-
2
-
-
20044386298
-
Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: Implications for Lewy body formation
-
Lim KL, Chew KC, Tan JM, et al. Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation. J Neurosci 2005;25:2002-2009.
-
(2005)
J Neurosci
, vol.25
, pp. 2002-2009
-
-
Lim, K.L.1
Chew, K.C.2
Tan, J.M.3
-
3
-
-
33947178563
-
Alzheimer disease, the two-hit hypothesis: An update
-
Zhu X, Lee HG, Perry G, Smith MA. Alzheimer disease, the two-hit hypothesis: an update. Biochim Biophys Acta 2007;1772: 494-502.
-
(2007)
Biochim Biophys Acta
, vol.1772
, pp. 494-502
-
-
Zhu, X.1
Lee, H.G.2
Perry, G.3
Smith, M.A.4
-
4
-
-
33947289969
-
Cell division in the CNS: Protective response or lethal event in post-mitotic neurons?
-
Yang Y, Herrup K. Cell division in the CNS: protective response or lethal event in post-mitotic neurons? Biochim Biophys Acta 2007;1772:457-466.
-
(2007)
Biochim Biophys Acta
, vol.1772
, pp. 457-466
-
-
Yang, Y.1
Herrup, K.2
-
5
-
-
69449084829
-
Neuronal migration and neurodegeneration: 2 sides of the same coin
-
Reiner O, Shmueli A, Sapir T. Neuronal migration and neurodegeneration: 2 sides of the same coin. Cereb Cortex 2009;19:142-148.
-
(2009)
Cereb Cortex
, vol.19
, pp. 142-148
-
-
Reiner, O.1
Shmueli, A.2
Sapir, T.3
-
6
-
-
57649174625
-
Intramembrane proteolysis by gamma-secretase
-
Steiner H, Fluhrer R, Haass C. Intramembrane proteolysis by gamma-secretase. J Biol Chem 2008;283:29627-29631.
-
(2008)
J Biol Chem
, vol.283
, pp. 29627-29631
-
-
Steiner, H.1
Fluhrer, R.2
Haass, C.3
-
7
-
-
17844410115
-
Notch signaling, brain development, and human disease
-
Lasky JL, Wu H. Notch signaling, brain development, and human disease. Pediatr Res 2005;57:104R-109R.
-
(2005)
Pediatr Res
, vol.57
-
-
Lasky, J.L.1
Wu, H.2
-
8
-
-
0034054499
-
P75 neurotrophin receptor in the nucleus basalis of Meynert in relation to age, sex, and Alzheimer's disease
-
Salehi A, Ocampo M, Verhaagen J, Swaab DF. P75 neurotrophin receptor in the nucleus basalis of Meynert in relation to age, sex, and Alzheimer's disease. Exp Neurol 2000;161:245-258.
-
(2000)
Exp Neurol
, vol.161
, pp. 245-258
-
-
Salehi, A.1
Ocampo, M.2
Verhaagen, J.3
Swaab, D.F.4
-
9
-
-
0142242199
-
Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor
-
Jung KM, Tan S, Landman N, et al. Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor. J Biol Chem 2003;278: 42161-42169.
-
(2003)
J Biol Chem
, vol.278
, pp. 42161-42169
-
-
Jung, K.M.1
Tan, S.2
Landman, N.3
-
10
-
-
42349090693
-
A model for neuronal competition during development
-
Deppmann CD, Mihalas S, Sharma N, et al. A model for neuronal competition during development. Science 2008;320:369-373.
-
(2008)
Science
, vol.320
, pp. 369-373
-
-
Deppmann, C.D.1
Mihalas, S.2
Sharma, N.3
-
11
-
-
0032809906
-
p75-mediated NF-kappaB activation enhances the survival response of developing sensory neurons to nerve growth factor
-
Hamanoue M, Middleton G, Wyatt S, et al. p75-mediated NF-kappaB activation enhances the survival response of developing sensory neurons to nerve growth factor. Mol Cell Neurosci 1999; 14:28-40.
