A Caenorhabditis elegans model of orotic aciduria reveals enlarged lysosome-related organelles in embryos lacking umps-1 function

FEBS Journal

Volumn 277, Issue 6, 2010, Pages 1420-1439

  Levitte, Steven ^a   Salesky, Rebecca ^a   King, Brian ^a   Coe Smith, Sage ^a   Depper, Micah ^a   Cole, Madeline ^a   Hermann, Greg J ^a  

^a LEWIS AND CLARK COLLEGE   (United States)

Author keywords

Gut granule; Lysosome related organelle; Orotic aciduria; UMPS

Indexed keywords

CARRIER PROTEIN; GREEN FLUORESCENT PROTEIN; OROTIC ACID; PROTEIN WHT 2; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; PYRIMIDINE; SYNTHETASE; UNCLASSIFIED DRUG; URIDINE 5' MONOPHOSPHATE SYNTHASE 1; URIDINE PHOSPHATE;

ACIDURIA; ALLELE; ARTICLE; BIOSYNTHESIS; CAENORHABDITIS ELEGANS; CELL COMPARTMENTALIZATION; CELL GRANULE; CELL ORGANELLE; CELL SWELLING; CYTOPLASM; EMBRYO; ENDOSOME; ENZYME MECHANISM; GENE; GENE FUNCTION; GENE MUTATION; INTESTINE CELL; LETHALITY; LYSOSOME; NONHUMAN; OSMOSIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PYR 1 GENE; REGULATORY MECHANISM; UMPS 1 GENE; UMPS GENE;

ANIMALS; BASE SEQUENCE; CAENORHABDITIS ELEGANS; CYTOPLASMIC GRANULES; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE KNOCKOUT TECHNIQUES; HUMANS; LARVA; LYSOSOMES; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; MUTATION; OROTATE PHOSPHORIBOSYLTRANSFERASE; OROTIC ACID; OROTIDINE-5'-PHOSPHATE DECARBOXYLASE; PARTICLE SIZE; PHENOTYPE;

CAENORHABDITIS ELEGANS;

EID: 77749308364     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2010.07573.x     Document Type: Article

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