The melanocortin receptor agonist NDP-MSH impairs the allostimulatory function of dendritic cells

Immunology

Volumn 129, Issue 4, 2010, Pages 610-619

  Rennalls, La'Verne P ^a   Seidl, Thomas ^b   Larkin, James M G ^c   Wellbrock, Claudia ^d   Gore, Martin E ^c   Eisen, Tim ^e   Bruno, Ludovica ^f  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c ROYAL MARSDEN HOSPITAL   (United Kingdom)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^f IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Nle4, DPhe7 melanocyte stimulating hormone; Allostimulation; Dendritic cells; Extracellular signal related protein kinase 1 2; Melanocortin receptors; Mixed lymphocyte reactions

Indexed keywords

CD83 ANTIGEN; CELL ADHESION MOLECULE; DECAY ACCELERATING FACTOR; INTERCELLULAR ADHESION MOLECULE 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MELANOCORTIN RECEPTOR AGONIST; MELANOTAN I; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; UNCLASSIFIED DRUG;

ANTIGEN PRESENTING CELL; ARTICLE; CELL FUNCTION; CELL SURFACE; DENDRITIC CELL; DOWN REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ALPHA-MSH; ANTIGENS, CD1; ANTIGENS, CD86; CELLS, CULTURED; DENDRITIC CELLS; DOWN-REGULATION; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; MITOGEN-ACTIVATED PROTEIN KINASE 1; PHOSPHORYLATION; RECEPTORS, MELANOCORTIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; T-LYMPHOCYTES; TRANSPLANTATION, HOMOLOGOUS;

EID: 77949412581     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2009.03210.x     Document Type: Article

References (46)

