Roles of sema4D-plexin-B1 interactions in the central nervous system for pathogenesis of experimental autoimmune encephalomyelitis

Journal of Immunology

Volumn 184, Issue 3, 2010, Pages 1499-1506

  Okuno, Tatsusada ^a,b,c   Nakatsuji, Yuji ^c   Moriya, Masayuki ^c   Takamatsu, Hyota ^a,b   Nojima, Satoshi ^a,b   Takegahara, Noriko ^a,b   Toyofuku, Toshihiko ^a,b   Nakagawa, Yukinobu ^a,b   Kang, Sujin ^a,b   Friedel, Roland H ^d,e   Sakoda, Saburo ^c   Kikutani, Hitoshi ^a   Kumanogoh, Atsushi ^a,b  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d INSTITUTE OF EPIDEMIOLOGY   (Germany)

^e MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INDUCIBLE NITRIC OXIDE SYNTHASE; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; PLEXIN; PLEXIN B1; PROTEIN ANTIBODY; SEMAPHORIN; SEMAPHORIN 4D; UNCLASSIFIED DRUG; CELL SURFACE RECEPTOR; NERVE PROTEIN; PLXNB1 PROTEIN, MOUSE; SEMA4D PROTEIN, MOUSE;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW; CELL INFILTRATION; CENTRAL NERVOUS SYSTEM; CHIMERA; CONTROLLED STUDY; DISEASE COURSE; IMMUNIZATION; LYMPHOCYTE TRANSFER; MICROGLIA; MONONUCLEAR CELL; MOUSE; NERVOUS SYSTEM INFLAMMATION; NEWBORN; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; T LYMPHOCYTE; WILD TYPE; AMINO ACID SEQUENCE; ANIMAL; BONE MARROW CELL; C57BL MOUSE; CELL CULTURE; ENZYMOLOGY; GENETICS; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; RADIATION CHIMERA; UPREGULATION;

AMINO ACID SEQUENCE; ANIMALS; BONE MARROW CELLS; CELLS, CULTURED; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROGLIA; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; RADIATION CHIMERA; RECEPTORS, CELL SURFACE; SEMAPHORINS; UP-REGULATION;

EID: 77949328929     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0903302     Document Type: Article

References (37)

