Effects of Nigella sativa L. and Cinnamomum zeylanicum Blume oils on some physiological parameters in streptozotocin-induced diabetic rats;Efectos de los aceites de Nigella sativa L. and Cinnamomum zeylanicum Blume sobre algunos parámetros fisiológicos en ratas diabéticas inducidas por estreptozotocina

Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas

Volumn 8, Issue 2, 2009, Pages 86-96

  Al Logmani, Ayed S ^a   Zari, Talal A ^b  

^a NORTHERN BORDER UNIVERSITY   (Saudi Arabia)

^b KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

Cinnamomum zeylanicum; Diabetes; Nigella sativa; Oil; Rats; Streptozotocin

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; CINNAMOMUM ZEYLANICUM BLUME OIL; ESSENTIAL OIL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NIGELLA SATIVA EXTRACT; PROTEIN; STREPTOZOCIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; URIC ACID;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLACK CUMIN; CHOLESTEROL BLOOD LEVEL; CINNAMOMUM ZEYLANICUM; CONTROLLED STUDY; DRUG EFFICACY; GLUCOSE BLOOD LEVEL; MALE; MEDICINAL PLANT; NONHUMAN; PROTEIN BLOOD LEVEL; RAT; STREPTOZOCIN DIABETES; TRIACYLGLYCEROL BLOOD LEVEL; URIC ACID BLOOD LEVEL;

CINNAMOMUM VERUM; NIGELLA SATIVA; RATTUS; RATTUS NORVEGICUS;

EID: 77749340742     PISSN: None     EISSN: 07177917     Source Type: Journal    
DOI: None     Document Type: Article

References (88)