-
(1999)
Mol Cell Neurosci
, vol.14
, pp. 28-40
-
-
Hamanoue, M.1
Middleton, G.2
Wyatt, S.3
-
12
-
-
26944498689
-
The intracellular domain of p75NTR as a determinant of cellular reducing potential and response to oxidant stress
-
Tyurina YY, Nylander KD, Mirnics ZK, et al. The intracellular domain of p75NTR as a determinant of cellular reducing potential and response to oxidant stress. Aging Cell 2005;4:187-196.
-
(2005)
Aging Cell
, vol.4
, pp. 187-196
-
-
Tyurina, Y.Y.1
Nylander, K.D.2
Mirnics, Z.K.3
-
13
-
-
1442295841
-
Apoptosis and dependence receptors: A molecular basis for cellular addiction
-
Bredesen DE, Mehlen P, Rabizadeh S. Apoptosis and dependence receptors: a molecular basis for cellular addiction. Physiol Rev 2004;84:411-430.
-
(2004)
Physiol Rev
, vol.84
, pp. 411-430
-
-
Bredesen, D.E.1
Mehlen, P.2
Rabizadeh, S.3
-
14
-
-
24944458934
-
Cholesterol biosynthesis and the pro-apoptotic effects of the p75 nerve growth factor receptor in PC12 pheochromocytoma cells
-
Yan Ch, Mirnics ZK, Portugal CF, et al. Cholesterol biosynthesis and the pro-apoptotic effects of the p75 nerve growth factor receptor in PC12 pheochromocytoma cells. Brain Res Mol Brain Res 2005;139:225-234.
-
(2005)
Brain Res Mol Brain Res
, vol.139
, pp. 225-234
-
-
Yan, C.1
Mirnics, Z.K.2
Portugal, C.F.3
-
15
-
-
34547726261
-
Expression and p75 neurotrophin receptor dependence of cholesterol synthetic enzymes in adult mouse brain
-
Korade Z, Mi Z, Portugal CF, Schor NF. Expression and p75 neurotrophin receptor dependence of cholesterol synthetic enzymes in adult mouse brain. Neurobiol Aging 2007;28:1522-1531.
-
(2007)
Neurobiol Aging
, vol.28
, pp. 1522-1531
-
-
Korade, Z.1
Mi, Z.2
Portugal, C.F.3
Schor, N.F.4
-
16
-
-
53749105377
-
Presenilins: Members of the gamma-secretase quartets, but part-time soloists too
-
Bethesda, Md
-
Wakabayashi T, De Strooper B. Presenilins: members of the gamma-secretase quartets, but part-time soloists too. Physiology (Bethesda, Md) 2008;23:194-204.
-
(2008)
Physiology
, vol.23
, pp. 194-204
-
-
Wakabayashi, T.1
De Strooper, B.2
-
17
-
-
0027407565
-
Apolipoprotein E: High-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease
-
Strittmatter WJ, Saunders AM, Schmechel D, et al. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci USA 1993;90:1977-1981.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 1977-1981
-
-
Strittmatter, W.J.1
Saunders, A.M.2
Schmechel, D.3
-
18
-
-
44649197748
-
ApoE promotes the proteolytic degradation of Abeta
-
Jiang Q, Lee CY, Mandrekar S, et al. ApoE promotes the proteolytic degradation of Abeta. Neuron 2008;58:681-693.
-
(2008)
Neuron
, vol.58
, pp. 681-693
-
-
Jiang, Q.1
Lee, C.Y.2
Mandrekar, S.3
-
19
-
-
0033213256
-
Reelin is a ligand for lipoprotein receptors
-
D'Arcangelo G, Homayouni R, Keshvara L, et al. Reelin is a ligand for lipoprotein receptors. Neuron 1999;24:471-479.
-
(1999)
Neuron
, vol.24
, pp. 471-479
-
-
D'Arcangelo, G.1
Homayouni, R.2
Keshvara, L.3
-
20
-
-
0032031914
-
Reeler: New tales on an old mutant mouse
-
D'Arcangelo G, Curran T. Reeler: new tales on an old mutant mouse. Bioessays 1998;20:235-244.
