메뉴 건너뛰기




Volumn 46, Issue 1, 2010, Pages 11-19

Cytochrome P450 expression profile of the PICM-19H pig liver cell line: Potential application to rapid liver toxicity assays

Author keywords

Cell; Cytochrome; Hepatocyte; Liver; Toxicology

Indexed keywords

AFLATOXIN B1; CYTOCHROME P450; ISOENZYME; PARACETAMOL; TESTOSTERONE;

EID: 77949274511     PISSN: 10712690     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11626-009-9244-z     Document Type: Article
Times cited : (10)

References (37)
  • 1
    • 14844320510 scopus 로고    scopus 로고
    • In vitro zonation and toxicity in a hepatocyte bioreactor
    • 10.1093/toxsci/kfi052 1:CAS:528:DC%2BD2MXhsFSnsbY%3D 15590888
    • JW Allen SR Khetani SN Bhatia 2005 In vitro zonation and toxicity in a hepatocyte bioreactor Toxicol Sci 84 110 119 10.1093/toxsci/kfi052 1:CAS:528:DC%2BD2MXhsFSnsbY%3D 15590888
    • (2005) Toxicol Sci , vol.84 , pp. 110-119
    • Allen, J.W.1    Khetani, S.R.2    Bhatia, S.N.3
  • 2
    • 0030935086 scopus 로고    scopus 로고
    • Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions
    • 10.2165/00003088-199732030-00004 1:CAS:528:DyaK2sXisV2ks7s%3D 9084960
    • RJ Bertz GR Granneman 1997 Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions Clin Pharmacokinet 32 210 258 10.2165/00003088-199732030-00004 1:CAS:528:DyaK2sXisV2ks7s%3D 9084960
    • (1997) Clin Pharmacokinet , vol.32 , pp. 210-258
    • Bertz, R.J.1    Granneman, G.R.2
  • 3
    • 0022290181 scopus 로고
    • Isolation and culture of parenchymal and nonparenchymal cells from neonatal swine liver
    • 1:CAS:528:DyaL28XmsFentw%3D%3D 4086406
    • TJ Caperna ML Failla ET Kornegay MP Richards NC Steele 1985 Isolation and culture of parenchymal and nonparenchymal cells from neonatal swine liver J Anim Sci 61 1576 1586 1:CAS:528:DyaL28XmsFentw%3D%3D 4086406
    • (1985) J Anim Sci , vol.61 , pp. 1576-1586
    • Caperna, T.J.1    Failla, M.L.2    Kornegay, E.T.3    Richards, M.P.4    Steele, N.C.5
  • 4
    • 26244431663 scopus 로고    scopus 로고
    • Hormonal regulation of leptin receptor expression in primary cultures of porcine hepatocytes
    • 10.1016/j.domaniend.2005.03.005 1:CAS:528:DC%2BD2MXhtVyms7%2FL 16213991
    • TJ Caperna AE Shannon SM Poch WM Garrett MP Richards 2005 Hormonal regulation of leptin receptor expression in primary cultures of porcine hepatocytes Domest Anim Endocrinol 29 582 592 10.1016/j.domaniend.2005.03.005 1:CAS:528:DC%2BD2MXhtVyms7%2FL 16213991
    • (2005) Domest Anim Endocrinol , vol.29 , pp. 582-592
    • Caperna, T.J.1    Shannon, A.E.2    Poch, S.M.3    Garrett, W.M.4    Richards, M.P.5
  • 5
    • 0029002112 scopus 로고
    • Cytotoxicity of acetaminophen in human cytochrome P4502E1-transfected HepG2 cells
    • 1:CAS:528:DyaK2MXmsVCnsrg%3D 7791125
