CD4+ T cell responses elicited by different subsets of human skin migratory dendritic cells

Journal of Immunology

Volumn 175, Issue 12, 2005, Pages 7905-7915

  Morelli, Adrian E ^a,b   Peter Rubin, J ^a   Erdos, Geza ^a   Tkacheva, Olga A ^a   Mathers, Alicia R ^a   Zahorchak, Alan F ^a,b   Thomson, Angus W ^a,b   Falo Jr , Louis D ^a   Larregina, Adriana T ^a,c  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; CD4 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 23; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PROTEIN P19; PROTEIN P40; PROTEIN P70; RECOMBINANT CYTOKINE; RECOMBINANT INTERLEUKIN 23; T6 ANTIGEN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ALLOTRANSPLANTATION; ANTIGEN PRESENTING CELL; ARTICLE; CELL INTERACTION; CELL MATURATION; CELL MIGRATION; CELL STIMULATION; CONTROLLED STUDY; DENDRITIC CELL; DERMIS; EPIDERMIS CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOLOGICAL TOLERANCE; MEMORY CELL; PRIORITY JOURNAL; SKIN CELL; T LYMPHOCYTE ACTIVATION; TH1 CELL;

EID: 29144470356     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.175.12.7905     Document Type: Article

References (52)

1. Banchereau, J., and R. M. Steinman. 1998. Dendritic cells and the control of immunity. Nature 392: 245-252.
2. Fitch, F. W., M. D. Mckisise, D. W. Lancki, and T. F. Gajewski. 1993. Differential regulation of murine T lymphocyte subsets. Annu. Rev. Immunol. 11: 29-48.
3. Street, N. E., and T. R. Mossman. 1991. Functional diversity of T lymphocytes due to secretion of different cytokine patterns. FASEB J. 5: 171-177.
4. Yewdell, J. W., and J. R. Bennik. 1992. Cell biology of antigen processing and presentation to MHC class I molecule restricted T lymphocytes. Adv. Immunol. 52: 1-42.
5. York, I. A., and K. L. Rock. 1996. Antigen processing and presentation by class I major histocompatibility complex. Annu. Rev. Immunol. 14: 369-396.
6. + T cells. J. Exp. Med. 83: 1001-1012.
7. Steinman, R. M., and M. C. Nussenzweig. 2002. Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc. Natl. Acad. Sci. USA 99: 351-358.
8. Hawiger, D., K. Inaba, Y. Dorsett, M. Guo, K. Mahnke, M. Rivera, J. V. Ravetch, R. M. Steinman, and M. C. Nussenzweig. 2001. Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J. Exp. Med. 194: 769-779.
9. Steinman, R. M., S. Turley, I. Mellman, and K. Inaba. 2000. The induction of tolerance by dendritic cells that have captured apoptotic cells. J. Exp. Med. 191: 411-416.
10. Morelli, A. E., and A. W. Thomson. 2003. Dendritic cells: regulators of alloimmunity and opportunities for tolerance induction. Immunol. Rev. 196: 125-146.
11. Iezzi, G., E. Scotet, D. Scheidegger, and A. Lanzavecchia. 1999. The interplay between the duration of TCR and cytokine signaling determines T cell polarization. Eur. J. Immunol. 29: 4092-4101.
12. Smits, H. H., E. C. de Jong, J. H. Schuitemaker, T. B. Geijtenbeek, Y. van Kooyk, M. L. Kapsenberg, and E. A. Wierenga. 2002. Intercellular adhesion molecule-1/LFA-1 ligation favors human Th1 development. J. Immunol. 168: 1710-1716.
13. Tanaka, H. C. E. Demeure, M. Rubio, G. Delespesse, and M. Sarfati. 2000. Human monocyte-derived dendritic cells induce naive T cell differentiation into T helper cell type 2 (Th2) or Th1/Th2 effectors: role of stimulator/responder ratio. J. Exp. Med. 192: 405-412.
14. + T cell differentiation. J. Immunol. 159: 5956-5963.
15. + T cell responses: the alternative approaches. Annu. Rev. Immunol. 15: 297-322.
16. Langenkamp, A., G. Casorati, C. Garavaglia, P. Dellabona, A. Lanzavecchia, and F. Sallusto. 2002. T cell priming by dendritic cells: thresholds for proliferation, differentiation and death and intraclonal functional diversification. Eur. J. Immunol. 32: 2046-2054.