-
(1998)
Bioessays
, vol.20
, pp. 235-244
-
-
D'Arcangelo, G.1
Curran, T.2
-
21
-
-
58149379046
-
Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway
-
Park TJ, Curran T. Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway. J Neurosci 2008;28:13551-13562.
-
(2008)
J Neurosci
, vol.28
, pp. 13551-13562
-
-
Park, T.J.1
Curran, T.2
-
22
-
-
53849138043
-
Interaction between Reelin and Notch signaling regulates neuronal migration in the cerebral cortex
-
Hashimoto-Torii K, Torii M, Sarkisian MR, et al. Interaction between Reelin and Notch signaling regulates neuronal migration in the cerebral cortex. Neuron 2008;60:273-284.
-
(2008)
Neuron
, vol.60
, pp. 273-284
-
-
Hashimoto-Torii, K.1
Torii, M.2
Sarkisian, M.R.3
-
23
-
-
34548661479
-
Reelin and mDab1 regulate the development of hippocampal connections
-
Borrell V, Pujadas L, Simó S, et al. Reelin and mDab1 regulate the development of hippocampal connections. Mol Cell Neurosci 2007;36:158-173.
-
(2007)
Mol Cell Neurosci
, vol.36
, pp. 158-173
-
-
Borrell, V.1
Pujadas, L.2
Simó, S.3
-
24
-
-
41949138166
-
Mutations in the very lowdensity lipoprotein receptor VLDLR cause cerebellar hypoplasia and quadrupedal locomotion in humans
-
Ozcelik T, Akarsu N, Uz E, et al. Mutations in the very lowdensity lipoprotein receptor VLDLR cause cerebellar hypoplasia and quadrupedal locomotion in humans. Proc Natl Acad Sci USA 2008;105:4232-4236.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 4232-4236
-
-
Ozcelik, T.1
Akarsu, N.2
Uz, E.3
-
25
-
-
8144229817
-
Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila
-
Merdes G, Soba P, Loewer A, et al. Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila. EMBO J 2004;23:4082-4095.
-
(2004)
EMBO J
, vol.23
, pp. 4082-4095
-
-
Merdes, G.1
Soba, P.2
Loewer, A.3
-
26
-
-
32044468963
-
Mouse disabled 1 regulates the nuclear position of neurons in a Drosophila eye model
-
Pramatarova A, Ochalski PG, Lee CH, Howell BW. Mouse disabled 1 regulates the nuclear position of neurons in a Drosophila eye model. Mol Cell Biol 2006;26:1510-1517.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 1510-1517
-
-
Pramatarova, A.1
Ochalski, P.G.2
Lee, C.H.3
Howell, B.W.4
-
27
-
-
39749154803
-
Amyloid precursor protein cytoplasmic domain antagonizes reelin neurite outgrowth inhibition of hippocampal neurons
-
Hoareau C, Borrell V, Soriano E, et al. Amyloid precursor protein cytoplasmic domain antagonizes reelin neurite outgrowth inhibition of hippocampal neurons. Neurobiol Aging 2008;29:542-553.
-
(2008)
Neurobiol Aging
, vol.29
, pp. 542-553
-
-
Hoareau, C.1
Borrell, V.2
Soriano, E.3
-
28
-
-
37349015897
-
A genetic interaction between the APP and Dab1 genes influences brain development
-
Pramatarova A, Chen K, Howell BW. A genetic interaction between the APP and Dab1 genes influences brain development. Mol Cell Neurosci 2008;37:178-186.
-
(2008)
Mol Cell Neurosci
, vol.37
, pp. 178-186
-
-
Pramatarova, A.1
Chen, K.2
Howell, B.W.3
-
29
-
-
0028985267
-
The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system
-
Iwai A, Masliah E, Yoshimoto M, et al. The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. Neuron 1995;14: 467-475.