    • Y Dai AI Cederbaum 1995 Cytotoxicity of acetaminophen in human cytochrome P4502E1-transfected HepG2 cells J Pharmacol Exp Ther 273 1497 1505 1:CAS:528:DyaK2MXmsVCnsrg%3D 7791125
    • (1995) J Pharmacol Exp Ther , vol.273 , pp. 1497-1505
    • Dai, Y.1    Cederbaum, A.I.2
  • 6
    • 0038171278 scopus 로고    scopus 로고
    • Phase II in vitro metabolism of 3-methylindole metabolites in porcine liver
    • 10.1080/0049825031000076186 1:CAS:528:DC%2BD3sXjvV2ktL8%3D 12746105
    • GJ Diaz EJ Squires 2003 Phase II in vitro metabolism of 3-methylindole metabolites in porcine liver Xenobiotica 33 485 498 10.1080/0049825031000076186 1:CAS:528:DC%2BD3sXjvV2ktL8%3D 12746105
    • (2003) Xenobiotica , vol.33 , pp. 485-498
    • Diaz, G.J.1    Squires, E.J.2
  • 8
    • 0033199820 scopus 로고    scopus 로고
    • Characterization of drug metabolizing activities in pig hepatocytes for use in bioartificial liver devices: Comparison with other hepatic cellular models
    • 10.1016/S0168-8278(99)80049-X 1:CAS:528:DyaK1MXmtFKns74%3D 10488716
    • MT Donato JV Castell MJ Gómez-Lechón 1999 Characterization of drug metabolizing activities in pig hepatocytes for use in bioartificial liver devices: comparison with other hepatic cellular models J Hepatol 31 542 549 10.1016/S0168-8278(99)80049-X 1:CAS:528:DyaK1MXmtFKns74%3D 10488716
    • (1999) J Hepatol , vol.31 , pp. 542-549
    • Donato, M.T.1    Castell, J.V.2    Gómez-Lechón, M.J.3
  • 9
    • 0027275495 scopus 로고
    • A microassay for measuring cytochrome P450IA1 and P450IIB1 activities in intact human and rat hepatocytes cultured on 96-well plates
    • 10.1006/abio.1993.1381 1:CAS:528:DyaK3sXlsFCmsLo%3D 8238878
    • MT Donato MJ Gómez-Lechón JV Castell 1993 A microassay for measuring cytochrome P450IA1 and P450IIB1 activities in intact human and rat hepatocytes cultured on 96-well plates Anal Biochem 213 29 33 10.1006/abio.1993.1381 1:CAS:528:DyaK3sXlsFCmsLo%3D 8238878
    • (1993) Anal Biochem , vol.213 , pp. 29-33
    • Donato, M.T.1    Gómez-Lechón, M.J.2    Castell, J.V.3
  • 10
    • 3042544349 scopus 로고    scopus 로고
    • Fluorescence-based assays for screening nine cytochrome P450 (P450) activities in intact cells expressing individual human P450 enzymes
    • 10.1124/dmd.32.7.699 1:CAS:528:DC%2BD2cXltlWqt7k%3D 15205384
    • MT Donato N Jiménez JV Castell MJ Gómez-Lechón 2004 Fluorescence-based assays for screening nine cytochrome P450 (P450) activities in intact cells expressing individual human P450 enzymes Drug Metab Dispos 32 699 706 10.1124/dmd.32.7.699 1:CAS:528:DC%2BD2cXltlWqt7k%3D 15205384
    • (2004) Drug Metab Dispos , vol.32 , pp. 699-706
    • Donato, M.T.1    Jiménez, N.2    Castell, J.V.3    Gómez-Lechón, M.J.4
  • 11
    • 18144437120 scopus 로고    scopus 로고