17. Lanzavecchia, A., and F. Sallusto. 2001. Antigen decoding by T lymphocytes: from synapses to fate determination. Nat. Immunol. 2: 487-492.
18. Langenkamp, A., M. Messi, A. Lanzavecchia, and F. Sallusto. 2000. Kinetics of dendritic cell activation: impact on priming of Th1, Th2 and nonpolarized T cells. Nat. Immunol. 1: 311-316.
19. Kalinski, P., C. M. U., Hilkens, G. A. Wieren, and M. L. Kapsenberg. 1999. Priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal. Immunol. Today 20: 561-567.
20. Ebner, S., G., Ratzinger, B. Krosbacher, M. Schmuth, A. Weiss, D. Reider, R. A. Kroczek, M. Herold, C. Heufler, P. Fritsch. et al. 2001. Production of IL-12 by human monocyte-derived dendritic cells is optimal when the stimulus is given at the onset of maturation, and is further enhanced by IL-4. J. Immunol. 166: 633-641.
21. Levings, M. K., R. Bacchetta, U. Schulz, and M. G. Roncarolo. 2002. The role of IL-10 and TGF-β in the differentiation and effector function of T regulatory cells. Int. Arch. Allergy Immunol. 129: 263-276.
22. Lutz, M. B., and G. Schuler. 2002. Immature, semi-mature and fully mature; dendritic cells: which signals induce tolerance or immunity? Trends Immunol. 23: 445-449.
23. Kopp, E. B., and R. Medzhitov. 1999. The Toll-receptor family and control of innate immunity. Curr. Opin. Immunol. 11: 13-18.
24. Alexopoulou, L., A. C. Holt, R. Medzhitov, and R. A. Flavell. 2001. Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3. Nature 413: 732-738.
25. Morelli, A. E., A. F. Zahorchak, A. T. Larregina, B. L. Colvin, A. J, Logar, T. Takayama, L. D. Falo, and A. W. Thomson. 2001. Cytokine production by mouse myeloid dendritic cells in relation to differentiation and terminal maturation induced by lipopolysaccharide or CD40 ligation. Blood 98: 1512-1523.
26. Larregina, A. T., and L. D. Falo, Jr. 2001. Dendritic cells in the context of skin immunity. In Dendritic Cells. 2nd Ed. M. T. Lotze and A. T. Thomson, eds. Academic Press. London, pp. 301-314.
27. Condon, C., S. C. Watkins, C. M. Celluzzi, K. Thompson, and L. D. Falo, Jr. 1996. DNA based immunization by in vivo transfection of dendritic cells. Nat. Med. 2: 1122-1128.
28. Larregina, A. T., and L. D. Falo. Jr. 2000. Generating and regulating immune responses through cutaneous gene delivery. Hum. Gene Ther. 11: 2301-2305.
29. Rulifson, I. C., G. L. Szot, E. Palmer, and J. A. Bluestone. 2002. Inability to induce tolerance through direct antigen presentation. Am. J. Transplant. 2: 510-519.
30. Wang, Z., A. Castellaneta, A. De Creus, W. J. Shufesky, A. E. Morelli, and A. W. Thomson. 2004. Heart, but not skin, allografts from donors lacking Flt3 ligand exhibit markedly prolonged survival time. J. Immunol. 172: 5924-5930.
31. + cells differentiate into Langerhans cells. Nat. Immunol. 2: 1151-1158.
32. Nestle, F. O., X. G. Zheng, C. B. Thompson, L. A. Turka, and B. J. Nickoloff, 1993. Characterization of dermal dendritic cells obtained from normal human skin reveals phenotypic and functionally distinctive subsets. J. Immunol. 151: 6535-6545.
33. + T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J. Exp. Med. 192: 1213-1222.
34. + hematopoietic progenitors stimulate greater cytolytic T lymphocyte activity in the absence of bioactive IL-12p70, by either single peptide presentation or cross-priming, than do dermal-interstitial or monocyte-derived dendritic cells. J. Immunol. 173: 2780-2791.
35. Peiser, M., R. Wanner, and G. Kolde. 2004. Human epidermal Langerhans cells differ from monocyte-derived Langerhans cells in CD80 expression and in secretion of IL-12 after CD40 cross-linking. J. Leukocyte. Biol. 76: 616-622.