-
(1995)
Neuron
, vol.14
, pp. 467-475
-
-
Iwai, A.1
Masliah, E.2
Yoshimoto, M.3
-
31
-
-
0345189364
-
Yeast cells provide insight into alpha-Synuclein biology and pathobiology
-
Outeiro TF, Lindquist S. Yeast cells provide insight into alpha-Synuclein biology and pathobiology. Science 2003;302: 1772-1775.
-
(2003)
Science
, vol.302
, pp. 1772-1775
-
-
Outeiro, T.F.1
Lindquist, S.2
-
32
-
-
0034077041
-
Mice lacking alpha-Synuclein display functional deficits in the nigrostriatal dopamine system
-
Abeliovich A, Schmitz Y, Fariñas I, et al. Mice lacking alpha-Synuclein display functional deficits in the nigrostriatal dopamine system. Neuron 2000;25:239-252.
-
(2000)
Neuron
, vol.25
, pp. 239-252
-
-
Abeliovich, A.1
Schmitz, Y.2
Fariñas, I.3
-
33
-
-
0035066885
-
Direct binding and functional coupling of alpha-Synuclein to the dopamine transporters accelerate dopamine-induced apoptosis
-
Lee FJ, Liu F, Pristupa ZB, Niznik HB. Direct binding and functional coupling of alpha-Synuclein to the dopamine transporters accelerate dopamine-induced apoptosis. FASEB J 2001;15:916-926.
-
(2001)
FASEB J
, vol.15
, pp. 916-926
-
-
Lee, F.J.1
Liu, F.2
Pristupa, Z.B.3
Niznik, H.B.4
-
35
-
-
33846471122
-
Proteasome-independent functions of ubiquitin in endocytosis and signaling
-
Mukhopadhyay D, Riezman H. Proteasome-independent functions of ubiquitin in endocytosis and signaling. Science 2007;315: 201-205.
-
(2007)
Science
, vol.315
, pp. 201-205
-
-
Mukhopadhyay, D.1
Riezman, H.2
-
36
-
-
65649118917
-
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation
-
Xiong H, Wang D, Chen L, et al. Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. J Clin Invest 2009;119:650-660.
-
(2009)
J Clin Invest
, vol.119
, pp. 650-660
-
-
Xiong, H.1
Wang, D.2
Chen, L.3
-
37
-
-
2442481789
-
Mitochondrial dysfunction and oxidative damage in Parkin-deficient mice
-
Palacino JJ, Sagi D, Goldberg MS, et al. Mitochondrial dysfunction and oxidative damage in Parkin-deficient mice. J Biol Chem 2004;279:18614-18622.
-
(2004)
J Biol Chem
, vol.279
, pp. 18614-18622
-
-
Palacino, J.J.1
Sagi, D.2
Goldberg, M.S.3
-
38
-
-
33746594215
-
A regulated interaction with the UIM protein Eps15 implicates Parkin in EGF receptor trafficking and PI(3)K-Akt signalling
-
Fallon L, Bélanger CM, Corera AT, et al. A regulated interaction with the UIM protein Eps15 implicates Parkin in EGF receptor trafficking and PI(3)K-Akt signalling. Nat Cell Biol 2006;8: 834-842.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 834-842
-
-
Fallon, L.1
Bélanger, C.M.2
Corera, A.T.3
-
39
-
-
67449132349
-
p75NTR modulation of cellular handling of reactive oxygen species
-
Mi Z, Rogers D, Mirnics ZK, Schor NF. p75NTR modulation of cellular handling of reactive oxygen species. J Neurochem 2009; 110:296-306.
-
(2009)
J Neurochem
, vol.110
, pp. 296-306
-
-
Mi, Z.1
Rogers, D.2
Mirnics, Z.K.3
Schor, N.F.4
-
40
-
-
34548489211
-
DJ-1 and UCH-L1 gene activity patterns in the brains of controls, Parkinson and schizophrenia patients and in rodents
-
Galter D, Westerlund M, Belin AC, Olson L. DJ-1 and UCH-L1 gene activity patterns in the brains of controls, Parkinson and schizophrenia patients and in rodents. Physiol Behav 2007;92:46-53.