    • The role of insulin, glucagon, dexamethasone, and leptin in the regulation of ketogenesis and glycogen storage in primary cultures of porcine hepatocytes prepared from 60 kg pigs
    • 10.1016/j.domaniend.2004.02.003 15219932
    • I Fernández-Fígares AE Shannon D Wray-Cahen TJ Caperna 2004 The role of insulin, glucagon, dexamethasone, and leptin in the regulation of ketogenesis and glycogen storage in primary cultures of porcine hepatocytes prepared from 60 kg pigs Domest Anim Endocrinol 27 125 140 10.1016/j.domaniend. 2004.02.003 15219932
    • (2004) Domest Anim Endocrinol , vol.27 , pp. 125-140
    • Fernández-Fígares, I.1    Shannon, A.E.2    Wray-Cahen, D.3    Caperna, T.J.4
  • 12
    • 0030339769 scopus 로고    scopus 로고
    • 1 oxidation by human cDNA-expressed and human liver microsomal cytochromes P450 1A2 and 3A4 by human liver microsomes
    • 10.1006/taap.1996.0326 1:CAS:528:DyaK2sXis1yktg%3D%3D 8975785
    • 1 oxidation by human cDNA-expressed and human liver microsomal cytochromes P450 1A2 and 3A4 by human liver microsomes Toxicol Appl Pharmacol 141 595 606 10.1006/taap.1996.0326 1:CAS:528:DyaK2sXis1yktg%3D%3D 8975785
    • (1996) Toxicol Appl Pharmacol , vol.141 , pp. 595-606
    • Gallagher, E.P.1    Kunze, K.L.2    Stapleton, P.L.3    Eaton, D.L.4
  • 13
    • 4644341747 scopus 로고    scopus 로고
    • Human hepatocytes in primary culture: The choice to investigate drug metabolism in man
    • 10.2174/1389200043335414 15544436
    • MJ Gómez-Lechón MT Donato JV Castell R Jover 2004 Human hepatocytes in primary culture: the choice to investigate drug metabolism in man Curr Drug Metab 5 443 462 10.2174/1389200043335414 15544436
    • (2004) Curr Drug Metab , vol.5 , pp. 443-462
    • Gómez-Lechón, M.J.1    Donato, M.T.2    Castell, J.V.3    Jover, R.4
  • 14
    • 0031832805 scopus 로고    scopus 로고
    • Liver cell models in in vitro toxicology
    • 10.2307/3433803 1:CAS:528:DyaK1cXjsF2isr4%3D 9599700
    • A Guillouzo 1998 Liver cell models in in vitro toxicology Environ Health Perspect 106 511 532 10.2307/3433803 1:CAS:528:DyaK1cXjsF2isr4%3D 9599700
    • (1998) Environ Health Perspect , vol.106 , pp. 511-532
    • Guillouzo, A.1
  • 15
    • 0036238857 scopus 로고    scopus 로고
    • Recent developments on human cell lines for the bioartificial liver
    • 1:CAS:528:DC%2BD38XksVygs70%3D 11999190
    • R Hoekstra RA Chamuleau 2002 Recent developments on human cell lines for the bioartificial liver Int J Artif Organs 25 182 191 1:CAS:528: DC%2BD38XksVygs70%3D 11999190
    • (2002) Int J Artif Organs , vol.25 , pp. 182-191
    • Hoekstra, R.1    Chamuleau, R.A.2
  • 16
    • 0029157248 scopus 로고
    • Novel cell proliferation and cytotoxicity assays using a tetrazolium salt that produces a water-soluble formazan dye