1. Ransohoff, R. M., and V. H. Perry. 2009. Microglial physiology: unique stimuli, specialized responses. Annu. Rev. Immunol. 27: 119-145.
2. Heppner, F. L., M. Greter, D. Marino, J. Falsig, G. Raivich, N. Hövelmeyer, A.Waisman, T. Rülicke, M. Prinz, J. Priller, et al. 2005. Experimental autoimmune encephalomyelitis repressed by microglial paralysis. Nat. Med. 11: 146-152.
3. Jack, C., F. Ruffini, A. Bar-Or, and J. P. Antel. 2005. Microglia and multiple sclerosis. J. Neurosci. Res. 81: 363-373.
4. Ponomarev, E. D., L. P. Shriver, and B. N. Dittel. 2006. CD40 expression by microglial cells is required for their completion of a two-step activation process during central nervous system autoimmune inflammation. J. Immunol. 176: 1402-1410.
5. Tan, J., T. Town, D. Paris, T. Mori, Z. Suo, F. Crawford, M. P. Mattson, R. A. Flavell, and M. Mullan. 1999. Microglial activation resulting from CD40-CD40L interaction after β-amyloid stimulation. Science 286: 2352-2355. (Pubitemid 30016899)
6. Becher, B., B. G. Durell, A. V. Miga, W. F. Hickey, and R. J. Noelle. 2001. The clinical course of experimental autoimmune encephalomyelitis and inflammation is controlled by the expression of CD40 within the central nervous system. J. Exp. Med. 193: 967-974.
7. Gerritse, K., J. D. Laman, R. J. Noelle, A. Aruffo, J. A. Ledbetter, W. J. Boersma, and E. Claassen. 1996. CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis. Proc. Natl. Acad. Sci. U.S.A. 93: 2499-2504.
8. Okuno, T., Y. Nakatsuji, A. Kumanogoh, M. Moriya, H. Ichinose, H. Sumi, H. Fujimura, H. Kikutani, and S. Sakoda. 2005. Loss of dopaminergic neurons by the induction of inducible nitric oxide synthase and cyclooxygenase-2 via CD 40: relevance to Parkinson's disease. J. Neurosci. Res. 81: 874-882.
9. Kolodkin, A. L., D. J. Matthes, and C. S. Goodman. 1993. The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules. Cell 75: 1389-1399. (Pubitemid 2030495)
10. Zhou, Y., R. A. Gunput, and R. J. Pasterkamp. 2008. Semaphorin signaling: progress made and promises ahead. Trends Biochem. Sci. 33: 161-170.
11. Suzuki, K., A. Kumanogoh, and H. Kikutani. 2008. Semaphorins and their receptors in immune cell interactions. Nat. Immunol. 9: 17-23.
12. Bougeret, C., I. G. Mansur, H. Dastot, M. Schmid, G. Mahouy, A. Bensussan, and L. Boumsell. 1992. Increased surface expression of a newly identified 150-kDa dimer early after human T lymphocyte activation. J. Immunol. 148: 318-323.
13. Shi, W., A. Kumanogoh, C. Watanabe, J. Uchida, X. Wang, T. Yasui, K. Yukawa, M. Ikawa, M. Okabe, J. R. Parnes, et al. 2000. The class IV semaphorin CD100 plays nonredundant roles in the immune system: defective B and T cell activation in CD100-deficient mice. Immunity 13: 633-642.
14. Tamagnone, L., S. Artigiani, H. Chen, Z. He, G. I. Ming, H. Song, A. Chedotal, M. L. Winberg, C. S. Goodman, M. Poo, et al. 1999. Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Cell 99: 71-80.
15. Kumanogoh, A., C. Watanabe, I. Lee, X. Wang, W. Shi, H. Araki, H. Hirata, K. Iwahori, J. Uchida, T. Yasui, et al. 2000. Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling. Immunity 13: 621-631.
16. Kumanogoh, A., K. Suzuki, E. Ch'ng, C. Watanabe, S. Marukawa, N. Takegahara, I. Ishida, T. Sato, S. Habu, K.Yoshida, et al. 2002. Requirement for the lymphocyte semaphorin, CD100, in the induction of antigen-specific T cells and the maturation of dendritic cells. J. Immunol. 169: 1175-1181.
17. Swiercz, J. M., R. Kuner, J. Behrens, and S. Offermanns. 2002. Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology. Neuron 35: 51-63.
18. Oinuma, I., Y. Ishikawa, H. Katoh, and M. Negishi. 2004. The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras. Science 305: 862-865.
19. Czopik, A. K., M. S. Bynoe, N. Palm, C. S. Raine, and R. Medzhitov. 2006. Semaphorin 7A is a negative regulator of T cell responses. Immunity 24: 591-600.