-
(2007)
Physiol Behav
, vol.92
, pp. 46-53
-
-
Galter, D.1
Westerlund, M.2
Belin, A.C.3
Olson, L.4
-
41
-
-
0037131567
-
The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-Synuclein degradation and Parkinson's disease susceptibility
-
Liu Y, Fallon L, Lashuel HA, et al. The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-Synuclein degradation and Parkinson's disease susceptibility. Cell 2002;111: 209-218.
-
(2002)
Cell
, vol.111
, pp. 209-218
-
-
Liu, Y.1
Fallon, L.2
Lashuel, H.A.3
-
42
-
-
31644448703
-
Ubiquitin C-terminal hydrolase L1 regulates the morphology of neural progenitor cells and modulates their differentiation
-
Sakurai M, Ayukawa K, Setsuie R, et al. Ubiquitin C-terminal hydrolase L1 regulates the morphology of neural progenitor cells and modulates their differentiation. J Cell Sci 2006;119:162-171.
-
(2006)
J Cell Sci
, vol.119
, pp. 162-171
-
-
Sakurai, M.1
Ayukawa, K.2
Setsuie, R.3
-
43
-
-
36049038504
-
Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by Parkin
-
Exner N, Treske B, Paquet D, et al. Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by Parkin. J Neurosci 2007;27:12413-12418.
-
(2007)
J Neurosci
, vol.27
, pp. 12413-12418
-
-
Exner, N.1
Treske, B.2
Paquet, D.3
-
44
-
-
2942684871
-
The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization
-
Canet-Avilés RM, Wilson MA, Miller DW, et al. The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization. Proc Natl Acad Sci USA 2004;101:9103-9108.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 9103-9108
-
-
Canet-Avilés, R.M.1
Wilson, M.A.2
Miller, D.W.3
-
45
-
-
59049105937
-
DJ-1/PARK7 is an important mediator of hypoxia-induced cellular responses
-
Vasseur S, Afzal S, Tardivel-Lacombe J, et al. DJ-1/PARK7 is an important mediator of hypoxia-induced cellular responses. Proc Natl Acad Sci USA 2009;106:1111-1116.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 1111-1116
-
-
Vasseur, S.1
Afzal, S.2
Tardivel-Lacombe, J.3
-
46
-
-
33646151866
-
LRRK2 in Parkinson's disease: Protein domains and functional insights
-
Mata IF, Wedemeyer WJ, Farrer MJ, et al. LRRK2 in Parkinson's disease: protein domains and functional insights. Trends Neurosci 2006;29:286-293.
-
(2006)
Trends Neurosci
, vol.29
, pp. 286-293
-
-
Mata, I.F.1
Wedemeyer, W.J.2
Farrer, M.J.3
-
47
-
-
40949145205
-
Developmental regulation of leucine-rich repeat kinase 1 and 2 expression in the brain and other rodent and human organs: Implications for Parkinson's disease
-
Westerlund M, Belin AC, Anvret A, et al. Developmental regulation of leucine-rich repeat kinase 1 and 2 expression in the brain and other rodent and human organs: implications for Parkinson's disease. Neuroscience 2008;152:429-436.
-
(2008)
Neuroscience
, vol.152
, pp. 429-436
-
-
Westerlund, M.1
Belin, A.C.2
Anvret, A.3
-
48
-
-
42149172511
-
RNA interference of LRRK2-microarray expression analysis of a Parkinson's disease key player
-
Hä big K, Walter M, Poths S, et al. RNA interference of LRRK2-microarray expression analysis of a Parkinson's disease key player. Neurogenetics 2008;9:83-94.
-
(2008)
Neurogenetics
, vol.9
, pp. 83-94
-
-
Hä big, K.1
Walter, M.2
Poths, S.3
-
49
-
-
51949090816
-
Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
-
Imai Y, Gehrke S, Wang HQ, et al. Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila. EMBO J 2008;27:2432-2443.
-
(2008)
EMBO J
, vol.27
, pp. 2432-2443
-
-
Imai, Y.1
Gehrke, S.2
Wang, H.Q.3
|