    • 1:CAS:528:DyaK2MXntlamtL4%3D
    • M Ishiyama H Tominaga M Shiga K Sasamoto Y Ohkura K Ueno M Watanabe 1995 Novel cell proliferation and cytotoxicity assays using a tetrazolium salt that produces a water-soluble formazan dye In Vitro Toxicol 8 187 190 1:CAS:528:DyaK2MXntlamtL4%3D
    • (1995) In Vitro Toxicol , vol.8 , pp. 187-190
    • Ishiyama, M.1    Tominaga, H.2    Shiga, M.3    Sasamoto, K.4    Ohkura, Y.5    Ueno, K.6    Watanabe, M.7
  • 17
    • 33646084391 scopus 로고    scopus 로고
    • Dominant contribution of P450 3A4 to the hepatic carcinogenic activation of aflatoxin B1
    • 10.1021/tx050358e 1:CAS:528:DC%2BD28XivVChtrw%3D 16608170
    • LK Kamdem I Meineke U Gödtel-Armbrust J Brockmöller L Wojnowski 2006 Dominant contribution of P450 3A4 to the hepatic carcinogenic activation of aflatoxin B1 Chem Res Toxicol 19 577 586 10.1021/tx050358e 1:CAS:528:DC%2BD28XivVChtrw%3D 16608170
    • (2006) Chem Res Toxicol , vol.19 , pp. 577-586
    • Kamdem, L.K.1    Meineke, I.2    Gödtel-Armbrust, U.3    Brockmöller, J.4    Wojnowski, L.5
  • 18
    • 0026595997 scopus 로고
    • An improved model of acetaminophen-induced fulminant hepatic failure in dogs
    • 10.1002/hep.1840150225 1:CAS:528:DyaK38Xht1KjtL0%3D 1735538
    • JH Kelly T Koussayer DE He MG Chong TA Shang HH Whisennand NL Sussman 1992 An improved model of acetaminophen-induced fulminant hepatic failure in dogs Hepatology 15 329 335 10.1002/hep.1840150225 1:CAS:528:DyaK38Xht1KjtL0%3D 1735538
    • (1992) Hepatology , vol.15 , pp. 329-335
    • Kelly, J.H.1    Koussayer, T.2    He, D.E.3    Chong, M.G.4    Shang, T.A.5    Whisennand, H.H.6    Sussman, N.L.7
  • 19
    • 0033000310 scopus 로고    scopus 로고
    • Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and the formation of reactive oxygen and nitrogen species
    • 10.1002/hep.510300104 1:CAS:528:DyaK1MXksVOqsLY%3D 10385655
    • SL Michael NR Pumford PR Mayeux MR Niesman JA Hinson 1999 Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and the formation of reactive oxygen and nitrogen species Hepatology 30 186 195 10.1002/hep.510300104 1:CAS:528:DyaK1MXksVOqsLY%3D 10385655
    • (1999) Hepatology , vol.30 , pp. 186-195
    • Michael, S.L.1    Pumford, N.R.2    Mayeux, P.R.3    Niesman, M.R.4    Hinson, J.A.5
  • 20
    • 0001959251 scopus 로고
    • Quantification of selected intracellular and secreted hydrolases of macrophages
    • H.T. Holden J.A. Bellanti A. Ghaffer (eds). Marcel Dekker Inc. New York
    • Nerurkar L. S.; Marino P. A.; Adams D. O. Quantification of selected intracellular and secreted hydrolases of macrophages. In: Holden H. T.; Bellanti J. A.; Ghaffer A. (eds) Manual of macrophage methodology (Herscowitz HB). Marcel Dekker Inc., New York, pp 229-247; 1981.
