Molecular dynamics simulations of the active matrix metalloproteinase-2: Positioning of the N-terminal fragment and binding of a small peptide substrate

Proteins: Structure, Function and Genetics

Volumn 72, Issue 1, 2008, Pages 50-61

  Díaz, Natalia ^a   Suárez, Dimas ^a  

^a UNIVERSITY OF OVIEDO   (Spain)

Author keywords

Enzyme catalysis; Hydrolysis; Metalloenzymes; Molecular modelling; Structural biology

Indexed keywords

COLLAGEN TYPE 1; ENZYME PRECURSOR; GELATINASE A; PEPTIDE;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ANALYTIC METHOD; ARTICLE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME STRUCTURE; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; MOLECULAR MIMICRY; PRIORITY JOURNAL; SIMULATION;

AMINO ACID SEQUENCE; CATALYSIS; CATALYTIC DOMAIN; COMPUTER SIMULATION; ENZYME ACTIVATION; ENZYME INHIBITORS; HYDROPHOBICITY; MATRIX METALLOPROTEINASE 2; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, SECONDARY; SOLVENTS; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 44949110147     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.21894     Document Type: Article

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