1. th:49-55.
2. Al-Awadi F, Khattar M, Gumaa K. 1985. On the mechanism of the hypoglycemic effect of a plant extract. Diabetologia 28:432-434.
3. Al-Hader A, Aqel M, Hasan Z. 1993. Hypoglycaemic effects of the volatile oil of Nigella sativa seeds. Int J Pharmacognosy 31:96-100.
4. AL-Rawi M. 2007. Effect of Trifolium sp. flowers extracts on the status of liver histology of streptozotocin- induced diabetic rats. Saudi J Bio Sci 14:21-28.
5. Al-Shamaony L, Al-khazrajoi S, Twaij H. 1994. Hypoglycaemic effect of Artemisia herba alba. II. Effect of a valuable extract on some blood parameters in diabetic animals. J Ethnopharmacol 43:167-171.
6. Ananthi J, Prakasam A, Pugalendi K. 2003. Antihyperglycemic activity of Eclipta alba leaf on alloxan-induced diabetic rats. Yale J Biol Med 76:97-102.
7. Augusti K, Sheela C. 1996. Antiperoxide effect of S-allyl cysteine sulfoxide, an insulin secretagogue, in diabetic rats. Experientia 52:115-120.
8. Ballero M, Fresu I. 1993. Le plante di uso officinale nella Barbagia di Scui (Sardegna Centrale). Fitoterapia 64:141-150.
9. Bamosa A, Ali B, Sowayan S. 1997. Effect of oral ingestion of Nigella sativa seeds on some blood parameters. Saudi Pharm J 5:126-129.
10. Battaglia S. 1995. The complete guide to aromatherapy. The Perfect Potion, Virginia, Queensland.
11. Besse S, Assayag P, Delcayre C, Carré F, Cheav SL, Lecarpentier Y, Swynghedauw B. 1993. Normal and hypertrophied senescent rat heart: mechanical and molecular characteristics. Am J Physiol 265:H183-H190.
12. Bnouham M, Ziyyat A, Mekhfi H, Tahri A, Legssyer A. 2006. Medicinal plants with potential antidiabetic activity - A review of ten years of herbal medicine research (1990-2000). Int J Diab Metab 14:1-25.
13. Bolkent S, Yanardag R, Karabulut-Bulen O, Ozsoy-Sacan O. 2004. The morphological and biochemical effects of glibornuride on rat liver in experimental diabetes. Hum Exp Toxicol 23:257-264.
14. Bolkent S, Yanardag R, Tunali S. 2005. Protective effect of vanadyl sulfate on the pancreas of streptozotocin- induced diabetic rats. Diabetes Res Clin Pract 70:103-109.
15. Bopanna K, Kannan J, Sushma G, Balaram R, Rathod S. 1997. Antidiabetic and antihyperlipaemic effects of neem seed kernel powder on alloxan diabetic rabbits. Indian J Pharmacol 29:162-167.
16. Burits M, Bucar F. 2000. Antioxidant activity of Nigella sativa essential oil. Phytotherapy Res 14:323-328.
17. Campos K, Diniz Y, Cataneo A, Faine L, Alves J, Novelli E. 2003. Hypoglycaemic and antioxidant effects of onion, Allium cepa: dietary onion addition, antioxidant activity and hypoglycaemic effects on diabetic rats. Int J Food Sci Nutr 54:241-246.
18. Canonica L, Jonuni G, Scolastico C, Boriati A. 1963. The pharmacologically active principle in Nigella saliva. Gazz Chim Ital 93:1404-1407.
19. Defronzo R, Hendeler R, Simonson D. 1982. Insulin resistance is a prominent feature of insulin dependent diabetes. Diabetes 31:795-801.
20. El-Alfy T, El-Fatatry H, Toama M. 1975. Isolation and structure assignment of an antimicrobial principle from the volatile oil of Nigella sativa L. seeds. Pharmazie 30:109-111.
21. El-Dakhakhuy M. 1963. Studies on the chemical constitution of Egyptian Nigtlla sativa L. seeds. The essential oil. Planta Med 11:465-470.
22. El-Dakhakhny M. 1965. Egyptian Nigella sativa. Arzneimittel-Forsch 15:1227-1229.
23. El-Hilaly J, Tahraoui A, Israili Z, Lyoussi B. 2006. Hypolipidemic effects of acute and subchronic administration of an aqueous extract of Ajuga iva L. whole plant in normal and diabetic rats. J Ethnopharmacol 105:441-448.
24. El-Kadi A, Kandil O. 1987. The black seed (Nigella sativa) and immunity: its effect on human T cell subset. Fed Proc 46:1222.
25. El-Tahir K, Ashour M, Al-Harbi M. 1993. The cardiovascular actions of the volatile otl of the black seed (Nigella sativa) in rats: Elucidation of the mechanism of action. Gen Pharm 24:1123-1131.
26. Ernst E. 1997. Plants with hypoglycemic activity in humans. Phytomedicine 4:73-78.
27. Facchini F, Chen Y, Hollenbeck C, Reaven G. 1991. Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance, and plasma uric acid concentration. JAMA 266:3008- 3011.
28. Farouque H, Meredith L. 2003. Effects of inhibition of ATP sensitive potassium channels on metabolic vasodilation in the human forearm. Clin Sci 104:39-46.
29. Fernstrom M, Fernstrom J. 1993. Large changes in serum free tryptophan levels do not alter tryptophan levels. Studies in streptozotocin, diabetic rats. Life Sci 52:907-916.
30. Fisman E, Tenenbaum A, Motro M, Adler Y. 2004. Oral antidiabetic therapy in patients with heart disease. A cardiologic standpoint. Herz 29:290-298.
31. Ganong W. 2003. Review of medical physiology, 21st Ed., Lange Medical Books, McGraw-Hill, New York.