    • (1981) Manual of Macrophage Methodology (Herscowitz HB) , pp. 229-247
    • Nerurkar, L.S.1    Marino, P.A.2    Adams, D.O.3
  • 21
    • 0028200582 scopus 로고
    • Primary hepatocytes outperform Hep G2 cells as the source of biotransformation functions in a bioartificial liver
    • 1:STN:280:DyaK2c3ps1Wktg%3D%3D 8024360
    • SL Nyberg RP Remmel HJ Mann MV Peshwa WS Hu FB Cerra 1994 Primary hepatocytes outperform Hep G2 cells as the source of biotransformation functions in a bioartificial liver Ann Surg 220 59 67 1:STN:280:DyaK2c3ps1Wktg%3D%3D 8024360
    • (1994) Ann Surg , vol.220 , pp. 59-67
    • Nyberg, S.L.1    Remmel, R.P.2    Mann, H.J.3    Peshwa, M.V.4    Hu, W.S.5    Cerra, F.B.6
  • 22
    • 0036301269 scopus 로고    scopus 로고
    • Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: Molecular mechanisms that determine lower expression in cultured cells
    • 10.1080/00498250210128675 12160483
    • C Rodríguez-Antona MT Donato A Boobis RJ Edwards PS Watts JV Castell J Gómez-Lechón 2002 Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells Xenobiotica 32 505 520 10.1080/00498250210128675 12160483
    • (2002) Xenobiotica , vol.32 , pp. 505-520
    • Rodríguez-Antona, C.1    Donato, M.T.2    Boobis, A.3    Edwards, R.J.4    Watts, P.S.5    Castell, J.V.6    Gómez-Lechón, J.7
  • 23
    • 0028237729 scopus 로고
    • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
    • 1:CAS:528:DyaK2cXlt1OmtL4%3D 8035341
    • T Shimada H Yamazaki M Mimura Y Inui FP Guengerich 1994 Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians J Pharmacol Exp Ther 270 414 423 1:CAS:528: DyaK2cXlt1OmtL4%3D 8035341
    • (1994) J Pharmacol Exp Ther , vol.270 , pp. 414-423
    • Shimada, T.1    Yamazaki, H.2    Mimura, M.3    Inui, Y.4    Guengerich, F.P.5
  • 24
    • 0034681182 scopus 로고    scopus 로고
    • Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor
    • 10.1073/pnas.97.2.779 1:CAS:528:DC%2BD3cXot1answ%3D%3D 10639156
    • Y Shimizu Y Nakatsuru M Ichinose Y Takahashi H Kume J Mimura Y Fujii-Kuriyama T Ishikawa 2000 Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor Proc Natl Acad Sci USA 97 779 782 10.1073/pnas.97.2.779 1:CAS:528:DC%2BD3cXot1answ%3D%3D 10639156
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 779-782
    • Shimizu, Y.1    Nakatsuru, Y.2    Ichinose, M.3    Takahashi, Y.4    Kume, H.5    Mimura, J.6    Fujii-Kuriyama, Y.7    Ishikawa, T.8
  • 25
    • 0032460841 scopus 로고    scopus 로고
    • Selective and organotypic culture of intrahepatic bile duct cells from adult pig liver
    • 10.1007/s11626-998-0033-x
    • NC Talbot TJ Caperna 1998 Selective and organotypic culture of intrahepatic bile duct cells from adult pig liver In Vitro Cell Dev Biol 34A 785 798 10.1007/s11626-998-0033-x
    • (1998) In Vitro Cell Dev Biol , vol.34 , pp. 785-798
    • Talbot, N.C.1    Caperna, T.J.2
  • 26
    • 0029924921 scopus 로고    scopus 로고
    • Ultrastructure, enzymatic, and transport properties of the PICM-19 bipotent liver cell line
    • 10.1006/excr.1996.0153 1:CAS:528:DyaK28XjtFOqtr8%3D 8635514
    • NC Talbot TJ Caperna LT Lebow D Moscioni VG Pursel CE Rexroad Jr 1996 Ultrastructure, enzymatic, and transport properties of the PICM-19 bipotent liver cell line Exp Cell Res 225 22 34 10.1006/excr.1996.0153 1:CAS:528:DyaK28XjtFOqtr8%3D 8635514