1. Buggy JJ. Binding of α-melanocyte-stimulating hormone to its G-protein-coupled receptor on B-lymphocytes activates the Jak/STAT pathway. Biochem J 1998; 331 (Pt 1):211-6.
2. Lee EJ, Lee SH, Jung JW et al. Differential regulation of cAMP-mediated gene transcription and ligand selectivity by MC3R and MC4R melanocortin receptors. Eur J Biochem 2001; 268:582-91.
3. Luger TA, Brzoska T, Scholzen TE, Kalden DH, Sunderkotter C, Armstrong C, Ansel J. The role of α-MSH as a modulator of cutaneous inflammation. Ann NY Acad Sci 2000; 917:232-8.
4. Luger TA, Scholzen T, Grabbe S. The role of α-melanocyte- stimulating hormone in cutaneous biology. J Investig Dermatol Symp Proc 1997; 2:87-93.
5. Star RA, Rajora N, Huang J, Stock RC, Catania A, Lipton JM. Evidence of autocrine modulation of macrophage nitric oxide synthase by α-melanocyte- stimulating hormone. Proc Natl Acad Sci USA 1995; 92:8016-20.
6. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998; 392:245-52.
7. Shen L, Barabino S, Taylor AW, Dana MR. Effect of the ocular microenvironment in regulating corneal dendritic cell maturation. Arch Ophthalmol 2007; 125:908-15.
8. Bhardwaj RS, Schwarz A, Becher E, Mahnke K, Aragane Y, Schwarz T, Luger TA. Proopiomelanocortin-derived peptides induce IL-10 production in human monocytes. J Immunol 1996; 156:2517-21.
9. Rajora N, Ceriani G, Catania A, Star RA, Murphy MT, Lipton JM. α-MSH production, receptors, and influence on neopterin in a human monocyte/macrophage cell line. J Leukoc Biol 1996; 59:248-53.
10. Xia Y, Muceniece R, Wikberg JE. Immunological localisation of melanocortin 1 receptor on the cell surface of WM266-4 human melanoma cells. Cancer Lett 1996; 98:157- 62.
11. Rescigno M, Martino M, Sutherland CL, Gold MR, Ricciardi-Castagnoli P. Dendritic cell survival and maturation are regulated by different signaling pathways. J Exp Med 1998; 188:2175-80.
12. Abdel Malek ZA, Kreutzfeld KL, Marwan MM, Hadley ME, Hruby VJ, Wilkes BC. Prolonged stimulation of S91 melanoma tyrosinase by [Nle4, D-Phe7]-substituted α-melanotropins. Cancer Res 1985; 45:4735-40.
13. Bhardwaj R, Becher E, Mahnke K, Hartmeyer M, Schwarz T, Scholzen T, Luger TA. Evidence for the differential expression of the functional α-melanocyte-stimulating hormone receptor MC-1 on human monocytes. J Immunol 1997; 158:3378-84.
14. Salazar-Onfray F, Lopez M, Lundqvist A et al. Tissue distribution and differential expression of melanocortin 1 receptor, a malignant melanoma marker. Br J Cancer 2002; 87:414-22.
15. Becher E, Mahnke K, Brzoska T, Kalden DH, Grabbe S, Luger TA. Human peripheral blood-derived dendritic cells express functional melanocortin receptor MC-1R. Ann NY Acad Sci 1999; 885:188-95.
16. Konda Y, Gantz I, DelValle J, Shimoto Y, Miwa H, Yamada T. Interaction of dual intracellular signaling pathways activated by the melanocortin-3 receptor. J Biol Chem 1994; 269:13162-6.
17. Getting SJ, Christian HC, Lam CW, Gavins FN, Flower RJ, Schioth HB, Perretti M. Redundancy of a functional melanocortin 1 receptor in the anti-inflammatory actions of melanocortin peptides: studies in the recessive yellow (e/e) mouse suggest an important role for melanocortin 3 receptor. J Immunol 2003; 170:3323-30.
18. Taherzadeh S, Sharma S, Chhajlani V et al. α-MSH and its receptors in regulation of tumor necrosis factor-α production by human monocyte/macrophages. Am J Physiol 1999; 276(5 Pt 2):R1289-94.
19. Catania A, Gatti S, Colombo G, Lipton JM. Targeting melanocortin receptors as a novel strategy to control inflammation. Pharmacol Rev 2004; 56:1-29.
20. Zhu N, Lalla R, Eves P, Brown TL, King A, Kemp EH, Haycock JW, MacNeil S. Melanoma cell migration is upregulated by tumour necrosis factor-α and suppressed by α-melanocyte-stimulating hormone. Br J Cancer 2004; 90:1457-63.
21. Luger TA, Scholzen TE, Brzoska T, Bohm M. New insights into the functions of α-MSH and related peptides in the immune system. Ann NY Acad Sci 2003; 994:133-40.
22. Gerlini G, Tun-Kyi A, Dudli C, Burg G, Pimpinelli N, Nestle FO. Metastatic melanoma secreted IL-10 down-regulates CD1 molecules on dendritic cells in metastatic tumor lesions. Am J Pathol 2004; 165:1853-63.
23. La Rocca G, Anzalone R, Bucchieri F, Farina F, Cappello F, Zummo G. CD1a and antitumour immune response. Immunol Lett 2004; 95:1-4.