36. Kang K., M. Kubin, K. D. Cooper, S. R. Lessin, G, Trinchieri, and A. H. Rook. 1996. IL-12 synthesis by human Langerhans cells. J. Immunol. 156: 1402-1407.
37. Hunger, R. E., N. Yawalkar, L. R. Braathen, and C. U. Brand. 2001. CD1a-positive dendritic cells transport the antigen DNCB intracellularly from the skin to the regional lymph nodes in the induction phase of allergic contact dermatitis. Arch. Dermatol. Res. 293: 420-426.
38. Brand, C. U., R. E. Hunger, N. Yawalkar, H. A. Gerber, T. Schaffner, and L. R. Braathen. 1999. Characterization of human skin-derived CD1a-positive lymph cells. Arch. Dermatol. Res. 291: 65-72.
39. Jonuleit, H., E. Schmitt, K. Steinbrink and A. H. Enk. 2001. Dendritic cells as a tool to induce anergic and regulatory T cells. Trends Immunol. 22: 394-400.
40. Mailliard, R. B., A. Wankowicz-Kalinska, Q. Cai, A. Wesa, C. M. Hilkens, M. L. Kapsenberg, J. M. Kirkwood, W. J. Storkus, and P. Kalinski. 2004. Alpha-type-1 polarized dendritic cells: a novel immunization tool with optimized CTL-inducing activity. Cancer Res. 64: 5934-5937.
41. Trinchieri, G. 2003, Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3: 133-146.
42. Oppmann, B., R. Lesley, B. Blom, J. C. Timans, Y. Xu, B. Hunte, F. Vega, N. Yu, J. Wang, J. K. Singh, et al. 2000. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13: 715-725.
43. Cua, D. J., J. Sherlock, Y. Chen, C. A. Murphy, B. Joyce, B. Seymour, L. Lucian, W. To, S. Kwan, T. Churakova, et al. 2003. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421: 744-748.
44. Langrish, C. L., B. S. McKenzie, N. J. Wilson, R. de Waal Malefyt, R. A. Kastelein, and D. J. Cua. 2004. IL-12 and IL-23: master regulators of innate and adaptive immunity. Immunol Rev. 202: 96-105.
45. Kopp, T., P. Lenz, C. Bello-Fernandez, R. A. Kastelein, T. S. Kupper, and G. Stingl. 2003. IL-23 production by cosecretion of endogenous p19 and transgenic p40 in keratin 14/p40 transgenic mice: evidence for enhanced cutaneous immunity. J. Immunol. 170: 5438-5444.
46. Vanden Eijnden, S., S. Goriely, D. De Wit, F. Willems, and M. Goldman. 2005. IL-23 up-regulates IL-10 and induces IL-17 synthesis by polyclonally activated naive T cells in human. Eur. J. Immunol. 35: 469-475.
47. Lee, E., W. L. Trepicchio, J. L. Oestreicher, D. Pittman, F. Wang, F. Chamian, M. Dhodapkar, and J. G. Krueger. 2004. Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris. J. Exp. Med. 199: 125-130.
48. Amsen, D., J. M. Blander, G. R. Lee, K. Tanigaki, T. Honjo, and R. A. Flavell. 2004. Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell 117: 515-526.
49. Hosoi, J., G. F, Murphy, C. L. Egan, E. A. Lerner, S. Grabbe, A. Asahina, and R. D. Granstein. 1993. Regulation of Langerhans cell function by nerves containing calcitonin'gene-related peptide. Nature 363: 159-163.
50. Yoshida, Y., K. Kang, M. Berger, G. Chen, A. C. Gilliam, A. Moser, L. Wu, C. Hammerberg, and K. D. Cooper, 1998. Monocyte induction of IL-10 and down-regulation of IL-12 by iC3b deposited in ultraviolet-exposed human skin. J. Immunol 161: 5873-5879.
51. Liu, K., T. Iyoda, M. Saternus, Y. Kimura, K. Inaba, and R. M. Steinman. 2002. Immune tolerance after delivery of dying cells to dendritic cells in situ. J. Exp. Med. 196: 1091-1097.
52. Morelli, A. E., A. T. Larregina, W. J. Shufesky, A. F. Zahorchak, A. J. Logar, G. D. Papworth, Z. Wang, S. C. Watkins, L. D. Falo, Jr., and A. W. Thomson. 2003. Internalization of circulating apoptotic cells by splenic marginal zone dendritic cells: dependence on complement receptors and effect on cytokine production. Blood 101: 611-620.