    • (1996) Exp Cell Res , vol.225 , pp. 22-34
    • Talbot, N.C.1    Caperna, T.J.2    Lebow, L.T.3    Moscioni, D.4    Pursel, V.G.5    Rexroad Jr, C.E.6
  • 27
    • 0036020381 scopus 로고    scopus 로고
    • The PICM-19 cell line as an in vitro model of liver bile ductules: Effects of cAMP inducers, biopeptides and pH
    • 10.1159/000063704 1:CAS:528:DC%2BD38XltVKltro%3D 12097833
    • NC Talbot TJ Caperna KD Wells 2002 The PICM-19 cell line as an in vitro model of liver bile ductules: effects of cAMP inducers, biopeptides and pH Cells Tissues Organs 171 99 116 10.1159/000063704 1:CAS:528:DC%2BD38XltVKltro%3D 12097833
    • (2002) Cells Tissues Organs , vol.171 , pp. 99-116
    • Talbot, N.C.1    Caperna, T.J.2    Wells, K.D.3
  • 28
    • 0030513690 scopus 로고    scopus 로고
    • Continuous culture of pig tissue-derived macrophages
    • 10.1007/BF00127909
    • NC Talbot MJ Paape 1996 Continuous culture of pig tissue-derived macrophages Methods Cell Sci 18 315 327 10.1007/BF00127909
    • (1996) Methods Cell Sci , vol.18 , pp. 315-327
    • Talbot, N.C.1    Paape, M.J.2
  • 29
    • 0028559461 scopus 로고
    • Colony isolation and secondary culture of fetal porcine hepatocytes on STO feeder cells
    • 10.1007/BF02639395 1:STN:280:DyaK2M3gt1WntQ%3D%3D
    • NC Talbot VG Pursel CE Rexroad Jr TJ Caperna AM Powell RT Stone 1994 Colony isolation and secondary culture of fetal porcine hepatocytes on STO feeder cells In Vitro Cell Dev Biol 30A 851 858 10.1007/BF02639395 1:STN:280:DyaK2M3gt1WntQ%3D%3D
    • (1994) In Vitro Cell Dev Biol , vol.30 , pp. 851-858
    • Talbot, N.C.1    Pursel, V.G.2    Rexroad Jr, C.E.3    Caperna, T.J.4    Powell, A.M.5    Stone, R.T.6
  • 30
    • 0027296558 scopus 로고
    • Culturing the epiblast cells of the pig blastocyst
    • 10.1007/BF02634148 1:STN:280:DyaK3szlvFCgsw%3D%3D
    • NC Talbot CE Rexroad Jr VG Pursel AM Powell ND Nel 1993 Culturing the epiblast cells of the pig blastocyst In Vitro Cell Dev Biol 29A 543 554 10.1007/BF02634148 1:STN:280:DyaK3szlvFCgsw%3D%3D
    • (1993) In Vitro Cell Dev Biol , vol.29 , pp. 543-554
    • Talbot, N.C.1    Rexroad Jr, C.E.2    Pursel, V.G.3    Powell, A.M.4    Nel, N.D.5
  • 31
    • 0028596075 scopus 로고
    • A continuous culture of pluripotent fetal hepatocytes derived from the 8-day epiblast of the pig
    • 10.1007/BF02639394 1:STN:280:DyaK2M3gt1WntA%3D%3D
    • NC Talbot CE Rexroad Jr AM Powell VG Pursel TJ Caperna SL Ogg ND Nel 1994 A continuous culture of pluripotent fetal hepatocytes derived from the 8-day epiblast of the pig In Vitro Cell Dev Biol 30A 843 850 10.1007/BF02639394 1:STN:280:DyaK2M3gt1WntA%3D%3D
    • (1994) In Vitro Cell Dev Biol , vol.30 , pp. 843-850
    • Talbot, N.C.1    Rexroad Jr, C.E.2    Powell, A.M.3    Pursel, V.G.4    Caperna, T.J.5    Ogg, S.L.6    Nel, N.D.7
  • 32
    • 0035976358 scopus 로고    scopus 로고
    • Cytotoxicity of natural compounds in hepatocyte cell culture models. the case of quaternary benzo[c]phenanthridine alkaloids
    • 10.1016/S0378-4274(01)00430-1 1:CAS:528:DC%2BD3MXotFSmu7s%3D 11701231
