Kinetic and binding effects in peptide substrate selectivity of matrix metalloproteinase-2: Molecular dynamics and QM/MM calculations

Proteins: Structure, Function and Bioinformatics

Volumn 78, Issue 1, 2010, Pages 1-11

  Díaz, Natalia ^a   Suárez, Dimas ^a   Suárez, Ernesto ^a  

^a UNIVERSITY OF OVIEDO   (Spain)

Author keywords

Enzyme catalysis; Hydrolysis; Metalloenzymes; Molecular modelling; Structural biology

Indexed keywords

GELATINASE A; PEPTIDE;

AQUEOUS SOLUTION; ARTICLE; CATALYSIS; ENTROPY; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; HYDROLYSIS; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MUTATION; PRIORITY JOURNAL; SIMULATION; AMINO ACID SEQUENCE; BINDING SITE; CHEMISTRY; COMPUTER SIMULATION; METABOLISM; MOLECULAR GENETICS; PROTEIN BINDING;

AMINO ACID SEQUENCE; BINDING SITES; COMPUTER SIMULATION; MATRIX METALLOPROTEINASE 2; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN BINDING; SUBSTRATE SPECIFICITY;

EID: 77949416782     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.22493     Document Type: Article

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