In vivo fluorescence imaging: A personal perspective

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology

Volumn 1, Issue 2, 2009, Pages 156-167

  Ghoroghchian, P Peter ^a   Therien, Michael J ^b   Hammer, Daniel A ^c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b DUKE UNIVERSITY   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORESCENCE IMAGING; MOLECULAR DIAGNOSTICS; NEAR INFRARED LIGHT; PERSONAL PERSPECTIVE; POST-TREATMENT MONITORING; QUANTITATIVE SCREENING; QUANTITATIVE SENSITIVITY; THERAPEUTIC APPLICATION;

DISEASES; FLUORESCENCE; IMAGING TECHNIQUES; INFRARED DEVICES; PATIENT TREATMENT;

DIAGNOSIS;

CONTRAST MEDIUM; DIAGNOSTIC AGENT; DRUG CARRIER; FLUORESCENT DYE; NANOPARTICLE;

CHEMISTRY; FLUORESCENCE MICROSCOPY; GENETIC PROCEDURES; METHODOLOGY; REVIEW; SYNTHESIS; ULTRASTRUCTURE;

CONTRAST MEDIA; DRUG CARRIERS; FLUORESCENT DYES; MICROSCOPY, FLUORESCENCE; MOLECULAR PROBE TECHNIQUES; NANOPARTICLES;

EID: 77949321399     PISSN: 19395116     EISSN: 19390041     Source Type: Journal    
DOI: 10.1002/wnan.7     Document Type: Article

References (80)

