JM: Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine. J Clin Invest 1986; 77: 1370-1376.
3. Nishinaga M, Ozawa T, Shimada K: Homocysteine, a thrombogenic agent, suppresses anticoagulant heparin sulfate expression in cultured porcine aortic endothelial cells. J Clin Invest 1993; 92: 1381-1386.
4. Ueland PM: Homocysteine species as components of plasma redox thiol status. Clin Chem 1995; 41: 340-342.
5. Parnetti L, Bottiglieri T, Lowenthal D: Role of homocysteine in age-related vascular and non-vascular diseases. Aging (Milano) 1997; 9: 241-257.
6. Kruman II, Kumaravel TS, Lohani A, Pedersen WA, Cutler RG, Kruman Y, Haughey N, Lee J, Evans M, Mattson MP: Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease. J Neurosci 2002; 22: 1752-1762.
7. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJ, den Heijer M, Kluijtmans LA, van den Heuvel LP: A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995; 10: 111-113.
8. Selhub J, Jacques PF, Wilson WF: Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA 1993; 270: 2693-2698.
9. Lehmann M, Gottfries CG, Regland B: Identification of cognitive impairment in the elderly: homocysteine is an early marker. Dement Geriatr Cogn Disord 1999; 10: 12-20.
10. Isobe C, Murata T, Sato C, Yasuo T: Increase of total homocysteine concentration in cerebrospinal fluid in patients with Alzheimer's disease and Parkinson's disease. Life Sci 2005; 77: 1836-1843.
11. Harman D: Aging: a theory based on free radical and radiation chemistry. J Gerontol 1956; 11: 298-300.
12. Floyd RA: Antioxidants, oxidative stress, and degenerative neurological disorders. Proc Soc Exp Biol Med 1999; 222: 236-245.
13. Smith MA, Harris RP, Sayre LM, Beckman JS, Perry G: Widespread peroxynitrite-mediated damage in Alzheimer's disease. J Neurosci 1997; 17: 2653-2657.
14. Tohgi H, Abe T, Yamazaki K, Murata T, Ishizaki E, Isobe C: Alteration of 3-nitrotyrosine concentration in the cerebrospinal fluid during aging and in patients with Alzheimer's disease. Neurosci Lett 1999; 269: 52-55.
15. Colton CA, Gilbert DL: Production of superoxide anions by a CNS macrophage, the microglia. FEBS Lett 1987; 223: 284-288.
16. Behl C, Davis JB, Lesley R, Schubert D: Hydrogen peroxide mediates amyloid beta protein toxicity. Cell 1994; 77: 817-827.
17. Akama KT, Albanese C, Pestell RG, van Eldik LJ: Amyloid beta-peptide stimulates nitric oxide production in astrocytes through an NF-κB- dependent mechanism. Proc Natl Acad Sci USA 1998; 95: 5795-5800.
18. Dani SU: Molecular turnover and aging; in Dani SU, Hori A, Walter GF (eds): Principles of Neural Aging. Amsterdam, Elsevier, 1997, pp 83-101.
19. Sayre LM, Perry G, Smith MA: In situ methods for detection and localization of oxidative stress: application in neurodegenerative disorders. Methods Enzymol 1999; 309: 133-152.
20. Nunomura A, Perry G, Aliev G, Hirai K, Takeda A, Balraj EK, Jones PK, Ghanbari H, Wataya T, Shimohama S, Chiba S, Atwood CS, Petersen RB, Smith MA: Oxidative damage is the earliest event in Alzheimer disease. J Neuropathol Exp Neurol 2001; 60: 759-767.
21. Abe T, Tohgi H, Murata T, Isobe C, Sato C: Remarkable increase in the concentration of 8-hydroxyguanosine in cerebrospinal fluid from patients with Alzheimer disease. J Neurosci Res 2002; 70: 447-450.
22. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, ed 4 (DSM-IV). Washington, American Psychiatric Association Press, 1994, pp 135- 155.
23. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984; 34: 939-944.
24. Hachinski VC, Iliff LD, Zilhka E: Cerebral blood flow in dementia. Arch Neurol 1975; 32: 632-637.
25. Folstein MF, Folstein SE, McHugh PR: Mini- Mental State: a practical method of grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12: 189-198.
26. Shigenaga MK, Aboujaoude EN, Chen Q, Ames BN: Assays of oxidative DNA damage biomarkers 8-oxo-2′-deoxyguanosine and 8-oxoguanine in nuclear DNA and biological fluids by high-performance liquid chromatography with electrochemical detection. Methods Enzymol 1994; 234: 16-33.
27. Selley ML, Close DR, Stern SE: The effect of increased concentration of homocysteine on the concentration of ( E )-4-hydroxy-2-nonenal in the plasma and cerebrospinal fluid of patients with Alzheimer's disease. Neurobiol Aging 2002; 23: 383-388.
28. White AR, Huang X, Jobling MF, Barrow CJ, Beyreuther K, Masters CL, Bush AI, Cappai R: Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary neuronal culture: possible risk factor in the Alzheimer-type neurodegenerative pathways. J Neurochem 2001; 76: 509-1520.
29. Nunomura A, Perry G, Pappolla MA, Wade R, Hirai K, Chiba S, Smith MA: RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease. J Neurosci 1999; 19: 1959-1964.
30. Nunomura A, Perry G, Pappolla MA, Friedland RP, Hirai K, Chiba S, Smith MA: Neuronal oxidative stress precedes amyloid-βdeposition in Down syndrome. J Neuropathol Exp Neurol 2000; 59: 1011-1017.
31. Fiala ES, Conaway CC, Mathis JE: Oxidative DNA and RNA damage in the livers of Sprague Dawley rats treated with the hepatocarcinogen 2-nitropropane. Cancer Res 1989; 49: 5518-5522.