    • J Ulrichova Z Dvorak J Vicar J Lata J Smrzova A Sedo V Simanek 2001 Cytotoxicity of natural compounds in hepatocyte cell culture models. The case of quaternary benzo[c]phenanthridine alkaloids Toxicol Lett 125 125 132 10.1016/S0378-4274(01)00430-1 1:CAS:528:DC%2BD3MXotFSmu7s%3D 11701231
    • (2001) Toxicol Lett , vol.125 , pp. 125-132
    • Ulrichova, J.1    Dvorak, Z.2    Vicar, J.3    Lata, J.4    Smrzova, J.5    Sedo, A.6    Simanek, V.7
  • 33
    • 33645959303 scopus 로고    scopus 로고
    • Cell-based models to study hepatic drug metabolism and enzyme induction in humans
    • 10.1517/17425255.1.1.75 1:CAS:528:DC%2BD2MXmvVGhs7o%3D 16922654
    • M Vermeir P Annaert RN Mamidi D Roymans W Meuldermans G Mannens 2005 Cell-based models to study hepatic drug metabolism and enzyme induction in humans Expert Opin Drug Metab Toxicol 1 75 90 10.1517/17425255.1.1.75 1:CAS:528:DC%2BD2MXmvVGhs7o%3D 16922654
    • (2005) Expert Opin Drug Metab Toxicol , vol.1 , pp. 75-90
    • Vermeir, M.1    Annaert, P.2    Mamidi, R.N.3    Roymans, D.4    Meuldermans, W.5    Mannens, G.6
  • 34
    • 0036692549 scopus 로고    scopus 로고
    • Advantages of in vitro cytotoxicity testing by using primary rat hepatocytes in comparison with established cell lines
    • 10.2131/jts.27.229 1:CAS:528:DC%2BD38Xot1Wgu7c%3D 12238146
    • K Wang H Shindoh T Inoue I Horii 2002 Advantages of in vitro cytotoxicity testing by using primary rat hepatocytes in comparison with established cell lines J Toxicol Sci 27 229 237 10.2131/jts.27.229 1:CAS:528:DC%2BD38Xot1Wgu7c%3D 12238146
    • (2002) J Toxicol Sci , vol.27 , pp. 229-237
    • Wang, K.1    Shindoh, H.2    Inoue, T.3    Horii, I.4
  • 35
    • 0042826346 scopus 로고    scopus 로고
    • Quantitative method for hydroxytestosterone by GC/MS and its application for measurement of P450 enzyme activity
    • N Watanbe R Goda H Ochiai K Yamashita 1997 Quantitative method for hydroxytestosterone by GC/MS and its application for measurement of P450 enzyme activity J Mass Spectrom Soc Jpn 45 367 375
    • (1997) J Mass Spectrom Soc Jpn , vol.45 , pp. 367-375
    • Watanbe, N.1    Goda, R.2    Ochiai, H.3    Yamashita, K.4
  • 36
    • 0042904900 scopus 로고    scopus 로고
    • Comparison of primary human hepatocytes and hepatoma cell line HepG2 with regard to their biotransformation properties
    • 10.1124/dmd.31.8.1035 1:CAS:528:DC%2BD3sXlvVOlsLc%3D 12867492
    • S Wilkening F Stahl A Bader 2003 Comparison of primary human hepatocytes and hepatoma cell line HepG2 with regard to their biotransformation properties Drug Metab Dispos 31 1035 1042 10.1124/dmd.31.8.1035 1:CAS:528: DC%2BD3sXlvVOlsLc%3D 12867492
    • (2003) Drug Metab Dispos , vol.31 , pp. 1035-1042
    • Wilkening, S.1    Stahl, F.2    Bader, A.3
  • 37
    • 0035523337 scopus 로고    scopus 로고
    • Metabolism profiling, and cytochrome P450 inhibition & induction in drug discovery
    • 10.2174/1568026013395001 1:CAS:528:DC%2BD3MXotFaksbg%3D 11899105
    • Z Yan GW Caldwell 2001 Metabolism profiling, and cytochrome P450 inhibition & induction in drug discovery Curr Top Med Chem 1 403 425 10.2174/1568026013395001 1:CAS:528:DC%2BD3MXotFaksbg%3D 11899105
    • (2001) Curr Top Med Chem , vol.1 , pp. 403-425
    • Yan, Z.1    Caldwell, G.W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.