1. Weissleder R. A clearer vision for in vivo imaging. Nat Biotechnol 2001, 19(4):316-317.
2. Weissleder R, Ntziachristos V. Shedding light onto live molecular targets. Nat Med 2003, 9(1):123-128.
3. Sevick-Muraca EM, Houston JP, Gurfinkel M. Fluorescence-enhanced, near infrared diagnostic imaging with contrast agents. Curr Opin Chem Biol 2002, 6(5):642-650.
4. Ntziachristos V, Bremer C, Weissleder R. Fluorescence imaging with near-infrared light: new technological advances that enable in vivo molecular imaging. Eur Radiol 2003, 13(1):195-208.
5. Graves EE, Weissleder R, Ntziachristos V. Fluorescence molecular imaging of small animal tumor models. Curr Mol Med 2004, 4(4):419-430.
6. Licha K, Olbrich C. Optical imaging in drug discovery and diagnostic applications. Adv Drug Deliv Rev 2005, 57(8):1087-1108.
7. Rao JH, Dragulescu-Andrasi A, Yao HQ. Fluorescence imaging in vivo: recent advances. Curr Opin Biotechnol 2007, 18(1):17-25.
8. Branch RA, James JA, Read AE. Clearance of antipyrine and indocyanine green in normal subjects and in patients with chronic liver-disease. Clin Pharmacol Ther 1976, 20(1):81-89.
9. Benson RC, Kues HA. Fluorescence properties of indocyanine green as related to angiography. Phys Med Biol 1978, 23(1):159-163.
10. Desmettre T, Devoisselle JM, Mordon S. Fluorescence properties and metabolic features of indocyanine green (ICG) as related to angiography. Surv Ophthalmol 2000, 45(1):15-27.
11. Chance B. In: Alfano R.R., ed. Advances in Optical Biopsy and Optical Mammography Series. New York: New York Academy of Science, 1998, 29-45.
12. Intes X, Ripoll J, Chen Y, Nioka S, Yodh AG, et al. In vivo continuous-wave optical breast imaging enhanced with indocyanine green. Med Phys 2003, 30(6):1039-1047.
13. McBride TO, Pogue BW, Jiang SD, Osterberg UL, Paulsen KD, et al. Initial studies of in vivo absorbing and scattering heterogeneity in near-infrared tomographic breast imaging. Opt Lett 2001, 26(11):822-824.
14. Landsman MLJ, Kwant G, Mook GA, Zijlstra WG. Light-absorbing properties, stability, and spectral stabilization of indocyanine green. J Appl Physiol 1976, 40(4):575-583.
15. Licha K, Riefke B, Ntziachristos V, Becker A, Chance B, et al. Hydrophilic cyanine dyes as contrast agents for near-infrared tumor imaging: synthesis, photophysical properties and spectroscopic in vivo characterization. Photochem Photobiol 2000, 72(3):392-398.
16. Ebert B, Sukowski U, Grosenick D, Wabnitz H, Moesta KT, et al. Near-infrared fluorescent dyes for enhanced contrast in optical mammography: phantom experiments. J Biomed Opt 2001, 6(2):134-140.
17. Reynolds JS, Troy TL, Mayer RH, Thompson AB, Waters DJ, et al. Imaging of spontaneous canine mammary tumors using fluorescent contrast agents. Photochem Photobiol 1999, 70(1):87-94.
18. Hawrysz DJ, Sevick-Muraca EM. Developments toward diagnostic breast cancer imaging using nearinfrared optical measurements and fluorescent contrast agents. Neoplasia 2000, 2(5):388-417.
19. Frangioni JV. In vivo near-infrared fluorescence imaging. Curr Opin Chem Biol 2003, 7(5):626-634. 20. Achilefu S, Jimenez HN, Dorshow RB, Bugaj JE, Webb EG, et al. Synthesis, in vitro receptor binding, and in vivo evaluation of fluorescein and carbocyanine peptide-based optical contrast agents. J Med Chem 2002, 45(10):2003-2015.
20. Achilefu S, Jimenez HN, Dorshow RB, Bugaj JE, Webb EG, et al. Synthesis, in vitro receptor binding, and in vivo evaluation of fluorescein and carbocyanine peptide-based optical contrast agents. J Med Chem 2002, 45(10):2003-2015.
21. Bugaj JE, Achilefu S, Dorshow RB, Rajagopalan R. Novel fluorescent contrast agents for optical imaging of in vivo tumors based on a receptor-targeted dye-peptide conjugate platform. J Biomed Opt 2001, 6(2):122-133.
22. Bhargava S, Licha K, Knaute T, Ebert B, Becker A, et al. A complete substitutional analysis of VIP for better tumor imaging properties. J Mol Recognit 2002, 15(3):145-153.
23. Becker A, Riefke B, Ebert B, Sukowski U, Rinneberg H, et al.Macromolecular contrast agents for optical imaging of tumors: comparison of indotricarbocyaninelabeled human serum albumin and transferrin. Photochem Photobiol 2000, 72(2):234-241.
24. Hildebrandt IJ, Iyer M, Wagner E, Gambhir SS. Optical imaging of transferrin targeted PEI/DNA complexes in living subjects. Gene Ther 2003, 10(9):758-764.
25. Schellenberger EA, Bogdanov A Jr, Petrovsky A, Ntziachristos V, Weissleder R, et al. Optical imaging of apoptosis as a biomarker of tumor response to chemotherapy. Neoplasia 2003, 5(3):187-192.
26. Petrovsky A, Schellenberger E, Josephson L, Weissleder R, Bogdanov A Jr. Near-infrared fluorescent imaging of tumor apoptosis. Cancer Res 2003, 63(8):1936-1942.