24. Moody DB, Young DC, Cheng TY et al. T cell activation by lipopeptide antigens. Science (New York, NY) 2004; 303:527-31.
25. Porcelli SA, Segelke BW, Sugita M, Wilson IA, Brenner MB. The CD1 family of lipid antigen-presenting molecules. Immunol Today 1998; 19:362-8.
26. Morelli AE, Rubin JP, Erdos G et al. CD4+ T cell responses elicited by different subsets of human skin migratory dendritic cells. J Immunol 2005; 175:7905-15.
27. Adachi S, Nakano T, Vliagoftis H, Metcalfe DD. Receptor-mediated modulation of murine mast cell function by α-melanocyte stimulating hormone. J Immunol 1999; 163:3363-8.
28. Bohm M, Schiller M, Nashan D, Stadler R, Luger TA, Metze D. Diffuse melanosis arising from metastatic melanoma: pathogenetic function of elevated melanocyte peptide growth factors. J Am Acad Dermatol 2001; 44:747-54.
29. Morandini R, Boeynaems JM, Hedley SJ, MacNeil S, Ghanem G. Modulation of ICAM-1 expression by α-MSH in human melanoma cells and melanocytes. J Cell Physiol 1998; 175:276-82.
30. Scholzen TE, Sunderkotter C, Kalden DH et al. α-Melanocyte stimulating hormone prevents lipopolysaccharide-induced vasculitis by down-regulating endothelial cell adhesion molecule expression. Endocrinology 2003; 144:360-70.
31. Kuhlman P, Moy VT, Lollo BA, Brian AA. The accessory function of murine intercellular adhesion molecule-1 in T lymphocyte activation. Contributions of adhesion and co-activation. J Immunol 1991; 146:1773-82.
32. Smits HH, de Jong EC, Schuitemaker JH, Geijtenbeek TB, van Kooyk Y, Kapsenberg ML, Wierenga EA. Intercellular adhesion molecule-1/LFA-1 ligation favors human Th1 development. J Immunol 2002; 168:1710-6.
33. Young JW, Baggers J, Soergel SA. High-dose UV-B radiation alters human dendritic cell costimulatory activity but does not allow dendritic cells to tolerize T lymphocytes to alloantigen in vitro. Blood 1993; 81:2987-97.
34. Miller MJ, Hejazi AS, Wei SH, Cahalan MD, Parker I. T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node. Proc Natl Acad Sci USA 2004; 101:998-1003.
35. Swetman Andersen CA, Handley M, Pollara G, Ridley AJ, Katz DR, Chain BM. β1-Integrins determine the dendritic morphology which enhances DC-SIGN-mediated particle capture by dendritic cells. Int Immunol 2006; 18:1295-303.
36. Ao Y, Park HY, Olaizola-Horn S, Gilchrest BA. Activation of cAMP-dependent protein kinase is required for optimal α-melanocyte- stimulating hormone-induced pigmentation. Exp Cell Res 1998; 244:117-24.
37. Busca R, Ballotti R. Cyclic AMP a key messenger in the regulation of skin pigmentation. Pigment Cell Res /sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2000; 13:60-9.
38. Chai B, Li JY, Zhang W, Ammori JB, Mulholland MW. Melanocortin-3 receptor activates MAP kinase via PI3 kinase. Regul Pept 2007; 3:115-21.
39. Daniels D, Patten CS, Roth JD, Yee DK, Fluharty SJ. Melanocortin receptor signaling through mitogen-activated protein kinase in vitro and in rat hypothalamus. Brain Res 2003; 2:1-11.
40. Puig-Kroger A, Relloso M, Fernandez-Capetillo O, Zubiaga A, Silva A, Bernabeu C, Corbi AL. Extracellular signal-regulated protein kinase signaling pathway negatively regulates the phenotypic and functional maturation of monocyte-derived human dendritic cells. Blood 2001; 98:2175-82.
41. Dumaz N, Marais R. Integrating signals between cAMP and the RAS/RAF/MEK/ERK signalling pathways. Based on the anniversary prize of the Gesellschaft fur Biochemie und Molekularbiologie Lecture delivered on 5 July 2003 at the Special FEBS Meeting in Brussels. FEBS J 2005; 272:3491-504.
42. Ghosh S, May MJ, Kopp EB. NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 1998; 16:225-60.
43. Manna SK, Aggarwal BB. α-Melanocyte-stimulating hormone inhibits the nuclear transcription factor NF-κB activation induced by various inflammatory agents. J Immunol 1998; 161:2873-80.
44. Luger TA, Kalden D, Scholzen TE, Brzoska T. α-Melanocyte- stimulating hormone as a mediator of tolerance induction. Pathobiology 1999; 67:318-21.
45. Dumaz N, Hayward R, Martin J et al. In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling. Cancer Res 2006; 66:9483-91.
46. Ghersa P, Hooft van Huijsduijnen R, Whelan J, Cambet Y, Pescini R, DeLamarter JF. Inhibition of E-selectin gene transcription through a cAMP-dependent protein kinase pathway. J Biol Chem 1994; 269:29129-37.