32. Gawronska-Szklarz B, Musial D, Pawlik A, Paprota B. 2003. Effect of experimental diabetes on pharmacokinetic parameters of lidocaine and MEGX in rats. Pol J Pharmacol 55:619-624.
33. Goodyear L, Hirshman M, Knutson S, Horton E, Horton E. 1988. Effect of exercise training on glucose homeostasis in normal and insulin-deficient diabetic rats. J Appl Physiol 65:844-851.
34. Hashim F, El-Kicy M. 1962. Nigella sativa seeds of Egypt. Pharmac Sci. United Arab Rep 3:121-133.
35. Hajhashemi V, Ghannadi A, Jafarabadi H. 2004. Black cumin seed essential oil, as a potent analgesic and antiinflammatory drug. Phyto Res 18:195-199.
36. Holman R, Turner R. 1991. Oral agents and insulin in the treatment of NIDDM. In Textbook of Diabetes. Blackwell. (Eds.), Pickup S, Williams G. Oxford, pp. 467-469.
37. Houghton P, Zarka R, Las Heras B, Hoult J 1995. Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta Med 61:33-36.
38. Howarth F, Jacobson M, Naseer O, Adeghate E. 2004. Short-term effects of streptozotocin-induced diabetes on the electrocardiogram, physical activity and body temperature in rats. Exp Physiol 90:237-245.
39. Islam S, Begun P, Ahsan T, Huque S, Ahsan M. 2004. Immunosuppressive and cytotocic properties of Nigella sativa. Phytother Res 8:395-398.
40. Jain R, Vyas C. 1975. Garlic in alloxan-induced diabetic rabbits. Am J Clin Nutr 28:684-685.
41. Jarvinen Y, Koivisto V. 1984. Insulin sensitivity in newly diagnosed type-I diabetes following ketoacidosis after a three month insulin therapy. J Clin Endocrinol Metab 59:371-378.
42. Jarvinen Y, Koivisto V. 1986. Natural course of insulin resistance in type-I diabetes. N Engl J Med 315:224-230.
43. Jayaprakasha G, Jaganmohan Rao L, Sakariah K. 1997. Chemical composition of the volatile oil from the fruits of Cinnamomum zeylanicum Blume. Flav Fragr J 12:331-333.
44. Jayaprakasha G, Jaganmohan Rao L, Sakariah K. 2000. Chemical composition of the flower oil of Cinnamomum zeylanicum Blume. J Agric Food Chem 48:4294-4295.
45. Jayaprakasha G, Negi P, Jena B, Jagan Mohan Rao L. 2007. Antioxidant and antimutagenic activities of Cinnamomum zeylanicum fruit extracts. J Food Comp Anal 20:330-336.
46. Jefferson L, Liao W, Peavy D, Miller, Appel M, Taylor J. 1983. Diabetes-induced alterations in liver protein synthesis: Changes in the relative abundance of mRNA for albumin and other plasma proteins. J Biol Chem 258:1369-1375.
47. Kameswara Rao B, Giri R, Kesavalu M, Appa Rao Ch. 1997. Herbal medicine in the management of diabetes mellitus. Manphar Vaidhya Patrika 1:33-35.
48. Kannappan S, Jayaraman T, Rajasekar P, Ravichandran M, Anuradha C. 2006 Cinnamon bark extract improves glucose metabolism and lipid profile in the fructose-fed rat. Singapore Med J 47:858-63.
49. Kham A, Safdar M, Alikhan M, Khattak K, Anderson R. 2003. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diab Care 26:3215-3218.
50. Kim S, Hyun S, Choung S. 2006. Anti- diabetic effect of cinnamon extract on blood glucose in db/db mice. J Ethnopharmacol 104:119-123.
51. Kumar G, Reddy K. 1999. Reduced nociceptive responses in mice with alloxan induced hyperglycemia after garlic (Allium sativum) treatment. Indian J Exp Biol 37:662-666.
52. Larner J. 1985. Insulin and oral hypoglycaemic drugs, glucagon. In The Pharmacological Basis of Therapeutics, (Eds.), Gilman A, Goodman L, Rall T, Murad F, Macmillan, New York, pp. 1490-1516.
53. Mahfouz M, El-Dakhakhny M. 1966. The isolation of a crystalline active principle from Nigella sativa seeds. J Pharmaceut Sci 1:9-19.
54. Mahfouz M, El-Dakhakhny M, Gemei A, Moussa H. 1962. Choleretic action of Nigella sativa seed oil. Egyp Pharmacol Bull 44:225-229.
55. Mai Le P, Benhaddou-Andaloussi A, Elimadi A, Settaf A, Cherrah Y, Haddad P. 2004. The petroleum ether extract of Nigella sativa exerts lipid-lowering and insulin-sensitizing actions in the rat. J Ethnopharmacol 94:251-259.
56. Markun J, Napoli R, Hirshman M, Davalli A, Cheatham B, Goodyear L. 1999. Effect of streptozocin-induced diabetes and ilst cell transplantation on insulin signaling in rat skeletal muscle. Endocrinol 140:106-111.
57. Meral I, Yener Z, Kahraman T, Mert N. 2001. Effect of Nigella sativa on glucose concentration, lipid peroxidation, anti-oxidant defence system and liver damaga in experimentally-induced diabetic rabbits. J Vet Med 48:593-599.
58. Navarro C, Montilla P, Martin A, Jimenez J, Utrilla P. 1993. Free radicals scavenger and antihepatotoxic activity of Rosmarinus. Planta Med 59:312-314.
59. Odetti P, Travers O, Cosso L, Noberasco G, Pronzato M, Marinariu M. 1996. Good glycemic control reduces oxidation and glycation end- products in collagen of diabetic rats. Diabetologia 39:1440-1447.
60. Ody P. 1993. The complete medicinal herbal. Viking Books. Ringwood.