27. Zheng G, Li H, Yang K, Blessington D, Licha K, et al. Tricarbocyanine cholesteryl laurates labeled LDL: new near infrared fluorescent probes (NIRFs) for monitoring tumors and gene therapy of familial hypercholesterolemia. Bioorg Med Chem Lett 2002, 12(11):1485-1488.
28. Zaheer A, Lenkinski RE, Mahmood A, Jones AG, Cantley LC, et al. In vivo near-infrared fluorescence imaging of osteoblastic activity. Nat Biotechnol 2001, 19(12):1148-1154.
29. Weissleder R, Mahmood U. Molecular imaging. Radiology 2001, 219(2):316-333.
30. Bremer C, Ntziachristos V, Weissleder R. Opticalbased molecular imaging: contrast agents and potential medical applications. Eur Radiol 2003, 13(2):231-243.
31. Gilbert A, Baggott JE. Essentials of Molecular Photochemistry. Oxford: Blackwell Science; 1991.
32. Tyagi S, Kramer FR. Molecular beacons: probes that fluoresce upon hybridization. Nat Biotechnol 1996, 14(3):303-308.
33. Achilefu S. Lighting up tumors with receptor-specific optical molecular probes. Technol Cancer Res Treat 2004, 3(4):393-409.
34. Weissleder R, Tung C-H, Mahmood U, Bogdanov A Jr. In vivo imaging of tumors with protease-activated near-infrared fluorescent probes. Nat Biotechnol 1999, 17(4):375-378.
35. Tung C-H, Bredow S, Mahmood U, Weissleder R. Preparation of a cathepsin D sensitive near-infrared fluorescence probe for imaging. Bioconjug Chem 1999, 10(5):892-896.
36. Tung C-H, Mahmood U, Bredow S, Weissleder R. In vivo imaging of proteolytic enzyme activity using a novel molecular reporter. Cancer Res 2000, 60(17):4953-4958.
37. Jaffer FA, Tung C-H, Gerszten RE, Weissleder R. In vivo imaging of thrombin activity in experimental thrombi with thrombin-sensitive near-infrared molecular probe. Arterioscler Thromb Vasc Biol 2002, 22(11):1929-1935.
38. Ntziachristos V, Tung C-H, Bremer C, Weissleder R. Fluorescence molecular tomography resolves protease activity in vivo. Nat Med 2002, 8(7):757-761.
39. Funovics M, Weissleder R, Tung C-H. Protease sensors for bioimaging. Anal Bioanal Chem 2003, 377(6):956-963.
40. Schuster B. Polymeric nanoparticles as imaging probes for protein kinase activity in cells. Angew Chem Int Ed 2007, 46(46):8744-8746.
41. Dubertret B, Skourides P, Norris DJ, Noireaux V, Brivanlou AH, et al. In vivo imaging of quantum dots encapsulated in phospholipid micelles. Science 2002, 298(5599):1759-1762.
42. Gao X, Cui Y, Levenson RM, Chung LWK, Nie S. In vivo cancer targeting and imaging with semiconductor quantum dots. Nat Biotechnol 2004, 22(8):969-976.
43. Smith AM, Gao X, Nie S. Quantum dot nanocrystals for in vivo molecular and cellular imaging. Photochem Photobiol 2004, 80((Nov/Dec)):377-385.
44. Michalet X, Pinaud FF, Bentolila LA, Tsay JM, Doose S, et al. Quantum dots for live cells, in vivo imaging, and diagnostics. Science 2005, 307(5709):538-544.
45. Santra S, Dutta D, Walter GA, Moudgil BM. Fluorescent nanoparticle probes for cancer imaging. Technol Cancer Res Treat 2005, 4(6):593-602.
46. Kim S, Lim YT, Soltesz EG, De Grand AM, Lee J, et al. Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping. Nat Biotechnol 2004, 22(1):93-97.
47. Chan WCW, Nile S. Quantum dot bioconjugates for ultrasensitive nonisotopic detection. Science 1998, 281(5385):2016-2018.
48. Han M, Gao X, Su JZ, Nie S. Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules. Nat Biotechnol 2001, 19(7):631-635.
49. Schellenberger EA, Reynolds F, Weissleder R, Josephson L. Surface-functionalized nanoparticle library yields probes for apoptotic cells. Chembiochem 2004, 5(3):275-279.
50. Frangioni JV. Self-illuminating quantum dots light the way. Nat Biotechnol 2006, 24(3):326-328.
51. Lin VS-Y, Dimagno SG, Therien MJ. Highly conjugated, acetylenyl bridged porphyrins - new models for light-harvesting antenna systems. Science 1994, 264(5162):1105-1111.
52. Lin VS-Y, Therien MJ. The role of porphyrin-toporphyrin linkage topology in the extensive modulation of the absorptive and emissive properties of a series of ethynyl-and butadiynyl-bridged bis-and tris(porphinato)zinc chromophores. Chem Eur J 1995, 1(9):645-651.
53. Angiolillo PJ, Lin VSY, Vanderkooi JM, Therien MJ. EPR spectroscopy and photophysics of the lowest photoactivated triplet state of a series of highly conjugated (porphinato)Zn arrays. J Am Chem Soc 1995, 117(50):12514-12527.
54. Susumu K, Therien MJ. Decoupling optical and potentiometric band gaps in pi-conjugated materials. J Am Chem Soc 2002, 124(29):8550-8552.
55. Rubtsov IV, Susumu K, Rubtsov GI, Therien MJ. Ultrafast singlet excited-state polarization in electronically asymmetric ethyne-bridged bis[(porphinato)zinc(II)] complexes. J Am Chem Soc 2003, 125(9):2687-2696.