20. Suzuki, K., T. Okuno, M. Yamamoto, R. J. Pasterkamp, N. Takegahara, H. Takamatsu, T. Kitao, J. Takagi, P. D. Rennert, A. L. Kolodkin, et al. 2007. Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin. Nature 446: 680-684.
21. Giraudon, P., P. Vincent, C. Vuaillat, O. Verlaeten, L. Cartier, A. Marie-Cardine, M. Mutin, A. Bensussan, M. F. Belin, and L. Boumsell. 2004. Semaphorin CD100 from activated T lymphocytes induces process extension collapse in oligodendrocytes and death of immature neural cells. J. Immunol. 172: 1246-1255.
22. Friedel, R. H., G. Kerjan, H. Rayburn, U. Schüller, C. Sotelo, M. Tessier-Lavigne, and A. Chédotal. 2007. Plexin-B2 controls the development of cerebellar granule cells. J. Neurosci. 27: 3921-3932. (Pubitemid 46557674)
23. Friedel, R. H., A. Plump, X. Lu, K. Spilker, C. Jolicoeur, K. Wong, T. R. Venkatesh, A. Yaron, M. Hynes, B. Chen, et al. 2005. Gene targeting using a promoterless gene trap vector ("targeted trapping") is an efficient method to mutate a large fraction of genes. Proc. Natl. Acad. Sci. USA 102: 13188-13193.
24. Pan, C., N. Baumgarth, and J. R. Parnes. 1999. CD72-deficient mice reveal nonredundant roles of CD72 in B cell development and activation. Immunity 11: 495-506. (Pubitemid 29504204)
25. Kanzawa, T., M. Sawada, K. Kato, K. Yamamoto, H. Mori, and R. Tanaka. 2000. Differentiated regulation of allo-antigen presentation by different types of murine microglial cell lines. J. Neurosci. Res. 62: 383-388.
26. Okuno, T., Y. Nakatsuji, A. Kumanogoh, K. Koguchi, M. Moriya, H. Fujimura, H. Kikutani, and S. Sakoda. 2004. Induction of cyclooxygenase-2 in reactive glial cells by the CD40 pathway: relevance to amyotrophic lateral sclerosis. J. Neurochem. 91: 404-412.
27. Jana, M., X. Liu, S. Koka, S. Ghosh, T. M. Petro, and K. Pahan. 2001. Ligation of CD40 stimulates the induction of nitric-oxide synthase in microglial cells. J. Biol. Chem. 276: 44527-44533.
28. Bhat, N. R., P. Zhang, J. C. Lee, and E. L. Hogan. 1998. Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-α gene expression in endotoxin-stimulated primary glial cultures. J. Neurosci. 18: 1633-1641.
29. Han, I. O., K. W. Kim, J. H. Ryu, and W. K. Kim. 2002. p38 mitogen-activated protein kinase mediates lipopolysaccharide, not interferon-γ, -induced inducible nitric oxide synthase expression in mouse BV2 microglial cells. Neurosci. Lett. 325: 9-12.
30. Wang, X., A. Kumanogoh, C. Watanabe, W. Shi, K. Yoshida, and H. Kikutani. 2001. Functional soluble CD100/Sema4D released from activated lymphocytes: possible role in normal and pathologic immune responses. Blood 97: 3498-3504.
31. Kumanogoh, A., and H. Kikutani. 2001. The CD100-CD72 interaction: a novel mechanism of immune regulation. Trends Immunol. 22: 670-676.
32. Han, I. O., H. S. Kim, H. C. Kim, E. H. Joe, and W. K. Kim. 2003. Synergistic expression of inducible nitric oxide synthase by phorbol ester and interferon-γ is mediated through NF-kappaB and ERK in microglial cells. J. Neurosci. Res. 73: 659-669.
33. Tan, J., T. Town, M. Saxe, D. Paris, Y. Wu, and M. Mullan. 1999. Ligation of microglial CD40 results in p44/42 mitogen-activated protein kinase-dependent TNF-α production that is opposed by TGF-b 1 and IL-10. J. Immunol. 163: 6614-6621.
34. Aurandt, J., W. Li, and K. L. Guan. 2006. Semaphorin 4D activates the MAPK pathway downstream of plexin-B1. Biochem. J. 394: 459-464.
35. Basile, J. R., J. Gavard, and J. S. Gutkind. 2007. Plexin-B1 utilizes RhoA and r kinase to promote the integrin-dependent activation of Akt and ERK and endothelial cell motility. J. Biol. Chem. 282: 34888-34895.
36. Swiercz, J. M., R. Kuner, and S. Offermanns. 2004. Plexin-B1/RhoGEF- mediated RhoA activation involves the receptor tyrosine kinase ErbB-2. J. Cell Biol. 165: 869-880.
37. Toguchi, M., D. Gonzalez, S. Furukawa, and S. Inagaki. 2009. Involvement of Sema4D in the control of microglia activation. Neurochem, Int. 55: 573-580.