Functional analysis of pyrimidine biosynthesis enzymes using the anticancer drug 5-fluorouracil in Caenorhabditis elegans

FEBS Journal

Volumn 276, Issue 17, 2009, Pages 4715-4726

  Kim, Seongseop ^a   Park, Dae Hun ^b   Kim, Tai Hoon ^a   Hwang, Moogak ^a   Shim, Jaegal ^a  

^a National Cancer Center   (South Korea)

^b Kangwon National University   (South Korea)

Author keywords

5 fluorouracil; C. elegans; UMPK; UMPS; Uridine phosphorylase

Indexed keywords

FLUOROURACIL; PROTEIN UPP 1; PYRIMIDINE DERIVATIVE; THYMIDINE PHOSPHORYLASE; UNCLASSIFIED DRUG; URIDINE; URIDINE MONOPHOSPHATE SYNTHETASE; URIDINE PHOSPHATE; URIDINE PHOSPHATE KINASE; URIDINE PHOSPHORYLASE;

ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; ENZYME ACTIVITY; GENE MUTATION; GENETIC SCREENING; HOMEOSTASIS; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYRIMIDINE SYNTHESIS; WILD TYPE; WORM;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; CAENORHABDITIS ELEGANS; DRUG RESISTANCE; FLUOROURACIL; GENE KNOCKDOWN TECHNIQUES; MULTIENZYME COMPLEXES; MUTATION; NUCLEOSIDE-PHOSPHATE KINASE; OROTATE PHOSPHORIBOSYLTRANSFERASE; OROTIDINE-5'-PHOSPHATE DECARBOXYLASE; POLYMORPHISM, SINGLE NUCLEOTIDE; PYRIMIDINES; URIDINE PHOSPHORYLASE;

CAENORHABDITIS ELEGANS; MAMMALIA; METAZOA;

EID: 68849095530     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2009.07168.x     Document Type: Article

References (37)