56. Duncan TV, Susumu K, Sinks LE, Therien MJ. Exceptional near-infrared fluorescence quantum yields and excited-state absorptivity of highly conjugated porphyrin arrays. J Am Chem Soc 2006, 128(28):9000-9001.
57. Susumu K, Frail PR, Angiolillo PJ, Therien MJ. Conjugated chromophore arrays with unusually large hole polaron delocalization lengths. J Am Chem Soc 2006, 128(26):8380-8381.
58. Wu SP, Lee I, Ghoroghchian PP, Frail PR, Zheng G, et al. Near-infrared optical Imaging of B16 melanoma cells via low-density lipoprotein-mediated uptake and delivery of high emission dipole strength tris (porphinato) zinc(II) fluorophores. Bioconjug Chem 2005, 16(3):542-550.
59. Discher BM, Won YY, Ege DS, Lee JCM, Bates FS, et al. Polymersomes: tough vesicles made from diblock copolymers. Science 1999, 284(5417):1143-1146.
60. Discher DE, Eisenberg A. Polymer vesicles. Science 2002, 297(5583):967-973.
61. Kita-Tokarczyk K, Grumelard J, Haefele T, Meier W. Block copolymer vesicles-using concepts from polymer chemistry to mimic biomembranes. Polymer 2005, 46(11):3540-3563.
62. Mecke A, Dittrich C,Meier W. Biomimetic membranes designed from amphiphilic block copolymers. Soft Matter 2006, 2(9):751-759.
63. Letchford K, Burt H. A review of the formation and classification of amphiphilic block copolymer nanoparticulate structures: micelles, nanospheres, nanocapsules and polymersomes. Eur J Pharm Biopharm 2007, 65(3):259-269.
64. Ghoroghchian PP, Frail PR, Susumu K, Blessington D, Brannan AK, et al. Near-infrared-emissive polymersomes: self-assembled soft matter for in vivo optical imaging. Proc Natl Acad Sci U S A 2005, 102(8):2922-2927.
65. Ghoroghchian PP, Lin JJ, Brannan AK, Frail PR, Bates FS, et al. Quantitativemembrane loading of polymer vesicles. Soft Matter 2006, 2(11):973-980.
66. Ghoroghchian PP, Frail PR, Susumu K, Park TH, Wu SP, et al. Broad spectral domain fluorescence wavelength modulation of visible and near-infrared emissive polymersomes. J Am Chem Soc 2005, 127(44):15388-15390.
67. Duncan TV, Ghoroghchian PP, Rubtsov GI, Hammer DA, Therien MJ. Ultrafast excited state dynamics of nanoscale near infrared emissive polymersomes. J Am Chem Soc 2008, 130(30):9773-9784.
68. Ghoroghchian PP, Li GZ, Levine DH, Davis KP, Bates FS, et al. Bioresorbable vesicles formed through spontaneous self-assembly of amphiphilic poly(ethylene oxide)-block-polycaprolactone. Macromolecules 2006, 39(5):1673-1675.
69. Zupancich JA, Bates FS, Hillmyer MA. Aqueous dispersions of poly(ethylene oxide)-b-poly(γ-methyl-ε-caprolactone) block copolymers. Macromolecules 2006, 39(13):4286-4288.
70. Ghoroghchian PP, Frail PR, Li GZ, Zupancich JA, Bates FS, et al. Controlling bulk optical properties of emissive polymersomes through intramembranous polymer-fluorophore interactions. Chem Mater 2007, 19(6):1309-1318.
71. Wagnieres G, Cheng SG, Zellweger M, Utke N, Braichotte D, et al. An optical phantom with tissue-like properties in the visible for use in PDT and fluorescence spectroscopy. Phys Med Biol 1997, 42(7):1415-1426.
72. Iizuka MN, Sherar MD, Vitkin IA. Optical phantom materials for near infrared laser photocoagulation studies. Lasers Surg Med 1999, 25(2):159-169.
73. Ebert B, Sukowski U, Grosenick D, Wabnitz H, Moesta TK, et al. Near-infrared fluorescent dyes for enhanced contrast in optical mammography: phantom experiments. J Biomed Opt 2001, 6(2):134-140.
74. Eidsath A, Chernomordik V, Gandjbakhche A, Smith P, Russo A. Three-dimensional localization of fluorescent masses deeply embedded in tissue. Phys Med Biol 2002, 47(22):4079-4092.
75. Fabbri F, Franceschini MA, Fantini S. Characterization of spatial and temporal variations in the optical properties of tissuelike media with diffuse reflectance imaging. Appl Opt 2003, 42(16):3063-3072.
76. Pfefer TJ, Matchette LS, Bennett CL, Gall JA, Wilke JN, et al. Reflectance-based determination of optical properties in highly attenuating tissue. J Biomed Opt 2003, 8(2):206-215.
77. Drakaki E, Psycharakis S, Makropolou M, Serafetinides AA. Optical properties and chromophore concentration measurements in tissue-like phantoms. Opt Commun 2005, 254(1-3):40-51.
78. Degrand AM, Lomnes SJ, Lee DS, Pietrzykowski M, Ohnishi S, et al. Tissue-like phantoms for near-infrared fluorescence imaging system assessment and the training of surgeons. J BiomedOpt 2006, 11(1):5581-5590.
79. Lin JJ, Ghoroghchian P, Zhang Y, Hammer DA. Adhesion of antibody-functionalized polymersomes. Langmuir 2006, 22(9):3975-3979.
80. Hammer DA, Robbins GR, Lin JJ, Smith LA, Ghoroghchian PP, Therien MJ, Bates FS. Leukopolymersomes. Faraday Disc 2008, 139():129-141.