61. Ohaeri O. 2001. Effect of garlic oil on the levels of various enzyme in the serum and tissue of streptozotocin diabetic rats. Bio Sci Rep 21:19-24.
62. Peavy D, Taylor J, Jefferson L. 1985. Time course of changes in albumin synthesis and mRNA in diabetic and insulin-treated diabetic rats. Am J Physiol 248: 656-663.
63. Plate A, Crankshaw D, Gallaher D. 2005. The effect of anesthesia by diethyl ether or isoflurane on activity of cytochrome P450 2E1 and P450 reductases in rat liver. Anesth Analg 101:1063-1064.
64. Pushparaj P, Tan C, Tan B. 2000. Effects of Averrhoe bilimli leaf extract on blood glucose and lipids in streptozotocin diabetic rats. J Ethnopharmacol 72:69-76.
65. Rajasekaran S, Ravi K, Savgananam K, Subramanian S. 2006. Beneficial effects of aloe vera leaf gel extract on lipid profile status in rats with streptozotocin diabetes. Clin Exp Pharmacol Physiol 33:232-237.
66. Rajasekaran S, Sivagnanam K, Subramanian S. 2005. Antioxidant effect of Aloe vera gel extract in streptozotocin-induced diabetes in rats. Pharmacol reports 57:90-96.
67. Ravi K, Ramachandra B, Subramanian S. 2004. Protective effect of Eugenia jambolana seed kernel on tissue antioxidants in streptozotocin induced diabetic rats. Biol Pharm Bull 27:1212-1217.
68. Ravi K, Rajasekaran S, Subramanian S. 2005. Antihyperlipidemic effect of Eugenia jambolana seed kernel on streptozotocin-induced diabetes in rats. Food Chem Toxicol 43:1433-1439.
69. Rchid H, Chevassus H, Nmila R, Guiral C, Petit P, Chokaïri M, Sauvaire Y. 2004. Nigella sativa extracts enhance glucose-induced insulin release from rat-isolated Langerhans islets. Fund Clin Pharmacol 18:525-529.
70. Sekar D, Sivagnanam K, Subramanian S. 2005. Antidiabetic activity of Momordica charantia seeds on streptozotocin induced diabetic rats. Pharmazie 60:383-7.
71. Senanayake U, Lee T, Wills R. 1978. Volatile constituents of cinnamon (Cinnamomum zey- lanicum) oils. J Agric Food Chem 26:822-824.
72. Sharma S, Nasir A, Prabhu K, Murthy P, Dev G. 2003. Hypoglycaemic and hypolipidemic effect of ethanolic extract of seeds of Eugenia jambolana in alloxan- induced diabetic rabbits. J Ethnopharmacol 85:201-206.
73. Singh N, Kamath V, Rajini P. 2005. Protective effect of potato peel powder in ameliorating oxidative stress in streptozotocin diabetic rats. Plant Foods Hum Nutr 60:49-54.
74. Stearns S, Tepperman H, Tepperman J. 1979. Studies on the utilization and mobilization of lipid in skeletal muscles from streptozotocin-diabetic and control rats. J Lipid Res 20:654-662.
75. Stenman S, Groop P, Laakkonen K, Wahlin-Boll E, Melander, A. 1990. Relationship between sulfonylurea dose and metabolic effect. Diabetes 39:108A.
76. Subash Babu P, Prabuseenivasan S, Ignacimuthu S. 2006. Cinnamaldehyde-A potential antidiabetic agent. Phytomedicine 14:15-22.
77. Szkudelski T. 2001. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol Res 50:537-546.
78. Tesch G, Nikolic-Paterson D. 2006. Recent insights into experimental mouse models of diabetic nephropathy. Nephron Exp Nephrol 104:57-62.
79. Tomaino A, Cimino F, Zimbalatti V, Venuti V, Sulfaro V, De Pasquale A, Saija A. 2005. Influence of heating on antioxidant activity and the chemical composition of some spice essential oils. Food Chem 89:549-554.
80. Toppozada H, Mazloum H, El-Dakhakhny M. 1965. The antibacterial properties of Nigella sativa seeds:active principle with some clinical application. J Egypt Med Assoc 48:187-202.
81. Tragl K, Reaven G. 1972. Effect of insulin deficiency on hepatic ribosomal aggregation. Diabetes 21:84-88.
82. Vats V, Yadav S, Grover J. 2004. Ethanolic extract of Ocimum sanctum leaves partially attenuates streptozotocin-induced alterations in glycogen content and carbohydrate metabolism in rats. J Ethnopharmacol 90:155-160.
83. Wallberg-Harrison H, Holoszy J. 1985. Activation of glucose transport in diabetic muscle:response to contraction and insulin. Am J Physiol 249:233-237.
84. Wanke L, Wong N. 1991. Diabetes mellitus decreases the activity of the albumin promotor in vitro. J Biol Chem 266:6068-6072.
85. Worthen D, Ghosheh O, Crooks P. 1998. The in vitro antitumor activity of some crude and purified components of Black seed Nigella sativa L. Anticancer Res 18:1527-1532.
86. Yassin M, Ashour A, Elyazji N. 2004. Alterations in body weight, protein profile, non-protein nitrogen constituents and kidney structure in diabetic rats under glibenclamide treatment. J Islam Univ Gaza 12:65-82.
87. Zaoui A, Cherrah Y, Alaoui K, Mahassine N, Amarouch H, Hassar M. 2002. Effects of Nigella sativa fixed oil on blood homeostasis in rat. J Ethnopharmacol 79:23-26.
88. Zari T, Al-Attar A. 2007. Effects of ginger and clove oils on some physiological parameters in streptozotocin- diabetic and non-diabetic rats. J Med Sci 7:267-275.