1. Nyhan WL (2005) Disorders of purine and pyrimidine metabolism. Mol Genet Metab 86, 25 33.
2. Maring JG, Groen HJ, Wachters FM, Uges DR de Vries EG (2005) Genetic factors influencing pyrimidine-antagonist chemotherapy. Pharmacogenomics J 5, 226 243.
3. Pinedo HM Peters GF (1988) Fluorouracil: biochemistry and pharmacology. J Clin Oncol 6, 1653 1664.
4. Banerjee D, Mayer-Kuckuk P, Capiaux G, Budak-Alpdogan T, Gorlick R Bertino JR (2002) Novel aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylate synthase. Biochim Biophys Acta 1587, 164 173.
5. Eliason JF Megyeri A (2004) Potential for predicting toxicity and response of fluoropyrimidines in patients. Curr Drug Targets 5, 383 388.
6. Ciaparrone M, Quirino M, Schinzari G, Zannoni G, Corsi DC, Vecchio FM, Cassano A, La Torre G Barone C (2006) Predictive role of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase expression in colorectal cancer patients receiving adjuvant 5-fluorouracil. Oncology 70, 366 377.
7. Pizzorno G, Cao D, Leffert JJ, Russell RL, Zhang D Handschumacher RE (2002) Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update. Biochim Biophys Acta 1587, 133 144.
8. Darnowski JW Handschumacher RE (1989) Enhancement of fluorouracil therapy by the manipulation of tissue uridine pools. Pharmacol Ther 41, 381 392.
9. Temmink OH, de Bruin M, Turksma AW, Cricca S, Laan AC Peters GJ (2007) Activity and substrate specificity of pyrimidine phosphorylases and their role in fluoropyrimidine sensitivity in colon cancer cell lines. Int J Biochem Cell Biol 39, 565 575.
10. Watanabe S Uchida T (1995) Cloning and expression of human uridine phosphorylase. Biochem Biophys Res Commun 216, 265 272.
11. Johansson M (2003) Identification of a novel human uridine phosphorylase. Biochem Biophys Res Commun 307, 41 46.
12. Cao D Pizzorno G (2004) Uridine phosophorylase: an important enzyme in pyrimidine metabolism and fluoropyrimidine activation. Drugs Today (Barc) 40, 431 443.
13. Yan R, Wan L, Pizzorno G Cao D (2006) Uridine phosphorylase in breast cancer: a new prognostic factor? Front Biosci 11, 2759 2766.
14. Ashour OM, Al Safarjalani ON, Naguib FN, Goudgaon NM, Schinazi RF el Kouni MH (2000) Modulation of plasma uridine concentration by 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase: relevance to chemotherapy. Cancer Chemother Pharmacol 45, 351 361.
15. Al Safarjalani ON, Rais R, Shi J, Schinazi RF, Naguib FN el Kouni MH (2006) Modulation of 5-fluorouracil host-toxicity and chemotherapeutic efficacy against human colon tumors by 5-(phenylthio)acyclouridine, a uridine phosphorylase inhibitor. Cancer Chemother Pharmacol 58, 692 698.
16. Deneen B, Hamidi H Denny CT (2003) Functional analysis of the EWS/ETS target gene uridine phosphorylase. Cancer Res 63, 4268 4274.
17. Miyashita H, Takebayashi Y, Eliason JF, Fujimori F, Nitta Y, Sato A, Morikawa H, Ohashi A, Motegi K, Fukumoto M et al. (2002) Uridine phosphorylase is a potential prognostic factor in patients with oral squamous cell carcinoma. Cancer 94, 2959 2966.
18. Cao D, Russell RL, Zhang D, Leffert JJ Pizzorno G (2002) Uridine phosphorylase (-/-) murine embryonic stem cells clarify the key role of this enzyme in the regulation of the pyrimidine salvage pathway and in the activation of fluoropyrimidines. Cancer Res 62, 2313 2317.
19. Cao D, Leffert JJ, McCabe J, Kim B Pizzorno G (2005) Abnormalities in uridine homeostatic regulation and pyrimidine nucleotide metabolism as a consequence of the deletion of the uridine phosphorylase gene. J Biol Chem 280, 21169 21175.
20. Haraguchi M, Tsujimoto H, Fukushima M, Higuchi I, Kuribayashi H, Utsumi H, Nakayama A, Hashizume Y, Hirato J, Yoshida H et al. (2002) Targeted deletion of both thymidine phosphorylase and uridine phosphorylase and consequent disorders in mice. Mol Cell Biol 22, 5212 5221.
21. Kim S Shim J (2008) A forward genetic approach for analyzing the mechanism of resistance to the anti-cancer drug, 5-fluorouracil, using Caenorhabditis elegans. Mol Cells 25, 119 123.
22. Kim S, Park DH Shim J (2008) Thymidylate synthase and dihydropyrimidine dehydrogenase levels are associated with response to 5-fluorouracil in Caenorhabditis elegans. Mol Cells 26, 344 349.
23. Tavernarakis N, Wang SL, Dorovkov M, Ryazanov A Driscoll M (2000) Heritable and inducible genetic interference by double-stranded RNA encoded by transgenes. Nat Genet 24, 180 183.
24. Nara T, Hshimoto T Aoki T (2000) Evolutionary implications of the mosaic pyrimidine-biosynthetic pathway in eukaryotes. Gene 257, 209 222.
25. Araki Y, Isomoto H Shirouzu K (2001) Dihydropyrimidine dehydrogenase activity and thymidylate synthase level are associated with response to 5-fluorouracil in human colorectal cancer. Kurume Med J 48, 93 98.
26. Beck A, Etienne MC, Cheradame S, Fischel JL, Formento P, Renee N Milano G (1994) A role for dihydropyrimidine dehydrogenase and thymidylate synthase in tumour sensitivity to fluorouracil. Eur J Cancer 30A, 1517 1522.
27. Osaki M, Tatebe S, Goto A, Hayashi H, Oshimura M Ito H (1997) 5-Fluorouracil (5-FU) induced apoptosis in gastric cancer cell lines: role of the p53 gene. Apoptosis 2, 221 226.
28. Yablonski MJ, Pasek DA, Han BD, Jones ME Traut TW (1996) Intrinsic activity and stability of bifunctional human UMP synthase and its two separate catalytic domains, orotate phosphoribosyltransferase and orotidine-5′- phosphate decarboxylase. J Biol Chem 271, 10704 10708.
29. Traut TW Temple BR (2000) The chemistry of the reaction determines the invariant amino acids during the evolution and divergence of orotidine 5′-monophosphate decarboxylase. J Biol Chem 275, 28675 28681.
30. Lackner MR, Kindt RM, Carroll PM, Brown K, Cancilla MR, Chen C, de Silva H, Franke Y, Guan B, Heuer T et al. (2005) Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors. Cancer Cell 7, 325 336.
31. Wicks SR, Yeh RT, Gish WR, Waterston RH Plasterk RH (2001) Rapid gene mapping in Caenorhabditis elegans using a high density polymorphism map. Nat Genet 28, 160 164.
32. Brenner S (1974) The genetics of Caenorhabditis elegans. Genetics 77, 71 94.
33. Fraser AG, Kamath RS, Zipperlen P, Martinez-Campos M, Sohrmann M Ahringer J (2000) Functional genomic analysis of C. elegans chromosome I by systematic RNA interference. Nature 408, 325 330.
34. el Kouni MH, Naguib FN, Niedzwicki JG, Iltzsch MH Cha S (1988) Uridine phosphorylase from Schistosoma mansoni. J Biol Chem 263, 6081 6086.
35. Li C, Gemma A, Minegishi Y, Matsuda K, Seike Y, Noro R, Shionoya A, Kawakami A, Ogawa N Kudoh S (2007) In vitro simulation study of individualized chemotherapy in lung cancer. J Nippon Med School (Nihon Ika Daigaku zasshi) 74, 217 222.
36. Krungkrai SR, Prapunwattana P, Horii T Krungkrai J (2004) Orotate phosphoribosyltransferase and orotidine 5′-monophosphate decarboxylase exist as multienzyme complex in human malaria parasite Plasmodium falciparum. Biochem Biophys Res Commun 318, 1012 1018.
37. Di Pierro D, Tavazzi B, Perno CF, Bartolini M, Balestra E, Calio R, Giardina B Lazzarino G (1995) An ion-pairing high-performance liquid chromatographic method for the direct simultaneous determination of nucleotides, deoxynucleotides, nicotinic coenzymes, oxypurines, nucleosides, and bases in perchloric acid cell extracts. Anal Biochem 231, 407 412.